Darzalex (daratumumab)

Zvemukati

• Chii chinonzi Darzalex?
• Iyo inoshandiswa sei
• Kubudirira
• Darzalex generic
• Darzalex mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Rutivi mhedzisiro mhedzisiro
• Darzalex mutengo
• Mari uye inishuwarenzi rubatsiro
• Darzalex muyero
• Mafomu emishonga uye simba
• Dosage yeakawanda myeloma
• Ko kana ndikapotsa dosi?
• Ndichada here kushandisa mushonga uyu kwenguva refu?
• Darzalex yeakawanda myeloma
• Kubudirira
• Darzalex yemamwe mamiriro
• Darzalex shandisa nemimwe mishonga yeakawanda myeloma
• Dzimwe nzira dzeDarzalex
• Darzalex vs. Empliciti
• About
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Darzalex vs. Kyprolis
• About
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Darzalex inoshanda sei
• Zvinotora nguva yakareba sei kuti zvishande?
• Darzalex uye doro
• Darzalex kudyidzana
• Darzalex uye marabhoritari bvunzo
• Iyo Darzalex inopihwa sei
• Nguva yekutora
• Kutora Darzalex nechikafu
• Darzalex uye nhumbu
• Darzalex ine lenalidomide kana pomalidomide
• Darzalex uye kuberekwa
• Darzalex ine lenalidomide kana pomalidomide
• Darzalex nekuyamwisa
• Darzalex ine lenalidomide kana pomalidomide
• Mibvunzo yakajairika nezve Darzalex
• Sei ndichifanira kutora maSteroid uye mimwe mishonga panguva dzandinogadzwa dzeDarzalex infusions?
• Ndichakwanisa kutyaira ndega kumba mushure meangu Darzalex infusion?
• Ndinogona here kushandisa Darzalex kana ndanga ndine shingles?
• Darzalex inoporesa myeloma yakawanda here?
• Darzalex matanho
• Ruzivo rwehunyanzvi rweDarzalex
• Zviratidzo
• Nzira yekuita
• Pharmacokinetics uye metabolism
• Contraindications
• Kuchengetedza

Chii chinonzi Darzalex?

Darzalex izita-zita mushonga mushonga. Inoshandiswa kurapa akawanda myeloma, inova mhando yekenza inobata mamwe machena masero eropa anonzi masero eplasma.

Darzalex ine daratumumab. Urwu ndirwo rudzi rwemushonga unonzi monoclonal antibody.

Darzalex haisi chemotherapy. Iyo mhando yekurapa kwakanangwa uye dzimwe nguva inonzi immunotherapy. Izvi zvinoreva kuti Darzalex yakagadzirirwa kushanda nema immune system (muviri wako kuzvidzivirira kubva kuhutachiona).

Mubatsiri wezvehutano anokupa iwe Darzalex seinopinda (IV) infusion muhofisi yechiremba wako kana kukiriniki. Kuiswa IV IV jekiseni mutsinga yako inopihwa kwenguva yakati.

Iyo inoshandiswa sei

Darzalex inogona kupihwa wega kana nemimwe mishonga. Chikafu neDrug Administration (FDA) yakabvumidza Darzalex kuti ishandiswe:

• Mune vanhu vakuru vane ichangobva kuongororwa yakawanda myeloma isingakwanise kugamuchira iyo autologous stem cell yekuisa. (Iine autologous stem cell yekuisa, ako maseru masero anoshandiswa.) Mune ino mamiriro:
  • Darzalex inogona kushandiswa nemishonga lenalidomide (Revlimid) uye dexamethasone.
  • Darzalex inogona zvakare kushandiswa nemishonga bortezomib (Velcade), melphalan, uye prednisone.
• Mune vanhu vakuru vakagamuchira imwe kana kupfuura marapirwo apfuura ayo asina kushanda zvakanaka kana ane akawanda myeloma akadzoka. Mune ino mamiriro, Darzalex inoshandiswa nelenalidomide uye dexamethasone.
• Muvanhu vakuru vakagamuchira imwe kana kupfuura zvakapfuura akawanda myeloma kurapwa (s). Mune ino mamiriro, Darzalex inoshandiswa ne bortezomib uye dexamethasone.
• Muvanhu vakuru vakagamuchira maviri kana anopfuura apfuura marapirwo e myeloma aisanganisira lenalidomide uye proteasome inhibitor, iri mhando yemushonga. Mune ino mamiriro, Darzalex inoshandiswa nemishonga pomalidomide (Pomalyst) uye dexamethasone.
• Muvanhu vakuru vakagamuchira matatu kana kupfuura apfuura marapirwo eakawanda emyeloma ayo aisanganisira proteasome inhibitor uye mushonga wekudzivirira muviri. Mune ino mamiriro, Darzalex inoshandiswa yega.
• Mune vanhu vakuru vakaedza proteasome inhibitor uye mushonga wekudzivirira muviri, asi hapana mushonga wakashanda kune myeloma yakawanda. Mune ino mamiriro, Darzalex inoshandiswa yega.

Kubudirira

Zvidzidzo zvitanhatu zvemakiriniki zvakatarisa kuti Darzalex yaive nemabatiro api pakurapa myeloma yakawanda, yega uye yakasanganiswa nemimwe mishonga yekurwisa kenza.Izvi zvidzidzo zvinonzi MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, uye SIRIUS. Tsvagurudzo yakaratidza kuti kurapwa kweakawanda myeloma kwainyanya kushanda kana Darzalex yakawedzerwa kune akajairwa marapirwo ekenza pane kana aya marapirwo akajairwa akapihwa ega. Kuti uwane rumwe ruzivo nezve kugona, ona iyo "Darzalex yeakawanda myeloma" chikamu pazasi.

Darzalex generic

Darzalex inowanikwa chete sezita-zita zita mishonga. Haisi ikozvino inowanikwa mune generic fomu.

Darzalex ine chinhu chinoshanda chemushonga chinodhaka: daratumumab.

Darzalex mhedzisiro

Darzalex inogona kukonzera munyoro kana zvakakomba mhedzisiro. Iri rinotevera runyorwa rine mamwe akakosha mhedzisiro mhedzisiro anogona kuitika uchitora Darzalex. Rondedzero iyi haisanganisi zvese zvinokanganisa mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvinogona kuitika mhedzisiro yeDarzalex, taura nachiremba wako kana wemishonga. Ivo vanogona kukupa iwe matipi ekuti ungatarise sei nechero mhedzisiro mhedzisiro inogona kunetsa.

Zvimwe zvakajairika mhedzisiro

Mhedzisiro mhedzisiro yeDarzalex inogona kusanganisira:

• kunzwa kuneta
• kushaya simba kana kushaya simba
• mhasuru mhasuru (dzinokanganisa)
• kusvotwa kana kurutsa
• kugumbura dumbu kusanganisira manyoka kana kupatira
• kuderera kwechido
• kunetseka kurara
• kupindwa nechando
• chills
• kutadza kufema kana kukosora
• chirwere chepamusoro chekufema, senge chando
• bronchitis, rudzi rwehutachiona hwemapapu
• muviri kurwadza
• kurwadziwa pamwe chete kana musana
• dzungu

Kana iyo mhedzisiro iwe yaunonzwa ichiratidzika kunge yakanyanya kuoma kana kuti isingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Matambudziko akakomba kubva kuDarzalex haana kujairika, asi anogona kuitika. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

• Kuwedzera infusion, rudzi rwemaergic reaction. Zviratidzo zvinogona kusanganisira:
  • kunetseka kufema
  • kuoma kwehuro
  • kunzwa musoro wakareruka kana dzungu kubva pasi yakaderera BP
  • kukosora kana kufema
  • inoyerera kana yakakora mhino
  • kusvotwa kana kurutsa
  • chills
  • kupindwa nechando
  • musoro
  • kuvava
• Pneumonia, rudzi rwehutachiona hwemapapu. Zviratidzo zvinogona kusanganisira:
  • kukosora phlegm (mucus)
  • fivha uye kutonhora
  • mweya wekufema
  • kurwadziwa pachipfuva
• Hepatitis B, kana wakambove nayo kare. Zviratidzo zvinogona kusanganisira:
  • kuwedzera kuneta
  • yero yeganda rako kana chena chikamu chemeso ako
• Peripheral sensory neuropathy (kukuvara kwenzara kunokonzeresa kurira, chiveve, kana kurwadziwa). Zviratidzo zvinogona kusanganisira:
  • chiveve kana kugwinha
  • kupisa marwadzo
  • kunzwisisika
  • kushaya simba mumaoko ako kana mutsoka
• Peripheral edema (kuzvimba kwemaoko nemakumbo). Zviratidzo zvinogona kusanganisira:
  • kuzvimba kwemaoko kana makumbo
  • ganda rakatambanudzwa
  • ganda rinodonha (makomba) parinodzvanywa kwemasekondi mashoma

Mimwe mhedzisiro yakakomba mhedzisiro, yakatsanangurwa zvakadzama pazasi mu "Side athari ruzivo," inosanganisira:

• neutachiona
• thrombocytopenia, mwero wakaderera wemaplatelet, ayo ari mhando yesero reropa rinobatsira kugwamba kweropa
• neutropenia, mwero wakaderera wema neutrophils, ayo ari mhando yesero jena reropa rinobatsira kurwisa hutachiona
• shingles (herpes zoster chirwere)

Rutivi mhedzisiro mhedzisiro

Unogona kushamisika kuti kangani mamwe maratidziro anoitika nemushonga uyu. Heano mamwe mhedzisiro pane zvakakomba mhedzisiro mhedzisiro iyi mushonga ingakonzere

Allergic reaction

Sezvo nemishonga yakawanda, vamwe vanhu vanogona kuita zvinopesana nehutachiona mushure mekutora Darzalex. Hazvizivikanwe kuti kangani vanhu vanoshandisa Darzalex vane allergiki maitiro. Zviratidzo zvehunhu husina kugadzikana hunogona kusanganisira:

• kuputika kweganda kana mikoko (itchy welts paganda rako)
• kuvava
• kuburitsa (kudziya uye kutsvuka mukati meganda rako)
• kupindwa nechando

Imwe yakanyanya kukonzeresa kusagadzikana isingawanzo asi inogoneka. Zviratidzo zveakanyanya kusagadzikana maitiro zvinogona kusanganisira:

• kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka
• kuzvimba kwerurimi rwako, muromo, kana huro
• kunetseka kufema

Fonera chiremba wako ipapo ipapo kana iwe uine chakanyanya kukanganiswa neakisi kuDarzalex. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Infusion reaction

Darzalex inopiwa intravenous (IV) infusion muhofisi yechiremba wako kana kukiriniki. Iyi jekiseni mutsinga yako inopihwa kwenguva yakati. Sezvo nemishonga yakawanda inopihwa se IV infusion, unogona kunge uine infusion reaction mushure mekugamuchira Darzalex. (An infusion reaction irudzi rweanorwisa maitiro.)

