Tsvaga Akanakisa Antipsychotic Yevana

Zvemukati

• Mauya
• Anoshanda Sei Atypical Antipsychotic Anoshanda uye Ndiani Anovada?
• Mamiriro Akaitwa neAtypical Antipsychotic
• Schizophrenia
• Bipolar Dambudziko
• Aripiprazole (Bvisa)
• Quetiapine (Seroquel)
• Olanzapine uye Risperidone
• Kupararira Kwekusimudzira Matambudziko
• Zvinokanganisa Maitiro Ekuzvibata
• Kuchengetedzwa kweAtypical Antipsychotic
• Kuchengetedzeka kunetsekana neatypical antipsychotic muvana nevechiri kuyaruka
• Kurema Kuwana
• Matambudziko Emwoyo uye Chirwere cheshuga
• Maitiro ekuzviuraya
• Mamwe Mativi Ekupedzisira
• Kusarudza Atypical Antipsychotic yeVana
• Kutaura Nachiremba Wako
• Takatarisa Sei Antipsychotic
• Kugovera Chirevo Ichi
• Nezvedu
• Mareferensi

• Pfupiso
• Mushumo Wakazara

Mishonga yemishonga inonzi atypical antipsychotic, iyo inosanganisira aripiprazole (Abilify), asenapine (Saphris), clozapine (Clozaril), iloperidone (Fanapt), olanzapine (Zyprexa), paliperidone (Invega), quetiapine (Seroquel), risperidone (Risperdone) (Geodon), inopihwa kuvana nevechiri kuyaruka kuti varape schizophrenia uye bipolar kusagadzikana. Iwo anoshandiswa zvakare kuyedza kudzikisira hutsinye, kusagadzikana, uye maitiro ekuzvikuvadza ane hukama nekupararira kwekukura kwekushushikana, kusanganisira autism uye Asperger syndrome, uye kusagadzikana kwehunhu hunhu. Asi kunyorera iyi mishonga kune vechidiki kunopokana nekuti ivo havana kunyatso dzidzwa, uye kuchengetedzwa kwenguva refu uye kushanda kwevana nevechidiki hazvizivikanwe.

Zvidzidzo muvakuru zvakawana kuti atypical antipsychotic inogona kukonzera zvakakomba mhedzisiro, saka kuchengetedzwa kwenguva refu ndiko kunetsekana nezvekushandisa kwavo muvana. Zvimwe zvinoshungurudza zvakanyanya zvinosanganisira kufamba kusingadzoreki uye kudedera kwakafanana nechirwere chaPasinson (chinozivikanwa se extrapyramidal zviratidzo), njodzi yakawedzera yechirwere cheshuga, kuwedzera uremu, uye kukwidziridzwa kwecholesterol uye triglyceride mazinga. Atypical antipsychotic zvinodhaka zvinogona zvakare kuwedzera njodzi yekufa nguva isati yakwana, kunyanya nekuda kwesitiroko, kune vakuru vakuru vane dementia. Njodzi idzi dzakadzidzwa zvakanyanya muvakuru; zvinoitika muvana hazvizivikanwe zvizere panguva ino.

Nekuda kwekushayikwa kweuchapupu, isu hatigone kusarudza Best Buy atypical antipsychotic yevana vane schizophrenia, bipolar kusagadzikana, kwakapararira kusagadzikana kwekuvandudza, kana kusagadzikana kwehunhu maitiro. Panzvimbo iyoyo, vanachipangamazano vedu vezvekurapa vanokurudzira kuti vabereki vafunge nezvenjodzi dzinogona kuitika uye mabhenefiti. Vana vane matambudziko aya vanofanirwa kurapwa kwakazara, uko kunosanganisira kurapwa kwehunhu, kudzidziswa kwevabereki, uye zvirongwa zvehunyanzvi, pamwe nechero mushonga wekurapa.

Kufunga nezvekushandisa imwe yemishonga iyi inofanira kuitwa pamwe chete nachiremba wemwana wako. Kufunga kwakakosha kunosanganisira mutengo, uyo unogona kunge wakakura, pamwe mhedzisiro, uye kana iwo mushonga wakaratidzwa kuti unoshanda kune akakosha mamiriro kana zviratidzo zvemwana wako. Kana mwana wako aine co-iripo mamiriro-semuenzaniso, ADHD kana kushushikana-iwe unofanirwa kuve nechokwadi chekuti vanorapwa nenzira kwayo, nekuti izvi zvinogona kuvandudza zviratidzo zvemwana wako.

Chirevo ichi chakaburitswa munaKurume 2012.

Zviri Mukati

• Chikamu 1: Kugamuchirwa
• Chikamu 2: Anoshanda Sei Atypical Antipsychotic Anoshanda uye Ndiani Anovada?
• Chikamu chechitatu: Kuchengetedzwa kweAtypical Antipsychotic
• Chikamu 4: Kusarudza Atypical Antipsychotic yeVana
• Chikamu 5: Kutaura Nachiremba Wako
• Chikamu chechitanhatu: Kuongorora Kwatakaita Antipsychotic
• Chikamu 7: Kugovana Chirevo Ichi
• Chikamu 8: Nezvedu
• Chikamu 9: Mareferenzi

Verenga zvimwe

Mauya

Chirevo ichi chinotarisa pakushandiswa kwemishonga yekunyorera inonzi atypical antipsychotic nevana uye vachiri kuyaruka, vane makore gumi nemasere zvichidzika. Atypical antipsychotic anoshandiswa kurapa schizophrenia uye bipolar kusagadzikana. Iwo anoshandiswa zvakare kuyedza kudzikisira hutsinye, kusagadzikana, kusagadzikana munharaunda / hurema, uye zvimwe zviratidzo muvana nevechiri kuyaruka vane hutachiona hwakakura hwekukura, kusanganisira autism uye Asperger syndrome, uye kusagadzikana kwehunhu hunhu (asi zvinofanirwa kucherechedzwa kuti atypical antipsychotic haadaro. batsira iyo yakakosha kutaurirana matambudziko eatism uye mamwe matambudziko.

Kunyora vana uye vachiri kuyaruka antipsychotic mishonga inopokana nekuti pane humbowo hushoma nezve kuchengetedzeka kana kugona kushandiswa mumazera aya.Zvizhinji zvezvatinoziva zvinobva kuzvidzidzo zvevakuru. Se Tafura 1 inoratidza, mazhinji atypical antipsychotic haatenderwe neKudya neDrug Administration kuti ishandiswe nevana. Asi ivo vanogona kushandiswa zviri pamutemo "off-label," zvinoreva kuti mushonga unogona kupihwa mushonga wekurapa mamiriro ayo asina FDA tendero. (Zvimwe pamusoro peizvi pachikamu 2.)

Kunyangwe kushomeka kweuchapupu, iyi mishonga inowanzo gadzirirwa vana nevechidiki. Izvi zvakabatsira kugadzira atypical antipsychotic yechishanu yepamusoro yekutengesa kirasi yemishonga muUS mu2010, iine $ 16.1 bhiriyoni mukutengesa, sekureva kweIMS Health.

Clozapine (Clozaril), iyo yakatanga kuwanikwa muU.S. muna 1989, ndiyo yaive yekutanga antipychotic antivotic inogamuchirwa neFDA. Nhasi, inowanzo kupihwa chete kana mimwe mishonga ikakundikana nekuti inogona kukonzera kukomba kweropa kwakakomba mune vamwe vanhu. Yakateverwa nemamwe akati wandei antipsychotic, anosanganisira aripiprazole (Abilify), asenapine (Saphris), iloperidone (Fanapt), olanzapine (Zyprexa), paliperidone (Invega), quetiapine (Seroquel), risperidone (Risperdal), uye ziprasidone (Geodon) . (Ona Tafura 1.)

Atypical antipsychotic inogona kukonzeresa zvinokanganisa mhedzisiro, kusanganisira mhasuru kuomarara, kufamba kunononoka uye kudedera kusingaite (kunozivikanwa se extrapyramidal zviratidzo), kuwedzera kwakanyanya uremu, njodzi yakawedzera yerudzi rwechipiri chirwere cheshuga, uye yakakwira cholesterol mazinga. (Side effects dzakanyorwa mu Tafura 2.) Vanhu vazhinji vanotanga kutora imwe havazvitore kwenguva yakareba, kunyangwe zvikaderedza zviratidzo zvavo, nekuti havagone kana havadi kutsungirira mhedzisiro.

