Munyori: Janice Evans
Zuva Rekusika: 26 Chikunguru 2021
Gadziridza Zuva: 15 Mbudzi 2024
Anonim
Critical evaluation of Safinamide – Video abstract [ID 77749]
Vhidhiyo: Critical evaluation of Safinamide – Video abstract [ID 77749]

Zvemukati

Safinamide inoshandiswa pamwe chete nemubatanidzwa welevodopa uye carbidopa (Duopa, Rytary, Sinemet, vamwe) kurapa `` kubvisa '' zvikamu (nguva dzekunetseka kufamba, kufamba, uye kutaura zvinogona kuitika semushonga unopera kana zvisina kurongeka) mu vanhu vane chirwere chePasinson (PD; kusagadzikana kwenzvimbo inokonzeresa matambudziko nekufamba, kudzora mhasuru, uye kuenzanisa). Safinamide iri muboka remishonga inonzi monoamine oxidase type B (MAO-B) inhibitors. Inoshanda nekuwedzera huwandu hwedopamine (chinhu chechisikigo chinodiwa kudzora kufamba) muuropi.

Safinamide inouya sehwendefa kutora nemuromo. Inowanzo kutorwa pamwe kana pasina chikafu kamwe pazuva. Tora safinamide kwakatenderedza nguva yakafanana mazuva ese. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora safinamide chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.


Chiremba wako angangotanga iwe padosi yakaderera yesafinamide uye anogona kuwedzera dhosi yako kamwe mushure memasvondo maviri ekurapwa.

Usarega kutora safinamide usina kutaura nachiremba wako. Chiremba wako angangoderedza dhizaini yako usati wamira. Kana iwe ukangoerekana warega kutora safinamide, unogona kusangana nezviratidzo zvekuregera zvakaita sefivha; kuomarara kwemhasuru; kuvhiringidzika; kana shanduko mukuziva. Udza chiremba wako kana iwe ukasangana nechimwe chezviratidzo izvi apo dosi yako yesafinamide yakaderera.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora safinamide,

