Hemoglobin electrophoresis

Hemoglobin ipuroteni inotakura oxygen muropa. Hemoglobin electrophoresis inoyera matanho emhando dzakasiyana dzeeprotein iri muropa.

Muenzaniso weropa unodiwa.

Mubazi, nyanzvi inoisa muyero weropa papepa rakakosha uye woisa magetsi. Mahemoglobini anofamba pamapepa uye ogadzira mabhendi anoratidza huwandu hwerudzi rumwe nerumwe rwehemoglobin.

Hapana gadziriro yakasarudzika inodikanwa bvunzo iyi.

Kana tsono ikaiswa kukweva ropa, vamwe vanhu vanonzwa kurwadziwa zvine mwero. Vamwe vanongonzwa kubaya kana kuruma. Mushure meizvozvo, panogona kuve nekurohwa kana kupwanya zvishoma. Izvi zvinokurumidza kuenda.

Unogona kuve nemuyedzo uyu kana wako wekuchengetedza hutano achifungidzira kuti une chirwere chinokonzerwa nemaitiro asina kujairika ehemoglobin (hemoglobinopathy).

Mhando dzakasiyana dzakasiyana dzehemoglobin (Hb) dziripo. Iwo akajairika ndeaya HbA, HbA2, HbE, HbF, HbS, HbC, HbH, uye HbM. Vanhu vakuru vane hutano vanongova nematanho akakosha eiyo chete HbA uye HbA2.

Vamwe vanhu vanogona zvakare kuve nemari shoma yeHbF. Iyi ndiyo mhando huru yehemoglobin mumuviri wemwana asati azvarwa. Zvimwe zvirwere zvinosanganiswa nehupamhi hweHbF (apo HbF inopfuura 2% yeiyo hemoglobin yakazara).

HbS chimiro chisina kujairika chehemoglobin inosanganisirwa nejeko cell anemia. Muvanhu vane chirwere ichi, masero matsvuku eropa dzimwe nguva ane chimiro kana chejere. Aya maseru anoputsa zviri nyore kana anogona kuvhara tsinga dzeropa diki.

HbC chimiro chisina kujairika chehemoglobin inosangana nehemolytic anemia. Zviratidzo zvacho zvakanyanyisa kupfuura zvavari muchirwere chesero anemia.

Zvimwe, zvishoma zvakajairika, zvisina kujairika Hb mamorekuru anokonzeresa mamwe marudzi eanemia.

Muvanhu vakuru, izvi ndizvo zvakajairwa zvikamu zvakasiyana zvehemoglobin mamorekuru:

• HbA: 95% kusvika 98% (0.95 kusvika 0.98)
• HbA2: 2% kusvika 3% (0.02 kusvika 0.03)
• HbE: Kusipo
• HbF: 0.8% kusvika 2% (0.008 kusvika 0.02)
• HbS: Kusipo
• HbC: Kusipo

Mune vacheche nevana, izvi zvakajairika muzana maHbF mamorekuru:

• HbF (achangozvarwa): 50% kusvika 80% (0.5 kusvika 0.8)
• HbF (mwedzi mitanhatu): 8%
• HbF (inopfuura mwedzi mitanhatu): 1% kusvika 2%

Zvakajairika kukosha masenduru anogona kusiyana zvishoma pakati pemarabhoritari akasiyana. Mamwe marabhu anoshandisa zviyero zvakasiyana kana anogona kuyedza masampuli akasiyana. Taura nemupi wako nezve zvinorehwa nemimwe miedzo yako.

Matanho akakosha easina kujairika hemoglobin anogona kuratidza:

• Hemoglobin C chirwere
• Kazhinji hemoglobinopathy
• Sickle cell anemia
• Yakagara nhaka kusagadzikana kweropa umo muviri unoita isina kujairika fomu yehemoglobin (thalassemia)

Iwe unogona kunge uine manyepo akajairika kana asina kujairika mhedzisiro kana iwe wakambowedzerwa ropa mukati memasvondo gumi nemaviri ebvunzo uyu.

Pane njodzi shoma inosanganisirwa nekutorwa kweropa rako. Tsinga uye tsinga zvinosiyana muhukuru kubva kumunhu kuenda kune mumwe uye kubva kune rimwe divi remuviri kuenda kune rimwe. Kutora ropa kubva kune vamwe vanhu kunogona kunge kwakaoma kupfuura kubva kune vamwe.

Dzimwe njodzi dzinosangana nekutorwa kweropa idiki asi dzinogona kusanganisira:

• Kuwedzera kubuda ropa
• Kufenda kana kunzwa kushaya musoro
• Hematoma (kuwanda kweropa pasi peganda)
• Utachiona (hushoma njodzi chero nguva ganda parinovhunika)

Hb electrophoresis; Hgb electrophoresis; Electrophoresis - hemoglobin; Thallasemia - electrophoresis; Sickle cell - electrophoresis; Hemoglobinopathy - electrophoresis

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Elghetany MT, Schexneider KI, Banki K. Erythrocytic kusagadzikana. Mune: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis uye Management nemaLabhoritari Maitiro. 23rd ed. St Louis, MO: Elsevier; 2017: chits. 32.

Zvinoreva RT. Kusvika kune anemias. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chitsiko 149.