Zvese zvaunoda Kuti Uzive Nezveazvino Psoriasis Kurapwa

Zvemukati

• Nyowani biologics
• Risankizumab-rzaa (Skyrizi)
• Certolizumab pegol (Cimzia)
• Tildrakizumab-asmn (Ilumya)
• Guselkumab (Tremfya)
• Brodalumab (Siliq)
• Ixekizumab (Taltz)
• Biosimilars
• Biosimilars kune adalimumab (Humira)
• Biosimilars kune etanercept (Enbrel)
• Biosimilars kune infliximab (Remicade)
• Mitsva mitsva yekurapa
• Halobetasol propionate-tazarotene lotion, 0.01% / 0.045% (Duobrii)
• Halobetasol propionate furo, 0.05% (Lexette)
• Halobetasol propionate lotion, 0.01% (Bryhali)
• Betamethasone dipropionate pfapfaidzo, 0.05% (Sernivo)
• Mishonga mitsva yevana
• Calcipotriene foam, 0.005% (Sorilux)
• Calcipotriene-betamethasone dipropionate foam, 0.005% / 0.064% (Enstilar)
• Calcipotriene-betamethasone dipropionate kukamiswa kwemisoro, 0.005% / 0.064% (Taclonex)
• Ustekinumab (Stelara)
• Etanercept (Enbrel)
• Mamwe marapiro ave pedyo nekutenderwa
• Bimekizumab
• Calcipotriene-betamethasone dipropionate cream, 0.005% / 0.064% (Wynzora)
• JAK inhibitors
• Tora woenda nazvo

Vatsvagiri vakadzidza zvakawanda zvakawanda mumakore achangopfuura nezve psoriasis uye nebasa rinoitwa nere immune system mune ino mamiriro. Izvi zvitsva zvakawanikwa zvakatungamira kune yakachengeteka, yakanangwa, uye inoshanda psoriasis kurapa.

Kunyangwe zvese zvekurapa zviripo, ongororo inoratidza kuti vanhu vazhinji vari kurapwa psoriasis havagutsikane nemushonga wavo kana vanogutsikana zvine mwero chete.

Kana iwe uri kutsvaga kuti uchinje marapirwo nekuti yako yazvino haichashandi kana kuti iwe unemhedzisiro, ipfungwa yakanaka kudzidza zvakanyanya sezvinobvira pamusoro pezvazvino sarudzo.

Nyowani biologics

Biologics inogadzirwa kubva kuzvinhu zvinowanikwa muzvinhu zvipenyu, senge mapuroteni, shuga, kana nucleic acids. Kamwe mumuviri, iyi mishonga inovhara chikamu chedziviriro yezvirwere icho chinopa kune ako psoriasis zviratidzo.

Biologics inopindira pane zvinotevera:

• bundu necrosis factor alpha (TNF-alpha), inova puroteni inosimudzira kuzvimba mumuviri
• T maseru, ayo ari machena masero eropa
• interleukins, ayo ari cytokines (mapuroteni madiki ekuzvimba) anobatanidzwa mupsoriasis

Iko kupindira kunobatsira kudzora kuzvimba.

Risankizumab-rzaa (Skyrizi)

Risankizumab-rzaa (Skyrizi) yakagamuchirwa neKudya neDrug Administration (FDA) muna Kubvumbi 2019.

Izvo zvakagadzirirwa vanhu vane zvine mwero kusvika kune yakaoma plaque psoriasis avo vari kukwikwidza phototherapy (light therapy) kana systemic (muviri-yakafara) kurapa.

Skyrizi inoshanda nekudzivirira chiito che interleukin-23 (IL-23).

Yese dosi ine maviri epasi peganda (pasi peganda) majekiseni. Iwo maviri ekutanga madosi akapatsanurwa mavhiki mana akapatsanurwa. Dzimwe dzese dzinopihwa kamwe chete pamwedzi mitatu.

