Biologics uye PsA: Ndezvipi Zvaungaita?

Zvemukati

• Chii chinonzi biologics?
• Ko biologics inoshandiswa sei kurapa PsA?
• Ndedzipi sarudzo dzangu dzekurapa PsA nebiologic?
• TNF-alpha inhibitors
• IL-12, IL-23, uye IL-17 inhibitors
• T-sero inhibitors
• JAK kinase inhibitor
• Izvo biologics yakachengeteka kune wese munhu ane PsA?
• Ndeipi mhedzisiro inokanganisa kutora biologic?
• Kutora

Mhedziso

Psoriatic arthritis, kana PsA, inokonzera kuzvimba, kuomarara, uye kurwadziwa kwemajoini. Iko hakuna kurapwa kwePSA, asi mararamiro ehupenyu anochinja uye mishonga inogona kubatsira kubata zviratidzo.

Mishonga inowanzo shandiswa ndeye nonsteroidal anti-inflammatory drug (NSAIDs), chirwere-chinogadzirisa antirheumatic zvinodhaka (DMARDs), uye biologics.

Biologics haisi nyowani, asi ivo vanopa yakanyanya kumberi kurapwa ikozvino kupfuura nakare kose. Nhungamiro nyowani inokurudzira aya madhiragi seimwe yematanho ekutanga ekurapa PsA.

Chii chinonzi biologics?

Mishonga yechinyakare ine zvigadzirwa zvekugadzira. Izvo zvakagadzirwa nemakemikari asina kuwanikwa mune zvakasikwa.

Zvinowanzoitika zvinodhaka izvo vanhu vanoziva uye kuvimba zvavanogadzira mumarabhoritari marongero kubva kune zvisiri biological zvinhu. Aspirin, semuenzaniso, yaienzanisirwa mushure mechinhu chiri muwillow bark, asi ikozvino yagadzirwa kubva kuzvinhu zvakagadzirwa.

Biologics, kune rimwe divi, inoumbwa nezvinhu zvehupenyu. Masayendisiti anoshandisa masero akazara, ma enzymes, antibodies, uye zvimwe zvinhu kugadzira mushonga une basa chairo.

Mikana yekuti iwe watove wakaratidzirwa kuhunyanzvi hwekurapa hwakagadzirwa kubva kuzvinhu zvinowanikwa mune zvakasikwa. Kana iwe wakambove nemushonga wekudzivirira kana kuwedzerwa kuwedzerwa ropa, wakambove nemushonga wekurapa uyo wakagadzirwa zvichibva pazvinhu zvehupenyu.

Nekuti biologics inonyanya kunyatso tarisa maseru, uye kutevedzera mamorekuru anowanikwa zvakasikwa mumuviri, anowanzo shanda. Ivo zvakare vane mashoma maratidziro pane zvinodhaka zvakagadzirwa kubva kumakemikari.

Ko biologics inoshandiswa sei kurapa PsA?

Kuzvimba kazhinji kunokonzeresa kuzvimba, kuomarara, uye kurwadziwa kwekubatana kunotsanangura PsA. Biologics inoshandiswa kurapa PsA yakanangana nenzira dzakasiyana mumuviri dzinogadzira kuzvimba. Izvi zvakasiyana nemishonga yechinyakare, inotarisa nhanho zhinji muma immune system.

Zvichienderana nezvako psoriatic arthritis zviratidzo uye nhoroondo yezvokurapa, chiremba wako anogona kukurudzira imwe yezvakawanda biologics yekuzorora.

Ndedzipi sarudzo dzangu dzekurapa PsA nebiologic?

Pane zvakawanda zvingasarudzwa zvekurapa yako PsA ne biologic. Iyi mishonga inogona kuunganidzwa pamwechete nachiremba wako zvichibva nemaitiro avanoita maererano ne immune system.

TNF-alpha inhibitors

Tumor necrosis factor-alpha (TNF-alpha) ipuroteni inotungamira mukuzvimba. Vanhu vane PsA vane yakawandisa yakawanda yeTNF-alpha paganda ravo kana mumajoini avo.

Iyi mishonga mishanu yakagadzirirwa kuvhara puroteni iyi:

• Cimzia (certolizumab pegol)
• Enbrel (etanercept)
• Humira (adalimumab)
• Remicade (infliximab)
• Simponi (golimumab)

Ivo vanoshanda nekumisa kuwandisa kwakanyanya kwemasero eganda uye kuzvimba izvo zvinogona kutungamira mukukuvara kwemajoini tishu.

