Munyori: William Ramirez
Zuva Rekusika: 16 Gunyana 2021
Gadziridza Zuva: 16 Mbudzi 2024
Anonim
What Doctors are saying about CBD? | Cannabidiol
Vhidhiyo: What Doctors are saying about CBD? | Cannabidiol

Zvemukati

Cannabidiol imakemikari muCannabis sativa chirimwa, inozivikanwawo sembanje kana hemp. Anopfuura makumi masere emakemikari, anozivikanwa se cannabinoids, akaonekwa muCannabis sativa chirimwa. Nepo delta-9-tetrahydrocannabinol (THC) iri chinhu chikuru chinobatira mbanje, cannabidiol inowanikwawo kubva kuhemp, iyo inongova nemari shoma kwazvo yeTC.

Kupasiswa kweBurazi Bhiri ra2018 kwakaita kuti zvive pamutemo kutengesa hemp uye hemp zvigadzirwa muU.S. Asi hazvireve kuti zvese zvigadzirwa zvehemp-zvinotorwa zve cannabidiol zviri pamutemo. Sezvo cannabidiol yakadzidzwa semushonga mutsva, haigone kuverengerwa zviri pamutemo muzvikafu kana zvekuwedzera zvekudya. Zvakare, cannabidiol haigone kuverengerwa muzvigadzirwa zvakashambadzirwa nezvirango zvekurapa. Cannabidiol inogona chete kuverengerwa mu "cosmetic" zvigadzirwa uye chete kana iine isingasviki 0.3% THC. Asi pane zvimwe zvigadzirwa zvakanyorwa sekudya zvinowedzera pamusika zvine cannabidiol. Huwandu hwe cannabidiol iri mune izvi zvigadzirwa haigare ichitaurwa nenzira kwayo pachigadzirwa chigadzirwa.

Cannabidiol inonyanya kushandiswa pakubata chirwere (pfari). Iyo inoshandiswawo kushushikana, kurwadziwa, kusagadzikana kwemhasuru kunonzi dystonia, chirwere cheParkinson, chirwere cheCrohn, uye mamwe akawanda mamiriro, asi hapana humbowo hwakanaka hwesainzi hunotsigira izvi zvinoshandiswa.

Natural Mishonga Inonzwisisika Dhatabhesi zvinowanisa kushanda kunoenderana neuchapupu hwesainzi zvinoenderana nezviyero zvinotevera: Zvinobudirira, Zvichida Zvinobudirira, Zvichida Zvinobudirira, Zvichida Hazvishande, Zvichida Hazvibatsiri, Hazvibatsiri, uye Huchakwana Huchapupu hweKutara.

Iko kushanda ratings kwe CANNABIDIOL (CBD) zvinotevera:


Zvichida zvinoshanda ...

  • Kufenda chirwere (pfari). Chinhu chakasarudzika chinonzi cannabidiol chigadzirwa (Epidiolex, GW Pharmaceuticals) yakaratidzirwa kudzikisira kufenda muvanhu vakuru nevana vane mamiriro akasiyana akabatana nekubatwa. Ichi chigadzirwa mushonga wekurapa wekurapa pfari dzinokonzerwa neDravet syndrome, Lennox-Gastaut syndrome, kana tuberous sclerosis yakaoma. Izvo zvakaratidzirwawo kudzikisira kubatwa muvanhu vane Sturge-Weber syndrome, febrile hutachiona-hune hukama nehunhu (FIRES), uye zvakasarudzika hutachiona hutachiona hunokonzera pfari encephalopathy. Asi hazvibvumirwi pakurapa aya mamwe marudzi ekubatwa. Ichi chigadzirwa chinowanzo kutorwa chakabatana pamwe neyakajairika anti-seizure mishonga. Mimwe michina ye cannabidiol inogadzirwa murabhorari iri kuverengerwawo pfari. Asi kutsvagisa kushoma, uye hapana chimwe cheizvi zvigadzirwa chinogamuchirwa semishonga yekunyorera.

Husingakwani humbowo hwekuyera kushanda kwe ...

  • Rudzi rwehutachiona hwechirwere (chirwere cheCrohn). Kutsvagurudza kwekutanga kunoratidza kuti kutora cannabidiol hakuderedze chirwere chiitiko kune vanhu vakuru vane chirwere cheCrohn.
  • Chirwere cheshuga. Kutsvagurudza kwekutanga kunoratidza kuti kutora cannabidiol hakuwedzere ropa reropa rekudzora vanhu vakuru vane mhando 2 chirwere cheshuga.
  • Chirwere chekufamba chinoratidzirwa nekusazvipira kwemhasuru contractions (dystonia). Hazvina kujeka kana cannabidiol inobatsira dystonia.
  • Mamiriro ezvinhu akagarwa nhaka anoonekwa nehurema pakudzidza (fragile- X syndrome). Kutsvagurudza kwekutanga kunoratidza kuti kushandisa cannabidiol gel kunogona kudzora kushushikana uye kugadzirisa hunhu muvana vane X isina kusimba X syndrome.
  • Mamiriro ezvinhu umo kupinza kunorwisa muviri (kubatanidza-kurwisa-kuitisa chirwere kana GVHD). Graft-versus-host disease chinetso chinogona kuitika mushure mekugadzirwa kwemongo wemapfupa. Kutsvagurudza kwekutanga kwakawana kuti kutora cannabidiol zuva nezuva kutanga mazuva manomwe pasati papfekwa mwongo uye kuenderera kwemazuva makumi matatu mushure mekuisirwa kunogona kuwedzera nguva inotora kuti munhu agadzire GVHD.
  • Dambudziko reuropi rakagara nhaka rinokanganisa mafambiro, manzwiro, uye kufunga (Huttington chirwere). Kutsvagurudza kwekutanga kunoratidza kuti kutora cannabidiol zuva nezuva hakuwedzere zviratidzo zvehosha yeHuntington.
  • Multiple sclerosis (MS). Kutsvagurudza kwekutanga kunoratidza kuti kushandisa cannabidiol kupuruzira pasi perurimi kunogona kuvandudza marwadzo uye kuomarara kwemhasuru kune vanhu vane MS.
  • Kurega kubva kuheroin, morphine, uye mamwe maopioid zvinodhaka. Kutsvagurudza kwekutanga kunoratidza kuti kutora cannabidiol kwemazuva matatu kunogona kudzora kushuvira uye kuzvidya mwoyo kune vanhu vane heroin yekushandisa kusagadzikana.
  • Parkinson chirwere. Kutsvagurudza kwekutanga kunoratidza kuti cannabidiol inogona kudzora kushushikana uye zviratidzo zvepfungwa mune vanhu vane chirwere chePasinson.
  • Schizophrenia. Ongororo yekutanga inoratidza kuti kutora cannabidiol kunovandudza zviratidzo uye hutano muvanhu vane schizophrenia.
  • Kurega kusvuta. Kutsvagurudza kwekutanga kunoratidza kuti kufema cannabidiol neinhaler kwevhiki imwe chete kunogona kudzikisira huwandu hwefodya inoputa nevaputi vanoedza kurega.
  • Rudzi rwekuzvidya mwoyo kunoratidzwa nekutya mune vamwe kana ese marongero enharaunda.. Kutsvagurudza kwekutanga kunoratidza kuti cannabidiol inogona kugadzirisa kunetseka kune vanhu vane chirwere ichi. Asi hazvizivikanwe kana zvichibatsira kudzikisa kushushikana panguva yekutaura pamberi pevanhu.
  • Boka remamiriro ezvinhu anorwadza anokanganisa kubatana kwejaya nemhasuru (temporomandibular kusagadzikana kana TMD). Kutsvagurudza kwekutanga kunoratidza kuti kuisa mafuta ane cannabidiol paganda kunogona kudzora marwadzo kune vanhu vane TMD.
  • Kukuvara kwemitsipa mumaoko nemakumbo (peripheral neuropathy).
  • Bipolar kusagadzikana.
  • Kusarara.
  • Mamwe mamiriro.
Humwe humbowo hunodiwa kuyera kushanda kwe cannabidiol kune izvi zvinoshandiswa.

Cannabidiol ine zvinokanganisa pauropi. Icho chaicho chikonzero cheiyi mhedzisiro hachina kujeka. Nekudaro, cannabidiol inoita kunge inodzivirira kuparara kwemakemikari muuropi ayo anokanganisa marwadzo, kushushikana, uye kushanda kwepfungwa. Kudzivirira kuparara kwekemikari iyi uye kuwedzera huwandu hwayo muropa zvinoita sekuderedza zviratidzo zvepfungwa zvine chekuita nemamiriro akaita seschizophrenia. Cannabidiol inogona zvakare kuvharira mamwe epfungwa anoshanda e delta-9-tetrahydrocannabinol (THC). Zvakare, cannabidiol inoita kunge inoderedza marwadzo uye kushushikana.

Kana ikatorwa nemuromo: Cannabidiol ari ZVINOKOSHA KUNENGE painotorwa nemuromo kana kumwaya pasi perurimi zvakakodzera. Cannabidiol mumadhora anosvika ku 300 mg mazuva ese akatorwa nemuromo zvakachengeteka kwemwedzi mitanhatu. Doses yepamusoro ye1200-1500 mg zuva nezuva yakatorwa nemuromo zvakachengeteka kwemavhiki mana. Chiremba cannabidiol chigadzirwa (Epidiolex) inobvumidzwa kutorwa nemuromo mumadosi anosvika 25 mg / kg zuva nezuva. Cannabidiol mapiritsi anoshandiswa pasi perurimi ave achishandiswa muzvikamu zve 2.5 mg kwemasvondo maviri.

Mimwe mhedzisiro yemigumisiro ye cannabidiol inosanganisira yakaoma mukanwa, yakaderera blood pressure, lightheading, uye hope. Zviratidzo zvekukuvara kwechiropa zvakataurwawo mune vamwe varwere, asi izvi hazvisi zvakajairika.

Kana ichishandiswa paganda: Iko hakuna kukwana kwakaringana ruzivo rwekuziva kana cannabidiol yakachengeteka kana kuti ndeipi mhedzisiro inogona kunge iri.

Special matanho & yambiro:

Kubata uye kuyamwisa: Cannabidiol ari ZVINOGONESESA KUTI ASINA Kachengeteka kushandisa kana iwe uri nepamuviri kana kuyamwisa. Zvigadzirwa zveCannabidiol zvinogona kusvibiswa nezvimwe zvinoshandiswa zvinogona kukuvadza mwana kana mucheche. Gara padivi rakachengeteka uye dzivisa kushandisa.

