Nilotinib

Zvemukati

• Usati watora nilotinib,
• Nilotinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo kana izvo zvakanyorwa mune CHINOKOSHA CHENYENZO chikamu, dana chiremba wako nekukurumidza:

Nilotinib inogona kukonzera kuwedzera kweQT (irregular moyo rhythm iyo inogona kutungamira mukufenda, kurasikirwa kwekuziva, kubatwa, kana kufa kamwe kamwe). Udza chiremba wako kana iwe kana chero munhu mumhuri yako ane kana akambove neakareba QT syndrome (iyo yakagara nhaka mamiriro umo munhu angangodaro ane QT kuwedzera) kana iwe kana wakambove uine yakaderera masosi e potasium kana magnesium muropa rako. , kurova kwemoyo zvisina kujairika, kana chirwere chechiropa. Udza chiremba wako uye wemishonga kana uri kutora amiodarone (Nexterone, Pacerone); antifungals senge ketoconazole, itraconazole (Onmel, Sporanox), kana voriconazole (Vfend); chloroquine (Plaquenil); clarithromycin (Biaxin, muPrevpac); disopyramide (Norpace); erythromycin (EES, Eryc, PCE); mimwe mishonga yehutachiona hwehutachiona hwehutachiona hweHIV (HIV) kana yakawanikwa immunodeficiency syndrome (AIDS) yakadai seatazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, muKaletra), uye saquinavir (Invirase); haloperidol (Haldol); methadone (Dolophine, Methadose); moxifloxacin (Avelox); nefazodone; pimozide (Orap); procainamide; quinidine (muNuedexta); sotalol (Betapace, Betapace AF, vamwe); telithromycin (Ketek); uye thioridazine. Kana iwe ukasangana nechimwe chezviratidzo zvinotevera, rega kutora nilotinib uye udane chiremba wako nekukurumidza: kukurumidza, kurova, kana kusagadzikana kwemwoyo; kufenda; kurasikirwa kwekuziva; kana kufenda.

Usadye chero chikafu kwemaawa maviri usati watora nilotinib uye kweawa rimwe mushure mekutora mushonga uyu.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira kumwe bvunzo, senge kuongororwa ropa uye maelectrocardiograms (EKGs, bvunzo dzinorekodha mashandiro emagetsi emoyo) usati uye panguva yekurapwa kwako kuve nechokwadi kuti zvakachengeteka kuti iwe utore nilotinib.

Chiremba wako kana wemishonga anokupa iro gadziriro yeruzivo yemurwere (Gwaro Rekurapa) paunotanga kurapwa ne nilotinib uye pese paunozadza mushonga wako. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kana webhusaiti yemugadziri kuti utore Gwaro reMishonga.

Taura nachiremba wako nezve njodzi dzekutora nilotinib.

Nilotinib inoshandiswa kurapa mamwe marudzi echirwere chisingaperi chemyeloid leukemia (CML; rudzi rwekenza yemasero machena eropa) avo vachangobva kuwana vane mamiriro aya muvakuru nevana vana vane makore 1 zvichikwira. Iyo inoshandiswawo kurapa mamwe marudzi eCML ayo chirwere chisingakwanise kurapwa zvinobudirira ne imatinib (Gleevec) kana vakuru vasingakwanise kutora imatinib. Nilotinib inoshandiswawo kurapa mamwe marudzi eCML muvana vane makore 1 ekuberekwa kana kupfuura avo chirwere chavo chisingakwanise kurapwa zvinobudirira neimwe tyrosine kinase inhibitor Therapies. Nilotinib ari mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito chepuroteni isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kumisa kana kunonoka kupararira kwekenza masero.