Mhedzisiro mikuru yeSkyrizi ndeiyi:

• zvirwere zvepamusoro zvekufema
• maitiro panzvimbo yejojo
• musoro
• kuneta
• fungal zvirwere

Certolizumab pegol (Cimzia)

Iyo FDA yakabvumidza certolizumab pegol (Cimzia) se psoriasis kurapwa muna Chivabvu 2018. Yakanga yatobvumidzwa kurapa mamiriro senge chirwere cheCrohn uye psoriatic arthritis (PsA).

Cimzia inobata zvine mwero kusvika kune yakaoma plaque psoriasis muvanhu vari kukwikwidza phototherapy kana systemic therapy. Inoshanda nekutarisa protein protein TNF-alpha.

Mushonga unopihwa seiri jekiseni repasi pega pega pasvondo.

Mhedzisiro inowanzoitika yeCimzia ndeiyi:

• epamusoro mweya wekufema
• mapundu
• Urinary turakiti hutachiona (UTIs)

Tildrakizumab-asmn (Ilumya)

Tildrakizumab-asmn (Ilumya) yaive FDA-yakatenderwa munaKurume 2018. Inoshandiswa kurapa plaque psoriasis kune vanhu vakuru vari kukwikwidza phototherapy kana systemic kurapa.

Mushonga uyu unoshanda nekudzivirira IL-23.

Ilumya inopihwa senge subcutaneous jekiseni. Majekiseni maviri ekutanga akapatsanurwa vhiki ina. Kubva ipapo zvichienda mberi, majekiseni anopihwa mwedzi mitatu zvakasiyana.

Iwo makuru mhedzisiro mhedzisiro yeIlumya ndeaya:

• maitiro panzvimbo yejojo
• zvirwere zvepamusoro zvekufema
• manyoka

Guselkumab (Tremfya)

Guselkumab (Tremfya) yaive FDA-yakatenderwa muna Chikunguru 2017. Inoshandiswa kurapa zvine mwero kusvika kune yakaoma plaque psoriasis muvanhu vari zvakare kukwikwidza kwefototherapy kana systemic kurapa.

Tremfya yaive yekutanga biologic kunongedza IL-23.

Yekutanga miviri yekutanga masero inopihwa masvondo mana akasiyana. Mushure mezvo, Tremfya inopihwa sejekiseni rinotapudza pasvondo rega rega.

Izvo zvinowanzoitika mhedzisiro zvinosanganisira:

• musoro
• zvirwere zvepamusoro zvekufema
• maitiro panzvimbo yejojo
• kurwadza kwemajoini
• manyoka
• dumbu furu

Brodalumab (Siliq)

Brodalumab (Siliq) yaive FDA-inogamuchirwa muna Kukadzi 2017. Yakagadzirirwa vanhu vanosangana nezvinotevera zvinotevera:

• vane zvine mwero kusvika kwakasimba plaque psoriasis
• vari kukwikwidza kurapwa kwemapiritsi kana systemic kurapa
• psoriasis yavo haipindure kune mamwe marapirwo ehurongwa

Inoshanda nekusunga kune iyo IL-17 receptor. Iyo IL-17 nzira inoitisa chinzvimbo mukuzvimba uye inobatanidzwa mukuvandudzwa kwe psoriasis plaques.

Mumakiriniki ekuedzwa, vatori vechikamu vakarapwa naSiliq vaive nemikana yakawanda kupfuura avo vakagamuchira placebo kuti vave neganda raionekwa serakajeka kana kupotsa rajeka.

Siliq inoshandiswa sejekiseni. Kana chiremba wako akaraira mushonga, unozogamuchira jekiseni rimwe chete pasvondo kwemavhiki matatu ekutanga. Mushure mezvo, unozogamuchira jekiseni rimwe chete masvondo maviri.

Kufanana nedzimwe biologics, Siliq inowedzera mukana wako wehutachiona. Chinyorwa chemushonga uyu zvakare chine nhema bhokisi rinonyevera nezve njodzi yakakwira yekuzviuraya pfungwa uye hunhu.

Vanhu vane nhoroondo yekuzviuraya maitiro kana kushushikana vanofanirwa kuongororwa pavanotora brodalumab.