Vana: Chiremba cannabidiol chigadzirwa (Epidiolex) iri ZVINOKOSHA KUNENGE painotorwa nemuromo mumadosi kusvika ku25 mg / kg zuva nezuva. Ichi chigadzirwa chinotenderwa kuti chiishandiswe mune vamwe vana vane makore 1 ekuberekwa zvichikwira

Chiropa chirwere: Vanhu vane chirwere chechiropa vangangoda kushandisa mwero wakaderera we cannabidiol uchienzaniswa nevarwere vane hutano.

Parkinson chirwere: Kumwe kutsvagurudza kwekutanga kunoratidza kuti kutora mazinga epamusoro e cannabidiol kunogona kuita kufamba kwemhasuru uye kudedera zvakanyanya kune vamwe vanhu vane chirwere chePalinson.

Pakati nepakati
Ive nekuchenjera nekubatanidzwa uku.
Brivaracetam (Briviact)
Brivaracetam inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa brivaracetam sei. Izvi zvinogona kuwedzera mazinga e brivaracetam mumuviri.
Carbamazepine (Tegretol)
Carbamazepine inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa sei carbamazepine. Izvi zvinogona kuwedzera mazinga e carbamazepine mumuviri uye kuwedzera ayo mhedzisiro.
Clobazam (Onfi)
Clobazam inoshandurwa uye kuputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza kuputsa clobazam. Izvi zvinogona kuwedzera mhedzisiro uye mhedzisiro mhedzisiro yeclobazam.
Eslicarbazepine (Aptiom)
Eslicarbazepine inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa sei eslicarbazepine. Izvi zvinogona kuwedzera mazinga eslicarbazepine mumuviri nemari shoma.
Everolimus (Zostress)
Everolimus inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa sei everolimus. Izvi zvinogona kuwedzera mazinga eeverolimus mumuviri.
Lithium
Kutora mwero wakakwirira we cannabidiol kunogona kuwedzera mwero we lithiamu. Izvi zvinogona kuwedzera njodzi ye lithiamu chepfu.
Mishonga yakashandurwa nechiropa (Cytochrome P450 1A1 (CYP1A1) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza kupwanya sei mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakashandurwa nechiropa inosanganisira chlorzoxazone (Lorzone) uye theophylline (Theo-Dur, mimwe).
Mishonga yakashandurwa nechiropa (Cytochrome P450 1A2 (CYP1A2) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakachinjwa nechiropa inosanganisira amitriptyline (Elavil), haloperidol (Haldol), ondansetron (Zofran), propranolol (Inderal), theophylline (Theo-Dur, vamwe), verapamil (Calan, Isoptin, vamwe), nevamwe.
Mishonga yakashandurwa nechiropa (Cytochrome P450 1B1 (CYP1B1) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakashandurwa nechiropa inosanganisira theophylline (Theo-Dur, vamwe), omeprazole (Prilosec, Omesec), clozapine (Clozaril, FazaClo), progesterone (Prometrium, vamwe), lansoprazole (Prevacid), flutamide (Eulexin), oxaliplatin (Eloxatin ), erlotinib (Tarceva), uye caffeine.
Mishonga yakashandurwa nechiropa (Cytochrome P450 2A6 (CYP2A6) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakachinjwa nechiropa inosanganisira nicotine, chlormethiazole (Heminevrin), coumarin, methoxyflurane (Penthrox), halothane (Fluothane), valproic acid (Depacon), disulfiram (Antabuse), nezvimwe.
Mishonga yakashandurwa nechiropa (Cytochrome P450 2B6 (CYP2B6) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakashandurwa nechiropa inosanganisira ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), uye dexamethasone (Decadron).
Mishonga yakashandurwa nechiropa (Cytochrome P450 2C19 (CYP2C19) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakashandurwa nechiropa inosanganisira proton pump inhibitors inosanganisira omeprazole (Prilosec), lansoprazole (Prevacid), uye pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); nevamwe.
Mishonga yakashandurwa nechiropa (Cytochrome P450 2C8 (CYP2C8) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.
Mimwe mishonga yakashandurwa nechiropa inosanganisira amiodarone (Cordarone), carbamazepine (Tegretol), chloroquine (Aralen), diclofenac (Voltaren), paclitaxel (Taxol), repaglinide (Prandin) uye mimwe.
Mishonga yakashandurwa nechiropa (Cytochrome P450 2C9 (CYP2C9) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakashandurwa nechiropa inosanganisira nonsteroidal anti-inflammatory drug (NSAIDs) senge diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), piroxicam (Feldene), uye celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); nevamwe.
Mishonga yakashandurwa nechiropa (Cytochrome P450 2D6 (CYP2D6) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakachinjwa nechiropa inosanganisira amitriptyline (Elavil), codeine, desipramine (Norpramin), flecainide (Tambocor), haloperidol (Haldol), imipramine (Tofranil), metoprolol (Lopressor, Toprol XL), ondansetron (Zofran), paroxetine (Paxil ), risperidone (Risperdal), tramadol (Ultram), venlafaxine (Effexor), nezvimwe.
Mishonga yakashandurwa nechiropa (Cytochrome P450 3A4 (CYP3A4) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakashandurwa nechiropa inosanganisira alprazolam (Xanax), amlodipine (Norvasc), clarithromycin (Biaxin), cyclosporine (Sandimmune), erythromycin, lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Halcion), verapamil (Calan, Isoptin) nevamwe vazhinji.
Mishonga yakashandurwa nechiropa (Cytochrome P450 3A5 (CYP3A5) substrates)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Mukufunga, kushandisa cannabidiol pamwe chete nemimwe mishonga inoputswa nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemimwe mishonga. Usati washandisa cannabidiol, taura nemupi wako wezvehutano kana iwe ukatora chero mishonga inoshandurwa nechiropa.

Mimwe mishonga yakashandurwa nechiropa inosanganisira testosterone, progesterone (Endometrin, Prometrium), nifedipine (Adalat CC, Procardia XL), cyclosporine (Sandimmune), nezvimwe.
Mishonga yakashandurwa nechiropa (Glucuronidated zvinodhaka)
Mimwe mishonga inoshandurwa uye inoputswa nechiropa. Cannabidiol inogona kudzikira kuti chiropa chinokurumidza sei kupwanya mimwe mishonga. Kutora cannabidiol pamwe chete nemimwe mishonga inoputsika nechiropa inogona kuwedzera mhedzisiro uye mhedzisiro yemishonga iyi.
Mimwe yemishonga iyi yakashandurwa nechiropa inosanganisira acetaminophen (Tylenol, vamwe) uye oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), nezvimwe.
Mishonga inoderedza kuputsika kwemimwe mishonga nechiropa (Cytochrome P450 2C19 (CYP2C19) inhibitors)
Cannabidiol yakaputsika nechiropa. Mimwe mishonga inogona kudzikira kuti chiropa chinokurumidza kupaza sei cannabidiol. Kutora cannabidiol pamwe chete nemishonga iyi kunogona kuwedzera mhedzisiro uye mhedzisiro ye cannabidiol.
Mimwe mishonga inogona kudzora kuputsika kwe cannabidiol muropa inosanganisira cimetidine (Tagamet), fluvoxamine (Luvox), omeprazole (Prilosec); ticlopidine (Ticlid), topiramate (Topamax), nevamwe.
Mishonga inoderedza kuputsika kwemimwe mishonga muropa (Cytochrome P450 3A4 (CYP3A4) inhibitors)
Cannabidiol yakaputsika nechiropa. Mimwe mishonga inogona kudzikira kuti chiropa chinokurumidza kupaza sei cannabidiol. Kutora cannabidiol pamwe chete nemishonga iyi kunogona kuwedzera mhedzisiro uye mhedzisiro ye cannabidiol.
Mimwe mishonga inogona kudzora kuti chiropa inokurumidza sei kuputsa cannabidiol inosanganisira amiodarone (Cordarone), clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin (E-mycin, Erythrocin), indinavir (Crixivan), ritonavir (Norvir), saquinavir (Fortovase) , Invirase), nevamwe vazhinji.
Mishonga inowedzera kuputsika kwemimwe mishonga nechiropa (Cytochrome P450 3A4 (CYP3A4) inducers)
Cannabidiol yakaputsika nechiropa. Mimwe mishonga inogona kuwedzera kuti chiropa chinoputsa nekukurumidza sei cannabidiol. Kutora cannabidiol pamwe chete nemishonga iyi kunogona kudzora mhedzisiro ye cannabidiol.
Mimwe yemishonga iyi inosanganisira carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), uye mimwe.
Mishonga inowedzera kuputsika kwemimwe mishonga nechiropa (Cytochrome P450 2C19 (CYP2C19) inducers)
Cannabidiol yakaputsika nechiropa. Mimwe mishonga inogona kuwedzera kuti chiropa chinoputsa nekukurumidza sei cannabidiol. Kutora cannabidiol pamwe chete nemishonga iyi kunogona kudzora mhedzisiro ye cannabidiol.
Mimwe mishonga inogona kuwedzera kuparara kwe cannabidiol muchiropa inosanganisira carbamazepine (Tegretol), prednisone (Deltasone), uye rifampin (Rifadin, Rimactane).
Methadone (Dolophine)
Methadone yakaputsika nechiropa. Cannabidiol inogona kudzora kuti chiropa chinokurumidza sei kuputsa methadone. Kutora cannabidiol pamwe ne methadone kunogona kuwedzera mhedzisiro uye mhedzisiro yemethadone.
Rufinamide (Banzel)
Rufinamide inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa sei rufinamide. Izvi zvinogona kuwedzera mazinga e rufinamide mumuviri nemari shoma.
Sedative mishonga (CNS inodzvinyirira)
Cannabidiol inogona kukonzera kurara uye kukotsira. Mishonga inokonzeresa kurara inonzi inonzi sedatives. Kutora cannabidiol pamwe chete nemishonga yekunyaradza kunogona kukonzera kurara zvakanyanya.

