Iyi Kambani Inopa Genetic Kuongororwa Kwegomarara Rezamu Kumba

Zvemukati

• Mashandiro anoita Bvunzo
• Kukwira kumusoro
• Zvinokanganisa
• Ndiani Anofanira Kutora Bvunzo?
• Ongororo ye

Muna 2017, unogona kuwana bvunzo yeDNA kune chero chinhu chine hukama nezvehutano. Kubva pamatehwe swabs ayo anokubatsira iwe kuona yako yakanaka yehutano regimen kune kuongororwa kweropa izvo zvinokuudza iwe chingave chiri chako chinobudirira chikafu chekudzora uremu, sarudzo hadziperi. CVS iri kutotakura kuenda kumba DNA bvunzo ne23andMe iyo skrini yemajini ane chekuita nehuremu, kusimba, uye hutano hwese. Uyezve, hongu, kune genetic test yekuwedzera njodzi yezvirwere zvakakomba, senge cancer, Alzheimer's, uye kunyangwe chirwere chemoyo. Sezvineiwo, bvunzo idzi dzinopa vanhu ruzivo rwunogona kuvabatsira kuita sarudzo dziri nani nezvehutano hwavo, asi kuwedzera kwekuwana kunomutsa mibvunzo, senge "Kumba bvunzo dzepamba dzinoshanda sedzinoitwa munzvimbo dzekiriniki?" Uye "Kuziva zvakawanda nezveDNA yako kunogara kuri chinhu chakanaka?" (Yakabatana: Nei Ndichiwana Bvunzo yeAlzheimer)

Munguva pfupi yadarika, kambani nyowani yehutano inodaidzwa kuti Colour yakatanga yakaderedzwa yakamira BRCA1 uye BRCA2 genetic test. Muedzo wemate unongoda madhora makumi mapfumbamwe nemapfumbamwe, uye unogona kuuraira online. Kunyangwe chiri chinhu chakanaka kuti vanhu vazhinji vaziviswe nezvemaitiro avo enjodzi yemazamu nekenza yemazamu (aya maviri kanzura iyo BRCAgene mutations inosanganiswa ne), nyanzvi dzekuongorora genetic dzinonetseka nezvekuita kuti bvunzo idzi dziwanikwe kune veruzhinji pasina kupa varwere zviwanikwa zvakakodzera.

Mashandiro anoita Bvunzo

Chimwe chezvinhu zvakanakisa nezve Ruvara rwemageneti bvunzo ndechekuti ivo vanorairwa nachiremba. Izvi zvinoreva kuti usati watora bvunzo, uchafanirwa kutaura nachiremba-ungave wako kana chiremba wakapihwa nekambani- nezve zvaunogona kuita. Zvadaro, kiti chinotumirwa kumba kwako kana kuhofisi yachiremba wako, iwe unotsvaira mukati medama rako kuti uwane sampu yemate, uye unotumira kuColor's lab kuti inoongororwa. Mushure memavhiki matatu kusvika mana, iwe unogamuchira mibairo yako, pamwe nesarudzo yekutaura ne genetic chipangamazano parunhare. (Zvakabatana: Kenza Yezamu Ndiko Kutyisidzira Kwemari Hapana Wekutaura Nezvazvo)

Kukwira kumusoro

Kunyange zvichingofungidzirwa kuti 1 muvanhu mazana mana vane BRCA1 kana BRCA2 shanduko, zvinofungidzirwawo kuti vanopfuura makumi mapfumbamwe muzana evanhu vakabatwa havasati vaonekwa. Izvi zvinoreva kuti vanhu vazhinji vanoda kuyedzwa; nguva. Nekuita kuti iro bvunzo riwanikwe pamutengo unodhura kune vanhu vangangodaro vasina kukwanisa kutora bvunzo, Ruvara ruri kubatsira kuvhara iro gwanza.

Kazhinji, kana iwe uchida kuti bvunzo ye BRCA iitwe kuburikidza nachiremba wako, unofanirwa kuwira mune chimwe chezvikamu zvitatu, sekureva kwaRyan Bisson, chipangamazano pamajini kuOrlando Health UF Health Cancer Center. Kutanga, kana iwe wakambove nekenza yemazamu kana ovari iwe pachako. Chechipiri, kana paine nhoroondo yemhuri yakadai sehama ine gomarara remuchibereko kana hama yepedyo ine gomarara rezamu kana kuti isati yasvika makore 45. Chekupedzisira, kana mumwe wemumhuri yepedyo akaongororwa uye akadzoka aine gomarara, munosanganawo. izvo zvinodiwa. Ruvara runopa sarudzo kune vanhu vasingawire mune chero eaya mapoka.

