Bosentan

Zvemukati

• Usati watora bosentan,
• Bosentan inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Zviratidzo zvinotevera zvakajairika, asi kana ukasangana nechimwe zvacho kana chakanyorwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:
• Zviratidzo zvekuwedzeredza zvinogona kusanganisira zvinotevera:

Kune varwere vevarume nevakadzi:

Bosentan inogona kukonzera kukuvara kwechiropa. Udza chiremba wako kana iwe wakambove kana wakambove nechirwere chechiropa. Chiremba wako acharaira kuongororwa kweropa kuti uve nechokwadi chekuti chiropa chako chiri kushanda zvakajairika usati watanga kutora bosentan uye mwedzi wega wega panguva yekurapwa kwako. Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Bosentan inogona kukuvadza chiropa isati yaunza zviratidzo. Kugara uchiongororwa ropa ndiyo chete nzira yekuwana kukuvara kwechiropa isati yagara uye yakaoma. Kana iwe ukasangana nechimwe chezviratidzo zvinotevera, danaidza chiremba wako nekukurumidza: kusvotwa, kurutsa, fivha, kurwadziwa mudumbu, yero yeganda kana maziso, kana kuneta kwakanyanya. Chiremba wako anogona kudzikisa dosi yako, kana kumbomira kwenguva pfupi kana zvachose kurapwa kwako ne bosentan kana iwe ukava nemhedzisiro kana uine akajairika marabhu mhedzisiro.

Kune varwere vechikadzi:

Usatore bosentan kana iwe uri nepamuviri kana kuronga kuve nepamuviri. Bosentan inogona kukuvadza fetus. Kana uchikwanisa kuve nepamuviri, uchafanirwa kutora nhumbu usati watanga kurapwa, mwedzi wega wega panguva yekurapwa, uye kwemwedzi mumwe mushure mekurapwa kwako kuratidza kuti hauna nhumbu. Chiremba wako anokuraira bvunzo dzepamuviri iwe. Iwe unofanirwa kushandisa nzira yakatendeka yekudzivirira kuberekwa panguva yekurapa kwako uye kwemwedzi mumwe mushure mekurapwa kwako. Hormonal contraceptive (mapiritsi ekudzivirira kubereka, zvigamba, mhete, maputi, uye zvigadzirwa zvemukati) zvinogona kusashanda zvakanaka kana zvichishandiswa ne bosentan uye hazvifanire kushandiswa senzira yako chete yekudzivirira kuberekwa. Taura nachiremba wako nezvenzira dzekudzivirira kuberekwa dzinokushandira. Muzviitiko zvakawanda iwe unozofanirwa kushandisa maviri maitiro ekudzivirira kuberekwa.

Fonera chiremba wako nekukasira kana iwe ukaita bonde zvisina kuzvidzivirira, funga kuti kuberekwa kwako kwakatadza, kupotsa nguva kana kufunga kuti unogona kuve nepamuviri iwe uri kutora bosentan. Usamirira kusvikira musangano wako unotevera kuti ukurukure izvi nachiremba wako.

Kana iwe uri mubereki kana muchengeti wemurwere wechikadzi anga asati asvika pakuyaruka, tarisa mwana wako nguva nenguva kuti aone kana ari kukura chero zviratidzo zvekuyaruka (mazamu mazamu, vhudzi rebvudzi) uye rega chiremba wake azive nezve chero shanduko.

Nekuda kwenjodzi dzekukuvara kwechiropa uye hurema hwekuzvara, bosentan inongowanikwa chete kuburikidza nechirongwa chakatemerwa chinonzi Tracleer Risk Evaluation uye Mitigation Strategy Chirongwa (Tracleer REMS). Kuti ugamuchire bosentan iwe nachiremba wako unofanirwa kunyoreswa neTracleer REMS, uye uteedzere zvirongwa zvinodikanwa senge kamwe pamwedzi kushanda kwechiropa uye kuyedza kwepamuviri. Chiremba wako achakunyoresa muchirongwa. Bosentan inongowanikwa kune mamwe mafamesi akanyoreswa neTracleer REMS. Kumbira chiremba wako kana wemishonga kana iwe uine chero mibvunzo nezvekuti ungazadza sei mushonga wako.

Iwe unozogamuchira gadziriro yemurwere yemapepa (Gwaro Rekurapa) paunotanga kurapwa ne bosentan uye pese paunozadza mushonga. Verenga ruzivo nokungwarira nguva dzese uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe zvakare unogona kuwana iyo Medication Gwaro kubva kune iyo FDA webhusaiti: http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm.

Taura nachiremba wako nezve njodzi dzekutora bosentan.

Bosentan inoshandiswa kurapa pulmonary arterial hypertension (PAH, kukwirisa kweropa mumidziyo inotakura ropa kumapapu) muvakuru nevana vana vane makore matatu zvichikwira. Bosentan inogona kuvandudza kugona kwekurovedza muviri uye kunonoka kuwedzera kwezviratidzo kune varwere vane PAH. Bosentan ari mukirasi yemishonga inonzi endothelin receptor vanopikisa. Inoshanda nekumisa chiito che endothelin, chinhu chechisikigo chinoita kuti tsinga dzeropa dziderere uye dzinodzivirira kuyerera kweropa kwakajairika kune vanhu vane PAH

Bosentan inouya sehwendefa uye sehwendefa inopararira (piritsi inogona kunyungudutswa mune mvura) kutora nemuromo. Inowanzo kutorwa pamwe kana pasina chikafu kaviri pazuva mangwanani nemanheru. Kuti ikubatsire kuyeuka kutora bosentan, tora panguva dzakatenderedza nguva dzakafanana zuva rega rega. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora bosentan chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Kana iwe uri kutora iyo inoparadzirwa piritsi, isa iyo piritsi mune diki diki yemvura usati watora iyo. Kana chiremba wako akakuudza kuti utore hafu yepiritsi, tsemura piritsi rinopararira zvakanyatsonaka pamutsetse. Tora iyo hafu piritsi sezvakarairwa, woisa imwe hafu kumashure mublister rakavhurika mupakeji. Shandisa imwe hafu yepiritsi mukati memazuva manomwe. Usatyora piritsi raparadzirwa kuita makamuri.

