Autophagy: Zvaunofanira Kuziva

Zvemukati

• Ndezvipi zvikomborero zvekuzvipira muviri?
• Kudya kuchinjika kunogona kusimudzira autophagy
• Chinokosha

Chii chinonzi autophagy?

Autophagy inzira yemuviri yekuchenesa maseru akakuvara, kuitira kuti uvandudze masero matsva, ane hutano, sekureva kwaPriya Khorana, PhD, mune dzidzo yezvikafu zvinovaka kubva kuColumbia University.

"Auto" zvinoreva wega uye "phagy" zvinoreva kudya. Saka zvinoreva "kuzvidya".

Inonziwo "kuzvidya." Kunyangwe izvo zvinganzwika sechinhu iwe chausingade kuti chiitike kumuviri wako, zvinonyanya kubatsira kune hutano hwako hwese.

Izvi zvinodaro nekuti autophagy inzira yekushanduka-yekuzvichengetedza nzira iyo muviri unogona kubvisa masero asina kushanda uye kudzokororazve mativi awo kumagetsi ekugadzirisa nekuchenesa, sekureva kwebhodhi-rakasimbiswa cardiologist, Dr. Luiza Petre.

Petre anotsanangura kuti chinangwa chekuzvipira ndeyokubvisa marara uye kuzvidzora-kudzoka kuita basa rakatsetseka.

“Iri kushandisa patsva pamwe nekuchenesa panguva imwe chete, sekungobaya bhatani rekugadzirisa muviri wako. Uyezve, inosimudzira kurarama uye kugadzirisa semhinduro kumatambudziko akasiyana siyana uye chepfu yakaunganidzwa mumasero edu, ”anowedzera.

Ndezvipi zvikomborero zvekuzvipira muviri?

Iwo mabhenefiti makuru e autophagy anoita kunge anouya muchimiro cheanopesana-kukwegura misimboti. Muchokwadi, Petre anoti inozivikanwa zvakanyanya senzira yemuviri yekudzosa wachi kumashure nekugadzira maseru madiki.

Khorana anonongedza kuti kana maseru edu akamanikidzwa, kuzvitakura kunowedzerwa kuitira kutichengetedza, izvo zvinobatsira kuwedzera hupenyu hwako.

Pamusoro pezvo, chiremba wezvekudya akanyoreswa, Scott Keatley, RD, CDN, anoti munguva dzenzara, kuzvitongesa muviri kunochengetedza muviri kuenda nekutyora maseru zvinhu nekuzvishandisazve kuitira maitiro anodikanwa.

"Ehe izvi zvinotora simba uye hazvigone kuenderera nekusingaperi, asi zvinotipa imwe nguva yekuwana chikafu," anowedzera.

Padanho remaseru, Petre anoti zvakanakira kuzvimba zvinosanganisira:

• kubvisa mapuroteni ane chepfu kubva mumasero ayo anonzi anokonzerwa nezvirwere zveeurodegenerative, senge Parkinson's neAlzheimer's
• marara akasara emapuroteni
• kupa simba uye mabhuroko ekuvakira maseru ayo achiri kugona kubatsirwa nekugadziriswa
• padanho rakakura, inokurudzira kumutsidzirwa uye maseru ane hutano

Autophagy iri kugamuchira kutarisisa kwakawanda kune iro basa raingaite mukudzivirira kana kurapa kenza, futi.

"Autophagy inoderera patinokwegura, saka izvi zvinoreva kuti masero asingachashandi kana anogona kukuvadza anotenderwa kuwanda, inova MO yemasero ekenza," anotsanangura Keatley.

Nepo kenza dzese dzichitanga kubva kune imwe mhando yemasero ane hurema, Petre anoti mutumbi unofanirwa kuziva uye kubvisa iwo maseru, kazhinji vachishandisa maitiro ekuzvionera. Ndosaka vamwe vaongorori vari kutsvaga mukana wekuti kuzvitemesa kunogona kudzikisa njodzi yekenza.