Iyo kambani inovimbwawo neakuru hutano hwehukama hwerudzi urwu rweyedzo yekuongorora uye pasi pemamwe mamiriro akasarudzika, izvo zvinoreva kuti haufanire kunetseka nezvehunhu hweMayedzo bvunzo. "Dhipatimendi reHenry Ford reMedical Genetics rinoshandisa Ruvara kune vanhu vanoda kuongororwa asi vasingasviki maitiro ekuongororwa, uye kune vakadzi vasingade mhinduro muzvinyorwa zvavo zvekurapa," anotsanangura Mary Helen Quigg, MD, chiremba muDhipatimendi. yeMedical Genetics kuHenry Ford Health System. Dzimwe nguva, vanhu havadi mhedzisiro yavo parekodhi nekuda kweinishuwarenzi. Uyezve, pane chinhu chiri nyore, anodaro Dr. Quigg. Kuedza kwekumba kuri nyore uye nyore.

Zvinokanganisa

Kunyangwe paine zvimwe zvinhu zvikuru pamusoro peye-pamba-BRCA bvunzo, nyanzvi dzinotaura matambudziko mana makuru nazvo.

Vanhu vazhinji vane zvisirizvo pamusoro pekuti kuongororwa kwemajini kunorevei kune njodzi yekenza.

Dzimwe nguva vanhu vanotarisa kuongororwa kwemajini kuti vape mhinduro dzakawanda kupfuura zvadzinogona. "Ndiri mutsigiri wezvevarwere vanoziva ruzivo rwavo," anodaro Bisson. Asi "kunyanya kubva pamaonero ekenza, vanhu vanoisa nzira yakawanda kwazvo mumageneti. Vanofunga kuti kenza yese iri nekuda kwemajini avo uye kuti kana vakaongororwa majini, ichavaudza zvese zvavanofanira kuziva." Muchokwadi, chete 5 kusvika 10 muzana yekenza inokonzerwa nekushanduka kwemajini, saka kunyangwe zvakakosha kuti unzwisise njodzi yako yenhaka, kuwana mhedzisiro yakaipa hazvirevi kuti hauzombofi wakabatwa kenza. Uye nepo mhedzisiro yakanaka ichiratidza njodzi yakawedzera, hazvireve kuti iwe kuda gomarara.

Kana zvasvika pakuongororwa kwemajini, kuwana iyo rudyi bvunzo dzakakosha.

Iyo BRCA bvunzo inopihwa neColor inogona kunge yakawandisa kune vamwe vanhu, uye yakatetepa kune vamwe. "BRCA 1 ne2 zvinongopa chikamu che25 muzana yekenza yemazamu yekuzvarwa," akadaro Dr. Quigg.Izvi zvinoreva kuti kungoedza chete izvo zviviri shanduko kunogona kuve kwakanyanya. Quigg nevamwe vake pavanoraira kuyedzwa kubva kuRuvara, vanowanzo raira kuwanda kwakakura kwekuyedza kupfuura kungoita BRCA 1 ne2, kazhinji vachisarudza Hereditary Cancer Test, iyo inoongorora majini makumi matatu anozivikanwa kuti ane chekuita negomarara.

Uyezve, mhedzisiro inobatsira kwazvo inouya kubva kuyakaedzwa bvunzo. "Tine dzinenge mazana maviri magene akasangana nekenza," anotsanangura kudaro Bisson. "Kubva pakuona kwekiriniki, tinogadzira bvunzo pane izvo zvatinoona munhoroondo yako pachako uye yemhuri." Saka dzimwe nguva, iyo 30-gene pani inogona kuve yakanyanya kusarudzika kana yakafara, zvichienderana nenhoroondo yemhuri yako.

Zvakare, kana nhengo yemhuri yemunhu yatove neyakaedzwa, bvunzo yeCAA yakawanda haisi iyo yakanyanya kunaka sarudzo. "Funga nezvemajini eBRCA sebhuku," anodaro Bisson. "Kana tikawana shanduko mune rimwe ramajene aya, lab rakaita bvunzo rinotitaurira chaizvo kuti ndeipi peji peji iyo shanduko yacho iriko, saka kuyedza munhu wese mumhuri kazhinji kunongova nekutarisa iyo imwechete yakachinjika kana 'peji nhamba .' Izvi zvinozivikanwa seyesingle-saiti kuyedzwa, izvo zvinoitwa neColor kuburikidza nachiremba asi hazvipihwe veruzhinji pawebhusaiti yavo.

Iwe haufanire kunge uchifanira kubhadhara kunze-kwe-muhomwe kuongororwa kwemajini.

Ichokwadi kuti vanhu vakawanda vanofanira kuwana bvunzo dzeBRCA, asi nenzira imwe chete iyo bvunzo pachayo inofanirwa kunanga, vanhu vanowana bvunzo vanofanirwa kubva muboka rakati: vanhu vanozadzisa maitiro ekuedzwa. "Varwere dzimwe nguva vanoona maitiro seimwewo hoop yekuti vasvetuke, asi zviri kuedza chaizvo kunongedza mhuri dzinogona kuwana ruzivo kubva pakuongorora majini," anodaro Bisson.