Mimwe mishonga yekunyaradza inosanganisira benzodiazepines, pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), nevamwe.
Sirolimus (Rapamune)
Sirolimus inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa sei sirolimus. Izvi zvinogona kuwedzera mazinga e sirolimus mumuviri.
Stiripentol (Diacomit)
Stiripentol inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa sei stiripentol. Izvi zvinogona kuwedzera mazinga erepipipentol mumuviri uye kuwedzera ayo mhedzisiro.
Tacrolimus (Prograf)
Tacrolimus inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa tacrolimus sei. Izvi zvinogona kuwedzera mazinga e tacrolimus mumuviri.
Topiramate (Tompamax)
Topiramate inoshandurwa uye kuputswa nemuviri. Cannabidiol inogona kudzikira kuti muviri unokurumidza kuputsa sei topiramate. Izvi zvinogona kuwedzera mazinga e topiramate mumuviri nemari shoma.
Valproate
Valproic acid inogona kukonzera kukuvara kwechiropa. Kutora cannabidiol nevalproic acid kunogona kuwedzera mukana wekukuvara kwechiropa. Cannabidiol uye / kana valproic acid ingangoda kumiswa, kana iyo dose ingangoda kudzikiswa.
Warfarin
Cannabidiol inogona kuwedzera mazinga ewarfarin, ayo anogona kuwedzera njodzi yekubuda ropa. Cannabidiol uye / kana warfarin ingangoda kumiswa, kana iyo dose ingangoda kudzikiswa.
Zonisamide
Zonisamide inoshandurwa nekutyorwa nemuviri. Cannabidiol inogona kudzora kuti muviri unokurumidza kuputsa sei zonisamide. Izvi zvinogona kuwedzera mazinga e zonisamide mumuviri nemari shoma.
Mishonga uye zvinowedzera zvine sedative zvivakwa
Cannabidiol inogona kukonzera kurara kana kukotsira. Kuishandisa pamwe nemamwe maruva uye zvinowedzera zvine maitiro akafanana zvinogona kukonzera kurara zvakanyanya. Mimwe yemishonga iyi uye zvinowedzera zvinosanganisira calamus, California poppy, catnip, hop, Jamaican dogwood, kava, L-tryptophan, melatonin, sage, SAMe, wort St. John's, sassafras, skullcap, nevamwe.
Doro (Ethanol)
Kutora cannabidiol nedoro kunowedzera huwandu hwe cannabidiol inodhonzwa nemuviri. Izvi zvinogona kuwedzera mhedzisiro uye mhedzisiro ye cannabidiol.
Mafuta uye chikafu chine mafuta
Kutora cannabidiol nechikafu chakakora mumafuta kana zvirinani chine mamwe mafuta, kunowedzera huwandu hwe cannabidiol iyo inosvitswa nemuviri. Izvi zvinogona kuwedzera mhedzisiro uye mhedzisiro ye cannabidiol.
Mukaka
Kutora cannabidiol nemukaka kunowedzera huwandu hwe cannabidiol inobatwa nemuviri. Izvi zvinogona kuwedzera mhedzisiro uye mhedzisiro ye cannabidiol.
Iyi inotevera doses yakadzidzwa mukutsvaga kwesainzi:

VAKURU

Nemuromo:
  • Zvepfari: Chiremba cannabidiol chigadzirwa (Epidiolex) chakashandiswa. Iyo yakakurudzirwa kutanga dosi yeLennox-Gastaut syndrome uye Dravet syndrome iri 2.5 mg / kg kaviri pazuva (5 mg / kg / zuva). Mushure mevhiki imwechete muyero unogona kuwedzerwa kusvika ku5 mg / kg kaviri pazuva (10 mg / kg / zuva). Kana munhu wacho akasapindura kune ino dosi, yakanyanya kukurudzirwa ndeye 10 mg / kg kaviri pazuva (20 mg / kg / zuva). Iyo yakakurudzirwa kutanga dosi ye tuberous sclerosis yakaoma ndeye 2.5 mg / kg kaviri pazuva (5 mg / kg / zuva). Izvi zvinogona kuwedzerwa nguva dzevhiki kana zvichidikanwa, inosvika pakureba kwe12.5 mg / kg kaviri pazuva (25 mg / kg / zuva). Hakuchina humbowo hwakasimba hwesainzi hwekuti kusagadziriswa cannabidiol zvigadzirwa zvinobatsira pfari.
VANA

Nemuromo:
  • Zvepfari: Chiremba cannabidiol chigadzirwa (Epidiolex) chakashandiswa. Iyo yakakurudzirwa kutanga dosi yeLennox-Gastaut syndrome uye Dravet syndrome ndeye 2.5 mg / kg kaviri pazuva (5 mg / kg / zuva). Mushure mevhiki imwechete muyero unogona kuwedzerwa kusvika ku5 mg / kg kaviri pazuva (10 mg / kg / zuva). Kana munhu wacho akasapindura kune ino dosi, yakanyanya kukurudzirwa ndeye 10 mg / kg kaviri pazuva (20 mg / kg / zuva). Iyo yakakurudzirwa kutanga dosi ye tuberous sclerosis yakaoma ndeye 2.5 mg / kg kaviri pazuva (5 mg / kg / zuva). Izvi zvinogona kuwedzerwa nguva dzevhiki kana zvichidikanwa, inosvika pakureba kwe12.5 mg / kg kaviri pazuva (25 mg / kg / zuva). Hakuchina humbowo hwakasimba hwesainzi hwekuti kusagadziriswa cannabidiol zvigadzirwa zvinobatsira pfari.
2 - [(1R, 6R) -3-Methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl] -5-pentylbenzene-1,3-diol, CBD.

Kuti udzidze zvakawanda nezvekuti chinyorwa ichi chakanyorwa sei, ndapota ona iyo Natural Mishonga Inonzwisisika Dhatabhesi nzira.


