Cobimetinib

Zvemukati

• Usati watora cobimetinib,
• Cobimetinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana icho chiri mune YAKAKOSHA PRECAUTIONS chikamu, dana chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Cobimetinib inoshandiswa pamwe nememurafenib (Zelboraf) kurapa mamwe marudzi e melanoma (rudzi rwegomarara reganda) isingakwanise kurapwa nekuvhiya kana yakapararira kune dzimwe nhengo dzemuviri. Cobimetinib iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito chepuroteni isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kudzora kana kumisa kupararira kwekenza maseru.

Cobimetinib inouya sehwendefa kutora nemuromo kana kana pasina chikafu. Inowanzo kutorwa kamwe chete zuva nezuva kwemazuva makumi maviri nemana ekutanga ezuva makumi maviri nemasere. Tora cobimetinib panguva dzakatenderedza nguva imwechete mazuva ese. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora cobimetinib chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Kana iwe ukarutsa mushure mekutora cobimetinib usatore imwe dosi. Enderera yako yenguva dzose dosing purogiramu.

Chiremba wako anogona kudzikisira muyero wako wecobimetinib kana zvachose kana kumbomira kurapwa kwenguva pfupi. Izvi zvinoenderana nekuti mushonga unoshanda sei kwauri uye nemhedzisiro iwe yaunosangana nayo. Ive neshuwa yekuudza chiremba wako kuti uri kunzwa sei panguva yekurapwa kwako necobimetinib.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora cobimetinib,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune cobimetinib, chero mimwe mishonga, kana chero chipi zvacho chemapiritsi ecobimetinib. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemiti yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: anticoagulants (ropa mutete) senge warfarin (Coumadin, Jantoven), carbamazepine (Carbatrol, Epitol, Tegretol), ciprofloxacin (Cipro), clarithromycin (Biaxin, muPrevpac), efavirenz (Sustiva, in Atripla), erythromycin (EES, E-Mycin, Erythrocin), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Ketozole, Nizoral), nefazodone, nelfinavir (Viracept), phenytoin Difin (Rifadin, Rimactane, muRifamate, muRifater), uye ritonavir (Norvir, muKaletra, muViekira Pak). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kubatana necobimetinib, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's Wort. Usatora St. John's Wort paunenge uchitora cobimetinib.
• udza chiremba wako kana iwe kana wakambove nemamiriro ezvinhu eganda kunze kwemaranoma; matambudziko ekubuda ropa; matambudziko ekuona; chero mamiriro ezvinhu anokanganisa mhasuru dzako; kana chirwere chemwoyo kana chechiropa.
• iwe unofanirwa kuziva kuti cobimetinib inogona kudzora kubereka muvarume nevakadzi. Nekudaro, iwe haufanire kufunga kuti iwe kana mumwe wako haugone kuve nepamuviri. Udza chiremba wako kana iwe uine pamuviri kana kuronga kuva nepamuviri. Shandisa nzira yakavimbika yekudzivirira kuberekwa kudzivirira kubata pamuviri panguva yekurapwa uye kwemavhiki maviri mushure mekumira kutora cobimetinib. Taura nachiremba wako nezvenzira dzekudzivirira kuberekwa dzinokushandira. Kana iwe ukava nepamuviri uchitora cobimetinib, dana chiremba wako pakarepo. Cobimetinib inogona kukuvadza fetus.
• udza chiremba wako kana iwe uchiyamwisa. Iwe haufanire kuyamwa uchi tora cobimetinib uye kwemavhiki maviri mushure mekupedzisira dosi.
• ronga kudzivirira kudzivirirwa zvisina kufanira kana kwenguva refu muchiedza chezuva uye kupfeka mbatya dzekudzivirira, magirazi ezuva, balm yemuromo uye sunscreen (SPF 30 kana kumusoro). Cobimetinib inogona kuita kuti ganda rako ribate chiedza chezuva.

Usadye grapefruit kana kunwa muto wemazambiringa uchinwa mushonga uyu.

Darika iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Cobimetinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• maronda emumuromo
• kurasikirwa nevhudzi
• manyoka

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana icho chiri mune YAKAKOSHA PRECAUTIONS chikamu, dana chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• mapundu anofukidza nzvimbo yakakura yemuviri wako, mablister, kana ganda rinobvaruka
• shanduko pakuonekwa kweganda
• nyowani nyowani
• ganda rinorwadza kana tsvuku bundu rinobuda ropa kana risingapore
• chinja saizi kana ruvara rwema mole
• kubuda ropa zvisina kujairika kana kupwanya
• kunonoka kana zvitema zvitema
• ropa mumurini
• kubuda kweropa zvisina kujairika
• musoro
• dzungu
• inokurumidza, isina kujairika, kana kurova kurova kwemoyo
• kukosora kana kufema
• mweya wekufema
• kuzvimba kwechiso, maoko, makumbo, makumbo, kana tsoka
• kuneta
• kurwadziwa kwemhasuru kana kushaya simba
• shanduko pane zvakaratidzwa, kusanganisira kuona halos (yakasviba tsananguro yakatenderedza zvinhu)
• yero yeganda kana maziso
• yakasviba-tema (tii-yakatsvuka) weti
• kurwadziwa kumusoro kwepamusoro chikamu chedumbu
• kusvotwa
• kurutsa
• kurasikirwa nenzara

Cobimetinib inogona kuwedzera njodzi yekuti iwe uchava nekenza nyowani yeganda. Taura nachiremba wako nezve njodzi dzekutora mushonga uyu.

Cobimetinib inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo runowanikwawo pamhepo pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira mamwe marabhoritari kuti aongorore mhinduro yemuviri wako panguva uye mushure mekurapwa. Chiremba wako anozotarisa ganda rako kuti paine shanduko here zvisati zvaitika, mwedzi miviri yega panguva yekurapwa kwako, uye kusvika pamwedzi mitanhatu mushure mekurapwa.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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