Munyori: Marcus Baldwin
Zuva Rekusika: 18 Chikumi 2021
Gadziridza Zuva: 16 Mbudzi 2024
Anonim
How does Dapagliflozin work? Understanding SGLT2 inhibitors.
Vhidhiyo: How does Dapagliflozin work? Understanding SGLT2 inhibitors.

Zvemukati

Dapagliflozin inoshandiswa pamwe nekudya uye kurovedza muviri, uye dzimwe nguva nemimwe mishonga, kudzikisa huwandu hweshuga yeropa kune vanhu vakuru vane chirwere cheshuga chechipiri (mamiriro umo shuga yeropa yakanyanyisa nekuti muviri haugadzi kana kushandisa insulin zvakajairika). Dapagliflozin inoshandiswawo kudzikisa njodzi yekuda kuiswa muchipatara nekuda kwekutadza kwemoyo kune vanhu vakuru vane chirwere cheshuga chechipiri pamwe nemoyo uye neropa chirwere chirwere kana vane mikana yakawanda yekukudziridza chirwere chemwoyo neropa. Dapagliflozin inoshandiswawo muvakuru vane kukundikana kwemoyo kudzikisa njodzi yekuda kuiswa muchipatara uye kufa nekuda kwechirwere chemwoyo neropa. Dapagliflozin iri mukirasi yemishonga inonzi sodium-glucose co-transporter 2 (SGLT2) inhibitors. Iyo inoderedza shuga yeropa nekukonzera itsvo kubvisa yakawanda glucose mumurini. Dapagliflozin haishandiswe kurapa rudzi rwekutanga chirwere cheshuga (mamiriro umo muviri usingaburitse insulin uye, nekudaro, haugone kudzora huwandu hweshuga muropa) kana chirwere cheshuga ketoacidosis (chakakomba mamiriro anogona kukura kana shuga yepamusoro yeropa isina kurapwa ).


Nekufamba kwenguva, vanhu vane chirwere cheshuga uye shuga yakakwira muropa vanogona kukura zvakakomba kana kutyisidzira hupenyu, kusanganisira chirwere chemwoyo, sitiroko, matambudziko eitsvo, kukuvara kwemitsipa uye matambudziko eziso. Kutora dapagliflozin, kugadzirisa mararamiro (semuenzaniso, kudya, kurovedza muviri, kurega kusvuta), uye kugara uchiongorora shuga yako yeropa kunogona kubatsira kubata chirwere cheshuga nekuvandudza hutano hwako. Iyi kurapa inogona zvakare kudzikisira mikana yako yekuve nekurwadziwa kwemoyo, sitiroko, kana zvimwe zvinetso zvine chekuita neshuga senge itsvo kutadza, kukuvara kwemitsipa (chiveve, kutonhora makumbo kana tsoka; kudzikira kugona bonde kune varume nevakadzi), matambudziko eziso, kusanganisira shanduko. kana kurasikirwa kwemaonero, kana chingamu chirwere. Chiremba wako nevamwe vanopa hutano vachataura newe nezvenzira yakanakisa yekurapa chirwere cheshuga.

Dapagliflozin inouya sehwendefa kutora nemuromo. Inotorwa kazhinji iine kana isina chikafu kamwe pazuva pazuva mangwanani. Tora dapagliflozin panguva dzakatenderedza nguva imwechete mazuva ese. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora dapagliflozin chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.


Chiremba wako anogona kukutanga pane yakaderera dapagliflozin uye wedzera yako dose kana zvichidikanwa.

Dapagliflozin inodzora mhando 2 chirwere cheshuga asi haichirape. Ramba uchitora dapagliflozin kunyangwe iwe uchinzwa zvakanaka. Usarega kutora dapagliflozin usina kutaura nachiremba wako.