  1. Singh RK, Dillon B, Tatum DA, Van Poppel KC, Bonthius DJ. Zvinodhaka-Zvinodhaka Kupindirana Pakati peCannabidiol neLithium. Mwana Neurol Akavhurwa. 2020; 7: 2329048X20947896. Wona zvisingabvumirwe.
  2. Izgelov D, Davidson E, Barasch D, Regev A, Domb AJ, Hoffman A. Pharmacokinetic kuferefeta kwekugadzira cannabidiol yemumuromo mafomu mune vane hutano vanozvipira. Eur J Pharm Biopharm. 2020; 154: 108-115. Wona zvisingabvumirwe.
  3. Gurley BJ, Murphy TP, Gul W, Walker LA, ElSohly M. Zvemukati zvinopesana neRebel Claims muCannabidiol (CBD) -Iyo Ine Zvigadzirwa Zvakawanikwa kubva Kumabhizimusi Ekutengesa muHurumende yeMississippi. J Kudya Suppl. 2020; 17: 599-607. Wona zvisingabvumirwe.
  4. McGuire P, Robson P, Cubala WJ, et al. Cannabidiol (CBD) seAdjunctive Therapy muSchizophrenia: Iyo Multicenter Randomized Inodzorwa Trial. Am J Psychiatry. 2018; 175: 225-231. Wona zvisingabvumirwe.
  5. Cortopassi J. Warfarin dhizaini yekugadzirisa inodikanwa mushure mekutanga kwe cannabidiol uye titration. Ndiri J Hutano Syst Pharm. 2020; 77: 1846-1851. Wona zvisingabvumirwe.
  6. Bloomfield MAP, Green SF, Hindocha C, et al. Mhedzisiro yeacute cannabidiol pane cerebral kuyerera kweropa uye hukama hwayo ndangariro: An arterial spin kunyora magineti resonance imaging kudzidza. J Psychopharmacol. 2020; 34: 981-989. Wona zvisingabvumirwe.
  7. Wang GS, Bourne DWA, Klawitter J, et al. Kugadziriswa kweMuromo Cannabidiol-Yakapfuma Cannabis Inoburitswa muVana vane Hosha. Kliniki Pharmacokinet. Tarisa zvinyorwa.
  8. Taylor L, Crockett J, Tayo B, Checketts D, Sommerville K. Kubviswa kwechimbichimbi kwe cannabidiol (CBD): Muedzo wakasarudzika. Pfari Behav. 2020; 104 (Pt A): 106938. Wona zvisingabvumirwe.
  9. McNamara NA, Dang LT, Sturza J, uye al. Thrombocytopenia muvarwere vevana pane imwe nguva cannabidiol uye valproic acid. Pfari. Tarisa zvinyorwa.
  10. Rianprakaisang T, Gerona R, Hendrickson RG. Zvekutengesa cannabidiol oiri yakasvibiswa neyakagadzirwa cannabinoid AB-FUBINACA yakapihwa kumurwere wevana. Clin Toxicol (Phila). 2020; 58: 215-216. Wona zvisingabvumirwe.
  11. Morrison G, Crockett J, Blakey G, Sommerville K. Chikamu 1, Open-Label, Pharmacokinetic Trial Yekuongorora Zvinogona Kubata Zvinodhaka-Zvinodhaka Kupindirana Pakati peClobazam, Stiripentol, kana Valproate neCannabidiol mune Hutano Zvidzidzo. Clin Pharmacol Zvinodhaka Dev. 2019; 8: 1009-1031. Wona zvisingabvumirwe.
  12. Miller Ini, Scheffer IE, Gunning B, et al. Dose-Inotenderedza Mhedzisiro yeAdjunctive Oral Cannabidiol vs Placebo paConvulsive Seizure Frequency muDravet Syndrome: Randomized Clinical Trial. JAMA Neurol. 2020; 77: 613-621. Wona zvisingabvumirwe.
  13. Lattanzi S, Trinka E, Striano P, et al. Cannabidiol kushanda uye chimiro clobazam: Kuongorora kwakarongeka uye meta-ongororo. Pfari. 2020; 61: 1090-1098. Wona zvisingabvumirwe.
  14. Hobbs JM, Vazquez AR, Remijan ND, et al. Kuongororwa kwe pharmacokinetics uye yakaoma yekurwisa-kuzvimba kugona kwemaviri emuromo cannabidiol kugadzirira mune vakuru vane hutano. Phytother Res. 2020; 34: 1696-1703. Wona zvisingabvumirwe.
  15. Ebrahimi-Fakhari D, Agricola KD, Tudor C, Krueger D, Franz DN. Cannabidiol Inosimudzira Mechiniki Target yeRapamycin Inhibitor Matanho muvarwere vane Tuberous Sclerosis Complex. Nyanzvi Neurol. 2020; 105: 59-61. Wona zvisingabvumirwe.
  16. de Carvalho Reis R, Almeida KJ, da Silva Lopes L, de Melo Mendes CM, Bor-Seng-Shu E. Kubudirira uye chiitiko chakaipa che cannabidiol nemushonga cannabis yekurapa-isingarapike pfari: Kuongorora kwakarongeka uye meta-ongororo. Pfari Behav. 2020; 102: 106635. Wona zvisingabvumirwe.
  17. Darweesh RS, Khamis TN, El-Elimat T. Mhedzisiro ye cannabidiol pane iyo pharmacokinetics ye carbamazepine mumakonzo. Naunyn Schmiedebergs Arch Pharmacol. Tarisa zvinyorwa.
  18. Crockett J, Critchley D, Tayo B, Berwaerts J, Morrison G. Chikamu 1, chakasarudzika, chemacrocokinetic kuyedzwa kwemhedzisiro yezvikamu zvakasiyana zvekudya, mukaka wese, uye doro pane cannabidiol kuratidzwa uye kuchengetedzeka mune zvine hutano zvidzidzo. Pfari. 2020; 61: 267-277. Wona zvisingabvumirwe.
  19. Chesney E, Oliver D, Green A, et al. Migumisiro yakaipa ye cannabidiol: kuongorora kwakarongeka uye meta-kuongororwa kwemaitiro emakiriniki akasarudzika. Neuropsychopharmacology. Tarisa zvinyorwa.
  20. Ben-Menachem E, Gunning B, Arenas Cabrera CM, et al. Chikamu chechipiri II Randomized Trial Kuongorora Izvo Zvingaitika zveFarmacokinetic Dhiragi-Dhiragi Kupindirana neStiripentol kana Valproate painosanganiswa neCannabidiol muvarwere vane pfari. CNS Zvinodhaka. 2020; 34: 661-672. Wona zvisingabvumirwe.
  21. Bass J, Linz DR. Chiitiko cheUturu kubva kuCannabidiol Gummy Kuiswa. Cureus. 2020; 12: e7688. Wona zvisingabvumirwe.
  22. Hampson AJ, Grimaldi M, Axelrod J, Wink D. Cannabidiol uye (-) Delta9-tetrahydrocannabinol ndeyeuroprotective antioxidants. Proc Natl Acad Sci U S A. 1998; 95: 8268-73. Wona zvisingabvumirwe.
  23. Hacke ACM, Lima D, de Costa F, uye al. Kuongorora chiitiko che antioxidant che [delta] -tetrahydrocannabinol uye cannabidiol muCannabis sativa zvinyorwa. Muongorori. 2019; 144: 4952-4961. Wona zvisingabvumirwe.
  24. Madden K, Tanco K, Bruera E. Clinical Inokosha Zvinodhaka-Zvinodhaka Kubatana Pakati peMethadone neCannabidiol. Pediatrics. 2020; e20193256. Wona zvisingabvumirwe.
  25. Hazekamp A. Dambudziko nemafuta eCDD. Med Cannabis Cannabinoids. 2018 Jun; 1: 65-72.
  26. Xu DH, Cullen BD, Tang M, Fang Y. Kubudirira kweTopical Cannabidiol Oiri muSyptomatic Ruregerero rwePeripheral Neuropathy yeZvekupedzisira Zvakanyanya. Curr Pharm Biotechnol. 2019 Zvita 1. Wona zvisingabvumirwe.
  27. de Faria SM, de Morais Fabrício D, Tumas V, et al. Mhedzisiro yeacute cannabidiol manejimendi pane kushushikana uye kudedera kunokonzerwa neSimulated Veruzhinji Kutaura Bvunzo muvarwere vane chirwere chePasinson. J Psychopharmacol. 2020 Ndira 7: 269881119895536. Wona zvisingabvumirwe.
  28. Nitecka-Buchta A, Nowak-Wachol A, Wachol K, et al. Myorelaxant Mhedzisiro yeTransdermal Cannabidiol Kunyorera mune Varwere vane TMD: Randomized, Double-Blind Trial. J Clin Med. 2019 Mbudzi 6; 8. pii: E1886. Wona zvisingabvumirwe.
  29. Masataka N. Anxiolytic Mhedzisiro Yekudzokororwazve kweCannabidiol Kurapa mune Vechidiki Vane Kushushikana Kwemagariro. Pamberi Psychol. 2019 Mbudzi 8; 10: 2466. Wona zvisingabvumirwe.
  30. Appiah-Kusi E, Petros N, Wilson R, et al. Mhedzisiro yenguva pfupi-yenguva cannabidiol kurapwa pakupindura kunetseka munharaunda mune zvidzidzo pakiriniki yakanyanya njodzi yekuvandudza psychosis. Psychopharmacology (Berl). 2020 Ndira 8. Wona zvisingabvumirwe.
  31. Hussain SA, Dlugos DJ, Cilio MR, Parikh N, Oh A, Sankar R. Synthetic mishonga giredhi cannabidiol yekurapa kweanopokana neasacheas spasms: A multicenter phase-2 kudzidza. Pfari Behav. 2020 Ndira; 102: 106826. Wona zvisingabvumirwe.
  32. Klotz KA, Grob D, Hirsch M, Metternich B, Schulze-Bonhage A, Jacobs J. Kubudirira uye Kushivirira kweSynthetic Cannabidiol yekurapa Kwezvinodzvinyirira Zvinodzvinyirira Zvinodhaka. Pamberi Neurol. 2019 Zvita 10; 10: 1313. Wona zvisingabvumirwe.
  33. "GW Pharmaceuticals plc uye Yayo U.S. Subsidiary Greenwich Biosciences, Inc. Yazivisa Kuti EPIDIOLEX® (cannabidiol) Oral Solution Yave Yakagadziriswa Uye Haisisiri Chinhu Chinodzorwa." GW Mishonga, 6 Kubvumbi 2020. http://ir.gwpharm.com/node/11356/pdf. Dhinda rekuburitsa.
  34. Wiemer-Kruel A, Stiller B, Bast T. Cannabidiol Inopindirana Zvakakosha na Everolimus-Mushumo weMurwere ane Tuberous Sclerosis Complex. Neuropediatrics. 2019. Wona zvisingabvumirwe.
  35. FDA Consumer Updates: Zvaunofanira Kuziva Nezve Kushandisa Cannabis, Kusanganisira CBD, Kana Une Pamuviri kana Kuyamwisa. U. S. Kudya neDrug Administration (FDA). Gumiguru 2019. Inowanikwa pa: https://www.fda.gov/consumers/consumer-updates/what-you-should-now-about-using-cannabis-including-cbd-when-pregnant-or-breastfeeding.
  36. Taylor L, Crockett J, Tayo B, Morrison G. A Phase 1, Open-Label, Parallel-Boka, Imwe-Dosi Kuedzwa kweFarmacokinetics uye Kudzivirirwa kweCannabidiol (CBD) mune Zvidzidzo zvine Nyoro Kuomarara Kuora KweHepatic. J Clin Pharmacol. 2019; 59: 1110-1119. Wona zvisingabvumirwe.
  37. Szaflarski JP, Hernando K, Bebin EM, uye al. Yepamusoro cannabidiol plasma mazinga anosanganisirwa zvirinani kubatwa mhinduro zvichitevera kurapwa neyemishonga giredhi cannabidiol. Pfari Behav. 2019; 95: 131-136. Wona zvisingabvumirwe.