Nilotinib inouya sekapuleti kutora nemuromo. Inowanzo kutorwa isina chikafu kaviri pazuva. Nilotinib inofanira kutorwa isina chinhu mudumbu, kanenge maawa maviri pamberi kana 1 awa mushure mekudya chero chikafu. Tora nilotinib kwakatenderedza nguva dzakafanana zuva rega rega. Edza kuisa nzvimbo yako madhora anenge gumi nemaviri akaparadzaniswa. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora nilotinib chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza macapsule akazara negirazi remvura; usatsemure, kutsenga, kana kuvapwanya. Kana iwe usingakwanise kumedza macapsules akazara, sanganisa zvirimo mune kapsule mune imwe teaspoon yeapurosiuce. Medza musanganiswa wacho nekukasira (mukati memaminitsi gumi nemashanu.)

Chiremba wako anogona kudzikisa yako nilotinib dose kana kumisa kurapa kwako zvichienderana nekuti mushonga unoshanda sei kwauri uye kana iwe uchinge uine chero mhedzisiro. Ramba uchitora nilotinib kunyangwe iwe uchinzwa zvakanaka. Usarega kutora nilotinib usina kutaura nachiremba wako.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora nilotinib,

• udza chiremba wako uye wemishonga kana uri weergoria kune nilotinib, chero mimwe mishonga, kana chero chinhu chinosanganiswa mune nilotinib capsules. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, uye zvinovaka muviri zvaunotora kana kuronga kutora. Ive neshuwa yekutaura mishonga yakanyorwa mune CHINOKOSHA CHENYENZO chikamu uye chero cheanotevera: mamwe angiotensin-receptor blockers senge irbesartan (Avapro, muAvalide) uye losartan (Cozaar, muHyzaar); anticoagulants ('' ropa rinoonda '') senge warfarin (Coumadin, Jantoven); aripiprazole (Abilify); mamwe benzodiazepines akadai sealprazolam (Xanax), diazepam (Valium), midazolam, uye triazolam (Halcion); buspirone (Buspar); mamwe macalcium chiteshi anovharira senge amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, vamwe), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), uye verapamil (Calan, Verelan, vamwe) ; mamwe cholesterol-ekudzikisa mishonga (statins) inosanganisira atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), uye simvastatin (Zocor); chlorpheniramine (Chlor-Trimeton, chimwe chikosoro uye zvigadzirwa zvinotonhora); dexamethasone; dihydroergotamine (DHHE 45, Migranal); ergotamine (muCafergot, muErgomar); fentanyl (Actiq, Duragesic, Subsys); flecainide (Tambocor); mimwe mishonga yekushungurudzika senge amitriptyline, desipramine (Norpramin); duloxetine (Cymbalta); imipramine (Tofranil); paroxetine (Brisdelle, Paxil, Pexeva); uye venlafaxine (Effexor); mimwe mishonga yemumuromo yeshuga yakadai se glipizide (Glucotrol) uye tolbutamide; mimwe mishonga inodzvinyirira immune system se cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), uye tacrolimus (Prograf); mimwe mishonga yekubatwa senge carbamazepine (Equetro, Tegretol, Teril), phenobarbital, uye phenytoin (Dilantin, Phenytek); mexiletine; mamwe asiri -steroidal anti-anogumbura zvinodhaka (NSAIDs) senge celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), uye piroxicam (Feldene); ondansetron (Zofran); propafenone (Rythmol); proton-pump inhibitors senge esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), uye rabeprazole (AcipHex); quinine (Qualaquin); rifabutin (Mycobutin); rifampin (Rifadin); rifapentine (Priftin); risperidone (Risperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, vamwe); timolol; torsemide; tramadol (Ultram, mu Ultracet); trazodone; uye vincristine. Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kusangana ne nilotinib, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
• kana iwe uri kutora antacids ine magnesium, aluminium (Maalox, Mylanta, Tums, vamwe), kana simethicone, tora antacid maawa maviri pamberi kana angangoita maawa maviri mushure mekutora nilotinib.
• kana iwe uri kutora mushonga wekugaya, kuora moyo, kana ulcers senge cimetidine (Tagamet), famotidine (Pepcid, muAxxis), nizatidine (Axid), kana ranitidine (Zantac), tora kanenge maawa gumi zvisati zvaitika kana angangoita 2 maawa mushure mekutora nilotinib.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's wort.
• udza chiremba wako kana iwe wakarohwa kana kuvhiyiwa kubvisa dumbu rese (yakazara gastrectomy). Zvakare, udza chiremba wako kana iwe kana wakambodzikira kuyerera kweropa kumakumbo ako, chero matambudziko emwoyo, matambudziko ekubuda ropa, pancreatitis (kuzvimba kwepancreas, gland kuseri kweiyo inogadzira zvinhu zvekubatsira kugaya), kana chero mamiriro zvinoita kuti zvikunetse kugaya lactose (mukaka shuga) kana zvimwe shuga.
• udza chiremba wako kana iwe uine pamuviri kana kuronga kuva nepamuviri. Iwe haufanire kuve nepamuviri iwe uchitora nilotinib. Iwe unofanirwa kushandisa inoshanda yekudzivirira kudzivirira kubata pamuviri panguva yekurapa kwako nilotinib uye kwemazuva gumi nemana mushure mekupedzisira kwedosi. Taura nachiremba wako nezve nzira dzekudzivirira kuberekwa dzaunogona kushandisa panguva yekurapa kwako. Kana iwe ukava nepamuviri uchitora nilotinib, dana chiremba wako pakarepo. Nilotinib inogona kukuvadza fetus.
• udza chiremba wako kana iwe uchiyamwisa. Iwe haufanire kuyamwisa iwe uchiri kutora nilotinib uye kwemazuva gumi nemana mushure mechiyero chako chekupedzisira.
• kana uri kuvhiyiwa, kusanganisira kuvhiya mazino, udza chiremba kana chiremba wemazino kuti urikutora nilotinib.