Ixekizumab (Taltz)

Ixekizumab (Taltz) yaive FDA-yakatenderwa munaKurume 2016 kurapa vanhu vakuru vane zvine mwero kune zvakanyanya psoriasis. Yakagadzirirwa vanhu vari kukwikwidza phototherapy, systemic kurapa, kana zvese zviri zviviri.

Taltz inotarisa protein IL-17A.

Mushonga unobaya jekiseni. Iwe unozogamuchira majekiseni maviri pazuva rako rekutanga, majekiseni mavhiki maviri ega ega kwemwedzi mitatu inotevera, uye majekiseni mavhiki mana ega ega ekurapwa kwako.

Kubvumidzwa kwaive kwakavakirwa pamhedzisiro yezvakawanda kiriniki zvidzidzo pamwe nevose 3,866 vatori vechikamu. Mune izvo zvidzidzo, vanhu vazhinji vanotora mushonga wakawana ganda raive rakajeka kana kupotsa kujekesa.

Iyo inowanzoitika mhedzisiro mhedzisiro yeTaltz inosanganisira:

• zvirwere zvepamusoro zvekufema
• maitiro panzvimbo yejojo
• fungal zvirwere

Biosimilars

Biosimilars haasi iwo chaiwo maratidziro ebiologics. Panzvimbo iyoyo, ivo vanodzoserwa-mainjiniya kuti vabudise mhedzisiro yakafanana neye biologics.

Kunge generic zvinodhaka, biosimilars inogadzirwa kana iyo yekutanga biologic yabva patent. Kubatsira kwema biosimilars ndechekuti ivo vanowanzo dhura zvakanyanya kushoma pane chigadzirwa chepakutanga.

Biosimilars ye psoriasis inosanganisira zvinotevera:

Biosimilars kune adalimumab (Humira)

• adalimumab-adaz (Hyrimoz)
• adalimumab-adbm (Cyltezo)
• adalimumab-afzb (Abrilada)
• adalimumab-atto (Amjevita)
• adalimumab-bwwd (Hadlima)

Biosimilars kune etanercept (Enbrel)

• etanercept-szzs (Erelzi)
• etanercept-ykro (Eticovo)

Biosimilars kune infliximab (Remicade)

• infliximab-abda (Renflexis)
• infliximab-axxq (Avsola)
• infliximab-dyyb (Inflectra)

Iyo Remicade biosimilar Inflectra ndiyo yekutanga psoriasis biosimilar kugamuchira FDA tendero. Yaiva muna Kubvumbi 2016.

Inflectra naRenflexis, imwe Remicade biosimilar, ndiyo chete iripo kutengwa kuUnited States. Izvi zvinonyanya nekuti patents yakachengetwa neve biologics 'vagadziri haisati yapera.

Mitsva mitsva yekurapa

Misoro yekurapa, kana yaunosvina paganda rako, kazhinji ndiwo marapirwo ekutanga varapi vanokurudzira psoriasis. Ivo vanoshanda nekuderedza kuzvimba uye kunonoka kuwanda kwekugadzirwa kwemasero eganda.

Halobetasol propionate-tazarotene lotion, 0.01% / 0.045% (Duobrii)

MunaEpril 2019, iyo FDA yakabvumidza halobetasol propionate-tazarotene lotion, 0.01 muzana / 0.045 muzana (Duobrii) yekurapa plaque psoriasis muvakuru.

Duobrii ndiyo lotion yekutanga yekubatanidza corticosteroid (halobetasol propionate) ine retinoid (tazarotene). Iyo inorwisa-kupisa corticosteroid inojekesa mabara, nepo vhitamini A-based retinoid inogumira kukura kwakanyanya kwemasero eganda.

Duobrii inoiswa kamwe chete pazuva kunzvimbo dzakakanganiswa dzeganda.

Iyo mhedzisiro mhedzisiro ndeiyi:

• kurwadziwa kunzvimbo yekushandisa
• mapundu
• folliculitis, kana yakatsva bvudzi follicles
• kupfeka kure neganda panoshandiswa mafuta
• excoriation, kana kutora ganda

Halobetasol propionate furo, 0.05% (Lexette)

Halobetasol propionate foam, 0.05 muzana ndeyemusoro corticosteroid iyo FDA yakatanga kubvumidza, seyakajairika, muna Chivabvu 2018. MunaEpril 2019, yakave ichiwanikwa pasi pezita rekuti Lexette.