  38. Pretzsch CM, Voinescu B, Mendez MA, uye al. Mhedzisiro ye cannabidiol (CBD) pane yakaderera-frequency chiitiko uye chinoshanda kubatana muhuropi hwevakuru vane uye vasina autism spectrum kusagadzikana (ASD). J Psychopharmacol. 2019: 269881119858306. Wona zvisingabvumirwe.
  39. Pretzsch CM, Freyberg J, Voinescu B, uye al. Mhedzisiro ye cannabidiol pakufadza kwehuropi uye masisitimu ekudzivirira; yakasarudzika placebo-inodzorwa imwe chete muyedzo muyedzo panguva yemagineti resonance spectroscopy mune vanhu vakuru vane uye vasina autism spectrum kusagadzikana. Neuropsychopharmacology. 2019; 44: 1398-1405. Wona zvisingabvumirwe.
  40. Patrician A, Vhezheni-Bratincevic M, Mijacika T, et al. Kuongororwa kweNzira Idzva Yekutumira yeOrnal Cannabidiol muVane Hutano Zvidzidzo: Yakagadziriswa, Yakapofumadzwa-Yakapofomadzwa, Placebo-Inodzorwa Pharmacokinetics Kudzidza. Adv Ther. 2019. Wona zvisingabvumirwe.
  41. Martin RC, Gaston TE, Thompson M, et al. Kushanda kwekuziva kunotevera kushandisa kwenguva refu cannabidiol kushandiswa kune vanhu vakuru vane kurapa-kusagadzikana pfari. Pfari Behav. 2019; 97: 105-110. Wona zvisingabvumirwe.
  42. Leino AD, Emoto C, Fukuda T, Privitera M, Vinks AA, Alloway RR. Uchapupu hwekiriniki yakakosha kudyidzana kwezvinodhaka-zvinodhaka pakati pe cannabidiol uye tacrolimus. Ndiri J Kudyara. 2019; 19: 2944-2948. Wona zvisingabvumirwe.
  43. Laux LC, Bebin EM, Checketts D, et al. Yekureba-kwenguva kuchengetedzeka uye kushanda kwe cannabidiol muvana nevakuru vane kurapwa nemishonga Lennox-Gastaut syndrome kana Dravet syndrome: Yakawedzeredzwa mhedzisiro chirongwa Pfari Res. 2019; 154: 13-20. Wona zvisingabvumirwe.
  44. Knaub K, Sartorius T, Dharsono T, Wacker R, Wilhelm M, Schön C. A Novel Self-Emulsifying Drug Delivery System (SEDDS) Kubva paVESIsorb Formulation Technology Kuvandudza Oral Bioavailability yeCannabidiol mune Hutano Zvidzidzo. Mamorekuru. 2019; 24. pii: E2967. Wona zvisingabvumirwe.
  45. Klotz KA, Hirsch M, Heers M, Schulze-Bonhage A, Jacobs J. Mhedzisiro ye cannabidiol pane brivaracetam plasma mazinga. Pfari. 2019; 60: e74-e77. Wona zvisingabvumirwe.
  46. Heussler H, Cohen J, Silove N, uye al. Chikamu che2 / 2, yakavhurika-revhizheni kuongororwa kwekuchengeteka, kushivirira, uye kushanda kweiyo transdermal cannabidiol (ZYN002) yekurapa kwevana vasina kusimba X syndrome. J Neurodev Kusawirirana. 2019; 11: 16. Wona zvisingabvumirwe.
  47. Mubhedha DG, Cook H, Ortori C, Barrett D, Lund JN, O'Sullivan SE. Palmitoylethanolamide uye Cannabidiol Kudzivirira Kuzvimba-kunokonzeresa Hyperpermeability yeMunhu Gut Mu Vitro uye MuVivo-A Randomized, Placebo-inodzorwa, Kaviri-bofu Inodzorwa Trial. Kufungidzira Bowel Dis. 2019; 25: 1006-1018. Wona zvisingabvumirwe.
  48. Birnbaum AK, Karanam A, Marino SE, et al. Chikafu chinogadzira pharmacokinetics ye cannabidiol yemuromo macapsules mune vakuru varwere vane refractory pfari Pfari. 2019 Aug; 60: 1586-1592. Wona zvisingabvumirwe.
  49. Arkell TR, Lintzeris N, Kevin RC, et al. Cannabidiol (CBD) zvemukati mune vaporized cannabis hazvidzivirire tetrahydrocannabinol (THC) -kukanganisa kukanganisa kwekutyaira uye kugona. Psychopharmacology (Berl). 2019; 236: 2713-2724. Wona zvisingabvumirwe.
  50. Anderson LL, Abhusaromu NL, Abelev SV, et al. Coadministered cannabidiol uye clobazam: Preclinical humbowo kune ese mashandisiro e pharmacodynamic uye pharmacokinetic kusangana. Pfari. 2019. Wona zvisingabvumirwe.
  51. Chigadzirwa ruzivo rweMarinol. AbbVie. North Chicago, IL 60064. Nyamavhuvhu 2017.Inowanikwa pa: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018651s029lbl.pdf.
  52. Epidiolex (cannabidiol) inorondedzera ruzivo. Greenwich Biosciences, Inc., Carlsbad, CA, 2019. Inowanikwa pa: https://www.epidiolex.com/sites/default/files/EPIDIOLEX_Full_Prescribing_Information.pdf (yakasvika 5/9/2019)
  53. Chirevo kubva kuna FDA Commissioner Scot Gottlieb, MD, pakusaina kweAgriculture Improvement Act uye mutemo wesangano rezvigadzirwa zvine cannabis nemakemikari anotorwa necannabis. U.S. Kudya uye Dhiraimendi Yekutonga Webhusaiti Inowanikwa pa: https://www.fda.gov/news-events/press-announcements/statement-fda-commissioner-scott-gottlieb-md-signing-agriculture-improvement-act-and-agencys. (Yakasvika May 7, 2019).
  54. Zvekurima Kuvandudza Mutemo, S. 10113, 115th Cong. kana S. 12619, 115th Cong. .
  55. Drug Enforcing Administration, Dhipatimendi Rezvemitemo. Zvirongwa zveZvinhu Zvinodzorwa: Kuiswa muChirongwa V cheMamwe madhiragi anotenderwa eDAA ane Cannabidiol; Inoenderana Shanduko kune Mvumo Zvinodiwa. Yekupedzisira odha. Fed Kunyoresa. 2018 Sep 28; 83: 48950-3. Wona zvisingabvumirwe.
  56. Schoedel KA, Szeto I, Setnik B, et al. Kushungurudza kugona kuongororwa kwe cannabidiol (CBD) muvaraidzo yevashandisi ve polydrug: Muedzo wakasarudzika, wakapofomara-wakapofomara, unodzorwa. Pfari Behav. 2018 Mbudzi; 88: 162-171. doi: 10.1016 / j.yebeh.2018.07.027. Epub 2018 Gumiguru 2. Wona zvisingabvumirwe.
  57. Devinsky O, Verducci C, Thiele EA, uye al. Kuvhura-chitaridzi kushandiswa kweiyo yakanatswa CBD (Epidiolex®) mune varwere vane CDKL5 kushomeka kusagadzikana uye Aicardi, Dup15q, uye Doose syndromes. Pfari Behav. 2018 Sep; 86: 131-137. Epub 2018 Jul 11. Wona zvisingabvumirwe.
  58. Szaflarski JP, Bebin EM, Mucheki G, DeWolfe J, et al. Cannabidiol inovandudza kuwanda uye kuomarara kwekugwinha uye inoderedza zviitiko zvakashata mune yakavhurika-regedhi yekuwedzera-pane inotarisirwa kudzidza. Pfari Behav. 2018 Gumiguru; 87: 131-136. Epub 2018 Aug 9. Wona zvisingabvumirwe.
  59. Linares IM, Zuardi AW, Pereira LC, et al. Cannabidiol inopa yakachinjika U-yakaumbwa dhizaini-mhinduro curve mune yakamisikidzwa yekutaura yeruzhinji bvunzo. Braz J Psychiatry. 2019 Jan-Kukadzi; 41: 9-14. Epub 2018 Gumiguru 11. Wona zvisingabvumirwe.
  60. Poklis JL, Mulder HA, Runyararo MR. Kuzivikanwa kusingatarisirwe kweiyo cannabimimetic, 5F-ADB, uye dextromethorphan mune yekutengesa inowanikwa cannabidiol e-zvinwiwa. Forensic Sci Int. 2019 Jan; 294: e25-e27. Epub 2018 Mbudzi 1. Wona zvisingabvumirwe.
  61. Akakuvara YL, Spriggs S, Alishayev J, et al. Cannabidiol yekudzora kweCue-Inokonzereswa Kushuva uye Kuzvidya Mwoyo Kune Vanodhakisa-Vanorega Vanhu Vane Heroin Kushandisa Dambudziko: Iyo Yakapofomara-Yakapetwa Randomized Placebo-Inodzorwa Trial. Ndiri J Psychiatry. 2019: appiajp201918101191. Wona zvisingabvumirwe.
  62. Thiele EA, Marsh ED, French JA, et al. Cannabidiol muvarwere vane pfari dzakabatana neLennox-Gastaut syndrome (GWPCARE4): yakasarudzika, yakapofomara-bofu, inodzora placebo-inodzorwa chikamu 3 kutongwa. Lancet. 2018 Kurume 17; 391: 1085-1096. Wona zvisingabvumirwe.
  63. Devinsky O, Patel AD, Muchinjikwa JH, et al. Mhedzisiro yeCannabidiol paDon Seizures muLennox-Gastaut Syndrome. N Engl J Med. 2018 Chivabvu 17; 378: 1888-1897. Wona zvisingabvumirwe.
  64. Pavlovic R, Nenna G, Calvi L, et al. Hunhu Hwehunhu hwe "Cannabidiol Oiri": Cannabinoids Zvemukati, Terpene Fingerprint uye Kugadzikana Kugadzikana kweEuropean Zvekutengesa Zviripo Kugadzirira. Mamorekuru. 2018 Chivabvu 20; 23. pii: E1230. Wona zvisingabvumirwe.
  65. Jannasch F, Kröger J, Schulze MB. Mapepa eDhijitari uye Type 2 Chirwere cheshuga: Kuongorora Kwakarongeka Mabhuku uye Meta-Kuongorora kweinotarisirwa Zvidzidzo. J Nutriti. 2017 Jun; 147: 1174-1182. Wona zvisingabvumirwe.
  66. Naftali T, Mechulam R, Marii A, et al. Low-dose cannabidiol yakachengeteka asi isingabatsiri pakurapa kweCrohn's Disease, kuongororwa kwakaitwa nemaitiro. Dig Dis Sci. 2017 Jun; 62: 1615-20. Wona zvisingabvumirwe.
  67. Kaplan EH, Offermann EA, Sievers JW, Comi AM. Cannabidiol kurapwa kwekugumburwa kunokanganisa muSturge-Weber Syndrome. Nyanzvi Neurol. 2017 Jun; 71: 18-23.e2. Wona zvisingabvumirwe.
  68. Yeshurun ​​M, Shpilberg O, Herscovici C, uye al. Cannabidiol yekudzivirira kubatanidzwa-kupesana-nehutachiona-chirwere mushure meallogeneic hematopoietic cell transplantation: mhedzisiro yechikamu chechipiri kudzidza. Biol Ropa Marrow Kuisa. 2015 Gumiguru; 21: 1770-5. Wona zvisingabvumirwe.
  69. Geffrey AL, Pollack SF, Bruno PL, Thiele EA. Kubatana kwezvinodhaka-zvinodhaka pakati peblobazam uye cannabidiol muvana vane pfari yekuratidzira. Pfari. 2015 Aug; 56: 1246-51. Wona zvisingabvumirwe.
  70. Devinsky O, Marsh E, Friedman D, et la. Cannabidiol muvarwere vane chirwere chisingarapiki pfari: rakavhurika-revhizheni kupindira kuyedza. Lancet Neurol. 2016 Kurume; 15: 270-8. Wona zvisingabvumirwe.
  71. 97021 Jadoon KA, Ratcliffe SH, Barrett DA, et al. Kubudirira uye chengetedzo ye cannabidiol uye tetrahydrocannabivarin pane glycemic uye lipid parameter mune varwere vane chirwere cheshuga 2: yakasarudzika, yakapofomara-bofu, inodzora-placebo-inodzorwa, yakafanana neboka mutyairi kudzidza. Chirwere cheshuga. 2016 Gumiguru; 39: 1777-86. Wona zvisingabvumirwe.