Kugadzirisa vana vane budiriro yekukura kana hunhu kunogona kunetsa kuvabereki navanachiremba. Nekuti zvishoma zvishoma zvinozivikanwa nezve kushandiswa kweatypical antipsychotic muvana, uye nekuda kwekunetseka kwakabatana nezvinetso izvi, Consumer Reports Best Buy Zvinodhaka haina kukurudzira nzira dzokurapa kana kusarudza Best Buy mune ino yakakosha mushumo. Pane kudaro, isu tinoongorora kutsvagisa kwekurapa kuti ikubatsire kunzwisisa zvakanakira uye njodzi dzeatypical antipsychotic kuitira kuti ugone kusarudza, nachiremba wemwana wako, kuti akakodzera here kumwana wako.

Chirevo ichi chikamu cheiyo Consumer Reports chirongwa chekukubatsira iwe kuwana yakachengeteka, inoshanda mishonga inokupa iwe kukosha kwazvo kune rako rezvehutano-dhora. Kuti udzidze zvakawanda nezve chirongwa uye mamwe madhiragi atakaongorora zvimwe zvirwere nemamiriro, enda kuCRBestBuyDrugs.org.

Tafura 1. Atypical Antipsychotic Mishonga Inotariswa muRondedzero iyi
Generic zita	Mazita ezita (s)	Generic Inowanikwa	FDA tendero yevana
Aripiprazole	Gonesa	Aihwa	Yakagamuchirwa kuti ishandiswe nevechiri kuyaruka vane schizophrenia, vachiri kuyaruka vane bipolar kusagadzikana kwakasanganiswa kana manic episodes, uye kusagadzikana kunosangana neautism.
Asenapine	Saphris	Aihwa	Aihwa
Clozapine	Clozaril Fazaclo	Ehe	Aihwa
Iloperidone	Fanapt	Aihwa	Aihwa
Olanzapine	Zyprexa Zyprexa Zydis	Aihwa*	Yakagamuchirwa kuti ishandiswe nevechiri kuyaruka vane schizophrenia, uye vachiri kuyaruka vane bipolar kusagadzikana kwakasanganiswa kana manic episodes.
Paliperidone	Invega	Aihwa	Aihwa
Quetiapine	Seroquel Seroquel XR	Aihwa*	Yakagamuchirwa kuti ishandiswe pakurapa kwevana vane manic episodes mubipolar kusagadzikana, uye vachiri kuyaruka vane schizophrenia.
Risperidone	Risperdal	Ehe	Yakagamuchirwa kuti ishandiswe nevechiri kuyaruka vane schizophrenia, vachiri kuyaruka vane bipolar kusagadzikana kwakasanganiswa kana manic episodes, uye nekutsamwa kwakabatana ne autism.
Ziprasidone	Geodon	Aihwa	Aihwa

Kudya neDrug Administration yakapa mvumo yekuedza yechigadzirwa asi hapana zviripo panguva ino.

Dzokera kumusoro Verenga zvakawanda Dzokera kuZvinyorwa

Anoshanda Sei Atypical Antipsychotic Anoshanda uye Ndiani Anovada?

Hazvizivikanwe chaizvo kuti antipsychotic inoshanda sei kubatsira kubvisa zviratidzo. Asi chatinoziva ndechekuti zvinokanganisa huwandu hwemakemikari muuropi anonzi maurotransmitter, ayo anotamba akakosha maitiro mukuzvibata uye kugona, pamwe nekurara, kushushikana, kutarisisa, ndangariro, uye kudzidza. Aya anogona kunge ari maratidziro avanoita psychotic zviratidzo, senge kufungidzira, kunyengera, kufunga zvisina kurongeka, uye kusagadzikana mune schizophrenia uye bipolar kusagadzikana. Izvo zvakare zvinogona kutsanangura maitiro avanogona kudzikisira hutsinye, kutsamwa, uye maitiro ekuzvikuvadza ane chekuita nekupararira kwekukura kwekusimudzira uye kusagadzikana kwehunhu hunhu. Asi kubva kune hushoma humbowo huripo, hazvisati zvanyatso kujeka kuti vanoita sei izvi, uye kuti vanoramba vachishanda pamusoro penguva refu.

Mamiriro Akaitwa neAtypical Antipsychotic

Mazhinji ezvidzidzo zveatypical antipsychotic akaisa pfungwa pakurapa schizophrenia uye bipolar kusagadzikana. Mimwe yemishonga ine FDA mvumo yekurapa iwo mamiriro muvana uye vachiri kuyaruka pamwe nevakuru. Asi ivo vanoshandiswa zvakare "off-label," zvinoreva kuti vanorairwa navanachiremba kuti varape mamiriro ayo anga asiri FDA-anotenderwa.

Kunze-chitambi kunyorera navanachiremba chiitiko chakajairika uye chepamutemo, kunyangwe zvisiri pamutemo kumakambani emishonga kusimudzira mishonga yavo kuti ishandiswe-kurebera. Kunze-chitambi kunoshandiswa kweatypical antipsychotic muvana kunosanganisira kurapwa kweanopararira ekukura kusagadzikana, senge autism uye Asperger syndrome, uye zvinokanganisa maitiro kusagadzikana. (Aripiprazole uye risperidone zvinogamuchirwa kune avo vane autism-spectrum kusagadzikana, asi imwe atypical antipsychotic haisi.)

Kune ese mana mamiriro-bipolar kusagadzikana, schizophrenia, kwakapararira kwekukura kusagadzikana, uye kukanganisa hunhu kusagadzikana-humbowo hunotsigira kushandiswa kweatypical antipsychotic nevechidiki inongogumira kune mashoma, mashoma epfupi-kwenguva zvidzidzo, pasina hunhu hwakanaka-hurefu kwenguva refu -term kushanda uye chengetedzo.

Pakazara, zvidzidzo zvekushandiswa kweatypical antipsychotic nevana zvakangobata dzinenge zviuru mazana maviri nemazana mana. Vanenge chiuru chevana vaive ne bipolar disorder, mazana matanhatu aive nekupararira kwekukura, 640 vaive nehunhu hwekuvhiringidza maitiro, uye vashoma pane mazana mana vaive neschizophrenia.

Bhokisi riri muchikamu chechipiri rinoratidza kuti ndeipi mishonga yakadzidzwa muvana, uye nemamiriro api ezvinhu. Aripiprazole chete (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel), uye risperidone (Risperdal) yakadzidzwa muvana vane bipolar disorder. Mune vechidiki vane new-kutanga schizophrenia, chete olanzapine (Zyprexa), quetiapine (Seroquel), uye risperidone (Risperdal) vakadzidza. Aripiprazole (Abilify), olanzapine (Zyprexa), uye risperidone (Risperdal) yakadzidzwa muvana vane hutachiona hwakakura hwekukura, nepo risperidone (Risperdal) chete yakadzidzwa muvana vane hunhu hunokanganisa hunhu.

Kune yega yeaya mamiriro ezvinhu muvana, humbowo chaihwo kuenzanisa imwe atypical antipsychotic kune imwe inogona kushomeka kana kusavapo. Humbowo hwebatsiro nekukuvara hunotaurwa pazasi nemamiriro emushonga wega wega.

Schizophrenia

Hazvizivikanwe kuti vana vangani vanotambura neschizophrenia nekuti chirwere ichi hachiwanzo kuongororwa kusvika vanhu vakuru, sekureva kweNational Institute of Mental Health. Schizophrenia yakaonekwa muvana vadiki sevashanu asi izvi hazviwanzo. Varume vanowanzoona zviratidzo zvekutanga mumakore avo ekupedzisira uye kutanga kusvika pakati pe20s; vakadzi vanowanzoonekwa vari mumakore avo makumi maviri kusvika pakati pemakumi matatu.

Vanhu vane schizophrenia vanotambura nekusawirirana uye kufunga zvisina musoro, asi zvinopesana nekutenda kwakakurumbira, havana hunhu hwakawanda. Vanogona kubviswa, kutya, uye kugumbuka, uye kusangana nekufungidzira uye kunyengera. Uye vanogona kuve nekutambudzika kukuru kwekubatana nevamwe pamoyo.

Vanhu vazhinji vane schizophrenia vanorarama hupenyu hune chinangwa uye vanoshanda nemabatiro akanaka. Zvizhinji zvidzidzo zveatypical antipsychotic zvinodhaka zvakanangana nevakuru vane schizophrenia. Vakawanikwa vachibatsira kudzikisa zviratidzo, kugadzirisa hupenyu, uye kudzikisira mukana wekuti munhu azvikuvadze iye kana vamwe. Asi zvidzidzo zvekushandiswa kweantipsychotic nevechiri kuyaruka vane schizophrenia yakaonekwa ichangobva kuwanikwa ishoma.