Kunyange pasina humbowo hwesainzi hwekutsigira izvi, Petre anoti vamwe vanoti masero mazhinji egomarara anogona kubviswa kuburikidza nekuzvipira.

"Aya ndiwo maratidziro anoita muviri vatadzi vegomarara," anotsanangura. "Kuziva nekuparadza zvakakanganisika nekukonzera mashandiro ekugadzirisa kunobatsira kudzikisa njodzi yekenza."

Vatsvagiri vanotenda kuti zvidzidzo zvitsva zvinotungamira mukunzwisisa kunozovabatsira kunongedza kuzvimiririra senzira yekurapa kenza.

Kudya kuchinjika kunogona kusimudzira autophagy

Rangarira kuti autophagy inoreva "kuzvidya wega." Saka, zvinonzwisisika kuti kutsanya kwepakati nepakati uye ketogenic kudya kunozivikanwa kukonzera autophagy.

"Kutsanya [ndiko] kumutsa kuzvimba," anotsanangura Petre.

"Ketosis, chikafu chine mafuta mazhinji uye chakaderera muma carbs chinounza mabhenefiti akafanana ekutsanya pasina kutsanya, senzira ipfupi yekukonzera shanduko imwechete yemetabolism," anowedzera. "Nekusaremedza muviri nemutoro wekunze, inopa muviri zororo rekutarisa pahutano hwayo uye kugadzirisa."

Mune keto chikafu, iwe unowana ingangoita 75 muzana yemakoriori ako ezuva nezuva kubva kumafuta, uye mashanu kusvika gumi muzana muzana emakori ako kubva ku carbs.

Iko shanduko mune macalorie sosi inokonzeresa muviri wako kuchinjisa ayo metabolic nzira. Inozotanga kushandisa mafuta kuita mafuta panzvimbo yeglucose inotorwa kubva kuma carbohydrate.

Mukupindura kurambidzo iyi, muviri wako unotanga kutanga kuburitsa ketone miviri ine yakawanda yekudzivirira mhedzisiro. Khorana anoti zvidzidzo zvinoratidza kuti ketosis inogona zvakare kukonzera nzara-inosimudzira autophagy, iyo ine neuroprotective mabasa.

"Low glucose level inowanikwa mune zvese zvekudya uye inosanganisirwa yakaderera insulin uye yakakwira glucagon mazinga," anotsanangura Petre. Uye glucagon level ndiyo inotangisa kuzvipira.

"Kana muviri wakashomeka neshuga kuburikidza nekutsanya kana ketosis, zvinounza kushushikana kwakanaka kunomutsa iyo yekugadzirisa kugadzirisa maitiro," anowedzera.

Imwe isiri-yekudya nzvimbo iyo inogona zvakare kutora chinzvimbo mukudzora autophagy iko kurovedza muviri. Sekureva kwemumwe mhuka, kurovedza muviri kunogona kukurudzira autophagy muzvikamu zviri chikamu chemagetsi maitiro.

Izvi zvinogona kusanganisira tsandanyama, chiropa, rwatata, uye adipose tishu.

Chinokosha

Autophagy icharamba ichiwana tarisiro sezvo vaongorori vachiitisa zvimwe zvidzidzo nezve kukanganisa kwazvinoita pahutano hwedu.

Parizvino, nyanzvi dzezvehutano nehutano dzakadai saKhorana vanonongedzera kuchokwadi chekuti kuchine zvakawanda zvatinoda kudzidza nezve autophagy uye nemabatiro atingaite zvakanaka.

Asi kana iwe uchifarira kuyedza kukurudzira autophagy mumuviri wako, iye anokurudzira kutanga nekuwedzera kutsanya uye kugara uchirovedza muviri mune yako tsika.

Nekudaro, iwe unofanirwa kubvunza chiremba wako kana iwe uri kutora chero mishonga, uine nhumbu, kuyamwisa, kana unoshuva kuve nepamuviri, kana uine chirwere chisingaperi, senge chirwere chemwoyo kana chirwere cheshuga.

Khorana anoyambira kuti haukurudzirwe kutsanya kana ukawira mune chero ezvikamu zviri pamusoro.