Palbociclib

Zvemukati

• Usati watora palbociclib,
• Palbociclib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

[Yakatumirwa 09/13/2019]

Vateereri: Murwere, Hutano Nyanzvi, Oncology

NYAYA: FDA iri kuyambira kuti palbociclib (Ibrance^®), ribociclib (Kisqali^®), uye abemaciclib (Verzenio^®) yaishandiswa kurapa vamwe varwere vane gomarara repamazamu repamberi inogona kukonzera kusagadzikana asi kwakanyanya kuzvimba kwemapapu. FDA yakabvumidza yambiro nyowani nezve njodzi iyi kunyorera ruzivo uye Patient Package Insert yekirasi yese yeiyi cyclin-inoenderana kinase 4/6 (CDK 4/6) inhibitor mishonga. Kubatsira kwese kweCDK 4/6 inhibitors kuchiri kwakakura kupfuura njodzi kana kuchishandiswa sekurairwa.

NZVIMBO: CDK 4/6 inhibitors kirasi yemushonga mishonga inoshandiswa mukubatana nemahormone ekurapa kurapa vanhu vakuru vane hormone receptor (HR) -positive, human epidermal growth factor 2 (HER2) -negative yepamusoro kana metastatic kenza yemazamu yakapararira kusvika dzimwe nhengo dzomuviri. CDK 4/6 inhibitors inovharira mamwe mamorekuru akabatanidzwa mukusimudzira kukura kwemasero ekenza. FDA yakatenderwa palbociclib muna2015, uye zvese ribociclib uye abemaciclib muna2017. CDK 4/6 inhibitors yakaratidzirwa kuvandudza huwandu hwenguva mushure mekutanga kwekurapwa gomarara harikure zvakanyanya uye murwere ari mupenyu, anonzi kufambira mberi- kwemahara (Ona Chinyorwa cheDAA-Yakagamuchirwa CDK 4/6 Inhibitors pazasi).

ZVOKUDZIDZA:Varwere inofanirwa kuzivisa nyanzvi yako yehutano ipapo kana iwe uine chero nyowani kana kuwedzera zviratidzo zvinosanganisira mapapu ako, sezvo anogona kuratidza zvisingawanzoitika asi zvinotyisidzira hupenyu zvinogona kutungamira kurufu. Zviratidzo zvekutarisa zvinosanganisira:

• Dambudziko kana kusagadzikana nekufema
• Kufema kwekufema panguva yekuzorora kana nebasa rakaderera

Usarege kutora mushonga wako usati watanga kutaura neako wehutano. Yese mishonga ine mhedzisiro kunyange kana ikashandiswa nemazvo sekurairwa, asi kazhinji zvakanakira kutora mishonga iyi kupfuura nenjodzi idzi. Zvakakosha kuziva kuti vanhu vanopindura zvakasiyana nemishonga yese zvichienderana nehutano hwavo, zvirwere zvavanazvo, majini zvinhu, mimwe mishonga yavari kutora, uye zvimwe zvinhu zvakawanda. Dzakanangana nenjodzi dzekuona kuti zvingangoita sei kuti mumwe munhu awane huturu hwakanyanya hwekuputika kana achitora palbociclib, ribociclib, kana abemaciclib zvisati zvazivikanwa.

Vashandi vezvehutano inofanirwa kuongorora varwere nguva dzose nekuda kwemapapu zviratidzo zvinoratidza kupindirana kwemapapu chirwere (ILD) uye / kana pneumonitis. Zviratidzo nezviratidzo zvinogona kusanganisira:

• hypoxia
• kukosora
• dyspnea
• kupindirana kunopinda pane radiologic bvunzo mune varwere vane hutachiona, neoplastic, uye zvimwe zvikonzero zvakasarudzika.

Kanganisa CDK 4/6 inhibitor kurapwa mune varwere vane matsva kana kuwedzera zviratidzo zvekufema, uye kumisa zvachose kurapwa kune varwere vane ILD yakaoma uye / kana pneumonitis.

Kuti uwane rumwe ruzivo shanyira iyo FDA webhusaiti pa: http://www.fda.gov/Safety/MedWatch/SafetyInformation uye http://www.fda.gov/Drugs/DrugSafety.

Palbociclib inoshandiswa musanganiswa ne anastrozole (Arimidex), exemestane (Aromasin), kana letrozole (Femara) kurapa imwe mhando yehormone receptor-yakanaka, kenza yemazamu yepamusoro (kenza yemazamu inoenderana nemahormone akadai esrogen kukura) kana zamu kenza yakapararira kune dzimwe nhengo dzomuviri muvakadzi vakasangana nekuguma kuenda kumwedzi (shanduko yehupenyu, kupera kwekuenda kumwedzi kumwedzi) kana muvarume. Palbociclib inoshandiswawo pamwe nefulvestrant (Faslodex) kurapa imwe mhando yehormone receptor-inovhenekera, gomarara repazamu repamberi (gomarara repazamu rinoenderana nemahomoni akadai seestrogen kukura) kana gomarara repazamu rakapararira kune dzimwe nhengo dzemuviri mu vanhu vakarapwa nemushonga weantestrogen senge tamoxifen (Nolvadex). Palbociclib iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito chepuroteni isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kumisa kana kunonoka kupararira kwekenza masero.

