Abemaciclib

Zvemukati

• Usati watora abemaciclib,
• Abemaciclib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana chero chiri mune YAKAKOSHA PRECAUTIONS chikamu, dana chiremba wako nekukurumidza:

[Yakatumirwa 09/13/2019]

Vateereri: Murwere, Hutano Nyanzvi, Oncology

NYAYA: FDA iri kuyambira kuti palbociclib (Ibrance^®), ribociclib (Kisqali^®), uye abemaciclib (Verzenio^®) yaishandiswa kurapa vamwe varwere vane gomarara repamazamu repamberi inogona kukonzera kusagadzikana asi kwakanyanya kuzvimba kwemapapu. FDA yakabvumidza yambiro nyowani nezve njodzi iyi kunyorera ruzivo uye Patient Package Insert yekirasi yese yeiyi cyclin-inoenderana kinase 4/6 (CDK 4/6) inhibitor mishonga. Kubatsira kwese kweCDK 4/6 inhibitors kuchiri kwakakura kupfuura njodzi kana kuchishandiswa sekurairwa.

NZVIMBO: CDK 4/6 inhibitors kirasi yemushonga mishonga inoshandiswa mukubatana nemahormone ekurapa kurapa vanhu vakuru vane hormone receptor (HR) -positive, human epidermal growth factor 2 (HER2) -negative yepamusoro kana metastatic kenza yemazamu yakapararira kusvika dzimwe nhengo dzomuviri. CDK 4/6 inhibitors inovharira mamwe mamorekuru akabatanidzwa mukusimudzira kukura kwemasero ekenza. FDA yakatenderwa palbociclib muna2015, uye zvese ribociclib uye abemaciclib muna2017. CDK 4/6 inhibitors yakaratidzirwa kuvandudza huwandu hwenguva mushure mekutanga kwekurapwa gomarara harikure zvakanyanya uye murwere ari mupenyu, anonzi kufambira mberi- kwemahara (Ona Chinyorwa cheDAA-Yakagamuchirwa CDK 4/6 Inhibitors pazasi).

ZVOKUDZIDZA:Varwere inofanirwa kuzivisa nyanzvi yako yehutano ipapo kana iwe uine chero nyowani kana kuwedzera zviratidzo zvinosanganisira mapapu ako, sezvo anogona kuratidza zvisingawanzoitika asi zvinotyisidzira hupenyu zvinogona kutungamira kurufu. Zviratidzo zvekutarisa zvinosanganisira:

• Dambudziko kana kusagadzikana nekufema
• Kufema kwekufema panguva yekuzorora kana nebasa rakaderera

Usarege kutora mushonga wako usati watanga kutaura neako wehutano. Yese mishonga ine mhedzisiro kunyange kana ikashandiswa nemazvo sekurairwa, asi kazhinji zvakanakira kutora mishonga iyi kupfuura nenjodzi idzi.Zvakakosha kuziva kuti vanhu vanopindura zvakasiyana nemishonga yese zvichienderana nehutano hwavo, zvirwere zvavanazvo, majini zvinhu, mimwe mishonga yavari kutora, uye zvimwe zvinhu zvakawanda. Dzakanangana nenjodzi dzekuona kuti zvingangoita sei kuti mumwe munhu awane huturu hwakanyanya hwekuputika kana achitora palbociclib, ribociclib, kana abemaciclib zvisati zvazivikanwa.

Vashandi vezvehutano inofanirwa kuongorora varwere nguva dzose nekuda kwemapapu zviratidzo zvinoratidza kupindirana kwemapapu chirwere (ILD) uye / kana pneumonitis. Zviratidzo nezviratidzo zvinogona kusanganisira:

• hypoxia
• kukosora
• dyspnea
• kupindirana kunopinda pane radiologic bvunzo mune varwere vane hutachiona, neoplastic, uye zvimwe zvikonzero zvakasarudzika.

Kanganisa CDK 4/6 inhibitor kurapwa mune varwere vane matsva kana kuwedzera zviratidzo zvekufema, uye kumisa zvachose kurapwa kune varwere vane ILD yakaoma uye / kana pneumonitis.

Kuti uwane rumwe ruzivo shanyira iyo FDA webhusaiti pa: http://www.fda.gov/Safety/MedWatch/SafetyInformation uye http://www.fda.gov/Drugs/DrugSafety.

Abemaciclib inoshandiswa pamwe nefulvestrant (Faslodex) kurapa imwe mhando yehormone receptor-inovhenekera, kenza yemazamu yepamusoro (kenza yemazamu inoenderana nemahormone senge estrogen kukura) kana kenza yemazamu yakapararira kune dzimwe nhengo dzemuviri mushure mekurapwa ine antiestrogen mishonga yakadai tamoxifen (Nolvadex). Abemaciclib inoshandiswa zvakare pamwe neanastrozole (Arimidex), exemestane (Aromasin), kana letrozole (Femara) sekutanga kurapwa kwehormone receptor-yakanaka, kenza yemazamu yepamusoro kana kenza yemazamu yakapararira kune zvimwe zvikamu zvemuviri. Abemaciclib inoshandiswawo yega kurapa imwe mhando yehormone receptor-yakanaka, gomarara repazamu repamberi kana gomarara repazamu iro rakapararira kune dzimwe nhengo dzemuviri muvanhu vakatotapwa nemushonga weantestrogen uye chemotherapy. Abemaciclib iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito chepuroteni isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kudzora kana kumisa kupararira kwekenza maseru.