Munguva yezvidzidzo zvekiriniki, infusion reaction yakaitika mune inenge hafu yevanhu vese vaibatwa neiyo Darzalex infusion. Kazhinji, maitiro akaitika panguva yekutanga infusion uye aive akapfava kusvika pakuenzanisa. Vazhinji vanhu vakagamuchira Darzalex vakaita maitiro mukati kana mukati memaawa mana ekuguma kweiyo infusion. Kugadziriswa kwekumanikidza kushoma kuti kuitike nemhedzisiro yekurapa. Muzvidzidzo, vanhu vakagashira mishonga isiri Darzalex havana kupihwa mishonga nenzira ye infusions.

Kana iwe uine infusion reaction iyo iri yakapfava kana ine mwero, chiremba wako anogona kumbomira yako infusion kuti arape maitiro. Vanogona kubva vatangazve kumisikidza pazasi rate (kumhanya) kuti iwe uwane mushonga zvishoma nezvishoma. Kana yako infusion reaction yakaoma kana anaphylactic (kutyisidzira hupenyu), chiremba wako anogona kumira zvachose kurapwa neDarzalex uye otanga kurapwa kwekukurumidzira.

Kuti uderedze mukana wekupindirwa, chiremba wako anokupa iwe musanganiswa wemishonga. Awa kusvika matatu maawa pamberi peimwe neimwe Darzalex infusion, iwe uchagamuchira:

• a corticosteroid (kuderedza kuzvimba)
• antipyretic (kudzivirira kana kuderedza kupisa muviri)
• antihistamine (kudzivirira kana kudzikisira zviratidzo zvekusagadzikana)

Iwe unogona zvakare kugamuchira corticosteroid 1 zuva mushure mekunyudzwa kuti udzivise kunonoka kuita. Asi kana iwe uri kutotora steroid yakadai se dexamethasone kana prednisone, iwe ungangove hauzodi iyo yekuwedzera steroid yekuwedzera.

Kana iwe uine chirwere chakakomba chemuviri kuDarzalex mushure mekunge wabva muhofisi yechiremba wako kana iyo yekumisikidza nzvimbo, fonera chiremba wako ipapo ipapo. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Ropa maseru kusagadzikana

Darzalex inogona kukonzera thrombocytopenia, iko kuderera padanho remaplatelet ako. (Aya ndiwo mhando yesero reropa rinobatsira kuvhara ropa.) Zviratidzo zvinogona kusanganisira kupwanya uye kubuda ropa.

Muzvidzidzo zvekiriniki, vangangoita makumi mana kubva muzana kusvika makumi mapfumbamwe kubva muzana yevanhu vakatora Darzalex kana Darzalex nemushonga wakajairika wekurapa myeloma vaive netrombocytopenia. Mukuenzanisa, 58% kusvika 88% yevanhu vaingova nemarapirwo akajairwa vaivewo netrombocytopenia.

Darzalex inogona zvakare kukonzera neutropenia. Uku kuderera padanho reyutrophils, inova mhando yesero reropa jena rinobatsira kurwisa hutachiona. Zviratidzo zvinogona kusanganisira kupisa uye hutachiona.

Mune kiriniki zvidzidzo, vangangoita 58% kusvika 95% yevanhu vakatora Darzalex kana Darzalex pamwe neyakajairwa yakawanda myeloma kurapwa yaive neutropenia. Mukuenzanisa, makumi mana kubva muzana kusvika makumi masere kubva muzana muzana yevanhu vaive nemarapirwo akajairwa vaivewo neutropenia.

Munguva yekurapa kwako Darzalex, chiremba wako anogara achitarisa yako platelet uye chena masero eropa. Ivo zvakare vanozokutarisa iwe kune chero kupwanya, kubuda ropa, kana hutachiona. Kana iwe ukagadzira chero cheizvi zviratidzo kana zviratidzo, udza chiremba wako.

Shingles

Paunenge uchitora Darzalex, unogona kukura hutachiona hunonzi shingles (herpes zoster). Izvi zvinodaro nekuti kuve neakawandisa myeloma uye kugamuchira akawanda myeloma kurapwa kunogona kuwedzera njodzi yako yehutachiona.

Paunowana shingles, unogona kunge uine:

• kupisa marwadzo
• kurira
• kuvava
• mapundu uye mapundu parutivi rumwe chete rwemuviri wako

Utachiona hwakafanana hunokonzeresa shingles hunokonzeresawo chickenpox. Kana iwe wakambove nehukuku munguva yakapfuura, hutachiona hahubve mumuviri wako mushure mekupora kubva kuhutachiona. Pane kudaro, hutachiona "hunoenda kunorara" mumitsipa yako.

Hapana anoziva chaizvo kuti sei, asi hutachiona hunogona kumutsiridza kana "kumuka" nezvimwe zvinokonzeresa senge isina simba immune system. (Maitiro ezvirwere zvemuviri kudzivirira muviri kuzvirwere.)

Kenza kana kurapwa kwekenza kunogona kushomeka immune system yako uye kumutsidzira herpes zoster virus. Kana ichinge yamuka, inozviratidza semashanga pachinzvimbo chehuku.

Mune zvidzidzo zvemakiriniki, shingles yakataurwa mu3% yevanhu vaibatwa neDarzalex chete. Mukuenzanisa, shingles yakaitika mu2% kusvika ku5% yevanhu vakatora Darzalex nemumwe mushonga wekenza.

Kana iwe uine chickenpox kana shingles munguva yakapfuura uye uri kutora Darzalex, chiremba wako anogona kukunyorera mushonga wehutachiona. Rudzi urwu rwemushonga runogona kubatsira kudzivirira shingles kubva mukukura mumuviri wako. Iwe unozofanirwa kutora antiviral kurapwa mukati me1 vhiki yekutanga kugamuchira Darzalex. Ipapo iwe unozoramba uchizvitora kwemwedzi mitatu mushure mekupedza kurapwa neDarzalex.

Chirwere chemabayo

Kutora Darzalex kunogona kukutungamira kuti uve nehutachiona hwemapapu hunonzi pneumonia. Izvi zvinodaro nekuti kana uine multiple myeloma, iwe uri mukana wekuwana hutachiona kupfuura vanhu vane hutano.

Muzvidzidzo zvemakiriniki, 11% kusvika 26% yevanhu vakatora Darzalex vakagadzira mabayo. Izvi zvinofananidzwa ne6% kusvika 14% yevanhu vakatora placebo (hapana kurapwa).

Pneumonia ndiyo yakanyanya kutaurwa zvakanyanya hutachiona. Kusvikira pa4% yevanhu pane ese eDarzalex zvidzidzo vaifanira kurega kutora mushonga nekuda kwemabayo. Rufu kubva pamabayo rwakanga rusinganyanyoitika. Asi kana kufa kukaitika, kwaive nekuda kwemabayo uye sepsis (inotyisidzira hupenyu kutapukirwa).

Zviratidzo zvemabayo zvinogona kusanganisira:

• kukosora phlegm (mucus)
• fivha uye kutonhora
• mweya wekufema
• kurwadziwa pachipfuva

Kana iwe ukaita chero zviratidzo zvemabayo, udza chiremba wako. Vanogona kumbomira yako Darzalex doses yekurapa mabayo. Muzvidzidzo zvemakiriniki, vangangoita 1% kusvika 4% yevanhu vakatora Darzalex kana kungorapwa kenza yakajairika vaifanira kumisa mishonga yavo nekuda kwechirwere chakakomba chemabayo.

Darzalex mutengo

Sezvo nemishonga yese, mutengo weDarzalex unogona kusiyana. Kuti uwane mitengo yazvino yeDarzalex munharaunda yako, tarisa WellRx.com. Mari yaunowana paWellRx.com ndiyo yaunogona kubhadhara pasina inishuwarenzi. Mutengo chaiwo wauchabhadhara unoenderana neinishuwarenzi yako yekuvhara uye pharmacy yaunoshandisa.

Yako inishuwarenzi chirongwa chinogona kuda kuti iwe uwane kumberi mvumo vasati vabvumidza kufukidzwa kweDarzalex. Izvi zvinoreva kuti chiremba wako achazoda kutumira chikumbiro kukambani yeinishuwarenzi achivabvunza kuti vavhare mushonga. Kambani yeinishuwarenzi inoongorora chikumbiro ichi uye kukuzivisa iwe nachiremba wako kana chirongwa chako chichafukidza Darzalex.

Kana usina chokwadi kana uchizoda kuwana mvumo yepamberi yeDarzalex, bata chirongwa chako cheinishuwarenzi.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari kubhadhara Darzalex, kana kana iwe uchida rubatsiro kuti unzwisise yako inishuwarenzi kufukidza, rubatsiro rwuripo.

Janssen Biotech, Inc., iyo inogadzira Darzalex, inopa chirongwa chinonzi Janssen CarePath. Kuti uwane rumwe ruzivo uye kuti uzive kana iwe uchikodzera rutsigiro, fonera 844-553-2792 kana shanyira iyo webhusaiti chirongwa.

Darzalex muyero

Iyo Darzalex muyero unorayirwa nachiremba wako inoenderana nezvakawanda zvinhu. Izvi zvinosanganisira:

• kana mamiriro ako achangobva kuongororwa kana iwe wakagamuchira imwe kana kupfuura apfuura akawanda myeloma kurapwa (s)
• chero kumwe kurapwa kwauri kugamuchira pamwe neDarzalex kurapa akawanda myeloma
• mamwe marapirwo aungave uine
• chero mhedzisiro isingaendi

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda. Kuti uwane zvakanyanyisa kubva pakurapwa uku, zvakakosha kuti uende kunzvimbo dzako dzese dzakatarwa uye usasvetuke chero mazuva.

Mafomu emishonga uye simba

Darzalex inouya semhinduro (yemvura musanganiswa) iyo yauchazogamuchira muchimiro chejekiseni. Mhinduro yacho inogona kunge isina ruvara kune yero yero. Darzalex inowanikwa mumhando mbiri:

• 100 mg / 5 mL mune imwe-vial vial
• 400 mg / 20 mL mune imwe-vial vial

Anopa hutano anosanganisa chikamu cheDarzalex ne 0.9% sodium chloride (rudzi rwemvura yemunyu mhinduro). Ipapo vanobva vakupa uyu mushonga kuburikidza netsono yakaiswa mutsinga yako. Izvi zvinodaidzwa kuti intravenous (IV) infusion.

Kazhinji, chiremba wako anokutanga iwe pane yakadomerwa dosi asi padanho repasi (kumhanya) kwekusvetwa. Nekufamba kwenguva, ivo vanozo gadziridza iyo infusion kune iyo chiyero chakanakira iwe. Izvi zvinoenderana nechero infusion reaction yauinayo.

