Tezacaftor uye Ivacaftor

Zvemukati

• Usati watora tezacaftor uye ivacaftor,
• Tezacaftor uye ivacaftor zvinogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi, rega kutora tezacaftor uye ivacaftor uye udane chiremba wako nekukurumidza:

Iko kusanganiswa kwe tezacaftor uye ivacaftor kunoshandiswa pamwe neivacaftor kurapa mamwe marudzi ecystic fibrosis (chirwere chinozvarwa chinokonzera matambudziko nekufema, kugaya, uye kubereka) muvanhu vakuru uye vana vane makore matanhatu ekuberekwa nekure. Tezacaftor uye ivacaftor dzinofanirwa kushandiswa chete muvanhu vane mamwe maitiro ekugadzira. Chiremba wako anogona kuraira kuongororwa kweropa kuti ubatsire kusarudza kana mushonga uyu wakanakira iwe. Tezacaftor iri mukirasi yemishonga inonzi cystic fibrosis transmembrane conductance regulator (CFTR) inogadzirisa. Ivacaftor iri mukirasi yemishonga inonzi cystic fibrosis transmembrane conductance regulator (CFTR) potentiators. Ose ari maviri emishonga iyi anoshanda nekuvandudza mashandiro eprotein mumuviri kudzikisira kuvaka-kwemukati mamota mumapapu nekuvandudza zvimwe cystic fibrosis zviratidzo.

Iko kusanganiswa kwe tezacaftor uye ivacaftor uye ivacaftor kunouya semapiritsi ekutora nemuromo. Mushonga uyu unouya muhomwe nemavhiki mana emishonga. Dhivha yega yega yezuva nezuva ine mhando dzakasiyana dzemapiritsi: piritsi rimwe chete ndiko kusanganiswa kwe tezacaftor uye ivacaftor uye imwe piritsi ivacaftor. Tora tezacaftor uye ivacaftor (1 yeyero piritsi) mangwanani ega ega nechikafu chine mafuta uye ivacaftor (1 piritsi rebhuruu) manheru ega ega nechikafu chine mafuta, maawa gumi nemaviri akaparadzana. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora mishonga iyi chaizvo sezvakarairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Medza mapiritsi akazara; usatsemure, kutsenga, kana kuvapwanya.

Tora mubatanidzwa we tezacaftor uye ivacaftor uye ivacaftor nezvakakora zvine mafuta senge mazai, bota, nzungu, nzungu ruomba, chizi pizza, uye yakazara-mukaka zvigadzirwa zvemukaka (semukaka wese, chizi, uye yogati). Taura nachiremba wako nezve zvimwe zvekudya zvine mafuta zvekudya nemishonga iyi.

Iko kusanganiswa kwe tezacaftor uye ivacaftor pamwe neivacaftor kunoshanda kudzora cystic fibrosis, asi hazvirape. Ramba uchitora mishonga iyi kunyangwe uchinzwa zvakanaka. Usarega kutora mishonga iyi usingatauri nachiremba wako.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora tezacaftor uye ivacaftor,

• udza chiremba wako uye wemishonga kana uri weergoria kune tezacaftor, ivacaftor, chero mimwe mishonga, kana chero chinhu chinowanikwa mu tezacaftor uye ivacaftor uye mahwendefa eivacaftor. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, zvekuwedzera zvinovaka muviri, zvauri kutora kana kuronga kutora. Ive neshuwa yekutaura chero eanotevera: mamwe maantibhakitiriya akadai clarithromycin (Biaxin, muPrevPac), erythromycin (EES, E-Mycin, Ery-Tab, Erythrocin), uye telithromycin (Ketek); mamwe maantifungal akadai fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), uye voriconazole (Vfend); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); everolimus (Afinitor, Zortress); mimwe mishonga yekubatwa kwakadai se carbamazepine (Carbatrol, Epitol, Tegretol, vamwe), phenobarbital, uye phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); rifampin (Rifadin, muRifamate, muRifater, Rimactane); sirolimus (Rapamune); kana tacrolimus (Astagraf, Prograf). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro. Mimwe mishonga yakawanda inogona zvakare kusangana ne tezacaftor uye ivacaftor, saka ive shuwa kuudza chiremba wako nezve yese mishonga yauri kutora, kunyangwe iyo isinga oneke pane ino runyorwa.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's wort. Chiremba wako angangokuudza kuti usatora St. John's wort uchitora mubatanidzwa we tezacaftor uye ivacaftor pamwe neivacaftor.
• udza chiremba wako kana iwe wakambove kana uine chirwere cheitsvo kana chiropa.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana uri kuyamwisa. Kana iwe ukava nepamuviri uchitora musanganiswa we tezacaftor uye ivacaftor pamwe neivacaftor, fonera chiremba wako.
• iwe unofanirwa kuziva kuti iyi mishonga inogona kukuita iwe uchikotsira. Usatyaire mota kana kushandisa michina kusvikira iwe waziva kuti mishonga iyi inokukanganisa sei.

Usadye grapefruit kana orenji eSeville kana kunwa muto wemazambiringa uchinwa mishonga iyi.

Kana iwe uchirangarira iyo yakarasika dhizaini yeimwe piritsi mukati maawa matanhatu yenguva yawakange wakarongerwa kuitora, tora iyo yakarasika dosi ipapo ipapo nechikafu chine mafuta. Nekudaro, kana anopfuura maawa matanhatu apfuura kubva panguva yakatarwa yekutora chero piritsi, ruka iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Tezacaftor uye ivacaftor zvinogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• musoro
• kuzara mumhino
• dzungu

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi, rega kutora tezacaftor uye ivacaftor uye udane chiremba wako nekukurumidza:

• yero yeganda kana maziso
• kurasikirwa nenzara
• kusvotwa
• kurutsa
• zvituru zvakachenuruka
• kurwadziwa nemudumbu
• weti yakasviba

Tezacaftor uye ivacaftor zvinogona kukonzera cataract (kufukidza lens yemeso iyo inogona kukonzera matambudziko ekuona) muvana nevechiri kuyaruka. Vana nevechidiki vari kutora tezacaftor uye ivacaftor vanofanirwa kuona chiremba wemaziso vasati uye panguva yekurapwa kwavo. Taura nachiremba wemwana wako nezve njodzi dzekupa tezacaftor uye ivacaftor kumwana wako.

Tezacaftor uye ivacaftor zvinogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nekupisa kwakanyanya uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako acharaira bvunzo yemaziso (yevana nevechiri kuyaruka) uye kumwe kuongororwa kwelebhu usati uye panguva yekurapwa kwako kuti utarise mhinduro yemuviri wako kune tezacaftor uye ivacaftor.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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