Atypical Antipsychotic Inodzidziswa muVana neVechidiki, neDambudziko
Zita Rokuzvarwa	Zita Rekushandisa	Kushungurudzika
		Vana vane bipolar kusagadzikana	Vechidiki vane nyowani-kutanga schizophrenia	Vana vane kusagadzikana kwehunhu maitiro	Vana vane hutachiona hwakakura hwakawanda
Aripiprazole	Gonesa	& tarisa;			& tarisa;
Olanzapine	Zyprexa	& tarisa;	& tarisa;		& tarisa;
Quetiapine	Seroquel	& tarisa;	& tarisa;
Risperidone	Risperdal	& tarisa;	& tarisa;	& tarisa;	& tarisa;

& tarisa; inoratidza kuti mushonga wakadzidzwa sekurapa kwechirwere ichocho muvana uye / kana vechidiki. Asenapine (Saphris), Clozpine (Clozaril), iloperidone (Fanapt), paliperidone, uye ziprasidone (Geodon) hazvina kunyorwa nekuti hazvina kudzidza muvana.

Zvidzidzo zvevakuru zvinoratidza kuti inenge hafu yeavo vane schizophrenia vanowana kudzikiswa kunezviratidzo muzviratidzo zvavo mushure mekutora mushonga unorapa. Zvimwe zviratidzo, senge kushushikana, zvinogona kuve nani mumazuva mashoma chete. Zvimwe, sekunyepedzera uye kufungidzira, zvinogona kutora vhiki ina kusvika matanhatu kuti zvidzikame. Nekuda kweizvozvo, angangoita munhu wese anoonekwa aine schizophrenia anowana antipsychotic drug.

Asi atypical antipsychotic haishande kune wese munhu. Vanosvika makumi maviri muzana yevanhu vane schizophrenia havawani rubatsiro kubva kwavari, uye vamwe makumi maviri neshanu muzana vanowana kudzikiswa kwezviratidzo.

Zvidzidzo zviviri zvidiki zvakaenzanirana nemhedzisiro yeatypical antipsychotic anoshandiswa nevechidiki vane schizophrenia havana kuwana mutsauko wakakura pakati pemishonga yakaedzwa. Olanzapine (Zyprexa) uye quetiapine (Seroquel) yakave nemhedzisiro yakafanana nezviratidzo mushure memwedzi mitanhatu muchidzidzo chidiki kwazvo chevechiri kuyaruka vaive newongororo itsva ye schizophrenia. Risperidone (Risperdal) uye olanzapine (Zyprexa) zvakatungamira mukuvandudzwa kwakafanana kwezviratidzo kwemavhiki masere.

Bipolar Dambudziko

Vazhinji vanhu vane bipolar kusagadzikana vanowanzo kupihwa kuongororwa mune avo vanonoka makore ekuyaruka kana ekutanga makumi maviri. National Institute of Mental Health inofungidzira kuti chirwere ichi chinokanganisa isingasvike zvikamu zvitatu kubva muzana zvevechiri kuyaruka, asi hutachiwana chaihwo hauziikanwe nekuti chirwere ichi chinonetsa kuongororwa muvana. Izvi zvinodaro nekuti zviratidzo zvacho hazvinyatso kujeka muvana pane vanhu vakuru, uye zvinogona kusangana pamwe nemamwe mamiriro ehucheche, senge ADHD kana kusagadzikana kwehunhu.

Zviratidzo zvinozivikanwa zve bipolar kusagadzikana kupinza kwakapinza pakati peakanyanya kushushikana-kana mania-uye akanyanya kudzikama-kana kushushikana. Muzviitiko zvakawanda, kunyanyisa kwemafungiro kunopera kwemavhiki akati wandei. Iko kunowanzo kuve kuri-pakati penguva ine "yakajairwa" mamiriro. Asi vamwe vanhu vane bipolar kusagadzikana vanogona kuve nenguva apo zviratidzo zvemania uye kushushikana zviripo panguva imwe chete. Izvi zvinodaidzwa "zvakasanganiswa" zvikamu.

Atypical antipsychotic kazhinji haishandiswe kurapa bipolar kusagadzikana kudzamara vanhu vatanga kuyedza mimwe mishonga, inosanganisira lithium, divalproex, uye carbamazepine.

Zvidzidzo zvevakuru zvakaona kuti ese antipsychotic anogona kubatsira kudzora mania zviratidzo zvebipolar kusagadzikana, iine makumi mana kusvika makumi manomwe neshanu muzana yevanhu vanoona kuderera kwezviratidzo. Asi pakave nezvidzidzo zvishoma pamhedzisiro yemishonga kune vanhu vakuru vane bipolar kusagadzikana pane neschizophrenia, uye kunyangwe vashoma pakati pevana vane bipolar kusagadzikana.

Hezvino izvo zvinozivikanwa kusvika zvino:

Aripiprazole (Bvisa)

Mune kumwe kuongorora, kupindura-kwenguva pfupi-zvinoreva kuti 50 muzana kana kudzikiswa kukuru kwezviratidzo-kwakaonekwa mu45 kusvika 64 muzana yevana nevechidiki vachiri kutora aripiprazole mushure memavhiki mana ekurapwa zvichienzaniswa ne26 muzana vakatora placebo. Kuregererwa-kuda kugadzirisa kwakazara kwezviratidzo- kwakawanikwa mu25 kusvika 72 muzana yevana vanotora aripiprazole zvichienzaniswa ne5 kusvika ku32 muzana pane placebo. Asi pakupera kwechidzidzo, vana vanotora aripiprazole vakapa hupenyu hwavo pasi pane avo vakarapwa ne placebo.

Quetiapine (Seroquel)

Mune kumwe kuongorora, 58 kusvika ku64 muzana yevana uye vachiri kuyaruka vane zviratidzo zvemania zvakaratidza mhinduro mushure memavhiki matatu ekurapwa nequetiapine zvichienzaniswa ne37 muzana vakatora placebo. Kuregererwa kwakaonekwa mune inopfuura hafu iyo yakatora quetiapine kana ichienzaniswa ne30 muzana pane placebo.

Kana quetiapine yaishandiswa nemumwe mushonga, di-valproex, nevachiri kuyaruka vane mania episodes, 87 muzana yakaratidza mhinduro mushure memavhiki matanhatu ichienzaniswa ne53 muzana vakatora divalproex chete. Mune kumwe kuongorora kwakafananidza quetiapine ne divalproex mune vechidiki vane bipolar kusagadzikana, ese madhiragi akakonzera kuvandudza hupenyu hwehupenyu pakupera kwemavhiki mana. Kunatsiridzwa kwakaonekwa mukukwanisa kwavo kuyanana nevamwe uye kutonga maitiro avo, zvichikonzera kusagadzikana kwakawanda muhupenyu hwemhuri. Uye ivo vabereki veavo vari paquetiapine vakati vana vavo vaishanda zvirinani muchikoro, zvese munharaunda nemudzidzo, uye zvakare vainzwa zvirinani pamusoro pavo.

Quetiapine haina nani pane placebo kana zvasvika pakusuwa kwenguva dzebipolar kusagadzikana. Mune ongororo yevechidiki makumi matatu nevaviri vane chinoshungurudza episode inosanganisirwa ne bipolar kusagadzikana, quetiapine haina kutungamira mukuvandudzwa kwezviratidzo kana huwandu hwakagadziriswa hwekuregererwa zvichitevera mavhiki masere ekurapwa kana ichienzaniswa ne placebo.

Olanzapine uye Risperidone

Imwe yedzidzo diki yakafananidza risperidone (Risperdal) uye olanzapine (Zyprexa) mune vana makumi matatu nevatatu vechikoro vane bipolar disorder avo vairatidza mania zviratidzo. Mishonga iyi yakaratidza kushanda kwakadaro mukubvisa zviratidzo zvichitevera vhiki sere dzekurapwa. Chidzidzo chikuru chinodiwa kuratidza izvo zvakawanikwa.

Zvidzidzo zvevechiri kuyaruka vane mania zviratidzo zvakawana kuti 59 kusvika 63 muzana vakatora risperidone (Risperdal) kwemavhiki matatu vakasangana nemhinduro kana ichienzaniswa ne26 muzana vakatora placebo. Mune ongororo yakafanana neolanzapine (Zyprexa), makumi mana nemapfumbamwe evachiri kuyaruka vanotora mushonga vakaratidza mhinduro kana zvichienzaniswa ne22 muzana vakatora placebo. Zvidzidzo zviviri izvi zvakare zvakaona kuti risperidone uye olanzapine zvakakonzera kuti vamwe varwere vawane kuregererwa zvichienzaniswa ne placebo.

Kupararira Kwekusimudzira Matambudziko

Matambudziko akakura anowedzera anosanganisira autism spectrum disorders (autism neAsperger syndrome) pamwe neRett syndrome, dambudziko rekuparara kwehucheche, pamwe nehurwere hwakawanda hwekukura (hunowanzozonzi "kupararira kwekukura kwekupararira, zvisina kutaurwa neimwe nzira").