  • udza chiremba wako uye wemishonga kana iwe uri weergoria kune safinamide (muromo kana rurimi kuzvimba, kupfupika kwemweya), chero mimwe mishonga, kana chero zvigadzirwa mumafiritsi e safinamide. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
  • udza chiremba wako kana iwe uri kutora chero eanotevera: amphetamines (zvinokurudzira, 'upper') senge amphetamine (Adderall, Adzenys, Dyanavel XR, muAdderall), dextroamphetamine (Dexedrine, muAdderall), uye methamphetamine (Desoxyn); mamwe mishonga yekudzvinyirira senge amitriptyline (Elavil), amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), mirtazapine (Remeron) uye trazodone; buspirone; cyclobenzaprine (Amrix); methylphenidate (Aptensio, Metadate, Ritalin, vamwe); maopioid akadai meperidine (Demerol), methadone (Dolophine, Methadose), propoxyphene (haichawanikwi muU.S.; Darvon), kana tramadol (Conzip, Ultram, muUltracet); inosarudza serotonin uye norepinephrine reuptake inhibitors (SSNRIs) senge duloxetine (Cymbalta) uye venlafaxine (Effexor); uye wort St. Uyezve udza chiremba wako kana uri kutora MAO inhibitor senge isocarboxazid (Marplan), linezolid (Zyvox), methylene bhuruu, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), kana tranylcypromine (Parnate) kana kuti varega kutora ivo mukati memavhiki maviri apfuura. Chiremba wako angangokuudza kuti haufanire kutora safinamide pamwe nechero ipi yemishonga iyi. Kana iwe ukarega kutora safinamide, iwe unofanirwa kumirira kwemazuva gumi nemana usati watanga kutora chero ipi yemishonga iyi. Zvakare, usatore dextromethorphan (muRobitussin DM; inowanikwa mune yakawanda isinganyore chikosoro uye zvigadzirwa zvinotonhora) pamwe nesafinamide.
  • udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemakwenzi yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: antipsychotic senge clozapine (Clozaril, Fazaclo, Versacloz) uye olanzapine (Zyprexa); benzodiazepines senge alprazolam (Xanax), diazepam (Diastat, Valium), lorazepam (Ativan), temazepam (Restoril), uye triazolam (Halcion); mishonga yekutonhora uye kurwara (decongestants) kusanganisira iyo yakaiswa muziso kana mhino; imatinib (Gleevec); irinotecan (Camptosar, Onivyde); isoniazid (Laniazid, muRifamate, muRifater); lapatinib (Tykerb); methotrexate (Otrexup, Rasuvo); metoclopramide (Reglan); mitoxantrone; rosuvastatin (Crestor); inosarudza serotonin reuptake inhibitors secitalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax, vamwe), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), uye sertraline (Zoloft); sulfasalazine (Azulfidine); uye topotecan (Hycamtin). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.
  • udza chiremba wako kana iwe une chirwere chechiropa. Chiremba wako angangokuudza kuti usatora safinamide.
  • udza chiremba wako kana iwe kana wakambove nechirwere chepfungwa senge schizophrenia (chirwere chepfungwa chinokanganisa kufunga kwakakanganisika, kurasikirwa kwekufarira muhupenyu, uye simba rakasimba kana risinganzwisisike , kana psychosis; kana kana uine yakakwira kana yakaderera BP; dyskinesia (kufamba zvisina kujairika); kana matambudziko ekurara. Uyezve udza chiremba wako kana iwe kana mumwe wemumhuri makambosangana nematambudziko neziso reziso remeso kana maalbinism (hunhu hwakagara nhaka hunokonzeresa kushayikwa kweruvara paganda, bvudzi nemaziso).
  • udza chiremba wako kana iwe uine pamuviri kana kuronga kuva nepamuviri. Kana iwe ukava nepamuviri uchitora safinamide, danaidza chiremba wako.
  • udza chiremba wako kana uri kuyamwisa kana kuronga kuyamwisa.
  • iwe unofanirwa kuziva kuti safinamide inogona kukutsira kana inogona kukukonzera iwe kukotsira kamwe kamwe panguva yemabasa ako ezuva nezuva. Iwe unogona kusanzwa kukotsira kana kuve nechero imwe zviratidzo zvekuyambira usati warara kamwe kamwe.Usafambisa mota, kushandisa michina, kushanda pakakwirira, kana kutora chikamu mune zvinogona kuita njodzi zviitiko pakutanga kwekurapwa kwako kusvika iwe waziva kuti mushonga unokubata sei. Kana iwe ukangoerekana warara iwe paunenge uchiita chimwe chinhu senge kutarisa terevhizheni, kutaura, kudya, kana kukwira mumotokari, kana kana iwe ukanyanya kukotsira, kunyanya panguva yemasikati, fonera chiremba wako. Usafambisa, shanda munzvimbo dzakakwirira, kana kushandisa michina kusvikira wataura nachiremba wako.
  • rangarira kuti doro rinogona kuwedzera kuhope dzinokonzerwa nemushonga uyu. Usanwa doro paunenge uchitora safinamide.
  • iwe unofanirwa kuziva kuti vamwe vanhu vakatora mishonga yakadai sa safinamide vakatanga matambudziko ekubhejera kana zvimwe zvinokurudzira zvakanyanya kana hunhu hwaive hwekumanikidza kana husina kujairika kwavari, sekuwedzera kwekushuva kwepabonde kana maitiro. Fonera chiremba wako kana iwe uine shungu yekubheja iyo yakaoma kudzora, iwe une zvakakomba kukurudzira, kana iwe uri kutadza kudzora maitiro ako. Udza nhengo dzemhuri yako nezve njodzi iyi kuitira kuti vafonere chiremba kunyangwe iwe usinga zive kuti kubhejera kwako kana zvimwe zvinokuchidzira zvakanyanya kana maitiro asina kujairika rave dambudziko.

Unogona kusangana nekuita kwakakomba kana iwe ukadya chikafu chakakwirira mu tyramine panguva yekurapa kwako nesafinamide. Tyramine inowanikwa mune zvakawanda zvekudya uye zvinwiwa, zvinosanganisira nyama, huku, hove, kana chizi izvo zvakaputa, zvakakwegura, zvisina kuchengetedzwa zvisina kukodzera, kana kushatiswa; mimwe michero, miriwo, uye bhinzi; zvinwiwa zvinodhaka; uye mbiriso zvigadzirwa zvakavira. Chiremba wako kana chiremba wezvekudya achakuudza kuti ndezvipi zvekudya zvaunofanira kudzivirira zvachose, uye ndezvipi zvekudya zvaunogona kudya zvishoma. Kana iwe uchidya chikafu chakakwira mu tyramine paunenge uchitora safinamide, bata chiremba wako.


Darika dosi rakarasika uye tora yako inotevera dosi panguva yakajairwa zuva rinotevera. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Safinamide inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

  • kusvotwa
  • kunetseka kurara kana kuramba wakarara

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe cheizvi zviratidzo, danaidza chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

  • kuwedzera kana kufamba kazhinji kwemuviri kwausingakwanise kudzora
  • maonero anochinja
  • kufungidzira (kuona zvinhu kana kunzwa manzwi zvisipo)
  • zvitendero zvekunyepedzera (kutenda zvinhu zvisiri zvechokwadi)
  • kushungurudzika, kuona zvisizvo, kupisa muviri, kudikitira, kuvhiringidzika, kurova kwehana nekukurumidza, kubvunda, kuomarara kwemhasuru kana kupunzika, kurasikirwa nekubatana, kuda kurutsa, kurutsa, kana manyoka.

Safinamide inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.


Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Panzvimbo iyoyo, nzira yakanakisa yekurasa mishonga yako ndeyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe uye kusvika kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakavharira makapu ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye kubva kwavari uye kusvika. http://www.upandaway.org

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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