Congenital fibrinogen kushomeka

Congenital fibrinogen kushomeka chinhu chisingawanzoitika, chakagara nhaka kusagadzikana kweropa uko iro ropa risingaputike zvakajairika. Inokanganisa protein inonzi fibrinogen. Iyi protein inodikanwa kuti ropa rigwamba.

Chirwere ichi chinokonzerwa nemajini asina kujairika. Fibrinogen inokanganiswa zvichienderana nekuti majini anogarwa sei.

• Kana iro geni risina kujairika rapfuudzwa pasi kubva kuvabereki vese, munhu anozove nekushomeka kwakazara kwefibrinogen (afibrinogenemia).
• Kana iro geni risingaenzaniswi rapfuudzwa pasi kubva kune mumwe mubereki, munhu anenge aine huwandu hwakadzikira hwefibrinogen (hypofibrinogenemia) kana dambudziko nebasa re fibrinogen (dysfibrinogenemia). Dzimwe nguva, aya maviri matambudziko e-fibrinogen anogona kuitika mumunhu mumwe chete.

Vanhu vane kushomeka kwakakwana kwefibrinogen vanogona kuve neanotevera ekubuda ropa zviratidzo:

• Kutuka zviri nyore
• Kubuda ropa kubva muhudyu mushure mekuzvarwa
• Ropa mu mucous membranes
• Kubuda ropa muuropi (zvisingawanzoitika)
• Kubuda ropa mumajoini
• Kubuda ropa kwakanyanya mushure mekukuvara kana kuvhiyiwa
• Mhino dzemhino dzisingamire nyore

Vanhu vane mwero wakadzikira wefibrinogen vanobuda ropa zvishoma uye kubuda ropa hakuna kunyanyisa. Avo vane dambudziko nebasa re fibrinogen kazhinji havana zviratidzo.

Kana mupi wako wezvehutano achifungidzira dambudziko iri, uchave nemabvunzo bvunzo kuti usimbise mhando uye kuomarara kwechirwere ichi.

Miedzo inosanganisira:

• Nguva yekubuda ropa
• Fibrinogen bvunzo uye reptilase nguva yekutarisa iyo fibrin nhanho uye mhando
• Yakasarudzika thromboplastin nguva (PTT)
• Prothrombin nguva (PT)
• Thrombin nguva

Iyi yekurapa inotevera inogona kushandiswa pakubuda ropa zvikamu kana kugadzirira kuvhiyiwa:

• Cryoprecipitate (chigadzirwa cheropa chine yakanyanyisa fibrinogen uye zvimwe zvinogwamba)
• Fibrinogen (RiaSTAP)
• Plasma (chikamu chemvura chine ropa rine zvinogwambisa)

Vanhu vane chirwere ichi vanofanirwa kuwana jekiseni rehepatitis B. Kuva neropa zhinji kunosimudza njodzi yako yekuwana hepatitis.

Ropa rakawandisa rakajairika nemamiriro aya. Izvi zvikamu zvinogona kunge zvakakomba, kana kutofa. Kubuda ropa muuropi ndiko kunokonzera kufa kwevanhu vane chirwere ichi.

Zvinetso zvinogona kusanganisira:

• Ropa rinovhara pamwe nekurapwa
• Kuvandudzwa kwemaantibhakitiriya (inhibitors) kune fibrinogen nekurapwa
• Kubuda ropa mudumbu
• Kusabvisa pamuviri
• Kubvaruka kwepleen
• Kunonoka kupora kwemaronda

Fonera mupiki wako kana tsvaga rubatsiro rwechimbichimbi kana uine kubuda ropa kwakanyanya.

Udza chiremba wako asati avhiyiwa kana iwe uchiziva kana kufungidzira kuti une chirwere chekubuda ropa.

Iyi inzvimbo yekugara nhaka. Iko hakuna kunozivikanwa kudzivirira.

Afibrinogenemia; Hypofibrinogenemia; Dysfibrinogenemia; Chinhu ini kushomeka

Gailani D, Wheeler AP, Neff AT. Kazhinji coagulation factor kushaikwa. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits. 137.

Ragni MV. Hemorrhagic kusagadzikana: coagulation factor kushomeka. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 174.