  72. Gofshteyn JS, Wilfong A, Devinsky O, uye al. Cannabidiol sechinhu chinogona kurapwa kwehutachiona hwehutachiona hune hukama nehutachiona hwehutachiona (FIRES) muzvikamu zvakanyanya uye zvisingaperi. J Mwana Neurol. 2017 Jan; 32: 35-40. Wona zvisingabvumirwe.
  73. Hess EJ, Moody KA, Geffrey AL, uye al. Cannabidiol senzira nyowani yekurapa kwekusabatirwa nemushonga pfari mune tuberous sclerosis yakaoma. Pfari. 2016 Oct; 57: 1617-24.
  74. Gaston TE, Bebin EM, Mucheki GR, Liu Y, Szaflarski JP; UAB CBD Chirongwa. Kubatana pakati pe cannabidiol uye inowanzo shandiswa antiepileptic zvinodhaka. Pfari. 2017 Sep; 58: 1586-92. Wona zvisingabvumirwe.
  75. Devinsky O, Muchinjikwa JH, Laux L, et al. Kuedzwa kwe cannabidiol yekubatwa nemishonga isingabatwe nemushonga muDravet Syndrome. N Engl J Med. 2017 Chivabvu 25; 376: 2011-2020. Wona zvisingabvumirwe.
  76. Bonn-Miller MO, Loflin MJE, Thomas BF, Marcu JP, Hyke T, Vandrey R. Kunyora kwakaringana kwe cannabidiol zvigadzirwa zvinotengeswa online. JAMA 2017 Mbudzi; 318: 1708-9. Wona zvisingabvumirwe.
  77. Malfait AM, Gallily R, Sumariwalla PF, et al. Iyo isiri-psychoactive cannabis-inoumba cannabidiol ndeyemuromo inorwisa-arthritic kurapwa mune murine collagen-inosimudzira arthritis. Proc Natl Acad Sci USA 2000; 97: 9561-6. Wona zvisingabvumirwe.
  78. Formukong EA, Evans AT, Evans FJ. Analgesic uye inopesana nekuzvimba chiitiko chematunhu eCannabis sativa L. Kuzvimba 1988; 12: 361-71. Wona zvisingabvumirwe.
  79. Valvassori SS, Elias G, de Souza B, et al. Mhedzisiro ye cannabidiol pane amphetamine-inosimudzira oxidative kusagadzikana chizvarwa mumhando yemhuka yemania. J Psychopharmacol 2011; 25: 274-80. Wona zvisingabvumirwe.
  80. Esposito G, Scuderi C, Savani C, et al. Cannabidiol mu vivo blunts beta-amyloid inosimudzira neuroinfigueation nekudzvanyirira IL-1beta uye iNOS kutaura. Br J Pharmacol 2007; 151: 1272-9. Wona zvisingabvumirwe.
  81. Esposito G, De Filippis D, Maiuri MC, et al. Cannabidiol inhibits inducible nitric oxide synthase protein expression uye nitric oxide yekugadzira mu beta-amyloid yakasimudzira PC12 neurons kuburikidza ne p38 MAP kinase uye NF-kappaB kubatanidzwa. Neurosci Lett 2006; 399 (1-2): 91-5. Wona zvisingabvumirwe.
  82. Iuvone T, Esposito G, De Filippis D, uye al. Cannabidiol: chivimbiso chitsva chemishonga yezvinetso zveurourogenerative? CNS Neurosci Ther 2009; 15: 65-75. Wona zvisingabvumirwe.
  83. Bisogno T, Di Marzo Y. Basa re endocannabinoid system muchirwere cheAlzheimer: chokwadi uye fungidziro. Curr Pharm Des 2008; 14: 2299-3305. Wona zvisingabvumirwe.
  84. Zuardi AW. Cannabidiol: kubva kune isingashande cannabinoid kune chinodhaka chine huwandu hwakawanda hwekuita. Rev Bras Psiquiatr 2008; 30: 271-80. Wona zvisingabvumirwe.
  85. Izzo AA, Borelli F, Capasso R, et al. Asiri-psychotropic chirimwa cannabinoids: mitsva yekurapa mikana kubva kune yekare miriwo. Maitiro Pharmacol Sci 2009; 30: 515-27. Wona zvisingabvumirwe.
  86. Booz GW. Cannabidiol senzira yekurapa yekurapa yekudzora kukanganiswa kwehutachiona pahutachiona hwehutachiona. Mahara Radic Biol Med 2011; 51: 1054-61. Wona zvisingabvumirwe.
  87. Anotora JT. Sedative chiitiko checannabis maererano neiyo delta'-trans-tetrahydrocannabinol uye cannabidiol zvemukati. Br J Pharmacol 1981; 72: 649-56. Wona zvisingabvumirwe.
  88. Monti JM. Hypnotic yakafanana mhedzisiro ye cannabidiol mumakonzo. Psychopharmacology (Berl) 1977; 55: 263-5. Wona zvisingabvumirwe.
  89. Karler R, Turkanis SA. Subacute cannabinoid kurapwa: anticonvulsant chiitiko uye kubvisa kufadza mumakonzo. Br J Pharmacol 1980; 68: 479-84. Wona zvisingabvumirwe.
  90. Karler R, Cely W, Turkanis SA. Iyo anticonvulsant chiitiko che cannabidiol uye cannabinol. Hupenyu Sci 1973; 13: 1527-31. Wona zvisingabvumirwe.
  91. Consroe PF, Wokin AL. Anticonvulsant kudyidzana kwe cannabidiol uye ethosuximide mumakonzo. J Pharm Pharmacol 1977; 29: 500-1. Wona zvisingabvumirwe.
  92. Consroe P, Wolkin A. Cannabidiol-antiepilpetic zvinodhaka zvinodhaka uye kuwirirana mukuedza kunokonzera kugumburwa mumakonzo. J Pharmacol Exp Ther 1977; 201: 26-32. Wona zvisingabvumirwe.
  93. Carlini EA, Leite JR, Tannhauser M, Berardi AC. Tsamba: Cannabidiol uye Cannabis sativa inobvisa inodzivirira mbeva nemakonzo kunopesana nevamiririri. J Pharm Pharmacol 1973; 25: 664-5. Wona zvisingabvumirwe.
  94. Cryan JF, Markou A, Lucki I. Kuongorora antidepressant chiitiko mumakonzo: zviitiko zvechangobva kuitika uye zvinodiwa mune ramangwana. Maitiro Pharmacol Sci 2002; 23: 238-45. Wona zvisingabvumirwe.
  95. El-Alfy AT, Ivey K, Robinson K, uye al. Antidepressant-senge mhedzisiro ye delta9-tetrahydrocannabinol uye mamwe ma cannabinoid akasarudzika kubva kuCannabis sativa L. Pharmacol Biochem Behav 2010; 95: 434-42. Wona zvisingabvumirwe.
  96. Dzorera LB, Tavares RF, Lisboa SF, et al. 5-HT1A receptors inobatanidzwa mune iyo cannabidiol-inokonzeresa kudzikisira kwehunhu uye nemoyo mhinduro kune kunetseka kwakanyanya mumakonzo. Br J Pharmacol 2009; 156: 181-8. Wona zvisingabvumirwe.
  97. Granjeiro EM, Gomes FV, ​​Guimaraes FS, et al. Mhedzisiro yekusagadzikana kwekutonga kwe cannabidiol pane yemoyo uye maitiro ekupindura kwakanyanya kudzvinyirira kusagadzikana. Pharmacol Biochem Behav 2011; 99: 743-8. Wona zvisingabvumirwe.
  98. Murillo-Rodriguez E, Millan-Aldaco D, Palomero-Rivero M, et al. Cannabidiol, nhengo yeCannabis sativa, inogadzirisa kurara mumakonzo. FEBS Lett 2006; 580: 4337-45. Wona zvisingabvumirwe.
  99. De Filippis D, Esposito G, Cirillo C, uye al. Cannabidiol inoderedza kuzvimba kwemukati kuburikidza nekutonga kweiyouroimmune axis. PLoS Imwe 2011; 6: e28159. Wona zvisingabvumirwe.
  100. Bhattacharyya S, Fusar-Poli P, Borgwardt S, et al. Kufananidza kwemidhiotemporal uye ventrostriatal basa muvanhu naDelta9-tetrahydrocannabinol: iyo neural hwaro hwemhedzisiro yeCannabis sativa pakudzidza uye psychosis. Arch Gen Psychiatry 2009; 66: 442-51. Wona zvisingabvumirwe.
  101. Dalton WS, Martz R, Lemberger L, et al. Kufuridzira kwe cannabidiol pane delta-9-tetrahydrocannabinol mhedzisiro. Kliniki Pharmacol Ther 1976; 19: 300-9. Wona zvisingabvumirwe.
  102. Guimaraes VM, Zuardi AW, Del Bel EA, Guimaraes FS. Cannabidiol inowedzera kutaura kweFos muiyo nucleus accumbens asi kwete mune dorsal striatum. Hupenyu Sci 2004; 75: 633-8. Wona zvisingabvumirwe.
  103. Moreira FA, Guimaraes FS. Cannabidiol inhibits iyo hyperlocomotion inokonzerwa ne psychomimetic zvinodhaka mumakonzo. Eur J Pharmacol 2005; 512 (2-3): 199-205. Wona zvisingabvumirwe.
  104. Yakareba LE, Chesworth R, Huang XF, et al. Kuenzanisa kwehunhu kweacute uye isingagumi Delta9-tetrahydrocannabinol uye cannabidiol muC57BL / 6JArc mbeva. Int J Neuropsychopharmacol 2010; 13: 861-76. Wona zvisingabvumirwe.
  105. Zuardi AW, Rodriguez JA, Cunha JM. Mhedzisiro ye cannabidiol mumhando dzemhuka kufungidzira kweantipsychotic chiitiko. Psychopharmacology (Berl) 1991; 104: 260-4. Wona zvisingabvumirwe.
  106. Malone DT, Jongejan D, Taylor DA. Cannabidiol inodzosera kuderedzwa kwekudyidzana kwevanhu kwakaburitswa nemushonga wakaderera Delta-tetrahydrocannabinol mumakonzo. Pharmacol Biochem Behav 2009; 93: 91-6. Wona zvisingabvumirwe.
  107. Schubart CD, Sommer IE, Fusar-Poli P, uye al. Cannabidiol sechinhu chinogona kurapwa chepfungwa. Eur Neuropsychopharmacol 2014; 24: 51-64. Wona zvisingabvumirwe.
  108. Campos AC, Moreira FA, Gomes FV, ​​et al. Nzira dzinoverengeka dzakabatanidzwa mune yakakura-spectrum yekurapa kugona kwe cannabidiol mumatambudziko epfungwa. Philos Trans R Soc Lond B Biol Sci 2012; 367: 3364-78. Wona zvisingabvumirwe.
  109. Fusar-Poli P, Allen P, Bhattacharyya S, uye al. Kufananidza kwekubatana kunoshanda panguva yekugadziriswa kwepamoyo naDelta 9-tetrahydrocannabinol uye cannabidiol. Int J Neuropsychopharmacol 2010; 13: 421-32. Wona zvisingabvumirwe.
  110. Casarotto PC, Gomes FV, ​​Resstel LB, Guimaraes FS. Cannabidiol inhibitory maitiro pamarble-yekuviga maitiro: kubatanidzwa kwe CB1 receptors. Behav Pharmacol 2010; 21: 353-8. Wona zvisingabvumirwe.
  111. Uribe-Marino A, Francisco A, Castiblanco-Urbina MA, et al. Anti-aversive mhedzisiro ye cannabidiol pane yekuzvarwa kutya-inosimudzira maitiro akakwenenzverwa nehunhu modhi yekuvhunduka kurwisa kunoenderana nemhuka kana nyoka yemusango Epicrates cenchria crassus yekukonana paradigm. Neuropsychopharmacology 2012; 37: 412-21. Wona zvisingabvumirwe.