Kuiswa kwako kwekutanga kweDarzalex kunogona kutora maawa manomwe. Izvi zvinodaro nekuti chiremba wako anozopa (kukupa) mishonga yako zvishoma nezvishoma kupinda mutsinga dzako. Mune ramangwana, infusions inogara kwemaawa matatu kusvika mashanu nekuti unenge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge wakura Anopa hutano anogara achikutarisa panguva yako infusions.

Dosage yeakawanda myeloma

Darzalex inorayirwa pachayo kana nemamwe marudzi ekenza kurapwa kwevakuru vane yakawanda myeloma. Iyo yekurapa chirongwa uye kureba zvinoenderana nekuti iwe uchangobva kuongororwa kana kuti wakambove nemarapirwo ekare. Darzalex haisati yadzidzwa muvana.

Iyo yakakurudzirwa dhiza yeDarzalex ndeye 16 milligrams / kilogram (mg / kg) yehuremu chaihwo hwemuviri se IV infusion. Semuenzaniso, mukadzi ane zana-pondo anorema anenge makumi mashanu kg. Izvi zvinoreva kuti dosi yake yakakurudzirwa Darzalex ichave iri makumi mashanu kg inowedzerwa ne16 mg / kg, inova 800 mg.

Vakuru vane achangobva kuongororwa akawanda myeloma asingakwanise kugamuchira iyo autologous stem sero kuisirwa

Uine autologous stem cell yekuisa, ako maseru masero anoshandiswa. Imwe nzira yekurapa ndeye Darzalex ine lenalidomide (Revlimid) uye dexamethasone. Iyo yakakurudzirwa muyero chirongwa ndeiyi:

• Mavhiki 1 kusvika 8: Dosi imwe chete pasvondo (yezviyero zvisere)
• Mavhiki 9 kusvika 24: Dosi imwe chete kwevhiki mbiri (kwehuwandu hwemasere masere)
• Vhiki 25 zvichienda mberi: Rimwechete masvondo mana

Imwe nzira yekurapa ndeye Darzalex ine bortezomib (Velcade), melphalan, uye prednisone. Iyo yakakurudzirwa muyero chirongwa ndeiyi:

• Mavhiki 1 kusvika ku6: Dosi imwe chete pasvondo (yezviyero zvitanhatu)
• Mavhiki 7 kusvika 54: Mumwe muvhi mavhiki matatu ese (kwehuwandu hwemasero gumi nematanhatu)
• Vhiki 55 zvichienda mberi: Rimwechete masvondo mana

Vakuru vakagamuchira imwe kana kupfuura marapirwo apfuura ayo asina kushanda zvakanaka kana ane akawanda myeloma akadzoka

Iwe uchagamuchira Darzalex ine lenalidomide uye dexamethasone. Iyo yakakurudzirwa muyero chirongwa ndeiyi:

• Mavhiki 1 kusvika 8: Dosi imwe chete pasvondo (yezviyero zvisere)
• Mavhiki 9 kusvika 24: Dosi imwe chete kwevhiki mbiri (kwehuwandu hwemasere masere)
• Vhiki 25 zvichienda mberi: Rimwechete masvondo mana

Vakuru vakagamuchira imwe kana kupfuura zvakapfuura akawanda myeloma kurapwa (s)

Iwe uchagamuchira Darzalex ne bortezomib uye dexamethasone. Iyo yakakurudzirwa muyero chirongwa ndeiyi:

• Mavhiki 1 kusvika 9: Dosi imwe chete pasvondo (yezviyero zvipfumbamwe)
• Mavhiki 10 kusvika 24: Dosi imwe chete pavhiki nhatu (kwehuwandu hwemasvomhu mashanu)
• Vhiki 25 zvichienda mberi: Rimwechete masvondo mana

Vakuru vakagamuchira maviri kana anopfuura akapfuura akawanda myeloma kurapwa, kusanganisira lenalidomide uye proteasome inhibitor

Iwe uchagamuchira Darzalex ine pomalidomide (Pomalyst) uye dexamethasone. Iyo yakakurudzirwa muyero chirongwa ndeiyi:

• Mavhiki 1 kusvika 8: Dosi imwe chete pasvondo (yezviyero zvisere)
• Mavhiki 9 kusvika 24: Dosi imwe chete kwevhiki mbiri (kwehuwandu hwemasere masere)
• Vhiki 25 zvichienda mberi: Rimwechete masvondo mana

Vakuru vakagamuchira matatu kana kupfuura akapfuura akawanda myeloma kurapwa, kusanganisira proteasome inhibitor uye immunomodulatory drug, kana vasina kupindura kune proteasome inhibitor uye mushonga unodomodulatory.

Iwe uchagamuchira chete Darzalex. Iyo yakakurudzirwa muyero chirongwa ndeiyi:

• Mavhiki 1 kusvika 8: Dosi imwe chete pasvondo (yezviyero zvisere)
• Mavhiki 9 kusvika 24: Dosi imwe chete kwevhiki mbiri (kwehuwandu hwemasere masere)
• Vhiki 25 zvichienda mberi: Rimwechete masvondo mana

Kuti uderedze mukana wekupindirwa, chiremba wako anokupa iwe musanganiswa wemishonga. Awa kusvika matatu maawa pamberi peimwe neimwe Darzalex infusion, iwe uchagamuchira:

• a corticosteroid (kuderedza kuzvimba)
• antipyretic (kudzivirira kana kudzikisa fivha)
• antihistamine (kudzivirira kana kudzikisira zviratidzo zvemaergic reaction).

Iwe unogona zvakare kugamuchira corticosteroid 1 zuva mushure mekunyudzwa kuti udzivise kunonoka kuita. Asi kana iwe uri kutotora steroid yakadai se dexamethasone kana prednisone, iwe ungangove hauzodi iyo yekuwedzera steroid yekuwedzera.

Ko kana ndikapotsa dosi?

Kana iwe ukarasikirwa musangano weDarzalex infusion, fonera chiremba wako ipapo ipapo kuti udzorezve. Ivo vanozo gadzirisa yako dosing purogiramu kuti uve nechokwadi chekuti iwe unogashira iyo chaiyo nhamba yekurapa mune yakakodzera nguva furemu.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Mune zvidzidzo zvemakiriniki, avhareji nguva yakatora kuti Darzalex itange kushanda yaive mwedzi mumwe.

Nekudaro, iwe unogona kupihwa yako madosi kwenguva yakareba kwenguva. Izvi zvinoenderana nekuti muviri wako unopindura sei Darzalex uye kana myeloma yako yakawanda ikatanga kuwedzera.

Kureba kwekurapa kunoenderana zvakare kana yako yakawanda myeloma ichangobva kuongororwa kana kuti iwe wakambove nekurapwa munguva yakapfuura.

Darzalex yeakawanda myeloma

Chikafu neDrug Administration (FDA) yakabvumidza Darzalex yekurapa kwakawanda myeloma.

Ichi chimiro checancer icho chinobata mamwe machena masero eropa anonzi plasma masero. Masero eplasma anoumba chikamu chemuviri wako uye anobatsira kurwisa hutachiona mumuviri wako. Mune akawanda myeloma, masero eplasma anochinja kuita akawanda myeloma masero. Sezvo masero akawanda emyeloma anokura uye achipararira, anogona kuwanda kunze kwemasero ane hutano uye nekukuvadza pfupa rakakomberedza

Darzalex inobvumidzwa kushandiswa:

• Mune vanhu vakuru vane ichangobva kuongororwa yakawanda myeloma isingakwanise kugamuchira iyo autologous stem cell yekuisa. (Iine autologous stem cell yekuisa, ako maseru masero anoshandiswa.) Mune ino mamiriro:
  • Darzalex inogona kushandiswa nemishonga lenalidomide (Revlimid) uye dexamethasone.
  • Darzalex inogona zvakare kushandiswa nemishonga bortezomib (Velcade), melphalan, uye prednisone.
• Mune vanhu vakuru vakagamuchira imwe kana kupfuura marapirwo apfuura ayo asina kushanda zvakanaka kana ane akawanda myeloma akadzoka. Mune ino mamiriro, Darzalex inoshandiswa nelenalidomide uye dexamethasone.
• Muvanhu vakuru vakagamuchira imwe kana kupfuura zvakapfuura akawanda myeloma kurapwa (s). Mune ino mamiriro, Darzalex inoshandiswa ne bortezomib uye dexamethasone.
• Muvanhu vakuru vakagamuchira maviri kana anopfuura apfuura marapirwo e myeloma aisanganisira lenalidomide uye proteasome inhibitor, iri mhando yemushonga. Mune ino mamiriro, Darzalex inoshandiswa nemishonga pomalidomide (Pomalyst) uye dexamethasone.
• Muvanhu vakuru vakagamuchira matatu kana kupfuura apfuura marapirwo eakawanda emyeloma ayo aisanganisira proteasome inhibitor uye mushonga wekudzivirira muviri. Mune ino mamiriro, Darzalex inoshandiswa yega.
• Muvanhu vakuru vakaedza proteasome inhibitor uye mushonga wekudzivirira muviri asi hapana mushonga wakashanda kune myeloma yakawanda. Mune ino mamiriro, Darzalex inoshandiswa yega.

Kubudirira

Zvidzidzo zvitanhatu zvemakiriniki zvakatarisa kuti Darzalex yaive nemabatiro api pakurapa myeloma yakawanda yega uye pamwe chete nemimwe mishonga yekurwisa gomarara. Izvi zvidzidzo zvinonzi MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, uye SIRIUS. Tsvagiridzo yakaratidza kuti kurapwa kwainyanya kushanda kana Darzalex yakawedzerwa kune akajairwa kurapwa gomarara pane kana aya marapirwo akajairwa akapihwa ega.

Iyo MAIA kudzidza

Chidzidzo cheMAIA chakatarisa vanhu vachangobva kuongororwa kuti vane myeloma yakawanda avo vasingakwanise kugamuchira autologous stem cell yekuisa. Vanhu vakagamuchira chero yakajairika kenza kurapwa kwelenalidomide (Revlimid) uye yakaderera-dose dexamethasone kana iyo imwecheteyo kurapwa pamwe Darzalex. Richienzaniswa neboka rakarapwa rekurapa, iro Darzalex boka raive ne44% panjodzi yakaderera yevakawanda myeloma yavo kuwedzera kana kufa.

Kwemwedzi makumi mana nemaviri yekudzidza, yakawanda myeloma haina kuwedzera zvakanyanya muvanhu vakatora Darzalex pamwe nekurapwa kwakajairwa. Kune vanhu vakatora kurapwa kwakajairika, zvakatora mwedzi ingangosvika 31.9 pasati myeloma yavo yakawanda yatanga kuwedzera. Iyo yakazara yekupindura mwero yaive 47.6% kune vanhu vaibatwa neDarzalex uye 24.9% kune avo vakagamuchira chete standard kurapwa. (Mhinduro yakazara zvinoreva kuti kenza yese yaenda uye hapana zviratidzo zvechirwere mumabara miedzo, maX-ray, kana bvunzo dzekiriniki.)

