Avapritinib

Zvemukati

• Usati watora avapritinib,
• Avapritinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:
• Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi, rega kutora avapritinib uye udane chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

Avapritinib inoshandiswa kurapa imwe mhando yematumbo stromal bundu (GIST; rudzi rwebundu rinokura mumadziro emudumbu, ura [ura], kana ziso [chubhu inobatanidza huro nedumbu]) kune vanhu vakuru vane kupararira kune dzimwe nhengo dzomuviri kana izvo zvisingakwanise kubviswa nekuvhiya. Avapritinib iri mukirasi yemishonga inonzi kinase inhibitors. Inoshanda nekudzivirira chiito chepuroteni isina kujairika iyo inoratidza masero ekenza kuti iwande. Izvi zvinobatsira kumisa kana kunonoka kupararira kwekenza masero.

Avapritinib inouya sehwendefa kutora nemuromo. Inowanzo kutorwa kamwe chete zuva nezuva pane isina chinhu mudumbu, ingangoita 1 awa pamberi uye maawa maviri mushure mekudya. Tora avapritinib panguva dzakatenderedza nguva imwechete mazuva ese. Tevedza zvinongedzo pane yako tsamba yekunyora zvakanyatsonaka, uye bvunza chiremba wako kana wemishonga kuti atsanangure chero chikamu chausinganzwisise. Tora avapritinib chaizvo sekurairwa. Usatore zvimwe kana zvishoma nezvayo kana kuitora kakawanda pane zvakatemwa nachiremba wako.

Kana iwe ukarutsa mushure mekutora avapritinib, usatore imwe dosi Enderera yako yenguva dzose dosing purogiramu.

Chiremba wako anogona kudzora yako avapritinib dose kana kumisa kurapwa kwako zvichienderana nekuti mushonga unoshanda sei kwauri uye kana iwe uchinge uine chero mhedzisiro. Ive neshuwa yekuudza chiremba wako kuti uri kunzwa sei panguva yekurapwa kwako neavapritinib. Usarega kutora avapritinib usina kutaura nachiremba wako.

Kumbira wemishonga wako kana chiremba kopi yemashoko emugadziri wemurwere.

Mushonga uyu unogona kupihwa zvimwe zvinoshandiswa; bvunza chiremba wako kana wemishonga kuti uwane rumwe ruzivo.

Usati watora avapritinib,

• udza chiremba wako uye wemishonga kana iwe uri weergoria kune avapritinib, chero mimwe mishonga, kana chimwe chezvinhu zvinoshandiswa mumapiritsi evapritinib. Kumbira wako wemishonga kuti uwane runyorwa rwezvigadzirwa.
• udza chiremba wako uye wemishonga kuti ndeipi imwe mishonga yekunyorera uye isina kunyoreswa, mavitamini, uye zvinovaka muviri zvaunotora kana kuronga kutora. Ive neshuwa yekutaura zvinotevera: aprepitant (Emend); mamwe antifungal mishonga yakadai se fluconazole (Diflucan), itraconazole (Onmel, Sporanox), kana ketoconazole; clarithromycin (Biaxin, muPrevpac); diltiazem (Cardizem, Tiazac, vamwe); erythromycin (EES, Erythrocin, vamwe); mimwe mishonga yeHIV yakadai seEfavirenz (Sustiva, muAtripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, muKaletra, vamwe), kana saquinavir (Invirase); modafinil (Provigil); nefazodone; oxcarbazepine (Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos, muActoplus, Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, muRifater); uye verapamil (Calan). Chiremba wako angangoda kushandura madosi emishonga yako kana kukutarisisa nokungwarira mhedzisiro.Mimwe mishonga yakawanda inogona zvakare kubatana neavapritinib, saka ive shuwa kuudza chiremba wako nezve yese mishonga iwe yauri kutora, kunyangwe iyo isingaonekwe pane ino chinyorwa.
• udza chiremba wako kuti ndezvipi zvigadzirwa zvemakwenzi zvauri kutora, kunyanya St. John's wort.
• udza chiremba wako kana iwe wakambove kana wakambove nechiropa kana itsvo chirwere.
• udza chiremba wako kana iwe uri nepamuviri, ronga kuve nepamuviri, kana kana iwe uronga nezve kubereka mwana. Kana iwe uri munhukadzi, iwe uchafanirwa kutora nhumbu yekubata usati watanga kurapwa uye kushandisa kuberekwa kudzivirira kudzivirira kubata pamuviri panguva yekurapwa kwako uye kwemavhiki matanhatu mushure medosi yako yekupedzisira. Kana iwe uri murume, iwe nemumwe wako munofanira kushandisa kuberekwa panguva yekurapwa uye kwemavhiki matanhatu mushure mekupedzisira dosi. Taura nachiremba wako nezve nzira dzekudzivirira kuberekwa dzaunogona kushandisa panguva yekurapa kwako. Kana iwe kana mumwe wako mukava nepamuviri muchitora avapritinib, danai chiremba wako nekukasira. Avapritinib inogona kukuvadza fetus.
• udza chiremba wako kana iwe uchiyamwisa. Iwe haufanire kuyamwisa mwana paunenge uchitora avapritinib uye kweanenge mavhiki maviri mushure mekupedzisira kwako.
• iwe unofanirwa kuziva kuti uyu mushonga unogona kudzora kubereka muvarume nevakadzi. Taura nachiremba wako nezve njodzi dzekutora avapritinib.
• iwe unofanirwa kuziva kuti avapritinib inogona kukuita dzungu, kutsimwaira, kana kuvhiringidzika. Usatyaire mota kana kushandisa michina kusvikira iwe waziva kuti uyu mushonga unokubata sei.