  112. Campos AC, Guimaraes FS. Kushanda kwe5HT1A receptors inopindirana neanonolytic mhedzisiro ye cannabidiol mune PTSD modhi. Behav Pharmacol 2009; 20: S54.
  113. Dzorera LB, Joca SR, Moreira FA, et al. Mhedzisiro ye cannabidiol uye diazepam pane zvehunhu uye zvemoyo mhinduro dzinokonzerwa nemamiriro ezvinhu akatya mumakonzo. Behav Brain Res 2006; 172: 294-8. Wona zvisingabvumirwe.
  114. Moreira FA, Aguiar DC, Guimaraes FS. Anxiolytic-senge mhedzisiro ye cannabidiol mune iyo rat Vogel kupokana bvunzo. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 1466-71. Wona zvisingabvumirwe.
  115. Onaivi ES, Green MR, Martin BR. Pharmacological hunhu hwe cannabinoids mune yakakwira yekuwedzera maze. J Pharmacol Exp Ther 1990; 253: 1002-9. Wona zvisingabvumirwe.
  116. Guimaraes FS, Chairetti TM, Graeff FG, Zuardi AW. Antianxiety mhedzisiro ye cannabidiol mune yakakwira yekuwedzera-maze. Psychopharmacology (Berl) 1990; 100: 558-9. Wona zvisingabvumirwe.
  117. Magen Ini, Avraham Y, Ackerman Z, et al. Cannabidiol inosimudzira kukanganisika uye kukanganisika kwemotokari mumakonzo ane bile duct ligation. J Hepatol 2009; 51: 528-34. Wona zvisingabvumirwe.
  118. Rajesh M, Mukhopadhyay P, Batkai S, et al. Cannabidiol inodzivisa kusagadzikana kwemoyo, kushushikana kweiyo oxidative, fibrosis, uye kuzvimba uye sero kufa kuratidza nzira munzira mune chirwere cheshuga cardiomyopathy. J Ndiri Coll Cardiol 2010; 56: 2115-25. Wona zvisingabvumirwe.
  119. El-Remessy AB, Khalifa Y, Ola S, et al. Cannabidiol inodzivirira retinal neurons nekuchengetedza glutamine synthetase chiitiko mune chirwere cheshuga. Mol Vis 2010; 16: 1487-95. Wona zvisingabvumirwe.
  120. El-Remessy AB, Al-Shabrawey M, Khalifa Y, et al. Neuroprotective uye ropa-retina chipingaidzo-chengetedza mhedzisiro ye cannabidiol mune yekuyedza chirwere cheshuga. Am J Pathol 2006; 168: 235-44. Wona zvisingabvumirwe.
  121. Rajesh M, Mukhopadhyay P, Batkai S, et al. Cannabidiol inodzivirira yakakwira glucose-inokonzeresa endothelial cell kupisa mhinduro uye chipingamupinyi kukanganiswa. Am J Physiol Mwoyo Denderedzwa Physiol 2007; 293: H610-H619. Wona zvisingabvumirwe.
  122. Toth CC, Jedrzejewski NM, Ellis CL, Frey WH. Cannabinoid-mediated modulation yeuropathic marwadzo uye microglial kuunganidzwa mune yemhando yemurine mhando 1 chirwere cheshuga peripheral neuropathic pain. Mol Nhamo 2010; 6: 16. Wona zvisingabvumirwe.
  123. Aviello G, Romano B, Borrelli F, et al. Chemopreventive mhedzisiro yeiyo isiri-psychotropic phytocannabinoid cannabidiol pane yekuyedza kenza yekoloni. J Mol Med (Berl) 2012; 90: 925-34. Wona zvisingabvumirwe.
  124. Lee CY, Wey SP, Liao MH, uye al. Chidzidzo chekufananidza pamusoro pe cannabidiol-induced apoptosis mu murine thymocytes uye EL-4 thymoma masero. Int Immunopharmacol 2008; 8: 732-40. Wona zvisingabvumirwe.
  125. Massi P, Valenti M, Vaccani A, et al. 5-Lipoxygenase uye anandamide hydrolase (FAAH) inopindirana neantitumor chiitiko che cannabidiol, isiri-psychoactive cannabinoid. J Neurochem 2008; 104: 1091-100. Wona zvisingabvumirwe.
  126. Valenti M, Massi P, Bolognini D, et al. Cannabidiol, isiri-psychoactive cannabinoid kemikari inodzivirira glioma cell kutama uye invasiveness. 34th National Congress yeItaly Society yeFarmacology 2009.
  127. Torres S, Lorente M, Rodriguez-Fornes F, uye al. Iyo yakasanganiswa preclinical kurapwa kwe cannabinoids uye temozolomide kurwisa glioma. Mol Kenza Ther 2011; 10: 90-103. Wona zvisingabvumirwe.
  128. Jacobsson SO, Rongard E, Stridh M, et al. Serum-inotaridzika mhedzisiro yetamoxifen uye cannabinoids pane C6 glioma cell inogoneka. Biochem Pharmacol 2000; 60: 1807-13. Wona zvisingabvumirwe.
  129. Shrivastava A, Kuzontkoski PM, Groopman JE, Prasad A. Cannabidiol inokonzeresa kurongerwa kufa kwemasero mumasero ekenza yemazamu nekubatanidza hurukuro yekuyambuka pakati peapoptosis uye autophagy Mol Kenza Ther 2011; 10: 1161-72. Wona zvisingabvumirwe.
  130. McAllister SD, Murase R, Christian RT, uye al. Nzira dzinopindirana nemhedzisiro ye cannabidiol pane kudzikisira kenza yemazamu kuwanda kwesero, kupinda nechisimba. Cancer Yemazamu Kubata 2011; 129: 37-47. Wona zvisingabvumirwe.
  131. McAllister SD, Christian RT, Horowitz MP, et al. Cannabidiol seinovhura inhibitor yeId-1 geni kutaura mune ane hasha kenza yemazamu maseru. Mol Kenza Ther 2007; 6: 2921-7. Wona zvisingabvumirwe.
  132. Ligresti A, Moriello AS, Starowicz K, et al. Antitumor chiitiko chemuti cannabinoids nekusimbisa mhedzisiro ye cannabidiol pane yemazamu yemunhu carcinoma. J Pharmacol Exp Ther 2006; 318: 1375-87. Wona zvisingabvumirwe.
  133. Massi P, Solinas M, Cinquina V, Parolaro D. Cannabidiol seanogona kunge anticancer mushonga. Br J Clin Pharmacol 2013; 75: 303-12. Wona zvisingabvumirwe.
  134. Schubart CD, Sommer IE, van Gastel WA, et al. Cannabis ine yakakwira cannabidiol zvemukati inosanganiswa neashoma psychotic zviitiko. Schizophr Res 2011; 130 (1-3): 216-21. Wona zvisingabvumirwe.
  135. Englund A, Morrison PD, Nottage J, et al. Cannabidiol inhibits THC-yakaratidza zviratidzo zveparanoid uye hippocampal-inoenderana nekukanganisa ndangariro. J Psychopharmacol 2013; 27: 19-27. Wona zvisingabvumirwe.
  136. Devinsky O, Cilio MR, Muchinjikwa H, et al. Cannabidiol: pharmacology uye inogona kurapa chinzvimbo mune pfari uye zvimwe neuropsychiatric kusagadzikana. Epilepsia 2014; 55: 791-802. Wona zvisingabvumirwe.
  137. Serpell MG, Notcutt W, Collin C. Sativex kushandiswa kwenguva refu: rakavhurika-revhizheni kutongwa kune varwere vane spasticity nekuda kweakawanda sclerosis. J Neurol 2013; 260: 285-95. Wona zvisingabvumirwe.
  138. Notcutt W, Langford R, Davies P, et al. A-placebo-inodzorwa, yakafanana neboka, rakarongeka rekuregedza kudzidza kwezvidzidzo zvine zviratidzo zvekusasarudzika nekuda kweakawanda sclerosis ari kugamuchira kwenguva refu Sativex (nabiximols). Mult Scler 2012; 18: 219-28. Wona zvisingabvumirwe.
  139. Brady CM, DasGupta R, Dalton C, uye al. Chidzidzo chakavhurika-checannabis-based extracts ye bladder dysfuntion mune yepamusoro multiple sclerosis. Mult Scler 2004; 10: 425-33. Wona zvisingabvumirwe.
  140. Kavia RB, De Ridder D, Constantinescu CS, uye al. Randomized kudzorerwa kutongwa kweSativex kubata detrusor kunyanyisa mu multiple sclerosis. Wakawanda Scler 2010; 16: 1349-59. Wona zvisingabvumirwe.
  141. Wade DT, Makela PM, Imba H, et al. Kugara-kwenguva yakareba kushandiswa kwecannabis-based kurapwa mu spasticity uye zvimwe zviratidzo mu multiple sclerosis. Wakawanda Scler 2006; 12: 639-45. Wona zvisingabvumirwe.
  142. Novotna A, Mares J, Ratcliffe S, et al. Yakasarudzika, yakapofomara-yakapofumara, inochengetedzwa necashibho, -yakatarisana-boka, yakagadziridzwa-dhizaini yekudzidza yaabiximols * (Sativex), sekuwedzera-pane kurapa, mune zvidzidzo zvine kupokana kunoparira kunokonzerwa neakawanda sclerosis. Eur J Neurol 2011; 18: 1122-31. Wona zvisingabvumirwe.
  143. Mhedziso. GW Pharmaceuticals Webhusaiti.Inowanikwa pa: http://www.gwpharm.com/about-us-overview.aspx. Yakasvika: May 31, 2015.
  144. Cannabidiol Ikozvino Kuratidzira Kumusoro MuDiary Supplements. Natural Medicines Webhusaiti. https://naturalmedicines.therapeuticresearch.com/news/news-items/2015/march/cannabidiol-now-showing-up-in-dietary-supplements.aspx. (Yakasvika May 31, 2015).
  145. Zuardi AW, Cosme RA, Graeff FG, Guimaraes FS. Migumisiro yepsapirone uye cannabidiol pane kushungurudzika kwevanhu kwekuedza. J Psychopharmacol 1993; 7 (1 Suppl): 82-8. Wona zvisingabvumirwe.
  146. Akasununguka EG, Fentiman AF Jr, Foltz RL. Yakareba-yakachengetwa metabolites ye delta9- uye delta8-tetrahydrocannabinols inozivikanwa senge inoverengeka fatty acid conjugates. Res Commun Chem Pathol Pharmacol 1976; 14: 13-28. Wona zvisingabvumirwe.
  147. Samara E, Bialer M, Mechoulam R. Pharmacokinetics ye cannabidiol muimbwa. Zvinodhaka Metab Dispos 1988; 16: 469-72. Wona zvisingabvumirwe.
  148. Consroe P, Sandyk R, Snider SR. Vhura chitaridzi ongororo ye cannabidiol mune dystonic kufamba kusagadzikana. Int J Neurosci 1986; 30: 277-82. Wona zvisingabvumirwe.
  149. Crippa JA, Derenusson GN, Ferrari TB, et al. Neural hwaro hwekuzvidya mwoyo mhedzisiro ye cannabidiol (CBD) mune yakajairwa kusagadzikana kwehukama kusagadzikana: chirevo chekutanga. J Psychopharmacol 2011; 25: 121-30. Wona zvisingabvumirwe.
  150. Bornheim LM, Everhart ET, Li J, Correia MA. Hunhu hwe cannabidiol-yakagadziriswa cytochrome P450 inactivation. Biochem Pharmacol 1993; 45: 1323-31. Wona zvisingabvumirwe.
  151. Harvey DJ. Kubvisa, kugovera, uye biotransformation yeiyo cannabinoids. Mbanje neMishonga. 1999; 91-103.