ALCYONE kudzidza

Chidzidzo che ALCYONE chakatarisa vanhu vachangobva kuongororwa kuti vane myeloma yakawanda avo vaisakwanisa kugamuchira autologous stem cell yekuisa. Vanhu ava vakagamuchira chero yakajairwa kenza kurapwa kwe bortezomib (Velcade), melphalan, uye prednisone kana iyo yekurapa pamwe neDarzalex. Zvichienzaniswa neboka rakarapwa rekurapa, iro Darzalex boka raive ne50% panjodzi yakaderera yevakawanda myeloma vachiwedzera kana kufa.

Pakati pevanhu vakagamuchira kurapwa kweDarzalex, 42.6% yaive nemhinduro yakazara. Izvi zvakafananidzwa ne24.4% yevanhu vakagamuchira chete kurapwa kwakaringana.

Iyo POLLUX kudzidza

Chidzidzo chePOLLUX chakatarisa kune vanhu vane yakawanda myeloma avo vaive nechero imwechete kurapwa kwekutanga. Vanhu vakatora angave marapirwo akajairwa elenalidomide uye dexamethasone kana kurapwa kumwe chete pamwe neDarzalex. Mhedzisiro yakaratidza kuti vangangoita 91.3% yevanhu vakapindura kurapwa naDarzalex maringe neanosvika 74.6% yevanhu vakagashira kurapwa kwakaringana.

Zvichienzaniswa neboka rakarapwa rekurapa, iro boka rakarapwa naDarzalex raive ne 63% panjodzi yakaderera yeakawanda myeloma achiwedzera. Mushure memwedzi gumi nematanhatu, 19% yeboka reDarzalex vakaona yavo yakawanda myeloma ichiwedzera kana ivo kufa. Izvi zvakafananidzwa ne41% yeboka rekurapa rakajairika.

Iyo CASTOR yekudzidza

Chidzidzo cheCASTOR chakatarisawo kune vanhu vane myeloma yakawanda vaive nekamwe kamwe kurapwa. Vanhu vakatora chero yakajairwa kurapwa kwe bortezomib uye dexamethasone kana kurapwa kumwe chete pamwe neDarzalex. Mhedzisiro yacho yaive yakafanana neiyo yekudzidza kwePOLLUX. About 73.9% yevanhu vakapindura kurapwa neDarzalex zvichienzaniswa neangangoita 59.9% yevanhu vakagamuchira chete kurapwa kwakaringana.

Zvichienzaniswa neyakajairwa kurapwa, iyo Darzalex kurapwa yainge yakabatana ne 61% yakaderera njodzi yeakawanda myeloma iri kuwedzera kuipa kana kufa. Vanhu vakatora Darzalex vakakwanisawo kugara mukuregererwa kwenguva yakareba. (Kuregererwa kunoreva kuti mwero wekenza unopararira wakadzikira.)

Iyo EQUULEUS kudzidza

Chidzidzo cheEQUULEUS chakatarisa vanhu makumi mapfumbamwe nevapfumbamwe vaine myeloma yakawanda avo vakamborapwa kanokwana kana kune yavo yakawanda myeloma. Vanhu ava vanga vatogamuchira mhando mbiri dzekurapwa: proteasome inhibitor uye mushonga wemuviri. Wese munhu ari muchidzidzo akatora kurapwa kwakajairika kwepomalidomide (Pomalyst) uye dexamethasone pamwe neDarzalex. Chinangwa chikuru chekudzidza ndechekuona kuti vanhu vangani vakapindura kurapwa.

Pakazara, kurapwa kwakatanga kushanda mukati memwedzi mumwe muvanhu vazhinji. Mushonga uyu wakashanda kweavhareji yemwedzi ingangosvika 13.6. Multiple myeloma zviratidzo zvinoderedzwa ne90% kana kupfuura mu42% yevanhu. Vamwe vanhu vakatove vasina kenza yakasara pakupera kwechidzidzo.

Iyo SIRIUS kudzidza

Chidzidzo cheSIRIUS chakatarisa kune vanhu zana negumi nevashanu vane myeloma yakawanda vairwara zvakanyanya uye vakagamuchira avhareji yemashanu ekurapwa kwakapfuura. Vanhu vese vari muchidzidzo vakapihwa chete Darzalex. Chinangwa chikuru chekudzidza ndechekuona kuti vanhu vangani vakapindura kurapwa.

Pakazara, vanhu makumi matatu nevatanhatu vakagamuchira Darzalex vane yavo yakawanda myeloma zviratidzo zvinoderera. About 64.8% yevanhu vakatora Darzalex muchidzidzo ichi vakapona kwemwedzi gumi nembiri.

Kuti kuderedze mukana wekuve neiyo infusion reaction, vanhu mune zvese izvi zvidzidzo vakapihwa musanganiswa wemishonga. Awa kusvika matatu maawa pamberi peese Darzalex infusion, ivo vakagamuchira:

• a corticosteroid (kuderedza kuzvimba)
• antipyretic (kudzivirira kana kudzikisa fivha)
• antihistamine (kudzivirira kana kudzikisira zviratidzo zvekusagadzikana)

Ivo vanogona kunge vakagamuchirawo corticosteroid 1 zuva mushure mekunyudzwa kuti vadzivise kunonoka kuita. Asi kana vanhu vanga vachitotora steroid yakadai sedexamethasone kana prednisone, vangangodaro vaisada yekuwedzera steroid yekuwedzera.

Darzalex yemamwe mamiriro

Mukuwedzera akawanda myeloma, Darzalex iri kuongororwa senzira yekurapa immunoglobulin mwenje cheni amyloidosis.

Darzalex ye immunoglobulin mwenje cheni amyloidosis (pasi pekudzidza)

Immunoglobulin mwenje cheni amyloidosis (AL) mamiriro mune mamwe mapuroteni anonzi macheni macheni anovaka munhengo dzako mumuviri wako wese. Kazhinji, moyo wako, itsvo, spleen, uye chiropa zvinokanganiswa. Iyo protein buildup inogona kukuvadza uye kukonzera idzi nhengo kutadza.

Darzalex haisi FDA-inogamuchirwa kurapa AL. Zvisinei, kune kumwe kutsvagurudza kushoma uchishandisa Darzalex off-label kurapa mamiriro aya. (Kunze-kwekushandisa kushandiswa ndipo panobvumidzwa mushonga kurapa imwe mamiriro kurapa imwe mamiriro.)

Mune kumwe kuongorora, Darzalex yakapihwa kune vanhu vane AL avo, paavhareji, vakagamuchira matatu marapirwo akasiyana aisashanda. Darzalex yakaburitsa mhinduro ingangozara kana yakazara mu76% yevanhu vakatora mushonga. (Mhinduro yakazara zvinoreva kuti hosha yese yaenda uye hapana zviratidzo zvechirwere mumabara miedzo, maX-ray, bvunzo dzekiriniki.) Vanhu ava vakave nemhedzisiro yakafanana neiya inotarisirwa kune vanhu vakatora Darzalex kurapa myeloma yakawanda. Mune zvimwe zviitiko zvakataurwa, Darzalex yaishanda pakurapa AL uye nekuvandudza hupenyu hwevanhu vakatora mushonga.

Dzimwe dzidzo dzinodiwa kuratidza kuti Darzalex inoshanda nemazvo uye yakachengeteka kana ichishandiswa muvanhu vane AL. Kusvika panguva iyoyo, vaongorori vangangoshandisa Darzalex kune vanhu vane AL vasina imwe sarudzo yekutanga, sarudzo dzekurapa dzakabvumidzwa neDAA dzakasara.

Darzalex shandisa nemimwe mishonga yeakawanda myeloma

Darzalex inorayirwa pachayo kana nemamwe marudzi ekenza kurapwa kwevakuru vane yakawanda myeloma. Iyo yekurapa chirongwa uye kureba zvinoenderana nekuti iwe uchangobva kuongororwa kana kuti wakambove nemarapirwo ekare.

Darzalex inobvumidzwa kushandiswa pamwe chete ne:

• lenalidomide (Revlimid) uye dexamethasone muvakuru vane ichangobva kuongororwa yakawanda myeloma isingakwanise kugamuchira autologous stem cell yekuisa. (Iine autologous stem cell yekuisa, ako maseru masero anoshandiswa.)
• lenalidomide uye dexamethasone muvakuru vakagamuchira imwe kana kupfuura marapirwo ekare asina kushanda zvakanaka kana ane akawanda myeloma akadzoka.
• bortezomib (Velcade), melphalan, uye prednisone muvakuru vane vachangobva kuongororwa multiple myeloma vasingakwanise kugamuchira autologous stem cell yekuisa.
• bortezomib uye dexamethasone muvakuru vakagamuchira imwe kana kupfuura zvakapfuura akawanda myeloma kurapwa (s).
• pomalidomide (Pomalyst) uye dexamethasone muvakuru vakagashira maviri kana anopfuura akapfuura akawanda myeloma mishonga. Aya marapirwo anofanira kunge aisanganisira lenalidomide uye proteasome inhibitor.

Zvidzidzo zvitanhatu zvemakiriniki zvakatarisa kuti Darzalex yaive nemabatiro api pakurapa myeloma yakawanda, yega uye yakasanganiswa nemimwe mishonga yekurwisa kenza. Izvi zvidzidzo zvinonzi MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, uye SIRIUS. Tsvagurudzo yakaratidza kuti kurapwa kweakawanda myeloma kwainyanya kushanda kana Darzalex yakawedzerwa kune akajairwa marapirwo ekenza pane kana aya marapirwo akajairwa akapihwa ega. Kuti uwane rumwe ruzivo nezve izvi zvidzidzo, ndapota ona iyo "Darzalex yeakawanda myeloma" chikamu pamusoro.

Dzimwe nzira dzeDarzalex

Mimwe mishonga iripo inogona kurapa akawanda myeloma. Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira yeDarzalex, taura nachiremba wako kuti udzidze zvakawanda nezvemimwe mishonga inogona kukushandira zvakanaka.