Palbociclib inouya sekapuleti kutora nemuromo. Inowanzo kutorwa nechingwa kamwe zuva nezuva kwemazuva ekutanga makumi maviri nemasere ezuva re28-zuva Chiremba wako anozofunga kuti kangani kaunofanirwa kudzokorora kuita uku. Tora palbociclib panguva dzakatenderedza nguva yakafanana zuva rega rega. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora palbociclib chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza macapsules akazara; usavhure, kutsenga, kana kuapwanya. Usatora macapsule akaputswa kana kutsemuka.

Kana iwe ukarutsa mushure mekutora palbociclib, usatore imwe dosi. Enderera yako yenguva dzose dosing purogiramu.

Chiremba wako anogona kudzora dhizaini yako kana kwechinguva kana zvachose kumisa kurapwa kwako kana iwe ukawana mamwe mhedzisiro. Ive neshuwa yekuudza chiremba wako kuti uri kunzwa sei panguva yekurapa kwako ne palbociclib.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora palbociclib,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune palbociclib, chero mimwe mishonga, kana chero chinhu chinowanikwa mu palbociclib capsules. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemiti yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: antifungals senge itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, posaconazole (Noxafil), uye voriconazole (Vfend); mimwe mishonga yekurapa seiz carbamazepine (Carbatrol, Equetro, Epitol, Tegretol, vamwe) uye phenytoin (Dilantin, Phenytek); clarithromycin; enzalutamide (Xtandi); ergot alkaloids senge dihydroergotamine (DHH 45, Migranal) uye ergotamine (Ergomar, muCafergot, muMigergot); mimwe mishonga yehutachiona hwehutachiona hweHIV (HIV) kana yakawanikwa immunodeficiency syndrome (AIDS) inosanganisira indinavir (Crixivan), lopinavir (muKaletra), nelfinavir (Viracept), ritonavir (Norvir, muKaletra, muViekira Pak), saquinavir (Invirase), uye telaprevir (haichawanikwi muUS); fentanyl (Abstral, Fentora, Lazanda, Subsys, vamwe); immunosuppressants akadai cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), uye tacrolimus (Astagraf XL, Envarsus XR, Prograf); midazolam; nefazodone; pimozide (Orap); quinidine (muNuedexta); rifampin (Rimactane, Rifadin, muRifater, muRifamate); uye telithromycin (Ketek). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kubatana nepalbociclib, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
• udza chiremba wako uye wemishonga kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's wort.
• udza chiremba wako kana uine chirwere kana iwe uine kana wakambove nechiropa kana itsvo chirwere.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana kana iwe uronga nezve kubereka mwana. Kana iwe uri munhukadzi, iwe unozofanirwa kutora kutora nhumbu usati watanga kurapwa uye kushandisa kuberekwa kudzivirira kubata pamuviri panguva yekurapwa kwako uye kweanenge mavhiki matatu mushure meyako yekupedzisira dosi. Kana iwe uri murume, iwe nemumwe wako munofanirwa kushandisa kuberekwa panguva yekurapa kwako ne palbociclib uye kwemwedzi mitatu mushure mekupedzisira dosi. Taura nachiremba wako nezve nzira dzekudzivirira kuberekwa dzaunogona kushandisa panguva yekurapa kwako. Kana iwe kana mumwe wako mukava nepamuviri muchitora palbociclib, danai chiremba wako nekukasira. Palbociclib inogona kukuvadza fetus.
• udza chiremba wako kana iwe uchiyamwisa. Iwe haufanire kuyamwa paunenge uchitora palbociclib uye kwemavhiki matatu mushure mekupedzisira muyero.
• kana uri kuvhiyiwa, kusanganisira kuvhiya mazino, udza chiremba kana chiremba wemazino kuti urikutora palbociclib.
• iwe unofanirwa kuziva kuti uyu mushonga unogona kudzora kubereka muvarume. Taura nachiremba wako nezve njodzi dzekutora palbociclib.

Usadye grapefruit kana kunwa muto wemazambiringa uchinwa mushonga uyu.

Darika iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri pazuva rimwe chete kuti uwane imwe yakarasika.

Palbociclib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• kusvotwa
• manyoka
• kurutsa
• kuderera kwechido
• shanduko mukuravira
• kuneta
• chiveve kana kugwinha mumaoko ako, maoko, makumbo, uye tsoka
• maronda pamuromo, pamuromo, kana pahuro
• kujairika kwebvudzi kuonda kana kurasikirwa nevhudzi
• ganda rakaoma
• mapundu

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• fivha, kutonhora, kana zviratidzo zvehutachiona
• mweya wekufema
• dzungu
• nekukurumidza, zvisina kujairika, kana kurova kurova kwemoyo
• kushaya simba
• kubuda ropa zvisina kujairika kana kupwanya
• mhino dzemhino

Palbociclib inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana.Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako anogona kuraira mamwe marabhoritari bvunzo usati uye panguva yekurapa kwako kuti utarise mhinduro yemuviri wako palbociclib.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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