Uye nepo bvunzo yacho ichitengeka nemari iri pasi pe $ 100, Ruvara harupi mukana wekuve neinishuwarenzi yekubhadharira iyo yakamira yega BRCA bvunzo. (Ivo vanopa iyo sarudzo yekuita inishuwarenzi kubhadharira mamwe emamwe maedzo avo.) Kana iwe ukasangana nematanho ekuongororwa kwemajini uye uine inishuwarenzi yehutano, hapana chikonzero chekubhadhara kunze-kwehomwe kuti uve nemajini ekuongororwa kwe BRCA shanduko. zvaitwa. Uye kana yako inishuwarenzi isingavhare kuyedza? "Kakawanda, avo ndivo vanhu vasingazobatsiri pakuongororwa. Mazhinji emakambani einishuwarenzi anoshandisa mitemo yenyika kubva kuNational Comprehensive Cancer Network, iyo iboka revanachiremba vanozvimiririra uye nyanzvi dzinoumba mazano, "anodaro Bisson. Hongu, pane nguva dzose kunze, uye kune avo vanhu, Bisson anoti iye ndingadaro kurudzira sevhisi yakaita seRuvara.

Genetic counselling mushure mekuwana mhedzisiro yako chaizvo inofanirwa.

Dzimwe nguva genetic test mhinduro inogona kukonzera mibvunzo yakawanda kupfuura mhinduro. Kana genetic mutation (kana shanduko mune gene) yawanikwa, kune nzira nhatu dzinogona kurongeka, maererano naBisson. Benign, zvinoreva kuti haina kukuvadza. Pathogenic, zvinoreva kuti inowedzera mukana wekenza. Uye musiyano wekukosha kusingazivikanwe (VUS), zvinoreva kuti hapana tsvagiridzo yakaringana pane shanduko yekuita mhedziso. "Pane mukana we4 kusvika ku5 muzana wekutsvaga VUS neBrCA kuongororwa," anodaro Bisson. "Kune varwere vazhinji, izvo zvakanyanyisa kupfuura mukana wekuwana pathogenic mutation." Rangarira kuti imwe pamitemo mazana mana kubva pakutanga? Izvi zvinoreva kuti zvinowanzoitika kuti pasina kusangana maitiro ekuyedzwa, unogona kusawana ruzivo rwemhando kubva mazviri. Ichi ndicho chimwe chezvikonzero zvikuru makambani einishuwarenzi anowanzoda kuti vanhu vasangane nenyanzvi kana mubatsiri vasati vaedzwa.

Ruvara runopa genetic counselling, asi zvinonyanya kuitika mushure mekunge bvunzo yaitwa. Kune chikwereti chavo, ivo vari pachena nezve chokwadi chekuti iwe unofanirwa kunge uchikurukura mhedzisiro yako nemubatsiri-wehutano, asi hazvidiwe. Nyaya iripo ndeyekuti vanhu kazhinji vanongodaidzira kurairwa kana vagamuchira mhedzisiro, anodaro Dr. Quigg. "Mhedzisiro yakaipa nezvakasiyana zvinodawo kurairwa kuitira kuti munhu anzwisise zvazvinoreva. Mhedzisiro yakaipa haireve kuti hapana shanduko. Zvinogona kureva kuti hatina kuwana shanduko - kana kuti chaicho zvisina kunaka. " Mhedzisiro yeVUS ihombodo yese yehonye inoda kurairwa chaiko, anodaro.

Ndiani Anofanira Kutora Bvunzo?

Zvichitaurwa zviri nyore, kana iwe uine inishuwarenzi uye nhoroondo yemhuri yemakenza ane hukama ne BRCA, unokwanisa kuzowana bvunzo kuburikidza neyakajairika chiteshi nemutengo wakaderera kana pasina muripo zvachose. Asi kana iwe usadaro une inishuwarenzi uye unosuwa zvishoma zviyero zvekuyedzwa, kana kana iwe usiri kuda mhedzisiro yako pane yako yekurapa rekodhi, Ruvara rweBRCA bvunzo inogona kunge yakakunakira iwe. (Hazvinei nengozi yako pachako, iwe uchada kuziva nezve iyi pink mwenje mudziyo unoti unogona kubatsira kuona gomarara rezamu kumba.) Asi hazvireve kuti unofanira kungoenda online woihodha. "Ndinokurudzira varwere kuti vapiwe mazano uye ipapo sarudza kana vachida kuyedzwa kumba, pamwe nesarudzo dzekuwana mazano akakodzera, "anodaro Dr. Quigg.

Pasi pepamusoro: Taura nachiremba wako usati watora. Iye kana iye anokwanisa kukubatsira iwe kuona kana kuyedzwa kuchizopa ruzivo rwunonyanya kubatsira uye kukuendesa iwe kuna chipangamazano wezvechibereko. Uye kana iwe ita sarudza kuenda kune yekumba sarudzo, yako doc inogona kutaura newe kuburikidza nemhedzisiro yako takatarisana-kumeso.

Ongororo ye