Pazasi pane runyorwa rwemishonga inokurudzirwa neNational Comprehensive Cancer Network nhungamiro yekurapa akawanda myeloma:

• Chemotherapy zvinodhaka, zvakadai se:
  • bendamustine (Bendeka kana Treanda)
  • cisplatin
  • cyclophosphamide (Cytoxan)
  • doxorubicin (Doxil)
  • etoposide (Etopophos)
  • melphalan (Alkeran)
• Proteasome inhibitors, senge:
  • bortezomib (Velcade)
  • carfilzomib (Kyprolis)
  • ixazomib (Ninlaro)
• Monoclonal antibodies, senge:
  • elotuzumab (Empliciti)
• Histone deacetylase inhibitors, senge:
  • panobinostat (Farydak)
• Immunomodulators, senge:
  • lenalidomide (Revlimid)
  • pomalidomide (Pomalyst)
  • thalidomide (Thalomid)
• Corticosteroids, akadai se:
  • dexamethasone (Decadron)

Ongorora: Mimwe yemishonga yakanyorwa pano inogona kushandiswa kure-chitambi kurapa akawanda myeloma.

Darzalex vs. Empliciti

Unogona kushamisika kuti Darzalex inofananidzwa sei nemimwe mishonga inorayirwa kuti ishandiswe zvakafanana. Pano tinotarisa kuti Darzalex neEmpliciti zvakafanana uye zvakasiyana.

About

Darzalex ine daratumumab, nepo Empliciti iine elotuzumab. Dzese Darzalex neEmpliciti ndezvekirasi yemishonga inonzi monoclonal antibodies. (Kirasi yemishonga iboka remishonga inoshanda nenzira yakafanana.) Dzese Darzalex neEmpliciti dzinoonekwa senge dzakanangwa marapirwo eakawanda myeloma.

Zvishandiso

Chikafu neDrug Administration (FDA) yakabvumidza ese Darzalex uye Empliciti kurapa akawanda myeloma.

Darzalex inobvumidzwa kushandiswa:

• Mune vanhu vakuru vane ichangobva kuongororwa yakawanda myeloma isingakwanise kugamuchira iyo autologous stem cell yekuisa. (Iine autologous stem cell yekuisa, ako maseru masero anoshandiswa.) Mune ino mamiriro:
  • Darzalex inogona kushandiswa nemishonga lenalidomide (Revlimid) uye dexamethasone.
  • Darzalex inogona zvakare kushandiswa nemishonga bortezomib (Velcade), melphalan, uye prednisone.
• Mune vanhu vakuru vakagamuchira imwe kana kupfuura marapirwo apfuura ayo asina kushanda zvakanaka kana ane akawanda myeloma akadzoka. Mune ino mamiriro, Darzalex inoshandiswa nelenalidomide uye dexamethasone.
• Muvanhu vakuru vakagamuchira imwe kana kupfuura zvakapfuura akawanda myeloma kurapwa (s). Mune ino mamiriro, Darzalex inoshandiswa ne bortezomib uye dexamethasone.
• Muvanhu vakuru vakagamuchira maviri kana anopfuura apfuura marapirwo e myeloma aisanganisira lenalidomide uye proteasome inhibitor, iri mhando yemushonga. Mune ino mamiriro, Darzalex inoshandiswa nemishonga pomalidomide (Pomalyst) uye dexamethasone.
• Muvanhu vakuru vakagamuchira matatu kana kupfuura apfuura marapirwo eakawanda emyeloma ayo aisanganisira proteasome inhibitor uye mushonga wekudzivirira muviri. Mune ino mamiriro, Darzalex inoshandiswa yega.
• Muvanhu vakuru vakaedza proteasome inhibitor uye mushonga wekudzivirira muviri asi hapana mushonga wakashanda kune myeloma yakawanda. Mune ino mamiriro, Darzalex inoshandiswa yega.

Empliciti inobvumidzwa kushandiswa:

• Muvanhu vakuru vakagashira imwe kana matatu ekutanga marapirwo eakawanda myeloma. Empliciti inoshandiswa nelenalidomide (Revlimid) uye dexamethasone.
• Mune vanhu vakuru vakagamuchira kanenge maviri ekutanga marapirwo aisanganisira lenalidomide uye proteasome inhibitor. Empliciti inoshandiswa ne pomalidomide (Pomalyst) uye dexamethasone.

Kazhinji, Empliciti inopihwa kana myeloma yako yakawanda yadzoka mushure memamwe marapirwo.

Mafomu emishonga uye manejimendi

Dzese Darzalex neEmpliciti zvinopihwa seinopinda (IV) infusion. Uyu jekiseni unodhonzwa zvishoma nezvishoma nekufamba kwenguva kuburikidza netsono inoiswa mutsinga yako.

Zve Darzalex

Darzalex inouya semhinduro (yemvura musanganiswa) iyo yauchazogamuchira muchimiro chejekiseni. Mhinduro yacho inogona kusava neruvara kune yero yero. Mushonga uyu unowanikwa mune mbiri saizi:

• 100 mg / 5 mL mune imwe-vial vial
• 400 mg / 20 mL mune imwe-vial vial

Kuti uderedze mukana wekupindirwa, chiremba wako anokupa iwe musanganiswa wemishonga. Awa kusvika matatu maawa pamberi peimwe neimwe Darzalex infusion, iwe uchagamuchira:

• corticosteroid yekudzora kuzvimba
• antipyretic yekudzivirira kana kuderedza kupisa muviri
• antihistamine yekudzivirira kana kudzikisa zviratidzo zvemaitiro ekusagadzikana

Iwe unogona zvakare kugamuchira corticosteroid 1 zuva mushure mekunyudzwa kuti udzivise kunonoka kuita. Asi kana iwe uri kutotora steroid yakadai se dexamethasone kana prednisone, iwe ungangove hauzodi iyo yekuwedzera steroid yekuwedzera.

Zve Empliciti

Empliciti inouya seye chena kune-chena hupfu. Anopa hutano anosanganisa izvi nemhinduro yekukupa sejekiseni. Empliciti inowanikwa musimba mbiri:

• 300 mg mune imwe-vial vial
• 400 mg mune imwe-vial vial

Kuti uderedze mukana wekupindirwa, chiremba wako anokupa iwe musanganiswa wemishonga. Inenge maminetsi makumi mana nemakumi mashanu kusvika makumi mapfumbamwe pamberi pekuputirwa kweEmpliciti, uchagamuchira

• acetaminophen kudzivirira kana kuderedza kupisa muviri
• diphenhydramine (Benadryl) kudzivirira kana kudzikisa zviratidzo zvemuviri
• ranitidine kudzivirira kana kudzikisa zviratidzo zvemaitiro ekusagadzikana
• dexamethasone yekudzora kuzvimba

Side migumisiro uye njodzi

Darzalex uye Empliciti zvese zvine mishonga inoshanda zvakafanana. Naizvozvo, ese ari maviri mishonga anogona kukonzera akafanana akafanana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yezvizhinji zvinowanzoitika mhedzisiro inogona kuitika neDarzalex, neEmpliciti, kana neese madhiragi (kana akatorwa ega).

• Zvinogona kuitika neDarzalex:
  • kushaya simba
  • muviri kurwadza kana kurwadza kwemajoini
  • kusvotwa
  • kunetseka kurara
  • bronchitis, rudzi rwehutachiona hwemapapu
  • dzungu
• Zvinogona kuitika neEmpliciti:
  • shuga yakakwira muropa *
  • kurwadziwa kunopisa mumaoko ako kana makumbo * *
• Zvinogona kuitika neese maviri Darzalex uye Empliciti:
  • kunzwa kuneta kana kushaya simba
  • kugumbura dumbu kusanganisira manyoka kana kupatira
  • kuderera kwechido
  • kupindwa nechando
  • chills
  • kutadza kufema kana kukosora
  • chirwere chepamusoro chekufema senge chando
  • mhasuru mhasuru (dzinokanganisa)
  • kurutsa
  • peripheral edema, kunova kuzvimba kwemaoko nemakumbo

** Kana Empliciti ichishandiswa nelenalidomide pamwe ne dexamethasone

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika neDarzalex, neEmpliciti, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika neDarzalex:
  • thrombocytopenia, mwero wakaderera wemaplatelet, ayo ari mhando yesero reropa rinobatsira kugwamba kweropa
  • neutropenia, mwero wakaderera wema neutrophils, ayo ari mhando yesero jena reropa rinobatsira kurwisa hutachiona
  • shingles (herpes zoster chirwere)
• Zvinogona kuitika neEmpliciti:
  • kanzura nyowani
  • matambudziko echiropa
• Zvinogona kuitika neese maviri Darzalex uye Empliciti:
  • infusion maitiro
  • mabayo, rudzi rwehutachiona hutachiona
  • peripheral sensory neuropathy, rudzi rwekukuvara kwenzara kunokonzeresa kurira, chiveve kana kurwadziwa

Kubudirira

Darzalex uye Empliciti vane akasiyana FDA-anotenderwa mashandisiro, asi iwo ari maviri anoshandiswa kurapa akawanda myeloma muvanhu vakuru.

Iyi mishonga haina kuenzaniswa zvakananga muzvidzidzo zvekiriniki (inonzi misoro-kusvika-misoro zvidzidzo). Zvisinei, kuongororwa kwezvidzidzo gumi nezvitanhatu zveDarzalex neEmpliciti zvakawana kuti madhiragi ese ari maviri aibatsira mukunonoka kufambira mberi (kuwedzera) kweakawanda myeloma.

Kune vanhu vane myeloma yakawanda yadzoka kana kuramba ichikura kunyangwe mushure mekurapwa kwakawanda, iyo National Comprehensive Cancer Network nhungamiro inokurudzira Darzalex kutanga. Kana Darzalex isingashande, kurapwa neEmpliciti ndeimwe sarudzo.

Mariro

Darzalex uye Empliciti ese ari maviri zita-zita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira pa WellRx.com, Darzalex kazhinji inodhura zvakaderera pane Empliciti. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa nenzvimbo yako.

Darzalex vs. Kyprolis

SaEmpliciti (pamusoro), mushonga Kyprolis anoshandisa zvakafanana neyaDarzalex. Ngatitarisei zvino kuti Darzalex neKyprolis zvakafanana uye zvakasiyana.

About

Darzalex ine daratumumab, nepo Kyprolis iine carfilzomib. Ose madhiragi anoonekwa seakananga kurapwa kweakawanda myeloma. Nekudaro, iyo mishonga iri mumapoka akasiyana emishonga. (Kirasi yemishonga iboka remishonga inoshanda nenzira yakafanana.) Darzalex rudzi rwemushonga unonzi monoclonal antibody. Kyprolis rudzi rwemushonga unonzi proteasome inhibitor.