Iyo inoshandiswa kurapa plaque psoriasis muvakuru. Chinangwa chayo ndechokubvisa ganda.

Kaviri pazuva, furo rinoiswa mune yakatetepa uye kukwizwa mukati meganda. Lexette inogona kushandiswa kweanosvika mavhiki maviri.

Mhedzisiro inowanzoitika yeLexette marwadzo panzvimbo yekushandisa uye nemusoro.

Halobetasol propionate lotion, 0.01% (Bryhali)

Halobetasol propionate lotion, 0.01 muzana (Bryhali) yakagamuchirwa neDFA munaNovember 2018. Yakagadzirirwa vanhu vakuru vane plaque psoriasis.

Zvimwe zvezviratidzo zvinobatsira kugadzirisa ndezvi:

• kuoma
• kubvunda
• kuzvimba
• plaque buildup

Bryhali anoiswa zuva nezuva. Mafuta anokwanisa kushandiswa kwemavhiki masere.

Mhedzisiro inowanzoitika inosanganisira:

• kusvirwa
• kubaya
• kuvava
• kuoma
• epamusoro mweya wekufema
• shuga yakakwira muropa

Betamethasone dipropionate pfapfaidzo, 0.05% (Sernivo)

Muna Kukadzi 2016, iyo FDA yakabvumidza betamethasone dipropionate spray, 0.05 muzana (Sernivo). Iyi yemusoro inobata zvinyoro kusvika zvine mwero plaque psoriasis muvanhu vane makore gumi nemasere nekure.

Sernivo inobatsira kubvisa psoriasis zviratidzo sekurumwa, kubaya, uye kutsvuka.

Unomwaya mushonga uyu we corticosteroid paganda kaviri pazuva uye woripora zvinyoronyoro mukati. Rinogona kushandiswa kusvika kumavhiki mana.

Mhedzisiro inowanzoitika ndeiyi:

• kuvava
• kusvirwa
• kubaya
• kurwadziwa kunzvimbo yekushandisa
• ganda atrophy

Mishonga mitsva yevana

Iwo mashoma psoriasis mishonga yaimbove yaingowanikwa chete kuvanhu vakuru munguva pfupi yapfuura yakave FDA-inogamuchirwa kuti irape vana futi.

Calcipotriene foam, 0.005% (Sorilux)

Muna 2019, iyo FDA yakawedzera mvumo yayo yechimiro chevhitamini D inonzi calcipotriene foam, 0.005 muzana (Sorilux). Inoshandiswa pakurapa kweplate psoriasis yeganda nemuviri.

MunaMay, yakagamuchira mvumo yekushandisa muvana vane makore gumi nemaviri kusvika gumi nemanomwe ekuberekwa. Inotevera Mbudzi, yakabvumidzwa kurapa plaque psoriasis yeganda nemuviri muvana vadiki semakore mana ekuberekwa.

Sorilux inobatsira inononoka isina kujairika ganda maseru kukura mu psoriasis. Iyi furo inoiswa munzvimbo dzakakanganisika dzeganda kaviri pazuva kweanosvika mavhiki masere. Kana zviratidzo zvikasavandudzika mushure memavhiki masere, bvunza chiremba wako.

Mhedzisiro inowanzoitika kutsvuka uye kurwadziwa panzvimbo yekushandisa.

Calcipotriene-betamethasone dipropionate foam, 0.005% / 0.064% (Enstilar)

Muna Chikunguru 2019, iyo FDA yakabvumidza calcipotriene-betamethasone dipropionate foam, 0.005 muzana / 0.064 muzana (Enstilar) yekushandisa muvachiri kuyaruka pakati pemakore gumi nemaviri negumi nemanomwe ekuberekwa. Yakagadzirirwa vanhu vane plaque psoriasis.