  152. Yamaori S, Ebisawa J, Okushima Y, et al. Simba rekudzivirira kwevanhu cytochrome P450 3A isoforms ne cannabidiol: basa re phenolic hydroxyl mapoka mu resorcinol moiety. Hupenyu Sci 2011; 88 (15-16): 730-6. Wona zvisingabvumirwe.
  153. Yamaori S, Okamoto Y, Yamamoto I, Watanabe K. Cannabidiol, chikuru phytocannabinoid, seyakasimba atypical inhibitor yeCYP2D6. Zvinodhaka Metab Dispos 2011; 39: 2049-56. Wona zvisingabvumirwe.
  154. Yamaori S, Maeda C, Yamamoto I, Watanabe K. Misiyano inhibition ye cytochrome yevanhu P450 2A6 uye 2B6 neakakura phytocannabinoids. Forensic Toxicol 2011; 29: 117-24.
  155. Yamaori S, Kushihara M, Yamamoto I, Watanabe K. Unhu hwezvakakura phytocannabinoids, cannabidiol uye cannabinol, seye isoform-inosarudzika ine simba inhibitors emunhu CYP1 enzymes. Biochem Pharmacol 2010; 79: 1691-8. Wona zvisingabvumirwe.
  156. Zuardi AW, Crippa JA, Hallak JE, et al. Cannabidiol yekurapa psychosis muchirwere chePasinson. J Psychopharmacol 2009; 23: 979-83. Wona zvisingabvumirwe.
  157. Morgan CJ, Das RK, Joye A, et al. Cannabidiol inoderedza kusvuta fodya muvanoputa fodya: zvekutanga zviwanikwa. Kupindwa muropa Behav 2013; 38: 2433-6. Wona zvisingabvumirwe.
  158. Pertwee RG. Izvo zvakasiyana CB1 uye CB2 receptor pharmacology yemiti mitatu cannabinoids: delta9-tetrahydrocannabinol, cannabidiol uye delat9-tetrahydrocannabivarin. Br J Pharmacol. 2008; 153: 199-215. Wona zvisingabvumirwe.
  159. Leweke FM, Kranaster L, Pahlisch F, et al. Kubudirira kwe cannabidiol mukurapa kwechichichiphrenia - nzira yekushandura. Schizophr Bull 2011; 37 (Chikwata 1): 313.
  160. Leweke FM, Piomelli D, Pahlisch F, et al. Cannabidiol inowedzera anandamide signaling uye inoderedza psychotic zviratidzo zvechichichiphrenia. Dudzira Psychiatry 2012; 2: e94. Wona zvisingabvumirwe.
  161. Carroll CB, Bain PG, Kuchema L, et al. Cannabis yedyskinesia muParkinson chirwere: yakasarudzika mbiri-bofu crossover yekudzidza. Neurology 2004; 63: 1245-50. Wona zvisingabvumirwe.
  162. Bergamaschi MM, Queiroz RH, Chagas MH, et al. Cannabidiol inoderedza kushushikana kunokonzerwa neyakafananidzwa neruzhinji kutaura mukurapa-naïve munharaunda phobia varwere. Neuropsychopharmacology 2011; 36: 1219-26. Wona zvisingabvumirwe.
  163. Zuardi AW, Crippa JA, Hallak JE, et al. Cannabidiol, Cannabis sativa inoumba, sechirwere chepfungwa chepfungwa. Braz J Med Biol Res 2006; 39: 421-9. Wona zvisingabvumirwe.
  164. Yadav V, Bever C Jr, Bowen J, et al. Pfupiso yeuchapupu-hwakavakirwa nhungamiro: inowedzerana uye imwe nzira mushonga mune dzakawanda sclerosis: chirevo cheinongedzo yekuvandudza subcommittee yeAmerican Academy yeNeurology. Neurology. 2014; 82: 1083-92. Wona zvisingabvumirwe.
  165. Trembly B, Sherman M. Kaviri-bofu kliniki yekudzidza ye cannabidiol seyechipiri anticonvulsant. Marijuana '90 Musangano Wepasi Pese weCannabis uye Cannabinoids 1990; 2: 5.
  166. Srivastava, M. D., Srivastava, B. I., naBrouhard, B. Delta9 tetrahydrocannabinol uye cannabidiol inoshandura kugadzirwa kwecytokine nemasero emunodzivirira vanhu. Immunopharmacology 1998; 40: 179-185. Wona zvisingabvumirwe.
  167. Cunha, JM, Carlini, EA, Pereira, AE, Ramos, OL, Pimentel, C., Gagliardi, R., Sanvito, WL, Lander, N., naMechoulam, R. Kusingaperi kutarisira cannabidiol kune vanozvipira vane hutano uye varwere vane pfari. . Pharmacology 1980; 21: 175-185. Wona zvisingabvumirwe.
  168. Carlini EA, Cunha JM. Hypnotic uye antiepileptic mhedzisiro ye cannabidiol. J Clin Pharmacol 1981; 21 (8-9 Suppl): 417S-27S. Wona zvisingabvumirwe.
  169. Zuardi, A. W., Shirakawa, I., Finkelfarb, E., naKarniol, I. G. Kuita kwe cannabidiol pane kushushikana uye zvimwe zvinokonzerwa ne delta 9-THC mune zvakajairika zvidzidzo. Psychopharmacology (Berl) 1982; 76: 245-250. Wona zvisingabvumirwe.
  170. Ames, F. R. uye Cridland, S. Anticonvulsant mhedzisiro ye cannabidiol. S.Afr.Med.J. 1-4-1986; 69:14. Wona zvisingabvumirwe.
  171. Ohlsson, A., Lindgren, J. E., Andersson, S., Agurell, S., Gillespie, H., naHollister, L. E. Imwe-dose kinetics ye deuterium-yakanyorwa cannabidiol mumurume mushure mekusvuta uye intravenous administration. Biomed.Environ Mass Spectrom. 1986; 13: 77-83. Wona zvisingabvumirwe.
  172. Wade, D.T, Collin, C., Stott, C., naDuncombe, P. Meta-ongororo yekubudirira pamwe nekuchengeteka kweSativex (nabiximols), pakunyanyisa kwevanhu vane multiple sclerosis. Mult.Scler. 2010; 16: 707-714. Wona zvisingabvumirwe.
  173. Collin, C., Ehler, E., Waberzinek, G., Alsindi, Z., Davies, P., Powell, K., Notcutt, W., O'Leary, C., Ratcliffe, S., Novakova, I. ., Zapletalova, O., Pikova, J., naAmbler, Z. A-blind-blind, randomized, placebo-controlled, yakafanana-boka rekudzidza kweSativex, mune zvidzidzo zvine zviratidzo zvekunyanyisa nekuda kwe multiple sclerosis. Neurol.Res. 2010; 32: 451-459. Wona zvisingabvumirwe.
  174. Crippa, J. A., Zuardi, A. W., Martin-Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., naFusar-Poli, P. Cannabis nekuzvidya mwoyo: kuongorora kwakakomba kweuchapupu. Hum.Psychopharmacol. 2009; 24: 515-523. Wona zvisingabvumirwe.
  175. Consroe, P., Laguna, J., Allender, J., Snider, S., Stern, L., Sandyk, R., Kennedy, K., naSchram, K. Anodzora kiriniki kutongwa kwe cannabidiol muchirwere cheHuntington. Pharmacol Makemikari. Behav. 1991; 40: 701-708. Wona zvisingabvumirwe.
  176. Harvey, D.J, Samara, E., naMechoulam, R. Kuenzanisa metabolism ye cannabidiol muimbwa, rat uye murume. Pharmacol Makemikari. Behav. 1991; 40: 523-532. Wona zvisingabvumirwe.
  177. Collin, C., Davies, P., Mutiboko, I.K, naRatcliffe, S. Randomized muyedzo unodzorwa wecannabis-based mushonga mu spasticity inokonzerwa neakawanda sclerosis. Eur.J. Neurol. 2007; 14: 290-296. Wona zvisingabvumirwe.
  178. Massi, P., Vaccani, A., Bianchessi, S., Costa, B., Macchi, P., naParolaro, D. Iyo isiri-psychoactive cannabidiol inokonzeresa kuchenesa kushandiswa uye kushushikana kweiyo oxidative mumasero eglioma evanhu. Cell Mol. Hupenyu Sci. 2006; 63: 2057-2066. Wona zvisingabvumirwe.
  179. Weiss, L., Zeira, M., Reich, S., Har-Noy, M., Mechoulam, R., Slavin, S., naGallily, R. Cannabidiol inoderedza kuitika kwechirwere cheshuga mune mbeva dzeshuga dzisina mafuta. Kuzvimiririra 2006; 39: 143-151. Wona zvisingabvumirwe.
  180. Watzl, B., Scuderi, P., uye Watson, R. R. Marijuana zvinhu zvinomutsidzira vanhu peripheral ropa mononuclear cell secretion ye interferon-gamma uye kudzvanyirira interleukin-1 alpha mu vitro. Int J Immunopharmacol. 1991; 13: 1091-1097. Wona zvisingabvumirwe.
  181. Consroe, P., Kennedy, K., uye Schram, K. Kuongororwa kweplasma cannabidiol ne capillary gasi chromatography / ion mutezo wehukuru hwekutarisa zvichitevera yakakwira-dose inodzokororwa zuva nezuva kutungamirwa kwemuromo muvanhu. Pharmacol Makemikari. Behav. 1991; 40: 517-522. Wona zvisingabvumirwe.
  182. Barnes, M. P. Sativex: kiriniki inoshanda uye kushivirira pakurapa kwezviratidzo zve multiple sclerosis uye marwadzo europathic. Nyanzvi.Opin.Pharmacother. 2006; 7: 607-615. Wona zvisingabvumirwe.
  183. Wade, D.T, Makela, P., Robson, P., House, H., naBateman, C. Zvibodzwa zvekurapa zvecannabis zvine huwandu kana hwakanangana nezviratidzo mu multiple sclerosis? Yechipiri-bofu, yakasarudzika, placebo-inodzorwa kudzidza pane 160 varwere. Mult.Scler. 2004; 10: 434-441. Wona zvisingabvumirwe.
  184. Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M., uye Izzo, AA Neuroprotective mhedzisiro ye cannabidiol, isiri-psychoactive chinhu kubva kuCannabis sativa, pane beta-amyloid-inosimudzira chepfu muPC12 masero. J Neurochem. 2004; 89: 134-141. Wona zvisingabvumirwe.
  185. Massi, P., Vaccani, A., Ceruti, S., Colombo, A., Abbracchio, M. P., naParolaro, D. Antitumor mhedzisiro ye cannabidiol, isingashande cannabinoid, pane glioma cell mitsara. J Pharmacol Tsanangura. 2004; 308: 838-845. Wona zvisingabvumirwe.
  186. Crippa, JA, Zuardi, AW, Garrido, GE, Wichert-Ana, L., Guarnieri, R., Ferrari, L., Azevedo-Marques, PM, Hallak, JE, McGuire, PK, uye Filho, Busatto G. Mhedzisiro. ye cannabidiol (CBD) padunhu renzara yeropa kuyerera. Neuropsychopharmacology 2004; 29: 417-426. Wona zvisingabvumirwe.
  187. Wade, D.T., Robson, P., Imba, H., Makela, P., naAram, J. Chidzidzo chekutanga chinotariswa kuona kuti zvizere-zvirimwa zvecannabis zvinogona kuvandudza zvisingaite zviratidzo zvehutachiona. Kliniki Rehabil. 2003; 17: 21-29. Wona zvisingabvumirwe.
  188. Covington TR, et al. Handbook Rezvisinganyorerwi Zvinodhaka. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
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