Paavhareji, mumwe muvana zana negumi muUS ane imwe nzira ye autistic kusagadzikana, sekureva kweCenters for Disease Control and Prevention. Autism, iyo inowanzoonekwa muvakomana kupfuura vasikana, inowanzo kuve pachena isati yasvika makore 3. Chikonzero hachizivikanwe. Vanhu vane autism vane dambudziko nehukama nehunyanzvi hwekutaurirana, uye kudzokedzana kwepamoyo, uye vanowanzo ratidza hunhu uye hunodzokororwa maitiro, zviitiko, uye zvido.

Iko hakuna mushonga, asi kune mishonga inogona kubatsira. Zvirongwa zvakarongeka zvedzidzo kana zvezuva nezuva zvekurarama zvinotarisana nehunyanzvi hwekuvandudza uye nzira dzekutaurirana dzinowanzo shandiswa, pamwe nehunhu-manejimendi manejimendi uye kugona kwehunhu maitiro. Antipsychotic inorayirwa, kana zvichidikanwa, nechinangwa chekudzora hunhu hunokanganisa, kusanganisira kusagadzikana, kusagadzikana, hasha, uye maitiro ekuzvikuvadza. Mimwe mishonga inogona kushandiswa kurapa mamwe matambudziko, senge kushushikana kana kushushikana.

Zvishoma zvidzidzo zvakatarisa kushandiswa kweantipsychotic nevana vane matambudziko aya. Chidzidzo chikurusa, chaisanganisira vana zana negumi nevana vane hutachiona hwakakura hwakawanda, vakawana kuti 69 muzana yeavo vakatora risperidone (Risperdal) yakanzi "yakavandudzwa" mushure memavhiki masere ekurapwa zvichienzaniswa ne12 muzana vakatora nzvimbo. Risperidone (Risperdal) ndiyo yega antipychotic antipsychotic iyo yakadzidzwa muvacheche vezera revana vane hutachiona hwehutachiona hwakapararira, asi haina kuwanikwa iri nani pane placebo.

Hazvisi pachena kana mabhenefiti e risperidone akapedzisira pamusoro penguva refu. Hushoma humbowo hunoratidza kuti mushure memwedzi mina yekurapwa, gumi muzana yevana vanoratidza kuvandudzika vanorega kutora mushonga uyu nekuti nekuti hauchashandi kana ivo vanowana mhedzisiro. Izvi zvakakonzera kudzokedzana-kudzoka kwezviratidzo kune yavo yekutanga nhanho-mu63 muzana, nepo chete 13 muzana yeavo vakaramba vachinwa mushonga mimwe mwedzi miviri vadzokazve.

Muzvidzidzo zviviri zvinosanganisira vana mazana matatu nemakumi matanhatu nevatanhatu, avo vakatora aripiprazole (Abilify) vaive nemikana yekuzvikuvadza kana kuratidza hukasha kune vamwe vachienzaniswa nevaya vakagamuchira placebo. Vakanga vasinganyanyi kutsamwa, vaine hasha shoma, vaitambura nekuchinja kushoma kwepfungwa kana kushushikana kwemoyo, uye vaive vasingatani kupopota kana kuridza mhere zvisina kukodzera.

Humboo hushoma kwazvo hunowanikwa pakushandiswa kweolanzapine (Zyprexa) nevana vane hutachiona hwakawanda hwekukura. Zvidzidzo zviviri chete zvinosanganisira vashoma pane vana makumi maviri nemashanu zviripo. Mhedzisiro yacho inoratidza kuti olanzapine iri pamusoro pane placebo uye yakafanana neyekare antipsychotic haloperidol (Haldol). Asi nekuda kwenhamba diki kwazvo yevana vakadzidza, zvidzidzo zvakakura zvinodiwa kuti uone kana izvo zviwanikwa zvinogona kushandiswa zvakanyanya kune vana vane hutachiona hwakakura hwebudiriro.

Zvinokanganisa Maitiro Ekuzvibata

Zvinokanganisa hunhu hunhu zvinosanganisira zvinopesana zvinopesana nekusagadzikana, kusagadzikana kwemaitiro, uye kukanganisa kunokanganisa maitiro (ayo mumabhuku ezvokurapa anowanzo kunzi "kukanganisa maitiro ehunhu, zvisina kutaurwa neimwe nzira"). Kupesana kunoshora kusagadzikana kunoitika mune ingangoita 1 kusvika ku6 muzana yevechidiki, uye kuita kusagadzikana kunowanikwa mune ingangoita 1 kusvika ku4 muzana.

Zviratidzo zvinoonekwa muvana vanowanikwa vaine kupikisa kushora kusagadzikana zvinosanganisira kuvengana, negativism, uye kushora kuzviremera. Inoonekwa isati yasvika makore masere, uye yakajairika muvakomana. Mune zvimwe zviitiko, kuoma kwezviratidzo kunogona kuwedzera nezera uye kuve nehunhu hwekuita kusagadzikana. Vana vakaonekwa kuti vane kusagadzikana kwehunhu hunhu kazhinji vanoratidza kushomeka kwekutarisira / kusagadzikana kwehutano (ADHD).

Vana vane hunhu hwekuzvibata vanoratidzira maitiro ehutsinye kuvanhu nemhuka, kuparadza uye / kana kuba kwepfuma, uye nekumwe kutyora kwemitemo kwakakomba, kazhinji vasina pfungwa yekuzvidemba. Kuzvibata kusagadzikana kunowanzoonekwa kusati kwasvika makore gumi nematanhatu, uye kunowanzoitika muvakomana. Ose anopikisa kushora kusagadzikana uye kusagadzikana kwehunhu zvinosanganiswa nematambudziko akakosha anoshanda pamba, kuchikoro, uye, gare gare, kubasa. Vana vane kupokana kunoshora kusagadzikana kazhinji vanowana matambudziko ekuranga muchikoro, uye kazhinji vane matambudziko epamutemo sevanhu vakuru.

Vana vane zvakafanana, asi zvisina kusimba zvakanyanya, maitiro ehunhu, achienzaniswa neavo vanoshora kushora kana kusagadzikana kwehunhu, vanogona kuongororwa vaine hunhu hunokanganisa maitiro kusagadzikana kana kusagadzikana kwehunhu kusagadzikana, zvisina kutaurwa neimwe nzira. Vana vane mamiriro aya vanoratidzira zvakanyanya im-paired yekudyidzana uye hukama hwemhuri, uye / kana kukanganiswa kushanda kwechikoro.

Iyo yekurapa kwekutanga kwekukanganisa hunhu hunhu ndeyemhuri-based uye inosanganisira vabereki manejimendi kudzidziswa. Kurapa kwemishonga kunoonekwa sekuwedzera uye kunoitirwa zviratidzo. Mukufunga kwekutanga mushonga, zvinowanzo kukosha kufunga nezve mamwe mamiriro angave nemwana. Semuenzaniso, mishonga yeADHD inogona kubatsira kana mwana aine zvese zvinokanganisa maitiro kusagadzikana uye ADHD. Muvana vane kusagadzikana kwemafambiro, zvinodzikamisa mafungiro, senge lithiamu uye valproate, zvinogona kubatsira. Antipsychotic inorayirwa kune vana vane hunhu hunovhiringidza kudzikisira hutsinye hune hukama nemamiriro aya, asi maviri chete maantipsychotic-risperidone uye quetiapine akafundirwa kushandiswa uku. Hapana mishonga inorwisa mabhakitiriya inogamuchirwa neDFA yekurapwa kwekukanganisa maitiro ehunhu.

Mune ongororo yevana vane zviratidzo zvakakomba zvekusagadzikana kwehunhu, avo vakagamuchira risperidone vakaratidza zvakapetwa kaviri chiyero chekuvandudzwa kwehunhu hunhu kweanopfuura mavhiki matanhatu kusvika gumi ekurapwa zvichienzaniswa neavo vakatora placebo. Vanenge makumi maviri nenomwe muzana evana vakaramba vachinwa risperidone kwemwedzi mitanhatu vakadzoka zvakare kana zvichienzaniswa ne42 muzana yevana vasina kupihwa mishonga, asi mwero wekuvandudza wakadzikira mumapoka ese ari maviri.

Mune ongororo yevechiri kuyaruka vane hunhu hunovhiringidza hunhu hunoda kuiswa muchipatara, risperidone yakavandudza kuongororwa kwavo kwese, ne21 muzana yakaongororwa se "zvakanyanya kuvhiringidzwa zvakanyanya" zvichienzaniswa ne84 muzana vachitora placebo.

Quetiapine (Seroquel) haina kuwanikwa ichishanda mukuvandudza hunhu hunosanganisirwa nehunhu hwekuzvibata. Muchidzidzo chega chiripo, quetiapine yanga isiri nani pane placebo pakudzora hukasha uye kusagadzikana muvachiri kuyaruka vane hunhu hwekuita uye hunhu-hune-hutsinye hunhu. Mumwe wevapfumbamwe vevana (11 muzana) akamira kutora mushonga nekuda kweakathisia, mhedzisiro iyo inoita kuti vanhu vanzwe sekunge vasingakwanise kugara vakadzikama. Quetiapine yaive yepamusoro pane placebo pamatanho epasirese ekuvandudza zviratidzo uye hupenyu hwehupenyu.