Usadye grapefruit, kunwa muto wemazambiringa, kana kutora chero chinowedzera chine grapefruit yakabviswa uchinwa mushonga uyu.

Darika iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Nilotinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• mapundu
• kuvava
• kusvotwa
• kurutsa
• manyoka
• kuvimbiswa
• chirungurira
• gasi
• kurasikirwa nenzara
• musoro
• dzungu
• kuneta
• kunetseka kurara kana kuramba wakarara
• husiku hweziya
• tsandanyama
• musana, bone, kubatana, nhengo, kana kurwadziwa kwemhasuru
• kurasikirwa nevhudzi
• ganda rakaoma kana rakatsvuka
• chiveve, kupisa, kana kugwinha maoko kana tsoka

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo kana izvo zvakanyorwa mune CHINOKOSHA CHENYENZO chikamu, dana chiremba wako nekukurumidza:

• kubuda ropa zvisina kujairika kana kupwanya
• ropa mune weti
• Ropa kana dema, zvigaro zvekugara
• kamwe-kamwe musoro, kuvhiringidzika, kana kuchinja mune zvakaratidzwa
• kuneta zvisina kujairika kana kushaya simba
• kurwadziwa pachifuva kana kusagadzikana
• matambudziko kufamba kana kutaura
• chiveve
• shanduko paganda reganda
• kurwadziwa kana kutonhora kwekunzwa mumakumbo
• kurwadziwa mudumbu nekusvotwa uye kurutsa
• fivha, kutonhora, huro, kuora kuri kuramba kuchiita uye kuzara, kana zvimwe zviratidzo zvehutachiona
• ganda rakachenuruka
• mweya wekufema
• kurema kuwedzera
• kuzvimba kwemaoko, makumbo, tsoka, kana kumeso
• kurwadziwa kana kusagadzikana mune yekurudyi kumusoro mudumbu nzvimbo
• yero yeganda nemaziso
• weti yakasviba
• kuita weti zvishoma nezvishoma kupfuura zvakajairwa

Nilotinib inogona kukonzera vana kukura zvishoma nezvishoma. Chiremba wemwana wako anozotarisa kukura kwemwana wako nokungwarira apo mwana wako ari kutora nilotinib. Taura nachiremba wemwana wako nezve njodzi dzekupa uyu mushonga kumwana wako.

Nilotinib inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

• fivha, huro, chironda, kana zvimwe zviratidzo zvehutachiona
• kurutsa
• kutsimwaira

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Tasigna^®