Calcipotriene inodzora kudzikama kwemasero eganda, nepo betamethasone dipropionate inobatsira kudzikisa kuzvimba.

Iyo furo inoiswa zuva nezuva kweanosvika mavhiki mana.

Mhedzisiro inowanzoitika inosanganisira:

• kuvava
• folliculitis
• mapundu ane akakwidza matsvuku mapundu kana mikoko
• kuwedzera psoriasis

Calcipotriene-betamethasone dipropionate kukamiswa kwemisoro, 0.005% / 0.064% (Taclonex)

Muna Chikunguru 2019, calcipotriene-betamethasone dipropionate topical kumiswa, 0.005 muzana / 0.064 muzana (Taclonex) yakagamuchirwawo neFDA kuti ishandiswe mune vane makore gumi nemaviri- kusvika gumi nemanomwe vane plaque psoriasis yemuviri.

Kumiswa kwemusoro wenyaya kwaimbove FDA-yakatenderwa kune vane makore gumi nemaviri- kusvika gumi nemanomwe vane plaque psoriasis yemusoro. Chizoro cheTaclonex chakambove FDA-inogamuchirwa kune vechidiki uye vakuru vane plaque psoriasis.

Kumiswa kweTaclonex kukamisikidzwa kunoitwa zuva nezuva kweanosvika mavhiki masere. Kune vane makore gumi nemaviri- kusvika gumi nemanomwe, yakanyanya kuyerwa vhiki nevhiki ndeye 60 gramu (g). Iyo yakanyanya kuwanda vhiki yevhiki yevakuru ndeye 100 g.

Mhedzisiro inowanzoitika inosanganisira:

• kuvava
• kusvirwa
• kutsamwa
• kutsvuka
• folliculitis

Ustekinumab (Stelara)

Muna Gumiguru 2017, iyo FDA yakabvumidza ustekinumab (Stelara) yevechiri kuyaruka vane makore gumi nemaviri zvichikwira. Inogona kushandiswa kune vechidiki vane zvine mwero kusvika kune yakaoma plaque psoriasis avo vari kukwikwidza phototherapy kana systemic kurapa.

Kubvumidzwa kwakauya mushure mekudzidza kwe2015 kwakawana kuti mushonga uyu wakanyatsobvisa ganda mushure memwedzi mitatu. Panyaya yekubviswa kweganda uye kuchengetedzeka, mhedzisiro yaive yakafanana neiya inoonekwa nevanhu vakuru.

Stelara anovharira mapuroteni maviri akakosha pakuvhiringidza maitiro, IL-12 uye IL-23.

Inopihwa seinopinda subcutaneous jekiseni. Dosing yakavakirwa pahuremu hwemuviri:

• Vechidiki vanorema isingasviki 60 kilograms (132 mapaundi) vanowana 0.75 milligrams (mg) pa kilogiramu yehuremu.
• Vechidiki vanoyera pakati pe60 kg (132 lbs.) Uye 100 kg (220 lbs.) Vanowana 45-mg dosi.
• Vechidiki vanorema anodarika zana kg (220 lbs.) Vanowana 90 mg, unova ndiwo muyero muyero wevakuru vehuremu hwakaenzana.

Idzi dosi mbiri dzekutanga dzinopihwa mavhiki mana dzakaparadzana. Mushure meizvozvo, mushonga unopihwa kamwe chete pamwedzi mitatu.

Mhedzisiro inowanzoitika ndeiyi:

• dzihwa nezvimwe zvirwere zvepamusoro zvekufema
• musoro
• kuneta

Etanercept (Enbrel)

MunaNovember 2016, iyo FDA yakabvumidza etanercept (Enbrel) kurapa chisingaperi zvine mwero kune chakasimba plaque psoriasis muvana vane makore mana kusvika gumi nemanomwe vane mukana wephototherapy kana systemic kurapa.

Enbrel yakagamuchirwa kurapa vanhu vakuru vane plaque psoriasis kubvira 2004 uye kubata vana vane vechidiki idiopathic arthritis (JIA) kubvira 1999.

Ichi chinodhaka chinodhaka chinoshanda nekuderedza zviitiko zveTNF-alpha.