Chiremba wako kana wemishonga anokupa iro gadziriro yeruzivo yemurwere (Mishonga Inotungamira) paunotanga kurapwa nedapagliflozin uye pese paunozadza mushonga wako. Verenga iwo ruzivo nokungwarira uye bvunza chiremba wako kana wemishonga kana iwe uine chero mibvunzo. Iwe unogona zvakare kushanyira Chikafu neDrug Administration (FDA) webhusaiti (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) kuti utore Gwaro reMishonga.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora dapagliflozin,

  • udza chiremba wako uye wemishonga kana iwe uri weergoria kune dapagliflozin, chero mimwe mishonga, kana chero chipi zvacho chemapiritsi epa dapagliflozin. Kumbira wemishonga wako kana tarisa Gwaro Rekurapa kuti uwane runyorwa rwezvigadzirwa.
  • udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemakwenzi yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: angiotensin-inoshandura enzyme (ACE) inhibitors senge benazepril (Lotensin, muLotrel), captopril, enalapril (Vasotec, muVaseretic), fosinopril, lisinopril (muZestoretic), moexipril (Univasc, Uniretic), perindopril (Aceon, muPrestalia), ramipril (Altace), uye trandolapril (Mavik, muTarka); angiotensin receptor blockers (ARB) senge azilsartan (Edarbi, muEdbybyclor), candesartan (Atacand, muAtacand HCT), eprosartan (Teveten), irbesartan (Avapro, muAvalide), losartan (Cozaar, muHyzaar), olmesartan (Benicar, muAzor, muBenicar HCT, muTribenzor), telmisartan (Micardis, muMicardis HCT, muTwynsta); asipurini uye mamwe nonsteroidal anti-anogumbura mishonga (NSAIDS) senge ibuprofen (Advil, Motrin) uye naproxen (Aleve, Naprosyn) mishonga yeshuga se glimepiride (Amaryl, muDuetact), glipizide (Glucotrol), glyburide (DiaBeta, Glynase), repaglinide (Prandin, muPandimet), uye tolbutamide; diuretics ('mapiritsi emvura'); uye insulin.
  • udza chiremba wako kana iwe uri pane dialysis uye kana iwe uine kana wakambove uine chirwere cheitsvo. Chiremba wako anogona kukuudza kuti usatore dapagliflozin.
  • udza chiremba wako kana iwe uchigara uchinwa doro kana dzimwe nguva unonwa yakawanda doro munguva pfupi (kunwa doro) kana kana iwe uri pane yakaderera sodium kudya. Uyezve udza chiremba wako kana iwe wakambove nekutadza kwemoyo, chirwere chepancreatic chinosanganisira pancreatitis (kuzvimba kwepancreas) kana kuti wakavhiyiwa pancreas, hutachiona hwehutachiona kana matambudziko kuita weti, yakaderera BP, utachiona hwembiriso munzvimbo yekubereka, itsvo kana chirwere chechiropa. Kana iwe uri murume, udza chiremba wako kana usati wadzingiswa. Uyezve udza chiremba wako, kana iwe uchidya zvishoma nekuda kwechirwere, kuvhiyiwa kana shanduko mukudya kwako, kana uchangobva kuita manyoka, kurutsa, kusanwa mvura yakakwana, wave muzuva rakareba zvakanyanya, kana wanga uchidikitira zvakanyanya, izvo zvinogona kukonzera kupera simba (kurasikirwa kwehuwandu hwakawanda hwemvura yemuviri).
  • udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Usamwisa mwana paunenge uchitora dapagliflozin. Kana iwe ukava nepamuviri uchitora dapagliflozin, fonera chiremba wako.
  • kana uri kuvhiyiwa, kusanganisira kuvhiya mazino, udza chiremba kana chiremba wemazino kuti urikutora dapagliflozin. Chiremba wako angangokuudza kuti rega kutora dapagliflozin kana mazuva matatu usati wavhiyiwa.
  • doro rinogona kukonzera shanduko muropa shuga. Kumbira chiremba wako nezve kushandiswa kwakachengeteka kwezvinwiwa zvinodhaka paunenge uchitora dapagliflozin.
  • iwe unofanirwa kuziva kuti dapagliflozin inogona kukonzeresa dzungu, huremu husina musoro, uye kupera simba paunosimuka nekukurumidza kubva panzvimbo yekunyepa. Kana uine dambudziko iri, fonera chiremba wako. Dambudziko iri rakajairika paunotanga kutora dapagliflozin. Kuti udzivise dambudziko iri, simuka pamubhedha zvishoma nezvishoma, uchizorora tsoka dzako pasi kwemaminetsi mashoma usati wasimuka.
  • bvunza chiremba wako zvekuita kana iwe ukarwara, ukava nehutachiona kana fivha, ukawana kushushikana kusingawanzo, kana kukuvara. Aya mamiriro anogona kukanganisa shuga yako yeropa uye huwandu hwedapagliflozin iwe yaungangoda.