Dzokera kumusoro Verenga zvakawanda Dzokera kuZvinyorwa

Kuchengetedzwa kweAtypical Antipsychotic

Atypical antipsychotic inogona kukonzeresa mhedzisiro mhedzisiro, iyo inogumira kwavo kwese kubatsira. (Ona Tafura 2, pazasi.) Vanhu vazhinji vanotanga kutora imwe havaitore kwenguva yakareba, kunyangwe ikadzora zviratidzo zvavo, nekuti havagone kana havadi kutsungirira mhedzisiro. Uye zvakare, vanhu vane schizophrenia uye bipolar kusagadzikana vanowanzo simisa mishonga yavo nekuda kwechimiro chechirwere chavo. Vanogona kusanzwisisa kuti vane chirwere chepfungwa, vanokundikana kugamuchira kuti vanobatsirwa nemushonga, vanokanganwa kuinwa, kana kurega kuinwa kana zviratidzo zvakakomba zvadzikira.

Imwe yakakomba mhedzisiro mhedzisiro yeatypical antipsychotic ndeyekufamba-yakabatana (extrapyramidal)-isingadzorwike tics uye kudedera kwakafanana nechirwere chaPasinson. Extrapyramidal mhedzisiro mhedzisiro inowanzoenda kana mushonga uchigumiswa kana iyo dosi yadzikiswa. Asi imwe hosha yekufamba inonzi tardive dyskinesia inogona kukura nekushandisa kwenguva yakareba uye inogona kupfuurira kunyangwe mushure mekunge murwere amira kutora antipsychotic.

Atypical antipsychotic zvinodhaka zvinokonzeresa zvimwe zvakakomba mhedzisiro, kusanganisira kuwedzera njodzi yerudzi rwechipiri chirwere cheshuga, kuwedzera huremu, uye kukwidziridzwa kwecholesterol uye triglyceride mazinga. Uye zvakare, ivo vakawanikwa vachiwedzera njodzi yekufa nguva isati yakwana, kunyanya nekuda kwesitiroko, kune vakuru vakuru vane dementia. Njodzi idzi dzakadzidzwa zvakanyanya muvakuru; zvinoitika muvana hazvizivikanwe zvizere panguva ino.

Tafura 2. Side Side Migumisiro Yakabatana neAtypical Antipsychotic
Minor kusvika Kumwero Zvakanyanya Zvakanyanya Side Mhedzisiro - Izvi zvinogona kudzikamisa kana kunyangarika nekufamba kwenguva, kana kudzikiswa kana muyero wakadzikiswa. Vanoenda kana mushonga wacho wamiswa. Rondedzero iripazasi ndeyorufabheti uye kwete mukukosha kwekukosha, kuomarara, kana kuwanda. Vanhu vazhinji vane zvinopfuura chimwe chezviitiko izvi. Asi ruzivo pamwe, uye kuomarara, kwemhedzisiro mhedzisiro inosiyana zvakanyanya nemunhu.
Mamiriro asina kujairika uye kufamba kwemuviri, mhasuru, kudedera uye kupora	Kusarara
Kuenda kumwedzi zvisina kujairika	Miromo inorova uye isina kujairika rurimi kufamba
Kuona kwakashata	Kuomesa kwemhasuru kana kushaya simba
Kuzvimbirwa	Kukurumidza kurova kwemoyo
Dzungu pakumira kana kufamba nekukurumidza	Kusadzikama
Muromo wakaoma	Kugara, kukotsira
Kunyanyisa mate	Kusagadzikana pabonde
Kunzwa nzara kupfuura zvakajairwa	Kuputika kweganda
Zvichida Zvakakomba Matambudziko Izvi zvinogona kuda kurega mushonga kana kuchinjira kune imwe. Ivo anowanzo kudzoserwa, asi anogona, mune dzimwe nguva, kuve anogara zvachose, uye, mune agranulocytosis, kunyange kutyisidzira hupenyu.
Agranulocytosis † - Kukundikana kwemongo wemapfupa kuburitsa chirwere-kurwisa chena masero eropa, izvo zvinogona kutungamira kuzvirwere zvakakomba kana zvinouraya. Iyi njodzi inosanganisirwa zvakanyanya ne clozapine, uye kugara uchiongororwa ropa kunodiwa kana uchiitora.
Shanduko mune metabolism izvo zvinokonzeresa kusagadzikana kweropa uye mamwe matambudziko, izvo zvinogona kukonzeresa kurudzi rwechipiri chirwere cheshuga uye nenjodzi yakakwira yechirwere chemwoyo uye sitiroko kuvanhu vakuru.
Myocarditis † - Kuzvimba kwetsandanyama yemoyo inogona kuuraya. Iyi njodzi inosanganisirwa zvakanyanya ne clozapine.
Kufenda † - Iyi njodzi inosanganisirwa zvakanyanya ne clozapine.
Kukosha kwekurema - 7 muzana kana kuwedzera kukuru kwekufanotangisa kurema kwemuviri (huwandu hwese zvinoenderana nehuremu hwemwana hwekutanga). Clozapine uye olanzapine zvese zvinokonzeresa kuwedzera uremu kupfuura mamwe maantipsychotic.
Tardive dyskinesia - Kufambisa kwemuviri kusingadzoreke kunogona kusanganisira kudedera uye kupora.

† Yakabatana zvakanyanya ne clozapine; kuongororwa ropa nguva dzose kunodiwa kana uchitora.

Pakazara, makumi masere kusvika makumi mapfumbamwe muzana evakuru vanotora mushonga wekupedza pfungwa chero upi zvawo unenge uine rimwe divi mhedzisiro; mazhinji achave neanopfuura rimwe. Kune avo vane mhedzisiro:

• 20 kusvika ku30 muzana ichave neakakomba kana asingashivirike mhedzisiro uye vorega kutora mushonga mukati memazuva, vhiki, kana mwedzi mishoma.
• 35 kusvika ku45 muzana vachamira kutora mushonga mukati memwedzi mitanhatu.
• 65 kusvika 80 muzana vanomira kutora mushonga mukati memwedzi gumi nemiviri kusvika gumi neshanu.

Kuchengetedzeka kunetsekana neatypical antipsychotic muvana nevechiri kuyaruka

Nekuda kwezvishoma zvidzidzo zvevana nevechiri kuyaruka, zvinokanganisa maatypical antipsychotic hazvizivikanwe zvizere. Iyo yeparutivi-mhedzisiro profile inosiyana nemushonga, saka kana uchifunga imwe yemwana wako, njodzi dzeimwe neimwe mishonga dzinofanirwa kutariswa zvichipesana nezvinogona kubatsira. Izvi zvinotevera zvikamu zveongororo yemhedzisiro inowanikwa mune zvidzidzo zvinosanganisira vana nevachiri kuyaruka.

Kurema Kuwana

Kurema huremu ingangove yakajairika mhedzisiro mhedzisiro inosanganisirwa neatypical antipsychotic inotorwa nevana nevachiri kuyaruka. Risperidone (Risperdal) inopihwa pamadosi mashoma, semuenzaniso, inotungamira kune huremu hwekuwedzera huremu hunosvika mapaundi mana muvana vane hutambudzo hwakakura hwekusimudzira kana kusagadzikana kwehunhu hunhu uchienzaniswa neavo vanopihwa placebo. Izvo hazvisati zvajeka kana huremu uhwu hunodzikama kana kuramba huchiwedzera pamusoro penguva refu. Uchapupu hwazvino hunoratidza kuenderera kwekuwedzera uremu, pamwe nekufungidzira kwemana kusvika pamapaundi gumi nemaviri mugore rimwe chete uye kusvika pamapaundi gumi nemasere mushure memakore maviri.

Kurera huremu zvakare kwakanyanya kunetsa mhedzisiro nearipiprazole (Abilify). Mune kumwe kuongorora, zvikamu gumi neshanu kubva muzana zvevana vanozvitora vakawana huremu hunorema (ingangoita 7 muzana pamusoro pekutanga uremu) kweanopfuura vhiki sere. Mune kumwe kuongorora, 32 muzana yevana vakasangana nehuremu hunorema vachiri paaripiprazole. Muzvidzidzo zvese izvi, vana vanotora placebo vakasangana nehuremu hwekureruka. Kunyangwe huremu hwekuwedzera hunosanganisirwa ne aripiprazole hunoenderera pamusoro penguva refu haina kujeka nekuti hapana ongororo dzenguva refu dzekuwedzera uremu nekuenderera mberi kwekurapwa kunowanikwa.