Taura nachiremba wako nezve kudya mazambiringa uye kunwa jisi remuzambiringa paunenge uchitora mushonga uyu.

Tora dosi rakarasika nekukurumidza kana uchinge warangarira. Nekudaro, kana iyo inotevera dosi iri kukodzera mune asingasviki maawa masere, ruka iro rakarasika dosi uye enderera yako yenguva dzose dosing purogiramu. Usatore dosi yakapetwa kaviri kuti uwane imwe yakarasika.

Avapritinib inogona kukonzera mhedzisiro. Udza chiremba wako kana chimwe chezviratidzo izvi chakanyanya kana kuti chisingaendi:

• kurwadziwa nemudumbu
• kurutsa
• kusvotwa
• manyoka
• chirungurira
• musoro
• kuneta
• kunetseka kurara kana kuramba wakarara
• kurasikirwa nevhudzi
• vhudzi rebvudzi rinochinja
• kuonda
• maziso ane misodzi
• kuravira shanduko

Mimwe mhedzisiro inogona kuve yakakomba. Kana iwe ukasangana nechimwe chezviratidzo izvi, rega kutora avapritinib uye udane chiremba wako nekukurumidza kana kuwana kurapwa kwekukurumidzira:

• kuzvimba kwechiso, maziso, muromo, kana huro
• kuzvimba kwemaoko, makumbo, kana tsoka
• kurutsa ropa kana zvinhu zvinoita kunge kofi nzvimbo kana tsvuku kana kunonoka zvituru zvitema
• kurwadziwa kwakanyanya kwemusoro, matambudziko ekuona, kukotsira, kuneta zvakanyanya, kana kushaya simba kudivi remuviri wako
• kukanganwa, kuvhiringidzika, kukotsira, dzungu, kunetseka kurara, kunetsekana kutaura, kuona zvisipo, kana kuchinja mafungiro kana maitiro
• mapundu
• mweya wekufema
• fever kana zvimwe zviratidzo zvehutachiona

Avapritinib inogona kukonzera mamwe mhedzisiro. Fonera chiremba wako kana uine chero matambudziko asina kujairika uchitora mushonga uyu.

Kana iwe ukawana chakakomba mhedzisiro, iwe kana chiremba wako ungatumira chirevo kuchirongwa cheKudya neDrug Administration's (FDA) MedWatch Yakashata Chiitiko Chirongwa online (http://www.fda.gov/Safety/MedWatch) kana nefoni ( 1-800-332-1088).

Chengetedza iyi mishonga mumudziyo iyo yakauya mukati, yakasungwa yakavharwa, uye isingasvike kune vana. Zvichengetedze pane tembiricha yemukati uye kure nechiedza chakapisa kupisa uye hunyoro (kwete muchimbuzi).

Izvo zvakakosha kuti chengetedza mishonga yese isingaonekwe nekusvikwa kwevana semidziyo yakawanda (senge vhiki nevhiki mapiritsi epfungwa uye ayo emadonhwe eziso, makirimu, zvigamba, uye inhalers) hazvirambe vana uye vana vadiki vanogona kuvhura zviri nyore. Kuchengetedza vana vadiki kubva kune chepfu, gara wakakiya makofia ekuchengetedza uye nekukurumidza isa mishonga munzvimbo yakachengeteka - imwe iri kumusoro uye kure uye isingaonekwe nevanosvika. http://www.upandaway.org

Mishonga isingadiwe inofanirwa kuraswa nenzira dzakakosha kuona kuti zvipfuyo, vana, nevamwe vanhu havagone kuzvidya. Nekudaro, iwe haufanire kuburitsa uyu mushonga pasi pechimbuzi. Pane kudaro, nzira yakanakisa yekurasa yako mishonga ndeye kuburikidza neyekurapa-kudzosa chirongwa. Taura nachiremba wako kana kuti taura nedhipatimendi rako remarara / rekudzokorora kuti udzidze nezve zvirongwa zvekudzosa munharaunda yako. Ona iyo FDA's Safe Disposal yeMedicine webhusaiti (http://goo.gl/c4Rm4p) kuti uwane rumwe ruzivo kana iwe usina mukana wekutora-kudzoka chirongwa.

Kana zvikaitika zvekudarika, fonera iyo chepfu yekudzora rubatsiro pa1-800-222-1222. Ruzivo rwunowanikwawo online pa https://www.poisonhelp.org/help. Kana munhu akabatwa akadonha, akabatwa nepfari, achinetseka kufema, kana kutadza kumutswa, pakarepo danaidza mabasa ekukurumidzira pa911.

Chengetedza zvese zvakagadzwa nachiremba wako uye murabhoritari. Chiremba wako anozoraira bvunzo bvunzo usati watanga kurapwa kwako kuti uone kana kenza yako ichirapwa neavapritinib. Chiremba wako anogona kuraira kumwe kuongorora kwebazi kuti atarise mhinduro yemuviri wako kuna avapritinib.

Usarega mumwe munhu achitora mushonga wako. Kumbira wemishonga wako chero mibvunzo yauinayo nezvekuzadza tsamba yako.

Izvo zvakakosha kuti iwe uchengete yakanyorwa rondedzero yeese emushonga uye asiri ekunyora (pamusoro-e-pikisheni) mishonga yauri kutora, pamwe nezvimwe zvigadzirwa zvakaita sevhitamini, zvicherwa, kana zvimwe zvekuwedzera zvekudya. Iwe unofanirwa kuuya nerondedzero iyi iwe nguva imwe neimwe paunoshanyira chiremba kana kana iwe uchigamuchirwa kuchipatara. Izvo zvakare zvakakosha ruzivo kutakura newe kana zvikaitika zvechimbi-chimbi.

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