Abemaciclib inouya sehwendefa kutora nemuromo. Inowanzo kutorwa kaviri pazuva kana pasina kana chikafu. Tora abemaciclib panguva dzakatenderedza nguva dzakafanana zuva rega rega. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora abemaciclib chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza mapiritsi akazara; usatsemure, kutsenga, kana kuvapwanya. Usatore mapiritsi akatyoka, akatsemuka, kana kukuvadzwa neimwe nzira.

Kana iwe ukarutsa mushure mekutora abemaciclib, usatore imwe dosi. Enderera yako yenguva dzose dosing purogiramu.

Chiremba wako anogona kudzora dhizaini yako kana kwechinguva kana zvachose kumisa kurapwa kwako kana iwe ukawana mamwe mhedzisiro. Izvi zvinoenderana nekuti mushonga unoshanda sei kwauri uye nemhedzisiro iwe yaunosangana nayo. Ive neshuwa yekuudza chiremba wako kuti uri kunzwa sei panguva yekurapwa kwako neabemaciclib.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora abemaciclib,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune abemaciclib, chero mimwe mishonga, kana chero chemusanganiswa mumapiritsi eabemaciclib. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvinowedzera zvinovaka muviri, uye mishonga yemiti yauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: clarithromycin (Biaxin, muPrevpac), diltiazem (Cardizem, Tiazac, vamwe), itraconazole (Sporanox), ketoconazole (Nizoral), rifampin (Rifadin, Rimactane, muRifater), uye verapamil (Calan , Verelan, vamwe). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kubatana neabemaciclib, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
• udza chiremba wako kana uine fivhiri, kutonhora, kana zvimwe zviratidzo zvehutachiona kana kana uine kana wakambove nechiropa kana hosha yeitsvo.
• udza chiremba wako kana iwe uine pamuviri kana kuronga kuva nepamuviri. Iwe unozofanirwa kutora nhumbu yekubata usati watanga kurapwa uye unofanirwa kushandisa kuberekwa kudzivirira kubata pamuviri panguva yekurapa kwako uye kweanenge mavhiki matatu mushure mekupedzisira kwako dosi. Kana iwe ukava nepamuviri uchitora abemaciclib, dana chiremba wako pakarepo. Abemaciclib inogona kukuvadza fetus.
• udza chiremba wako kana iwe uchiyamwisa kana kuronga kuyamwisa. Iwe haufanire kuyamwa uchi tora abemaciclib uye kweanenge mavhiki matatu mushure mekuita kwako kwekupedzisira.
• iwe unofanirwa kuziva kuti uyu mushonga unogona kudzora kubereka muvarume. Taura nachiremba wako nezve njodzi dzekutora abemaciclib.
• iwe unofanirwa kuziva kuti abemaciclib inowanzo kukonzera manyoka, ayo anogona kunge akanyanya. Chiremba wako anogona kuzokuudza kuti unwe zvinwiwa zvakawanda uye utore mishonga yekurwisa manyoka kudzivirira kupera simba (kurasikirwa nemvura yakawandisa kubva mumuviri wako) paunotanga kusangana nemanyoka kana zvituru zvakasununguka. Shevedza chiremba wako nekukasira kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchiona mvura.

Usadye grapefruit kana kunwa muto wemazambiringa uchinwa mushonga uyu.

Darika iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Abemaciclib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• kusvotwa
• kurutsa
• kurwadziwa nemudumbu
• kuvimbiswa
• maronda pamuromo, pamuromo, kana pahuro
• kuderera kwechido
• kuonda
• kurasikirwa nevhudzi
• kuvava
• mapundu
• musoro
• shanduko mukuravira
• dzungu
• kurwadza kwemajoini

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi kana chero chiri mune YAKAKOSHA PRECAUTIONS chikamu, dana chiremba wako nekukurumidza:

• kuneta
• kurwadziwa kumusoro kwepamusoro chikamu chedumbu
• yero yeganda kana maziso
• kurasikirwa nenzara
• kubuda ropa kana kupwanya nyore
• kurwadziwa mumaoko kana makumbo
• kuzvimba kwemaoko, tsoka, makumbo kana makumbo
• mweya wekufema
• kurwadziwa pachipfuva
• kukurumidza kufema
• nekukurumidza, zvisina kujairika, kana kurova kurova kwemoyo
• fivha, kutonhora, kukosora kana zvimwe zviratidzo zvehutachiona
• ganda rakachenuruka

Abemaciclib inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako anogona kuraira mamwe marabhoritari emiedzo usati uye panguva yekurapa kwako kuti utarise mhinduro yemuviri wako kune abemaciclib.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

• Verzenio^®