Olanzapine (Zyprexa) inosanganisirwa nehuremu hwekuwedzera, nevana vachiwana mapaundi 7.5 kusvika mapfumbamwe pamasvondo matanhatu kusvika gumi ekurapwa. Imwe ongororo yakaona kuti zvikamu zviviri kubva muzvitatu zvevana zvakawana kanokwana kuita 7 muzana kubva pahuremu hwavo. Sezvazviri mune aripiprazole (Abilify), zvidzidzo zvehuremu muvana vanoramba vachitora olanzapine kwenguva yakareba hazviwanikwi.

Tafura 3. Kurema Kuwana neAtypical Antipsychotic muVana neVechidiki
Zvinodhaka	Kurema huremu mumapaundi kweanopfuura mavhiki matanhatu kusvika masere
	Yakapararira Yekuvandudza Dambudziko kana Inokanganisa Maitiro Dambudziko	Bipolar Dambudziko	Schizophrenia
Aripiprazole (Bvisa)	3-4	<1	–
Olanzapine (Zyprexa)	7.5 kusvika 9	7.4	–
Quetiapine (Seroquel)	–	3	4-5
Risperidone (Risperdal)	4	2	2

Quetiapine zvakare inokonzera kuwedzera uremu. Semuenzaniso, mune ongororo mune vana vane chirwere chakashungurudzika che bipolar disorder, avo vakagamuchira quetiapine vakawana anenge mapaundi matatu kupfuura avo vakagamuchira placebo.

Matambudziko Emwoyo uye Chirwere cheshuga

Mamwe atypical antipsychotic zvinodhaka zvinogona kuwedzera cholesterol yakazara (LDL uye triglycerides). Uye zvakare, iwo madhiragi-pamwe neanogona kunze kwearipiprazole (Abilify) -anogona kuwedzera shuga yeropa, kana zvimwe zviratidzo zvechirwere cheshuga, mune vamwe vana, kana kuwedzera kuwanda kweshuga muropa kune avo vane chirwere cheshuga chisati chavapo.

Izvo hazvigoneke kutaura kuti yakawanda sei njodzi yakawedzerwa iyo mishonga inowedzera, kana kana mumwe mushonga wakanyanyisa kupfuura mumwe wevana. Kubva pane zvidzidzo zvakaburitswa, olanzapine (Zyprexa) inogona kukonzera kuwedzera kukuru kwecholesterol muvana pane vakuru.

Nepo moyo-mutinhimira maitiro (EKGs) zvaive zvakajairika, kumwe kuongorora kwakaratidza kuwedzera kwechinguva mukurova kwemoyo ne risperidone mukati memavhiki maviri ekutanga ekurapwa. Mitengo yevatori vechikamu yakadzokera pane zvakajairwa mushure memavhiki maviri ekurapwa.

Maitiro ekuzviuraya

Mune zvidzidzo zvevana vanotora antypychotic antipychotic, paive nevashoma vairatidza maitiro ekuzviuraya, asi hazvigoneke kutaura kana izvi zvichimiririra kuwedzera kana kuderera kwenjodzi yekuzviuraya, kana kusava nebasa zvachose.

Psychoactive mishonga, senge mamwe maanodzvinyirira, akawanikwa achiwedzera njodzi iyi mukuyaruka. Nekuti aripiprazole (Abilify) uye quetiapine (Seroquel) vanogovana zvimwechete zveeurotransmitter chiitiko muuropi seaya anodzvinyirira, mishonga iyi inoyambira zvakanyanya kuti vanogona kuwedzera njodzi yekuzviuraya kufunga nehunhu, kunyangwe hazvo humbowo husiri pachena.

Muvanhu vakuru vane schizophrenia, clozapine (Clozaril, Fazaclo ODT) ndiyo yega mishonga inorwisa antipychotic yakawanikwa ichideredza njodzi yekuzviuraya kana kuzviuraya. Izvi hazvina kuongororwa muvana.

Mamwe Mativi Ekupedzisira

Zvidzidzo zve risperidone (Risperdal) zvakawana yakaderera mitengo yemimwe mhedzisiro, asi izvi zvinogona kunge zvichikonzerwa nemadosi akaderera anoshandiswa, uye ipfupi inotevera. Nhengo dzisina kujairika uye kufamba kwemuviri (extrapyramidal zviratidzo), zvaiwanzoitika mumiedzo yenguva pfupi, asi zvakataurwa kakawanda kupfuura nevarwere vanotora placebo.

Risperidone inozivikanwa kukonzeresa kuwanda kwehomoni prolactin, iyo inobatsira mukugadzirwa kwemukaka wemukaka mushure mekuzvitakura. Mune vasiri vakadzi vane pamuviri nevarume, kuwanda kweprolactin kunogona kukonzera kuwedzera mazamu uye matambudziko nebasa repabonde. Zvidzidzo zvevana zvakawana kuti risperidone yakakwidziridza prolactin mazinga, asi hapana chakaratidza zviratidzo kana zviratidzo senge kuwedzera kwechifuva. Hazvina kujeka kana, nekufamba kwenguva, prolactin mazinga anogara akakwidziridzwa kana kudzokera kune zvakajairwa.

Mimwe mhedzisiro inoonekwa kazhinji ne aripiprazole (Abilify) pane placebo inosanganisira kurara, kudonhedza, kudedera, kusvotwa, kana kurutsa. Kufambisa kusingaenzanisike kwemaoko, makumbo, kana muviri kwakaonekwawo kazhinji muvana vanotora aripiprazole. Kuenderera mberi nekudzidza kunodiwa kuti uone kana iyi mhedzisiro inogadzirisa, ramba uchigara, kana kuwedzeredza nekufamba kwenguva nekuenderera mberi kurapwa.

Mune ongororo yekushandiswa kwequetiapine (Seroquel) pakurapa kwevechiri kuyaruka vane kusagadzikana kwekuzvibata, gumi muzana revaya vari kutora mushonga vakamira nekuda kweakisia, mamiriro apo munhu anonzwa kusagadzikana, sekunge vasingagone kugara. Zvikasadaro, mushonga uyu wainyatsoshivirirwa.

Mimwe mhedzisiro mhedzisiro inotaurwa nevana vanotora olanzapine yaisanganisira sedation uye kuwedzera chishuwo chekuda.

Pakazara, mhedzisiro yakataurwa kakawanda ne olanzapine (Zyprexa) pane iine quetiapine (Seroquel) kana risperidone (Risperdal). Rigidity yaiwanzo kuwanikwa kune varwere vaibatwa neolanzapine zvichienzaniswa nequetiapine, uye kuneta kwaiwanzoitika neolanzapine zvichienzaniswa ne risperidone. Asi vamwe varwere vanotora risperidone vakarondedzera mafambiro ane chekuita nechero achienzaniswa neavo vanotora olanzapine.

Dzokera kumusoro Verenga zvakawanda Dzokera kuZvinyorwa

Kusarudza Atypical Antipsychotic yeVana

Nekuda kweiyo diki diki yeuchapupu nezvekushandiswa kweatypical antipsychotic nevana uye vachiri kuyaruka, zvinonetsa kuona kwavo kwenguva pfupi kushanda uye kuchengetedzeka. Uye hapana chinozivikanwa nezve kwavo kwenguva refu chengetedzo uye nekubudirira nekuti izvo zvidzidzo zvinosanganisira vechidiki zvave zvidiki uye zvipfupi mukureba.

Saka isu hatigone kusarudza Best Buy atypical antipsychotic yekushandisa nevana uye vachiri kuyaruka vane schizophrenia, bipolar kusagadzikana, kwakapararira kusagadzikana kwekukura, kana kukanganisa kunokanganisa maitiro. Pane kudaro, vanachipangamazano vedu vezvekurapa vanokurudzira kuti vabereki vanyatsoyera njodzi pamwe nezvakanakira. Chirongwa chakazara chekurapa chevana vane kusagadzikana uku chinofanira kusanganisira kuziva kwehunhu hwekurapa, kudzidziswa kwevabereki-manejimendi uye zvirongwa zvehunyanzvi zvekudzidzisa, pamwe nechero mukana wekurapa zvinodhaka.

Kufunga nezvekushandisa imwe yemishonga iyi zvachose, uye kana zvirizvo, ndeipi, inofanira kuitwa pamwe chete nachiremba wemwana wako uye inofanirwa kunge yakavakirwa pane zvakati wandei kufunga. Semuenzaniso, ndezvipi zvinonyanya kukosha, zvinoshungurudza, kana zvinokanganisa zviratidzo zvemwana wako? Zviratidzo izvi here kuti antipsychotic zvinodhaka zvakawanikwa kuti zvibvise? Iko mabhenefiti akakwana kana akakosha iwe nemwana wako?