Chidzidzo che2016 chevanosvika makumi manomwe evana vane makore mana kusvika pamakore gumi nemanomwe vakaona kuti Enbrel yaive yakachengeteka uye yakaramba ichishanda kusvika kumakore mashanu.

Vhiki rega rega, vana nevachiri kuyaruka vanogamuchira 0.8 mg yechirwere pa kilogiramu yehuremu hwavo. Muyero wepamusoro unorayirwa nachiremba ndowe 50 mg pasvondo, unova ndiwo muyero wevanhu vakuru.

Iwo akanyanya kujairika mhedzisiro mitezo panzvimbo yejekiseni uye epamusoro kufema nzira dzekuporesa.

Mamwe marapiro ave pedyo nekutenderwa

Mimwe mishonga yave pedyo nekutenderwa neDFA.

Bimekizumab

Bimekizumab jekiseni rejekiseni rebhaoloji iro riri kuongororwa senzira yekurapa chisingaperi plaque psoriasis. Inoshanda nekudzivirira IL-17.

Bimekizumab parizvino iri muchikamu chechitatu cheongororo. Parizvino, tsvagiridzo yakaratidza kuti yakachengeteka uye inoshanda.

MuBE SURE Kliniki yekuyedzwa, bimekizumab yainyanya kushanda kupfuura adalimumab (Humira) mukubatsira vanhu kuwana makumi mapfumbamwe muzana ekuvandudza muzvikamu zvinoshandiswa kuyera kuomarara kwechirwere.

Calcipotriene-betamethasone dipropionate cream, 0.005% / 0.064% (Wynzora)

Muna 2019, chikumbiro chitsva chemishonga chakaendeswa kune iyo FDA yeWynzora. Wynzora iri kamwe-zuva nezuva kirimu inosanganisa calcipotriene uye betamethasone dipropionate.

Muchikamu chechitatu cheongororo, Wynzora ainyanya kushanda pakubvisa ganda mushure memavhiki masere kupfuura Taclonex kukamiswa kwemisoro nekirimu.

Wynzora ine mukana wekusava neshungu, izvo vatori vechikamu vechidzidzo vakaona zviri nyore.

JAK inhibitors

JAK inhibitors rimwe boka rezvirwere-zvinoshandura zvinodhaka. Ivo vanoshanda nekutarisa nzira dzinobatsira muviri kugadzira mapuroteni ekuwedzera.

Ivo vatove kushandiswa kurapa:

• psoriatic arthritis
• rheumatoid arthritis
• urikanwi colitis

Vashoma vari muchikamu chechipiri uye chikamu chechitatu miedzo yepakati uye yakaoma psoriasis. Idzo dzinodzidziswa psoriasis ndiyo yemumuromo zvinodhaka tofacitinib (Xeljanz), baricitinib (Olumiant), uye abrocitinib. Musoro weJAK inhibitor uri pasi pekuferefetwa.

Parizvino, zvidzidzo zvakawana JAK inhibitors kuve inoshanda kune psoriasis. Ivo vanenge vakachengeteka sezviripo biologic zvinodhaka. Imwe mukana ndeyekuti vanouya mune fomu yepiritsi uye havafanirwe kupihwa majekiseni.

Izvo zvidzidzo zvakaitwa kusvika parizvino zvave zvenguva pfupi. Kuwedzera kutsvagurudza kunodiwa kuti uzive kana JAK inhibitors iri kuramba ichishanda kwenguva yakareba.

Tora woenda nazvo

Kugara uine ruzivo pamusoro pesarudzo nyowani dzekurapa psoriasis zvakakosha kugadzirisa mamiriro ako.

Iko hakuna imwe-saizi-inokodzera-ese kurapa kweiyo psoriasis. Zvichida uchafanirwa kuedza marapirwo akasiyana siyana usati wawana imwe inoshanda zvakanyanya kwauri uye isingakonzere mhedzisiro.

Zvitsva zvinowanikwa mu psoriasis zvinoitika nguva dzose. Ive neshuwa yekutaura nachiremba wako nezve itsva marapirwo sarudzo.