Porphyrins kuongororwa kweropa

Porphyrins anobatsira kuumba zvinhu zvakawanda zvakakosha mumuviri. Imwe yeiyi hemoglobin. Iyi ndiyo protein iri mumasero matsvuku eropa anotakura okisijeni muropa.

Porphyrins inogona kuyerwa muropa kana weti. Ichi chinyorwa chinokurukura kuongororwa kweropa.

Muenzaniso weropa unodiwa.

Muenzaniso wacho unobva waiswa muchando woendeswa pakarepo murabhoritari. Matatu porphyrins anowanzo kuyerwa muzvishoma muropa remunhu. Vari:

• Coproporphyrin
• Protoporphyrin (PROTO)
• Uroporphyrin

Protoporphyrin inowanzo kuwanikwa mune yakanyanya mwero. Mimwe miedzo inodiwa kuratidza iwo mazinga eakananga porphyrins.

Iwe haufanire kudya kwemaawa gumi nemaviri kusvika gumi nemana usati waedzwa uyu. Unogona kunwa mvura usati waedzwa. Mhedzisiro yako inogona kukanganisika kana iwe ukasateedzera aya mirairo.

Kana tsono ikaiswa kukweva ropa, vamwe vanhu vanonzwa kurwadziwa zvine mwero. Vamwe vanongonzwa kubaya kana kubaya. Mushure meizvozvo, panogona kuve nekurohwa kana kupwanya zvishoma. Izvi zvinokurumidza kuenda.

Uyu muedzo unoshandiswa kuongorora porphyrias. Iri iboka rezvirwere zvisingawanzoitika zvinowanzo pfuudzwa kuburikidza nenhengo dzemhuri.

Inogona zvakare kushandiswa pamwe chete nedzimwe bvunzo kuongorora huturu hwehutobvu uye imwe hunyanzvi system uye kusagadzikana kweganda.

Uyu bvunzo unonyatso kuyera huwandu hwe porphyrin mazinga. Asi, mareferensi ehunhu (huwandu hwetsika dzinoonekwa muboka revanhu vane hutano) yezvinhu zvega zvinosanganisirwa.

• Yese porphyrin mazinga: 0 kusvika 1.0 mcg / dL (0 kusvika 15 nmol / L)
• Chikamu cheCoproporphyrin: 2 mcg / dL (30 nmol / L)
• Protoporphyrin level: 16 kusvika 60 mcg / dL (0.28 kusvika 1.07 7mol / L)
• Chikamu cheUroporphyrin: 2 mcg / dL (2.4 nmol / L)

Zvakajairika kukosha masenduru anogona kusiyana zvishoma pakati pemarabhoritari akasiyana. Mamwe marabhu anoshandisa zviyero zvakasiyana kana kuyedza akasiyana sampuli. Taura nachiremba wako nezve zvinorehwa nemimwe miedzo yako.

Yakawedzera mazinga eopoproporphyrins anogona kunge ari chiratidzo che:

• Kuberekwa erythropoietic porphyria
• Hepatic koproporphyria
• Sideroblastic kupererwa neropa
• Variegate porphyria

Yakawedzera protoporphyrin level inogona kunge iri chiratidzo che:

• Anemia yechirwere chisingaperi
• Kuberekwa erythropoietic protoporphyria
• Kuwedzera erythropoiesis
• Utachiona
• Iron kushomeka anemia
• Kutungamira muchetura
• Sideroblastic kupererwa neropa
• Thalassemia
• Variegate porphyria

Yakawedzera uroporphyrin level inogona kunge iri chiratidzo che:

• Kuberekwa erythropoietic porphyria
• Porphyria cutanea tarda

Pane njodzi shoma inosanganisirwa nekutorwa kweropa rako. Tsinga uye tsinga zvinosiyana muhukuru kubva kumunhu kuenda kune mumwe, uye kubva kune rimwe divi remuviri kuenda kune rimwe. Kuwana muyero weropa kubva kune vamwe vanhu kunogona kunetsa kupfuura kune vamwe.

Dzimwe njodzi dzinosangana nekutorwa kweropa idiki, asi dzinogona kusanganisira:

• Kuwedzera kubuda ropa
• Kufenda kana kunzwa kushaya musoro
• Akawanda punctures ekutsvaga mutsinga
• Hematoma (ropa rinoungana pasi peganda)
• Utachiona (hushoma njodzi chero nguva ganda parinovhunika)

Protoporphyrin mazinga; Porphyrins - yakazara; Coproporphyrin mazinga; PROTO bvunzo

• Kuongorora ropa

Chernecky CC, Berger BJ. Porphyrins, huwandu - ropa. Mune: Chernecky CC, Berger BJ, eds. Rabhoritari Kuyedza uye Maitiro Ekuongorora. 6th ed. St Louis, MO: Elsevier Saunders; 2013: 891-892.

Yakazara SJ, Wiley JS. Heme biosynthesis uye kusagadzikana kwayo: porphyrias uye sideroblastic anemias. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chitsiko 38.