Iwe unofanirwa zvakare kufunga nezve mutengo wemushonga, izvo zvinogona kunge zvichikwanisika. Uye tarisa mhedzisiro yemushonga muchiedza nhoroondo yehutano hwemwana wako kuti uone kuti zvakakodzera. Iyi mishonga yakave isina kukwana kudzidza muvana zvine chekuita nemhedzisiro, saka iwe uchafanirwa zvakare kufunga humbowo kubva kune zvidzidzo zvevakuru.

Kana mwana wako aine co-iripo mamiriro - semuenzaniso, ADHD kana kushushikana - iwe unofanirwa kuve nechokwadi chekuti izvi zvinorapwa. Izvi zvinogona kuvandudza zviratidzo zvemwana wako. Nezve bipolar kusagadzikana, kune zvimwe, zvakanyatso tsvakurudzwa zvinodhaka zviripo, senge lithiamu, divalproex, uye carbamazepine, iyo inofanirwa kuyedzwa kutanga usati watarisa atypical antipsychotic.

Kana iwe ukafunga kupa mwana wako antipsychotic, isu tinokurudzira kushandisa yakaderera inoshanda dosi kudzikisira mukana wemhedzisiro. Uye ita shuwa kuti mwana wako anoongororwa nguva nenguva nachiremba kuti aone kana mushonga wacho uchiri kubatsira uye kudikanwa.

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Kutaura Nachiremba Wako

Ruzivo rwatinopa apa haruna kuitirwa kutsiva kutonga kwechiremba. Asi isu tinovimba ichabatsira iwe uye chiremba wemwana wako kuona kana antipsychotic yakakodzera.

Ziva kuti vanhu vazhinji vanozeza kutaura nezve mutengo wemishonga nachiremba wavo, uye izvo zvidzidzo zvakaona kuti vanachiremba havawanzo tarisa mutengo pavanenge vachipa mushonga. Kunze kwekunge iwe wauya nazvo, chiremba wako anogona kufunga kuti mutengo hachisi chinhu kwauri.

Vanhu vazhinji (kusanganisira varapi) vanofunga kuti mitsva mishonga iri nani. Kunyange iri fungidziro yechisikigo yekuita, hazvisi zvechokwadi. Zvidzidzo zvinowona kuti mishonga mizhinji yechinyakare yakanaka se-uye mune dzimwe nguva iri nani pane-mutsva mushonga. Funga nezvavo se "vakaedzwa uye vechokwadi," kunyanya kana zvasvika pakuchengeteka kwavo. Mishonga mitsva haisati yasangana nemuedzo wenguva, uye matambudziko asingatarisirwi anogona uye kukwira kana vangosvika pamusika.

Ehezve, mimwe mishonga mitsva yetsamba iri kunyatso shanda uye yakachengeteka. Taura nachiremba wako nezvezvakanaka nezvisina kufanira zvemushonga mutsva kana mukuru, kusanganisira zvinodhaka zvakajairwa.

Mishonga yekunyorera inoenda "generic" apo patent yekambani pairi inopera, kazhinji mushure memakore gumi nemaviri kusvika gumi nemashanu. Panguva iyoyo, mamwe makambani anogona kugadzira nekutengesa mushonga.

Magetsi anonyanya kudhura pane mutsva mushonga zita, asi iwo haasi mashoma emhando yemishonga. Chokwadi, akawanda ejeniki anoramba achishanda makore mazhinji mushure mekutanga kutengeswa. Ndosaka zvinopfuura makumi matanhatu muzana zvezvinyorwa zvese muU.S. nhasi zvakanyorerwa zvemagetsi.

Imwe nyaya yakakosha yekutaura nezvako nachiremba wako ndeyekuchengetedza zvinyorwa zvemishonga yauri kutora. Pane zvikonzero zvinoverengeka zveizvi:

• Kutanga, kana iwe ukaona vanachiremba vakati wandei, mumwe nemumwe anogona kunge asingazive zvemushonga zvakatemwa nevamwe.
• Chechipiri, sezvo vanhu vachisiyana mukupindura kwavo kumushonga, zvakajairika kuti vanachiremba nhasi vape mishonga yakati wandei vasati vawana imwe inoshanda zvakanaka kana zvakanakisa.
• Yetatu, vanhu vazhinji vanotora akati wandei mishonga yekunyorera, isina kunyoreswa zvinodhaka, uye zvekudya zvinowedzera panguva imwe chete. Vanogona kupindirana munzira dzinogona kudzora bhenefiti yaunowana kubva kumushonga kana kuve nenjodzi.
• Chekupedzisira, iwo mazita emishonga yekunyorera-ese akajairika uye brand-anowanzo kuve akaoma kududza nekurangarira.

Kune ese izvo zvikonzero, zvakakosha kuti uchengete yakanyorwa rondedzero yemishonga yese uye zvinowedzera iwe zvauri kutora, uye kuti nguva nenguva uzviongorore pamwe nachiremba wako.

Uye gara uine chokwadi chekuti unonzwisisa muyero wemushonga urikunyorerwa iwe uye kuti mangani mapiritsi aunotarisirwa kunwa zuva rega rega. Chiremba wako anofanira kukuudza ruzivo urwu. Paunozadza mushonga kufamasi kana kana ukauwana nepositi, tarisa kuti uone kuti muyero uye huwandu hwemapiritsi pazuva pane mudziyo wemapiritsi zvinoenderana nemari yawakaudzwa nachiremba wako.

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Takatarisa Sei Antipsychotic

Ongororo yedu inonyanya kukoshesa ongororo yakazvimirira yesainzi yehuchapupu pamusoro pekubudirira, chengetedzo, pamwe nemhedzisiro yemhedzisiro yemaantipsychotic.Chikwata chevarapi nevanoongorora kuOregon Health & Science University Evidence-Based Practice Center yakaitisa ongororo iyi sechikamu cheDrug Effectiveness Review Project, kana DERP. DERP ndeyekutanga-ye-iyo-mhando-yakawanda nyika danho rekuyera kuenzanisa kugona uye chengetedzo yemazana emishonga yekunyorera.

Chinyorwa chekuongorora kweDERP kwemaantipsychotic chinoumba hwaro hwechirevo ichi. Chipangamazano kune Consumer Reports Best Buy Zvinodhaka zvakare inhengo yeOregon-based research timu, iyo isina mari mune chero kambani yemishonga kana chigadzirwa.

Iyo yakazara DERP ongororo yeantipsychotic inowanikwa pa //derp.ohsu.edu/about/final-documentdisplay.cfm. (Iri igwaro rakareba uye rehunyanzvi rakanyorerwa vanachiremba.)

Iyo Yevatengi Mishumo Yakanakisisa Tenga Zvinodhaka nzira inotsanangurwa zvakadzama muchikamu cheMethods kuCRBestBuyDrugs.org.

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Kugovera Chirevo Ichi

Chirevo chekodzero iyi chinogona kuburitswa mahara, kutsikirwazve, nekuparadzirwa kumunhu wese asiri wekutengesa pasina mvumo kubva kuMutengi Reports & kutenderedzwaR; Chero bedzi zvichinyatso kuoneswa kuComputer Reports Best Buy Drugs. ™ Tinokurudzira kuparadzirwa kwaro kwakawanda pamwe nechinangwa chekuzivisa vatengi. Asi Consumer Reports haibvumire kushandiswa kwezita rayo kana zvigadzirwa zvekutengesa, kushambadzira, kana kukurudzira zvinangwa. Chero sangano rinofarira kugoverwa kwakawanda kwemushumo uyu rinofanira kutumira email [email protected]. Consumer Reports Best Buy Drugs ™ inzvimbo yekutengesa yeConsumers Union. Zvese zvakatorwa kubva muchinyorwa zvinofanirwa kudoma Consumer Reports Best Buy Zvinodhaka ™ sosi sosi.

© 2012 Consumers Union of U.S. Inc.

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Nezvedu

Consumers Union, muparidzi we Consumer Reports & circledR; magazini, isangano rakazvimirira uye risingabatsiri rine chinangwa kubva muna 1936 kwave kupa vatengi ruzivo rusina rusaruro pazvinhu nemasevhisi uye kugadzira musika wakaringana. Ndiyo webhusaiti iyi www.CRBestBuyDrugs.org. Webhusaiti yemagazini ndeye ConsumerReports.org.

Zvishandiso izvi zvakagoneswa nerubatsiro kubva kuhurumende Gweta General Consumer uye Prescriber Dzidzo Grant Chirongwa, icho chinopihwa mari nekugadziriswa kwakawanda kwevatengi-kubiridzira zvirevo zvine chekuita nezve kushambadzira kwachiremba mushonga we Neur Neurontin.