Zvishandiso

Chikafu neDrug Administration (FDA) yakabvumidza Darzalex kuti ishandiswe:

• Mune vanhu vakuru vane ichangobva kuongororwa yakawanda myeloma isingakwanise kugamuchira iyo autologous stem cell yekuisa. (Iine autologous stem cell yekuisa, ako maseru masero anoshandiswa.) Mune ino mamiriro:
  • Darzalex inogona kushandiswa nemishonga lenalidomide (Revlimid) uye dexamethasone.
  • Darzalex inogona zvakare kushandiswa nemishonga bortezomib (Velcade), melphalan, uye prednisone.
• Mune vanhu vakuru vakagamuchira imwe kana kupfuura marapirwo apfuura ayo asina kushanda zvakanaka kana ane akawanda myeloma akadzoka. Mune ino mamiriro, Darzalex inoshandiswa nelenalidomide uye dexamethasone.
• Muvanhu vakuru vakagamuchira imwe kana kupfuura zvakapfuura akawanda myeloma kurapwa (s). Mune ino mamiriro, Darzalex inoshandiswa ne bortezomib uye dexamethasone.
• Muvanhu vakuru vakagamuchira maviri kana anopfuura apfuura marapirwo e myeloma aisanganisira lenalidomide uye proteasome inhibitor, iri mhando yemushonga. Mune ino mamiriro, Darzalex inoshandiswa nemishonga pomalidomide (Pomalyst) uye dexamethasone.
• Muvanhu vakuru vakagamuchira matatu kana kupfuura apfuura marapirwo eakawanda emyeloma ayo aisanganisira proteasome inhibitor uye mushonga wekudzivirira muviri. Mune ino mamiriro, Darzalex inoshandiswa yega.
• Muvanhu vakuru vakaedza proteasome inhibitor uye mushonga wekudzivirira muviri asi hapana mushonga wakashanda kune myeloma yakawanda. Mune ino mamiriro, Darzalex inoshandiswa yega.

Kyprolis FDA-inogamuchirwa kuti ishandiswe:

• Muvanhu vakuru vakagashira imwe kana matatu ekutanga marapirwo eakawanda myeloma. Kyprolis inoshandiswa ne dexamethasone kana nelenalidomide uye dexamethasone.
• Muvanhu vakuru vakagamuchira imwe kana kupfuura marapirwo ekare ezvakawanda zvemaeloma avo akawanda. Kyprolis inoshandiswa pachayo.

Mafomu emishonga uye manejimendi

Dzese Darzalex neKyprolis dzinopihwa seyakaiswa intravenous (IV). Uyu jekiseni unodhonzwa zvishoma nezvishoma nekufamba kwenguva kuburikidza netsono inoiswa mutsinga yako.

Zve Darzalex

Darzalex inouya semhinduro (yemvura musanganiswa) iyo yauchazogamuchira muchimiro chejekiseni. Mhinduro yacho inogona kusava neruvara kune yero yero. Mushonga uyu unowanikwa mune mbiri saizi:

• 100 mg / 5 mL mune imwe-vial vial
• 400 mg / 20 mL mune imwe-vial vial

Kuti uderedze mukana wekupindirwa, chiremba wako anokupa iwe mubatanidzwa. zvinodhaka. Awa kusvika matatu maawa pamberi peimwe neimwe Darzalex infusion, iwe uchagamuchira:

• corticosteroid yekudzora kuzvimba
• antipyretic yekudzivirira kana kuderedza kupisa muviri
• antihistamine yekudzivirira kana kudzikisa zviratidzo zvemaitiro ekusagadzikana

Iwe unogona zvakare kugamuchira corticosteroid 1 zuva mushure mekunyudzwa kuti udzivise kunonoka kuita. Asi kana iwe uri kutotora steroid yakadai se dexamethasone kana prednisone, iwe ungangove hauzodi iyo yekuwedzera steroid yekuwedzera.

ZveKyprolis

Kyprolis inouya mune keke kana fomu yeupfu mune imwe-vial vial. Iyo inouya nemasimba matatu: 10 mg, 30 mg, uye 60 mg.

Kuti uderedze mukana wekuve nekumukirwa maitiro, chiremba wako anokupa iwe steroid. Iwe uchagamuchira iyo steroid 30 maminetsi kusvika 4 maawa pamberi pako Kyprolis infusion. Asi kana iwe uchitotora steroid yakadai sedexamethasone, chiremba wako haazodi kukupa iyo yekuwedzera dosi.

Side migumisiro uye njodzi

Darzalex naKyprolis zvinogona kukonzera mhedzisiro yakafanana. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yezvinowanzoitika mhedzisiro mhedzisiro inogona kuitika neDarzalex, neKyprolis, kana nezvose zviri zviviri zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika neDarzalex:
  • kushaya simba kana kushaya simba
  • bronchitis, rudzi rwehutachiona hwemapapu
  • muviri kurwadza kana kurwadza kwemajoini
• Zvinogona kuitika neKyprolis:
  • yakadzika tsvuku masero eropa kuverenga
  • yakadzika chena masero eropa kuverenga
  • kunetseka kufema
  • yakaderera potasiamu mazinga
• Zvinogona kuitika neese maviri Darzalex uye Kyprolis:
  • mhasuru mhasuru (dzinokanganisa)
  • kunetseka kurara
  • kunzwa kuneta
  • kugumbura dumbu kusanganisira manyoka kana kupatira
  • kupindwa nechando
  • chills
  • mweya wekufema
  • kukosora
  • chirwere chepamusoro chekufema, senge chando
  • kusvotwa kana kurutsa
  • kuderera kwechido
  • peripheral edema, kunova kuzvimba kwemaoko nemakumbo
  • dzungu

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika neDarzalex, neKyprolis, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika neDarzalex:
  • neutropenia, mwero wakaderera wema neutrophils, inova mhando yesero reropa chena rinobatsira kurwisa hutachiona
  • shingles (herpes zoster chirwere)
  • peripheral sensory neuropathy, rudzi rwekukuvara kwenzara kunokonzeresa kurira, chiveve kana kurwadziwa
• Zvinogona kuitika neKyprolis:
  • kukuvara kwemapapu sekubuda ropa, kugwamba kweropa, kuzvimba, kana kutapukira mumapapu
  • kukuvara kwemoyo kana kukundikana kwemoyo
  • matambudziko echiropa, senge kuwedzera kwehuremu hweropa mapuroteni kana kutadza kwechiropa
  • itsvo kutadza
  • tumor lysis syndrome, mamiriro ayo masero ekenza anofa nekukurumidza uye zvirimo zvinoteukira muropa rako
  • posterior reversible encephalopathy syndrome, chirwere chemitsipa muuropi
  • BP
  • pulmonary hypertension, iri yakakwira BP mumapapu
  • kugwamba kweropa
  • matambudziko ekubuda ropa zvakanyanya sekubuda ropa mudumbu, mumapapu, kana muuropi
• Zvinogona kuitika neese maviri Darzalex uye Kyprolis:
  • infusion maitiro
  • thrombocytopenia, mwero wakaderera wemaplatelet, inova mhando yesero reropa rinobatsira kugwamba kweropa
  • mabayo, rudzi rwehutachiona hutachiona

Kubudirira

Darzalex uye Kyprolis vane akasiyana FDA-anotenderwa mashandisiro, asi iwo ari maviri anoshandiswa kurapa akawanda myeloma.

Iko kushandiswa kweDarzalex neKyprolis yeakawanda myeloma hakuna kuenzaniswa zvakananga muzvidzidzo zvekiriniki. Nekudaro, zvidzidzo zvakawana ese Darzalex uye Kyprolis kuti ave anoshanda pakurapa akawanda myeloma.

Vatsvagidzi vava kudzidza mashandisiro emishonga iyi miviri pamwe ne dexamethasone kurapa rudzi urwu rwegomarara. Mhedzisiro yacho yakaratidza kuti vanhu vanga vatorapwa for myeloma yakawanda vakapindura mushe pakurapa kwekubatanidza. Asi mimwe miedzo inodiwa FDA isati yabvumidza kurapwa kwakabatana kweDarzalex uye Kyprolis yeakawanda myeloma.

Mariro

Darzalex uye Kyprolis ese ari maviri mazita ezita zvinodhaka. Ikozvino hapana mafomu akajairika eimwe mishonga. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira pa WellRx.com, Darzalex kazhinji inodhura zvakaderera pane Kyprolis. Mutengo chaiwo wauchabhadhara chero mushonga unobva pane yako inishuwarenzi chirongwa nenzvimbo yako.

Darzalex inoshanda sei

Multiple myeloma kenza inotanga mune imwe mhando yemuchena weropa inonzi plasma sero. Masero eplasma anoumba chikamu chemuviri wako uye anobatsira kurwisa hutachiona mumuviri wako.

Dzimwe nguva shanduko dzinongoerekana dzaitika mumajini ako, anonzi magene, dzinogona kushandura masero ane hutano kuita cancer. (MaGeneti seti yemirairo inobatsira kudzora nzira iyo maseru ako anokura uye nekuzvibata). Kana masero eplasma achinja kuita akawanda myeloma maseru, anotanga kuvaka mumwongo wemapfupa (mukati memapfupa ako). Sezvo masero akawanda emyeloma achikura uye achipararira, anogona kudzikamisa maseru ane hutano nekukuvadza pfupa rakakomberedza.

Darzalex mushonga wakagadzirwa nevanhu unonzi monoclonal antibody. (MaMonoclonal antibodies mapuroteni mune ako immune system. Akagadzirirwa kunongedza nekurwisa chikamu chakati checancer cell.)

Kana masero eplasma akashanduka kuita akawanda masero eemaeloma, anokura huwandu hwakawanda hweprotein inonzi CD38 pamusoro payo. Iyo monoclonal antibody Darzalex inoshanda nekubatanidza kune CD38 protein pane yakawanda myeloma cell. Nekuita izvi, Darzalex inouraya zvakananga kana kubatsira immune system yako kuparadza yakawanda myeloma cell.

Zvinotora nguva yakareba sei kuti zvishande?

Muzvidzidzo zvekiriniki, avhareji nguva yakatora Darzalex kutanga kushanda yaive mwedzi mumwe. Nekudaro, iwe unogona kupihwa yako madosi kwenguva yakareba kwenguva. Izvi zvinoenderana nekuti muviri wako unopindura sei Darzalex uye kana myeloma yako yakawanda ikatanga kuwedzera. Kureba kwekurapa kunoenderanawo kana myeloma yako yakawanda ichangobva kuongororwa kana kuti watove nemishonga kare.

Darzalex uye doro

Iko hakuna kumwe kuzivikanwa kuwirirana pakati peDarzalex nedoro. Asi zvinokurudzirwa kuti urege kunwa doro uchitora Darzalex. Izvi zvine chekuita nekuti zvinotora nguva yakareba sei kuti ugamuchire mushonga.

Darzalex inopihwa senge intravenous (IV) infusion. Iyi jekiseni mutsinga yako inopihwa kwenguva yakati. Infusions yeDarzalex inogona kutora kubva maawa matatu kusvika manomwe. Saka zvakakosha kuti ugare uine hydrated usati uye panguva yako infusions. Zvinwiwa zvinodhaka zvinogona kuita kuti uome, saka dzivisa doro uchitora Darzalex.