Chiremba wako angangotanga iwe pane yakaderera dosi ye bosentan uye wedzera yako dose mushure memasvondo mana.

Bosentan inodzora zviratidzo zvePAH asi hairape. Zvinogona kutora 1 kusvika kumwedzi miviri kana kupfuura usati wanzwa kuzara kwakazara kwe bosentan. Ramba uchitora bosentan kunyangwe uchinzwa zvakanaka. Usarega kutora bosentan usina kutaura nachiremba wako. Kana iwe ukangoerekana warega kutora bosentan, zviratidzo zvako zvinogona kuwedzera. Chiremba wako anogona kudzora dosi rako zvishoma nezvishoma.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora bosentan,

• udza chiremba wako uye wemishonga kana uri weergoria kune bosentan, chero mimwe mishonga, kana chero chinhu chinowanikwa mumapiritsi e bosentan kana mapiritsi anopararira.
• usatora cyclosporine (Gengraf, Neoral, Sandimmune) kana glyburide (DiaBeta, Glynase) uchitora bosentan.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzerwa nezvehutano, uye mishonga yemakwenzi yauri kutora. Ive neshuwa yekutaura chero eanotevera: amiodarone (Nexterone, Pacerone); cholesterol-kudzikisa mishonga (masitamin) senge atorvastatin (Lipitor, muCaduet), lovastatin (Altoprev), uye simvastatin (Flolopid, Zocor, muVytorin); diltiazem (Cardizem, Cartia, Diltzac, vamwe); erythromycin (EES, Eryc, PCE); fluconazole (Diflucan); gemfibrozil (Lopid); itraconazole (Onmel, Sporanox); ketoconazole; rifampin (Rifadin, Rimactane, muRifater, Rifamate); ritonavir (Norvir, muKaletra, Viekira Pak, Technivie); voriconazole (Vfend); uye warfarin (Coumadin, Jantoven). Mimwe mishonga yakawanda inogona zvakare kusangana ne bosentan, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa. Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
• udza chiremba wako kana iwe wakambove nemoyo wekutadza (mamiriro apo moyo usingakwanise kupomba ropa rakakwana kune mamwe mativi emuviri).
• udza chiremba wako kana iwe uchiyamwisa kana kuronga kuyamwisa. Chiremba wako anogona kuzokuudza kuti usamwisa mukanwa uchitora bosentan.
• kana iwe uine phenylketonuria (PKU, chinzvimbo chakagarwa nhaka umo chikafu chakasarudzika chinofanira kuteverwa kudzivirira kudzora kwepfungwa), iwe unofanirwa kuziva kuti mapiritsi anoparadzirwa anotapira neaspartame, sosi ye phenylalanine

Taura nachiremba wako nezve kunwa muto wemazambiringa paunenge uchitora mushonga uyu.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira. Zvisinei, kana yava nguva yenguva inotevera, svetuka chirwere chakarasika uye ramba uchiita purogiramu yako yenguva dzose. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Bosentan inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• musoro
• kufashaira
• inomhanya mhino, huro, uye zvimwe zvinotonhora zviratidzo
• kurwadza kwemajoini

Mimwe mhedzisiro inogona kuve yakakomba. Zviratidzo zvinotevera zvakajairika, asi kana ukasangana nechimwe zvacho kana chakanyorwa muchikamu CHINOKOSHA CHENYENZO, fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• mikoko; mapundu; kuvava; kunetseka kufema kana kumedza; kuzvimba kwechiso, huro, rurimi, miromo, uye maziso; hoarseness; kupindwa nechando; kuzvimba lymph nodes; kuneta
• kuzvimba kwetsoka, makumbo, kana makumbo ezasi, kuwedzera uremu nekukasira, kunetseka zvakanyanya nekufema kupfuura zvakajairwa
• kutsva kana kuwedzera kufema kwekufema; chitsva kana kuwedzera kukosora pamwe kana pasina ropa; kurwadziwa muchipfuva; nekukurumidza, kurovera, kana kurova kwemoyo zvisina kujairika
• kufenda
• dzungu; ganda rakachenuruka; mweya wekufema; kushaya simba; nekukurumidza, kurovera, kana kurova kwemoyo zvisina kujairika

Mombe dzemarabhoritari mhuka dzakapihwa mishonga yakafanana ne bosentan dzakatanga matambudziko nemachende avo uye dzikaburitsa urume hushoma (masero ekubereka echirume) kupfuura zvakajairwa. Hazvizivikanwe kuti bosentan inokuvadza machende here kana kudzikisa huwandu hwesperm inogadzirwa nevarume. Taura nachiremba wako nezve njodzi dzekutora bosentan kana uchida kuva nevana mune ramangwana.

Bosentan inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira zvinotevera:

• musoro
• kusvotwa
• kurutsa
• kukurumidza kurova kwemoyo
• kufenda
• vangadikitira
• dzungu
• kusaona zvakanaka

Usarega mumwe munhu achitora mushonga wako. Kumbira chiremba wako chero mibvunzo yaunayo pamusoro pekuzadza mushonga wako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Tracleer^®