Ive neshuwa yekutevera zvese zvekurovedza muviri uye zvekudya zvinokurudzirwa zvakaitwa nachiremba wako kana wezvekudya. Zvakakosha kudya kudya kunovaka muviri uye kurovedza muviri nguva dzose.


Tevedza rairo yechiremba wako nezve kunwa mvura yakakwana zuva rese iwe uchinge uri pamushonga uyu.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira. Zvisinei, kana yava nguva yenguva inotevera, svetuka chirwere chakarasika uye ramba uchiita purogiramu yako yenguva dzose. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Mushonga uyu unogona kukonzera shanduko muropa rako shuga. Iwe unofanirwa kuziva zviratidzo zveshuga yakadzika uye yakakwira yeropa uye zvekuita kana iwe uine izvi zviratidzo.

Dapagliflozin inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

  • kuita weti yakawanda, kusanganisira nehusiku
  • kuwedzera nyota

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukasira:

  • kazhinji, kukurumidza, kupisa, kana kurwadza weti
  • weti ine makore, tsvuku, pingi, kana shava
  • weti yakasimba inonhuwa
  • kuderera muhuwandu weti
  • pelvic kana rectal kurwadziwa
  • (mune vakadzi) kunhuhwirira kwemukadzi, chena kana yero yenyuchi kubuda (kungave kune bundu kana kutaridzika sekottage chizi), kana kusangana nekutsi kwemukadzi
  • (mune varume) kutsvuka, kuchenesa, kana kuzvimba kwenhengo yemurume; mapundu panhengo yesikarudzi; kusvibiswa kunhuwa kubva peni; kana kurwadziwa paganda rakatenderedza nhengo yemurume
  • kunzwa kuneta, kushaya simba, kana kusagadzikana; pamwe nefivha uye kurwadziwa, hunyoro, kutsvuka, uye kuzvimba kwenhengo dzesikarudzi kana nzvimbo iri pakati pesikarudzi nerekure
  • kuzvimba kwemakumbo kana tsoka

Kana iwe ukawana chero yeanotevera zviratidzo, rega kutora dapagliflozin uye fonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

  • mapundu
  • mikoko
  • kuvava
  • kunetseka kufema kana kumedza
  • kuzvimba kwechiso, huro, rurimi, miromo, muromo, kana maziso
  • hoarseness

Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchiona ketoacidosis, rega kutora dapagliflozin uye kufonera chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidza. Kana zvichikwanisika, tarisa ketoni mumuguta wako kana uine zviratidzo izvi, kunyangwe shuga yako yeropa iri pasi pe250 mg / dL:

  • kusvotwa
  • kurutsa
  • dumbu-nzvimbo kurwadziwa
  • kuneta
  • kunetseka kufema

Dapagliflozin inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe uye kusvika kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakavharira makapu ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye kubva kwavari uye kusvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako angangoda kuraira kumwe kuongorora kwerabhoritari usati uye panguva yekurapa kwako kuti utarise mhinduro yemuviri wako kune dapagliflozin.

Mashuga eropa rako anofanirwa kuongororwa nguva nenguva kuti uone kupindura kwako kune dapagliflozin. Chiremba wako acharaira mamwe bvunzo bvunzo, kusanganisira glycosylated hemoglobin (HbA1c), kutarisa mhinduro yako kune dapagliflozin. Chiremba wako anokuudzawo maitiro ekutarisa mhinduro yako kumushonga uyu nekuyera huwandu hweshuga yeropa kumba. Tevedza rairo idzi zvakanyatsonaka.

Usati waita chero bvunzo yerabhoritari, udza chiremba wako nevashandi veirabhoritari kuti uri kutora dapagliflozin. Nekuda kwemabatiro anoita mushonga uyu, weti yako inogona kuyedza kuita glucose.

Iwe unofanirwa kugara uchipfeka cheshuga chitupa chiziviso kuti uve nechokwadi chekuti unowana kurapwa kwakakodzera mune emergency.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

  • Farxiga®
  • Qtern® (iine Dapagliflozin, Saxagliptin)
  • Qternmet® XR (iine Dapagliflozin, Metformin, Saxagliptin)
  • Xigduo® XR (iine Dapagliflozin, Metformin)
Yekupedzisira Yakagadziridzwa - 06/15/2020

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