Kana iwe uine mibvunzo nezve doro uye Darzalex, bvunza chiremba wako.

Darzalex kudyidzana

Usati watora Darzalex, ita shuwa yekuudza chiremba wako uye wemishonga nezve zvese zvirevo, pamusoro-pe-counter, uye mimwe mishonga yaunotora. Vaudzewo nezve chero mavitamini, mahebhu, uye zvinowedzera zvaunoshandisa. Kugovera ruzivo urwu kunogona kubatsira iwe kudzivirira kusangana kunogona kuitika.

Kana iwe uine mibvunzo nezve kudyidzana kwezvinodhaka zvinogona kukukanganisa, bvunza chiremba wako kana wemishonga.

Darzalex uye marabhoritari bvunzo

Kutora Darzalex kunogona kuchinja mhedzisiro yeimwe bvunzo bvunzo.

Ropa rerudzi zvikanganiso

Kana iwe uri kutora Darzalex uye uine kuongororwa kweropa kuti uenzane neropa rako mhando, mhedzisiro yacho inogona kunge isiri iyo chaiyo. Zvikanganiso pane izvi bvunzo zvinogona kupedza kusvika kumwedzi mitanhatu mushure mekupedzisira kwedosi rako reDarzalex.

Darzalex inoshanda nekubatanidza iyo CD38 protein pane pamusoro peakawanda myeloma cell uye ichikuvadza iyo protein. Dzimwe nguva masero matsvuku eropa anogona zvakare kunge aine CD38 mapuroteni paari. Darzalex inogona netsaona kuzvisungirira pachayo kune CD38 protein pane sero tsvuku reropa panzvimbo yeakawanda myeloma cell. Kana izvi zvikaitika, zvinoshandura nzira iyo sero dzvuku reropa "rinotarisa" pakuongororwa kweropa. Zvisinei, Darzalex haigoni kukanganisa ropa rako.

Kuti udzivise kukanganisa kwekutaipa kweropa, chiremba wako anozoongorora yako yeropa mhando usati waenda wako wekutanga weDarzalex. Vachaita izvi kuitira kana iwe uchida kuwedzerwa ropa mune ramangwana.

Iyo Darzalex inopihwa sei

Kuti ugamuchire dosi yako yeDarzalex, uchaenda kuhofisi yechiremba wako kana nzvimbo yekumukisa. Iyo mishonga inouya semhinduro (yemvura musanganiswa). Anopa hutano anosanganisa Darzalex ne 0.9% sodium chloride (rudzi rwemvura yemunyu mhinduro). Ipapo vanozokupa mushonga uyu nekufamba kwenguva kuburikidza netsono yakaiswa mutsinga yako. Izvi zvinodaidzwa kuti intravenous (IV) infusion. Iwe unogona kugamuchira Darzalex pachako kana nemamwe marapirwo.

Chiremba wako anozofunga kuti ingani Darzalex yekukupa iwe zvichienderana nehuremu hwako uye nehurongwa hwako hwekurapa. Anopa hutano anogara achikutarisa iwe panguva yekumukirwa.

Nguva yekutora

Chiremba wako achasarudza pane iyo nguva pakati pemadhosi uye mangani marapirwo auchazoda. Izvi zvinoenderana nekuti uri kutora Darzalex wega kana nemamwe marapirwo. Kumbira chiremba wako kuti akurudzire zuva rakanakisa uye nguva yekuwana yako infusions zvichibva pane zvaunoita zuva nezuva.

Iwe kangani iwe unowana Darzalex uye iyo yakareba yenguva yekumisikidzwa inoderera nekufamba kwenguva. Kuiswa kwako kwekutanga kweDarzalex kunogona kutora maawa manomwe. Izvi zvinodaro nekuti chiremba wako anozopinza mushonga wacho zvishoma nezvishoma mumutsipa wako. Kukanganiswa mune ramangwana kunotora nguva shoma uye kunotora maawa matatu kusvika mashanu nekuti unenge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge

Kutora Darzalex nechikafu

Darzalex infusion nguva inogona kubva kubva pa3 kusvika kumaawa manomwe, zvinoenderana nehurongwa hwako hwekurapa. Ndosaka iri zano rakanaka kuti uuye wakagadzirira nezvikafu zvishoma uye zvinwiwa zvine hutano kana zvakanaka nachiremba wako.

Darzalex uye nhumbu

Darzalex haisati yadzidzwa mumadzimai ane nhumbu kana mhuka. Asi Darzalex ndeye monoclonal antibody, iri mhando yemushonga inotarisa maseru ekenza. Uye monoclonal antibodies inozivikanwa kuyambuka iyo placenta. (Iyo placenta inhengo iri mukati medumbu rako inoendesa zvinovaka muviri kubva mumuviri wako kuenda kumwana wako.)

Zvichienderana nenzira iyo Darzalex inoshanda, iyo mishonga inogona kukonzera kudzikira kwehuwandu hwemapfupa mumwana asati aberekwa. Zvinogona zvakare kudzikisa huwandu hweropa uye maseru ekudzivirira anoita mwana ari kukura.

Usati watanga kutora Darzalex, iva nechokwadi chekuudza chiremba wako kana iwe uri nepamuviri, unogona kuva nepamuviri, kana kuronga kuva nepamuviri.

Darzalex ine lenalidomide kana pomalidomide

Darzalex dzimwe nguva inotorwa nemushonga unonzi lenalidomide (Revlimid) kana pomalidomide (Pomalyst) yeakawanda myeloma. Lenalidomide uye pomalidomide vese vane yambiro yebhokisi "yehurema hwakasimba uye hunotyisa hupenyu. Kana iwe uri mukadzi uye chiremba wako anoraira Darzalex ine lenalidomide kana pomalidomide, haufanire kubata pamuviri:

• kweanenge mavhiki mana usati watanga kurapwa
• paunenge uchitora kurapwa
• panguva yekumbomira pakurapwa
• kweanopfuura mavhiki mana mushure mekumisa lenalidomide kana pomalidomide

Kana iwe uine mibvunzo nezve kutora Darzalex, lenalidomide, kana pomalidomide uchiri nepamuviri, taura nachiremba wako.

Darzalex uye kuberekwa

Kana paine mukana wekuti iwe unogona kubata pamuviri, zvinokurudzirwa kuti iwe ushandise kudzora kubereka uchitora Darzalex. Iwe unofanirwa kuramba uchishandisa kudzora kwemwedzi mitatu mushure mekurapwa kwako kweDarzalex kwapera. Izvi zvinodaro nekuti mushonga unogona kugara musystem yako kwenguva pfupi mushure mekumira kuitora.

Kana iwe uri murume uye uchiita zvepabonde nemukadzi, pane mukana wekuti nhumbu iitike. Funga kushandisa nzira yekudzivirira yekuzvarwa, senge kondomu, kunyangwe kana wauri kurara naye achishandisawo kuberekwa.

Darzalex ine lenalidomide kana pomalidomide

Mune zvimwe zviitiko, unogona kutora Darzalex nemishonga inonzi lenalidomide (Revlimid) kana pomalidomide (Pomalyst). Kana iwe uri mukadzi uye uri kutora Darzalex ine lenalidomide kana pomalidomide, unofanira kubvuma kushandisa maitiro maviri ekudzivirira kuberekwa. Iwe unozofanirwa kutanga kushandisa kuberekwa kweinenge mavhiki mana usati watanga kurapwa nemishonga. Ramba uchishandisa bhaisikopo paunenge uchitora Darzalex uye lenalidomide kana pomalidomide, uye panguva chero yekumbomira pakurapa. Iwe zvakare unofanirwa kuramba uchishandisa kushandisa kuberekwa kweanenge mavhiki mana mushure mekumira kutora lenalidomide kana pomalidomide.

Lenalidomide uye pomalidomide inogona kupfuura muhunhu hwevanhu. Saka varume vese vanofanirwa kushandisa latex kana synthetic kondomu kana vachiita bonde nemukadzi anogona kubata pamuviri. Varume vanofanirwa kushandisa iyi nzira yekudzivirira kubereka kwenguva imwechete iyo iyo wavanobata naye achitora kubereka.

Kana iwe uchiita zvepabonde uye iwe kana wako wepabonde unogona kutora pamuviri, taura nachiremba wako. Ivo vanogona kukubatsira iwe kusarudza pane ako ekuberekwa kudzora zvaunoda iwe uri kushandisa Darzalex.

Darzalex nekuyamwisa

Hazvizivikanwe kana Darzalex inogona kupinda mumukaka wemukaka kana kuti mushonga ungakanganisa sei mukaka wemukaka. Izvo hazvizivikanwe kana Darzalex inogona kukanganisa mwana anoyamwa.

Darzalex ine lenalidomide kana pomalidomide

Mune zvimwe zviitiko, unogona kutora Darzalex nemishonga inonzi lenalidomide (Revlimid) kana pomalidomide (Pomalyst). Kana iwe uri mukadzi ari kuyamwisa, haufanire kushandisa lenalidomide kana pomalidomide. Hazvizivikanwe kana mushonga uyu ungapfuure mumukaka wako wepamu uye nekukuvadza mwana wako.

Kana iwe uchida kuyamwisa mwana wako uye uri kufunga nezve kutora Darzalex, taura nachiremba wako. Vanogona kukuudza nezvezvakanaka nezvayakaipira kushandisa mushonga uyu uchiyamwisa.

Mibvunzo yakajairika nezve Darzalex

Heano mhinduro kumimwe inowanzo bvunzwa mibvunzo nezve Darzalex.

Sei ndichifanira kutora maSteroid uye mimwe mishonga panguva dzandinogadzwa dzeDarzalex infusions?

Paunogamuchira Darzalex, unogona kunge uine zvinopesana neyakaitika. Kuti ubatsire kudzivirira izvi, chiremba wako anogona kukupa mishonga inonzi corticosteroids nemimwe mishonga.

Mubatsiri wezvehutano anokupa iwe Darzalex seinopinda (IV) infusion muhofisi yechiremba wako kana kukiriniki. Iyi jekiseni mutsinga yako inopihwa kwenguva yakati. Awa kusvika matatu maawa pamberi pega pega Darzalex infusion, iwe unowanzo gamuchira zvinotevera zvinodhaka:

• a corticosteroid (kuderedza kuzvimba)
• antipyretic (kudzivirira kana kuderedza kupisa muviri)
• antihistamine (kudzivirira kana kudzikisira zviratidzo zvekusagadzikana)

Iwe unogona zvakare kugamuchira corticosteroid 1 zuva mushure mekunyudzwa kuti udzivise kunonoka kuita. Asi kana iwe uri kutotora steroid yakadai se dexamethasone kana prednisone, iwe ungangove hauzodi iyo yekuwedzera steroid yekuwedzera.