IL-12, IL-23, uye IL-17 inhibitors

Interleukin-12, interleukin-17, uye interleukin-23 mapuroteni akasiyana anosangana nekuzvimba. Zvishanu biologics zviripo parizvino zvinokanganisa chiitiko kana neyakaenderana receptor yeaya mapuroteni.

Iyi mishonga yakagadzirirwa kudzivirira kuzvimba:

• Stelara (ustekinumab): IL-12/23
• Cosentyx (secukinumab): IL-17
• Taltz (ixekizumab): IL-17
• Siliq (brodalumab): IL-17
• Tremfya (guselkumab): IL-23

T-sero inhibitors

Mune vanhu vane arthritis, T-lymphocyte maseru, kana T-maseru, anogoneswa, izvo zvinogona kukonzera kuwanda kwemasero aya. Vamwe vanhu vane arthritis vanozovandudza yakawandisa yeT-maseru.

Aya ndiwo masero ekudzivirira muviri, ayo isu tese tinoda. Asi muhuwandu hwakawanda, ivo vanogadzira makemikari anotungamira mukukuvara kwemajoini, kurwadziwa, uye kuzvimba.

Orencia (abatacept) mushonga unobata T-masero. Orencia haideredze huwandu hweT-maseru, asi inomisa kuburitsa kwemakemikari anokonzera zviratidzo nekuvharidzira T-cell activation.

JAK kinase inhibitor

Xeljanz (tofacitinib) mumwe mushonga unobvumidzwa PsA. Iyo JAK kinase inhibitor, iyo inoreva kune molekemu diki inovhara nzira inobatanidzwa mumhinduro yekuzvimba yehutachiona.

Iyi mishonga haisi yehunyanzvi biologic, asi chiremba wako anogona kutaura newe nezvazvo. Inowanzo kuve yakabatanidzwa pamwe ne biologics mune hurukuro pamusoro pevamwe vanonongedzwa vamiririri ve autoimmunity.

Izvo biologics yakachengeteka kune wese munhu ane PsA?

Biologics inokurudzirwa kune avo vanorarama zvine mwero kusvika kune yakaoma PsA. Asi vamwe vanhu havasi kukwikwidza biologics.

Izvi zvinodaro nekuti mhedzisiro yemushonga inogona kukuvadza kupfuura kunaka. Vanhu vane hutachiona hwehutachiona hwakakanganiswa kana hutachiona hunoshanda havafanirwe kutora biologics yePsA yavo. Iyi mishonga inodzvinyirira immune immune uye inogona kuve isina kuchengetedzeka kana yako yatokanganiswa neimwe nzira.

Mutengo uye kunze-kwehomwe mari ye biologics inogona zvakare kuve chipingamupinyi kune vamwe vanhu.

Ndeipi mhedzisiro inokanganisa kutora biologic?

Imwe neimwe PsA biologic yakasiyana. Imwe neimwe ine yayo mhedzisiro mhedzisiro. Zvisinei, kune zvimwe zvakafanana mukirasi iyi yemishonga. Iyo yakajairika mhedzisiro mhedzisiro kune ese biologics inguva yakawedzera yehusina kujairika, kana mukana, hutachiona.

Kana iwe nachiremba wako mukasarudza kuyedza iyi nzira yekurapa neiyo biologic, unogona kusangana nezviratidzo zvechirwere kana zvirwere zvekufema. Sezvo biologics inopihwa jekiseni kana IV, iwe unogona zvakare kunzwa kusagadzikana uko tsono inobaya ganda rako.

Biologics inogona kutungamira kune mamwe akanyanya mhedzisiro mhedzisiro, senge kukanganiswa kweropa kana gomarara. Nezvikonzero izvi, ipfungwa yakanaka kukudziridza hukama hwakasimba nachiremba wako. Pamwe chete, munogona kusarudza kuti biologic ndiyo chaiyo yekurapa kwako psoriatic arthritis.

Kutora

Biologics yakaunza yakanangwa nzira dzekurapa kune avo vanorarama zvine mwero kusvika kune yakaoma PsA. Havasi vese vatsva, asi izvozvi vanoonekwa sekurapa-mutsara wekutanga wekurapa PsA.