Kuberekwa nephrotic syndrome

Congenital nephrotic syndrome chirwere chinopfuura nemumhuri umo mwana anova neprotein mumuguta uye kuzvimba kwemuviri.

Congenital nephrotic syndrome ndeye autosomal yakawandisa geni kusagadzikana. Izvi zvinoreva kuti mubereki wega wega anofanirwa kupfuudza kopi yemagenhi asina kukwana kuitira kuti mwana awane chirwere.

Kunyangwe hazvo congenital zvinoreva zviripo kubva pakuzvarwa, uye negengen nephrotic syndrome, zviratidzo zvechirwere zvinoitika mumwedzi mitatu yekutanga yehupenyu.

Congenital nephrotic syndrome isiri nzira isingawanzoitika yeephrotic syndrome.

Nephrotic syndrome iboka rezviratidzo zvinosanganisira:

• Mapuroteni mumurini
• Mapuroteni eropa mashoma muropa
• Yakakwira cholesterol mazinga
• Yakakwirira triglyceride mazinga
• Kuzvimba

Vana vane chirwere ichi vane chimiro chisina kujairika cheprotein inonzi nephrin. Mafirita eitsvo (glomeruli) anoda protein iyi kuti ishande zvakajairika.

Zviratidzo zvephrotic syndrome zvinosanganisira:

• Kukosora
• Yakaderera weti kubuda
• Kupenga furo weti
• Kurema kwekuzvarwa uremu
• Chido chisina kunaka
• Kuzvimba (muviri wese)

Iyo ultrasound inoitwa pana amai vane nhumbu inogona kuratidza yakakura-kupfuura-yakajairwa placenta. Iyo placenta inhengo inokura panguva yepamuviri yekupa mwana ari kukura kukura.

Vanamai vane nhumbu vanogona kuita bvunzo yekuongorora inoitwa panguva yekuzvitakura kuti vatarise mamiriro aya. Iyo bvunzo inotarisa yakakwira-kupfuura-yakajairwa mazinga ealpha-fetoprotein mune imwe sampuro yeamniotic fluid. Genetic bvunzo dzinobva dzashandiswa kusimbisa kuongororwa kana bvunzo yekuongorora iri yakanaka.

Mushure mekuzvarwa, mucheche acharatidza zviratidzo zvekuchengetwa kwemvura kwakanyanya uye kuzvimba. Anopa hutano anonzwa manzwi asina kujairika kana achiteerera kumoyo wemapapu nemapapu ane stethoscope. Kuwedzera kweropa kunogona kunge kwakakwira. Panogona kunge paine zviratidzo zvekushaya kudya zvinovaka muviri.

Kuongorora urinalis kunoratidza mafuta uye akawanda mapuroteni mumuti. Yakazara mapuroteni muropa anogona kunge ari mashoma.

Kurapa kwekutanga uye nehasha kunodiwa kudzora kusagadzikana uku.

Kurapa kunogona kusanganisira:

• Mishonga inorwisa mabhakitiriya kudzora hutachiona
• Ropa rekumanikidza mishonga inonzi angiotensin-inoshandura enzyme (ACE) inhibitors uye angiotensin receptor blockers (ARBs) kudzikisa huwandu hweproteinini inodonha mumuti
• Diuretics ("mapiritsi emvura") kubvisa zvakawandisa mvura
• NSAIDs, senge indomethacin, kudzikisa huwandu hweproteinini inodonha mumuti

Fluid inogona kugumirwa kubatsira kudzora kuzvimba.

Mupiro anogona kukurudzira kubvisa itsvo kumisa kurasikirwa kweprotein. Izvi zvinogona kuteverwa nedialysis kana kuiswa kweitsvo.

Iyo hosha inowanzo kutungamira kuhutachiona, kushomeka kwezvakakwana, uye itsvo kutadza. Inogona kutungamira kurufu nezera rechishanu, uye vana vazhinji vanofa mukati megore rekutanga. Congenital nephrotic syndrome inogona kudzorwa mune dzimwe nguva nekutanga uye nehasha kurapwa, kusanganisira yekutanga itsvo kupinza.

Zvinetso zveichi chiitiko zvinosanganisira:

• Yakakomba itsvo kutadza
• Ropa rinovhara
• Kusingaperi itsvo kutadza
• End-danho chirwere cheitsvo
• Kazhinji, zvakakomba hutachiona
• Kushaya zvinovaka muviri uye zvimwewo zvirwere

Fonera waunopa kana mwana wako aine zviratidzo zvekuberekwa nephrotic syndrome.

Nephrotic syndrome - yekuzvarwa

• Yechikadzi weti turakiti
• Varume urinary turakiti

Erkan E. Nephrotic chirwere. Mune: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Chinyorwa chePediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020: chap 545.

Schlöndorff J, Pollak MR. Nhaka kusagadzikana kweiyo glomerulus. Mune: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner uye Rector Iyo Itsvo. 11th ed. Philadelphia, PA: Elsevier; 2020: chitsiko 43.

Vogt BA, Springel T. Iyo itsvo uye weti turakiti yeaneonate. Mune: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff naMartin's Neonatal-Perinatal Mushonga: Zvirwere zveMucheche neMucheche. 11th ed. Philadelphia, PA: Elsevier; 2020: chits. 93.