Biased Clinical Trials Kureva Kuti Hatigare Tichiziva Kuti Kurapa Kunobata Sei Vakadzi

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• Ongororo ye

Iwe unogona kunge uchitoziva kuti kutora aspirin kunogona kubatsira kudzivirira kurwiswa kwemoyo-ndiyo hwaro hweBayer Aspirin brand's advertising campaign. Asi iwe pamwe hauzive kuti izvozvi-zvine mukurumbira 1989 chishamiso kudzidza kwakasimbisa kugona kwemushonga mumamiriro ezvinhu aya kwaisanganisira vanopfuura zviuru makumi maviri zvevarume nevarume zero.

Sei izvi? Kune yakawanda nhoroondo yezvekurapa, varume (uye mhuka dzechirume) vanga vari "guinea nguruve" dzekuyedza-mhedzisiro, madhiri, uye mhedzisiro yakayerwa pane zvakanyanya kana zvizere zvechirume zvidzidzo. Mukurapa kwemazuva ano, varume vave vari muenzaniso; vakadzi vanowanzo funga.

Zvinosuruvarisa, maitiro ekufuratira migumisiro yemishonga muvakadzi inoenderera mberi nhasi. Muna 2013, makore makumi maviri mushure mekutanga kwemushonga, Chikafu neDrug Administration (FDA) yakacheka muyero wakakurudzirwa weAbien kuvakadzi muhafu (kubva pa10 mg kusvika pa5 mg yeiyo ingango buritswa vhezheni). Zvinoitika kuti vakadzi-vashanu muzana avo vanotaura vachishandisa mishonga yekurara yekurapa kana zvichienzaniswa ne3 chete muzana yevarume-vakagadzirisa mushonga zvishoma nezvishoma kupfuura varume, zvichireva kuti vanganzwa kudonha mukati mezuva padanho repamusoro. Iyi divi mhedzisiro inouya nemhedzisiro yakakomba, kusanganisira tsaona dzekutyaira.

Imwe tsvakurudzo inoratidza kuti vakadzi vanoita kune zvakasiyana-siyana zvemishonga zvakasiyana zvikuru nevarume. Semuenzaniso, mune kumwe kuyedza, vatori vechikamu vechirume vaitora masitamin vaive nekushomeka kwekurwadziwa kwemoyo uye kurohwa, asi varwere vechikadzi havana kuratidza iwo iwo maitiro makuru. Saka zvinogona, kutaura zvazviri, kuva zvinokuvadza kupa ma statins-ayo anowanzo kuuya nemukurumbira usingafadzi mhedzisiro-kune vakadzi vane kana vasina njodzi yematambudziko emwoyo.

Mune zvimwe zviitiko, vakadzi vanoita zvirinani kupfuura varume vari paSSRI mishonga yekudzvinyirira, uye kumwe kutsvagurudza kunoratidza kuti varume vane budiriro huru nemishonga yetricyclic. Zvakare, vakadzi vakapindwa muropa necocaine vanoratidza misiyano muhuropi chiitiko ichienzaniswa nevarume, zvichiratidza mashandiro ayo vakadzi vanogona kuvimba nawo nemushonga nekukurumidza. Naizvozvo, kusiya vakadzi mamodheru kunze kwezvidzidzo zvekupindwa muropa, semuenzaniso, zvingangoita zvine hukasha zvakanyanya kumishonga uye zviyero zvekutarisira izvo zvinozogadzirirwa kushandira vakapindwa muropa.

Isu tinoziva zvakare kuti madzimai anoratidza zviratidzo zvakasiyana mune zvimwe zvirwere zvakakomba. Kana vakadzi vane hosha yemoyo, semuenzaniso, vanogona kana kusanzwa kusarudzika kwemarwadzo echipfuva. Pane kudaro, ivo vanowanzoita kupfuura varume kuti vawane kupfupika kwekufema, kutonhora ziya, uye nemusoro wakareruka. Kunyangwe bonde risiri chinhu muzvinhu zvese zvehutano, kana zvirizvo, zvinowanzova zvakakomba.

"Hatisati taziva kuti [bonde] richava nebasa here muchirwere chese, mumamiriro ese ezvinhu, asi tinofanirwa kuziva kuti zvine basa riini," anodaro Phyllis Greenberger, mutungamiri uye CEO weSosaiti yeVakadzi Hutano. Kutsvakurudza. Aive nguva pfupi yadarika chikamu chemusangano wemusangano wekuzeya basa rekusiyana kwepabonde mukutsvagisa kwekurapa, achitsigirwa nesangano rake uye The Endocrine Society.

Sangano raGreenberger raivewo rakakosha kubatsira 1993 NIH Revitalization Act kupfuura, iyo yaida kuti maNational Institutes of Health (NIH) abhadharwe miedzo yemakiriniki kusanganisa vakadzi nevashoma vatori vechikamu. Parizvino, iri boka nderimwe revazhinji vari kushanda kuti vawane kutarisisa kumwechete kumhuka nemaseru anoshandiswa mukutsvagurudza kwepamberi- kwete vanhu chete.

Nechemumoyo, NIH iri kusundira kuita shanduko yakakura mukutsvaga. Kutanga munaGunyana wegore rapfuura, yakatanga kuburitsa akateedzana marongero, mirau, uye mari inokurudzira kukurudzira (uye muzviitiko zvakawanda zvinoda) vaongorori kuti vazive bonde rezvakaberekwa sechinhu chakakosha pabasa ravo. [Verenga nyaya izere paRefinery29!]

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