Engelberg Foundation yakapa mari hombe yekutsigira chirongwa ichi kubva muna 2004 kusvika 2007. Imwe mari yekutanga yakabva kuNational Library yeMishonga, chikamu cheNational Institutes of Health. Imwe tsananguro yakadzama yeprojekti inowanikwa kuCRBestBuyDrugs.org.

Isu takateedzera maitiro akaomarara edhisheni kuti tione kuti ruzivo ruri mumushumo uyu uye pamusoro peVatengi Reports Best Buy Zvinodhaka webhusaiti ndezvechokwadi uye zvinotsanangura zvakagamuchirwa tsika dzekuchipatara. Kana isu tikawana kukanganisa kana kunyeverwa kune imwe tinoigadzirisa nekukurumidza sezvazvinogona. Asi Consumer Reports nevanyori vayo, vapepeti, vaparidzi, marezinesi, uye vanotengesa havagone kuve nemhosva yezvikanganiso zvekurapa kana kusiiwa, kana chero mhedzisiro kubva mukushandiswa kweruzivo ruri pane ino saiti. Ndokumbira utarise kubvumirano yedu yemushandisi paCRBestBuyDrugs.org kuti uwane rumwe ruzivo.

Consumer Reports Zvakanakisisa Tenga Zvinodhaka hazvifanirwe kutariswa sechinotsiva kubvunzana nachiremba kana nyanzvi yehutano. Chirevo ichi neruzivo rweCRBestBuyDrugs.org zvinopihwa kuti uwedzere kutaurirana nachiremba wako pane kuti utsive.

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Mareferensi

1. Zvirongwa J, Winkler J, Jandrisevits MD, Apps J, Winkler J, Jandrisevits MD. Bipolar kusagadzikana: zviratidzo uye kurapwa muvana nevechiri kuyaruka. Pediatr Mukoti. 2008; 34 (1): 84-8.
2. Arango C, Robles O, Parellada M, Fraguas D, Ruiz-Sancho A, Medina O, Zabala A, Bombin I, Moreno D. Olanzapine achienzaniswa nequetiapine muvachiri kuyaruka neyekutanga psychotic episode. Eur Mucheche Adolesc Psychiatry. 2009; 18 (7): 418-28.
3. Barzman DH, DelBello MP, Adler CM, Stanford KE, Strakowski SM. Kubudirira uye kushivirira kwequetiapine kana divalproex yekurapwa kwekushushikana uye kuita zvechisimba muvachiri kuyaruka vane co-kuitika bipolar kusagadzikana uye kukanganisa hunhu kusagadzikana (s). Zvinyorwa zveMwana & Adolescent Psychopharmacology. 2006; 16 (6): 665-70.
4. Nzvimbo dzeDaase Control. Kuwandisa kweAutism Spectrum Dambudziko-Autism uye Kuvandudza Kuremara Kuongorora Network, United States, 2006. MMWR. 2009; 58 (SS10): 1-20.
5. Correll CU, Manu P, Olshanskiy V, Napolitano B, Kane JM, Malhotra AK. Cardiometabolic njodzi yechipiri-chizvarwa antipsychotic mishonga panguva yekutanga-kushandiswa muvana nevechiri kuyaruka. Zvinyorwa zveAmerican Medical Association. 28 Gumiguru 2009. 302 (16): 1765-1773.
6. Kushungurudza CM, Fristad MA, Cummings CM, Fristad MA. Chiremba bipolar kusagadzikana: Kuzivikanwa mukutarisirwa kwekutanga. Curr Opin Pediatr. 2008; 20 (5): 560-5.
7. Kutsvaga RI, McNamara NK, Branicky LA, Schluchter MD, Lemon E, Blumer JL. Yechipiri-bofu mutyairi wendege wekuongorora risperidone mukurapa kwehunhu hwekusagadzikana. Zvinyorwa zveAmerican Academy yeMwana & Adolescent Psychiatry. 2000; 39 (4): 509-16.
8. Kutsvaga RL, Nyilas M, Forbes RA, McQuade RD, Jin N, Iwamoto T, Ivanova S, Carson WH, Chang K. Kurapa kwakanyanya kwevana bipolar I kusagadzikana, manic kana yakavhenganiswa episode, ine aripiprazole: Yakasarudzika, yakapofumadza, placebo-inodzorwa kudzidza. Zvinyorwa zveKiriniki Psychiatry. 2009; 70 (10): 1441-51.
9. Goldstein BI. Chiremba bipolar kusagadzikana: Kupfuura chinetso chehasha. Pediatrics. 2010; 125 (6): 1283-5.
10. Haas M, Delbello MP, Pandina G, Kushner S, Van Hove I, Augustyns I, Quiroz J, Kusumakar V. Risperidone yekurapa kwakanyanya mania muvana nevechiri kuyaruka vane bipolar kusagadzikana kudzidza. Bipolar Dambudziko. 2009; 11 (7): 687-700.
11. Hazell P, Williams R, Hazell P, Williams R. Kuongorora kwekuchinja: Kuchinja maonero pavadiki bipolar kusagadzikana uye kwakapararira kwekukura kusagadzikana. Curr Opin Psychiatry. 2008; 21 (4): 328-31.
12. Luby J, Mrakotsky C, Stalets MM, Belden A, Heffelfinger A, Williams M, Spitznagel E. Risperidone muvana vepachikoro chevana vane autistic spectrum kusagadzikana: Kuongorora kwekuchengetedza uye kugona. Zvinyorwa zveMwana & Adolescent Psychopharmacology. 2006; 16 (5): 575-87.
13. Maglione M, et al. Kunze-Chiraira Kushandisa kweAtypical Antipsychotic: An Gadziriso. Kuenzanisa Kubudirira Kuongorora Nha. 43. (Yakagadzirirwa neSouthern California / RAND Uchapupu-hwakavakirwa PracticeCenter pasi peChibvumirano Nha. HHSA290-2007-10062-1.) AHRQ Kuburitswa Nha. Rockville, MD: Sangano reHutano Hwekutsvagisa uye Hunhu. Gunyana 2011.
14. Marcus RN, Owen R, Kamen l, Manos G, McQuade RD, Carson WH, Aman MG. Iyo placebo-inodzorwa, yakagadziriswa-dhizaini yekuongorora aripiprazole muvana nevechiri kuyaruka vane kusagadzikana kunosangana ne autistic kusagadzikana. Zvinyorwa zveAmerican Academy yeMwana & Adolescent Psychiatry. 2009; 48 (11): 1110-9.
15. McCracken JT, et al. Risperidone muvana vane autism uye zvakakomba maitiro ekuzvibata. New England Chinyorwa cheMishonga. 2002; 347 (5): 314-21.
16. National Institute yeMental Health. Bipolar kusagadzikana pakati pevana. Inowanikwa pa nimh.nih.gov/ Statistics / 1bipolar_child.shtml. Yakasvika musi waMarch 10, 20011.
17. National Institute yeMental Health. Schizophrenia. Inowanikwa pa nimh.nih.gov/statistics/ 1SCHIZ.shtml. Yakasvika musi waMarch 10, 20011.
18. Zvekutsvagisa Unyanzvi paPediatric Psychopharmacology Autism Network. Risperidone kurapwa kwe autistic kusagadzikana: Yakareba-temu mabhenefiti uye kupofumadza kurega mushure memwedzi mitanhatu. American Nhoroondo yePsychiatry. 2005; 162 (7): 1361-9.
19. Seeman P. Atypical antipsychotic: Maitiro ekuita. Unogona J Psychiatry. 2002 Kukadzi; 47 (1): 27-38.
20. Snyder R, Turgay A, Aman M, Binder C, Fisman S, Carroll A. Mhedzisiro ye risperidone pamafambiro uye kukanganisa kunokanganisa maitiro muvana vane subaverage IQs. Zvinyorwa zveAmerican Academy yeMwana & Adolescent Psychiatry. 2002; 41 (9): 1026-36.

Dzokera kumusoro Verenga zvakawanda

Ongorora: Kana iro bhokisi remutengo riine , izvo zvinoratidza kuti mwero wechinodhaka ichocho chingangowanikwa pamutengo wakaderera pamwedzi kuburikidza nezvirongwa zvekudzikisira zvinopihwa nezvitoro zvikuru. Semuenzaniso, Kroger, Sam's Club, Target, uye Walmart vanopa kupihwa kwemwedzi kwemishonga yakasarudzika yakasarudzika yemadhora mana kana kupihwa kwemwedzi mitatu ye $ 10. Zvimwe zvitoro zvemaketani, zvakadai seCostco, CVS, Kmart, uye Walgreens, zvinopa zvirongwa zvakafanana. Mamwe mapurogiramu ane zvirambidzo kana mari yehunhengo, saka tarisa zvinyatso kujeka nezvezvirambidzo uye kuti uve nechokwadi chekuti mushonga wako wakafukidzwa.

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