Kana iwe uine mibvunzo nezve chero yemishonga yakapihwa neDarzalex infusions, bvunza chiremba wako.

Ndichakwanisa kutyaira ndega kumba mushure meangu Darzalex infusion?

Hazvikurudzirwi. Izvi zvinodaro nekuti zvakajairika kuti unzwe kuneta mushure mekunyudzwa kana kunyangwe uine infusion reaction. .

Teerera kune manzwiro aunoita mushure mekubata kwako uye chengeta diary yezviratidzo zvako. Izvi zvinogona kukubatsira kuti usarudze kana uchigona kutyaira pachako, kana iwe uchizomboda kudaro.

Kana ukasakwanisa kuwana mutyairi, Janssen Biotech, Inc., iyo inogadzira Darzalex, inogona kukwanisa kubatsira. Unogona kutaura naJanssen CarePath murongi nezve kuenda nekubva kumisangano yako nekugamuchira rubatsiro nemari yekufamba. Kuti udzidze zvakawanda, fona 844-553-2792 kana kushanyira iyo Darzalex webhusaiti.

Ndinogona here kushandisa Darzalex kana ndanga ndine shingles?

Hongu, unogona kushandisa Darzalex kana iwe uine hutachiona hunonzi shingles. Asi usati watora Darzalex, zvakakosha kuti uudze chiremba wako kana iwe wakambove uine shingles kana chickenpox. (Utachiona uhu hunokonzeresa shingles hunokonzeresawo chhuku.)

Kana iwe wakambove nehukuku munguva yakapfuura, hutachiona hahubve mumuviri wako mushure mekupora kubva kuhutachiona. Pane kudaro, hutachiona "hunoenda kunorara" mumitsipa yako.

Hapana anoziva chaizvo kuti sei, asi hutachiona hunogona kumutsiridza kana "kumuka" nezvimwe zvinokonzeresa senge isina simba immune system. (Maitiro ezvirwere zvemuviri kudzivirira muviri kuzvirwere.)

Kurapa kwecancer senge Darzalex kunogona kunetesa immune system yako uye kumutsiridza hutachiona. Kana ichinge yamuka, inozviratidza semashanga pachinzvimbo chehuku.

Saka kana iwe uine shingles kana chickenpox, chiremba wako achapa mushonga weantiviral kudzivirira shingles kubva mukukudzirazve mumuviri wako. Iwe unozofanirwa kutora antiviral kurapwa mukati me1 vhiki yekutanga kutanga kutora Darzalex. Ipapo iwe unozoramba uchitora antiviral kwemwedzi mitatu mushure mekupedza kurapwa neDarzalex.

Kana iwe usina chokwadi kana wanga uine shingles kana chickenpox, taura nachiremba wako.

Darzalex inoporesa myeloma yakawanda here?

Parizvino, hapana mushonga weakawanda myeloma. Asi izvo zvinogona kuitwa naDarzalex kunatsiridza hunhu hwako uye hurefu hwehupenyu, zvinoenderana nekuongororwa kwako. Chiremba wako anogona kukuudza zvakawanda.

Darzalex matanho

Usati watora Darzalex, taura nachiremba wako nezve nhoroondo yako yehutano. Darzalex inogona kunge isingave yakakunakira iwe kana uine mamwe marapirwo kana zvimwe zvinhu zvinokanganisa hutano hwako. Izvi zvinosanganisira:

• Hepatitis B. Kana iwe ungave uine hepatitis B kana kuti wakambove nayo munguva yakapfuura, kutora Darzalex kunogona kukonzera kuti ive inoshanda zvakare. Usati watanga kutora Darzalex, chiremba wako achakutarisa hepatitis B. Vanozokuongororawo mushure mekupedza kurapwa kwako. Zviratidzo zvehepatitis B zvinosanganisira kuneta kunowedzera, uye yero yeruvara rweganda rako uye nechena kwemaziso ako. Kana iwe ukacherekedza izvi zviratidzo, udza chiremba wako.
• Shingles. Paunenge uchitora Darzalex, unogona kugadzira hutachiona hunonzi shingles. Utachiona hwakafanana hunokonzeresa shingles hunokonzeresawo chickenpox. Saka kana iwe wakambove nehukuku kana shingles munguva yakapfuura uye uri kutora Darzalex, chiremba wako anogona kukunyorera mushonga wehutachiona. Rudzi urwu rwemushonga runogona kubatsira kudzivirira shingles kubva mukukura mumuviri wako.
• Chirwere chisingaperi chinodzivirira pulmonary chirwere (COPD). Kana iwe uine nhoroondo yechirwere chekufema chinonzi chisingaperi obstructive pulmonary chirwere (COPD), udza chiremba wako usati watanga kutora Darzalex. Ivo vanogona kukupa iwe inhaler kuti ikubatsire iwe kufema nyore uye corticosteroids kubatsira kubatsira kudzora kuzvimba mumapapu ako.
• Kubata. Darzalex haisati yadzidzwa mumadzimai akazvitakura. Asi imhando yemushonga inogona kuyambuka rukuvhute. (Iyo placenta inhengo iri mukati medumbu rako inoendesa zvinovaka muviri kubva mumuviri wako kuenda kumwana wako.) Kuti uwane rumwe ruzivo, ndokumbira uone chikamu che "Darzalex nepamuviri" pamusoro.
• Kuyamwisa. Hazvizivikanwe kana zvakachengeteka kuyamwisa uchitora Darzalex. Kuti uwane rumwe ruzivo, ndapota ona chikamu che "Darzalex nekuyamwisa" pamusoro.

Udza mupi wako wezvehutano kana iwe ukavandudza chero eaya mamiriro panguva kana mushure mekurapwa naDarzalex.

Ongorora: Kuti uwane rumwe ruzivo nezve zvingangoitika zvakaipa zveDarzalex, ona iyo "Darzalex Side Mhedzisiro" chikamu chiri pamusoro.

Ruzivo rwehunyanzvi rweDarzalex

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Zviratidzo

Chikafu neDrug Administration (FDA) yakabvumidza uye yakaratidza Darzalex kuti ishandiswe:

• Mune vanhu vakuru vane ichangobva kuongororwa yakawanda myeloma isingakwanise kugamuchira iyo autologous stem cell yekuisa. (Iine autologous stem cell yekuisa, ako maseru masero anoshandiswa.) Mune ino mamiriro:
  • Darzalex inogona kushandiswa nemishonga lenalidomide (Revlimid) uye dexamethasone.
  • Darzalex inogona zvakare kushandiswa nemishonga bortezomib (Velcade), melphalan, uye prednisone.
• Mune vanhu vakuru vakagamuchira imwe kana kupfuura marapirwo apfuura ayo asina kushanda zvakanaka kana ane akawanda myeloma akadzoka. Mune ino mamiriro, Darzalex inoshandiswa nelenalidomide uye dexamethasone.
• Muvanhu vakuru vakagamuchira imwe kana kupfuura zvakapfuura akawanda myeloma kurapwa (s). Mune ino mamiriro, Darzalex inoshandiswa ne bortezomib uye dexamethasone.
• Muvanhu vakuru vakagamuchira maviri kana anopfuura apfuura marapirwo e myeloma aisanganisira lenalidomide uye proteasome inhibitor, iri mhando yemushonga. Mune ino mamiriro, Darzalex inoshandiswa nemishonga pomalidomide (Pomalyst) uye dexamethasone.
• Muvanhu vakuru vakagamuchira matatu kana kupfuura apfuura marapirwo eakawanda emyeloma ayo aisanganisira proteasome inhibitor uye mushonga wekudzivirira muviri. Mune ino mamiriro, Darzalex inoshandiswa yega.
• Muvanhu vakuru vakaedza proteasome inhibitor uye mushonga wekudzivirira muviri asi hapana mushonga wakashanda kune myeloma yakawanda. Mune ino mamiriro, Darzalex inoshandiswa yega.

Nzira yekuita

Darzalex inorwisa monoclonal antibody uye inodzivirira kana kuparadza bundu sero kukura kwemazhinji masero eemaeloma. Kana masero eplasma akashanduka kuita akawanda myeloma maseru, anokura huwandu hukuru hwemapuroteni epamusoro anonzi CD38. Darzalex inovavarira uye inonamira pachayo kune aya ma CD38 mapuroteni. Kubudikidza ne immune-mediated uye yakanangana ne-bundu zviito, Darzalex inodzivisa kukura kweakawanda myeloma cell uye inotanga maitiro eapoptosis (sero kufa).

Pharmacokinetics uye metabolism

Hapana makiriniki akakosha misiyano mu pharmacokinetics yeDarzalex se monotherapy kana seyakasanganiswa yekurapa yakaonekwa zvichibva pane vamwe vanhu.

Kutevera kumisikidzwa kweiyo inokurudzirwa dosi yeDarzalex chete kana seyakasangana yekurapa, kuwanda kweropa kweDarzalex kwaive kwakapetwa katatu kumusoro pakupera kweiyo vhiki dosing tichienzanisa neyokutanga dosi.

Kupatsanura muyero wekutanga weDarzalex kwakakonzera kuwanda kweropa kwakasiyana pane kana munhu akagamuchira dosi rekutanga rakazara. Nekudaro, misoro yakafanana uye zvidimbu zvekusunganidzwa kweropa zvakaonekwa uye zvakafanotaurwa mushure mekugamuchira wechipiri kupatsanura dhivhisi pavhiki 1, zuva 2 rekurapwa.

Apo Darzalex yakapihwa yega, yakadzikama yekumanikidzwa kweropa (mwero wakadzikama) yakasvikwa ingangoita mwedzi mishanu mune yega yega-yevhiki vhiki dosing nguva (neiyo 21 infusion). Panzvimbo yakadzikama, Darzalex inoreva kuwanda kwehuwandu hwehuwandu hwekumanikidzwa kweropa hwaive 1.6.

Kugoverwa:

• monotherapy: 4.7 ± 1.3 L
• mubatanidzwa kurapa: 4.4 ± 1.5 L

Hafu-yehupenyu kubviswa kwemonotherapy uye yekubatanidza kurapwa yaive 18 ± 9 mazuva. Kuchenesa kweDarzalex kwakadzikira nekuwedzera kwedosi uye neakawanda dosing. Kuchenesa kwaifungidzirwa kuve 171.4 ± 95.3 mL / zuva. Sezvo huremu hwemuviri huchiwedzera, huwandu hwekupararira uye chiyero chakabviswa Darzalex kubva mumuviri chakawedzera.

Contraindications

Darzalex inopesana nevarwere vane nhoroondo yeakakomba anaphylactic maitiro kune daratumumab kana chero yeanoburitsa fomula yemushonga. Zviitiko zvakakura zve neutropenia, thrombocytopenia, kana infusion reaction nekuda kwekurapa zvinogona kuda kuti Darzalex imiswe kana kumiswa zvachose.

Kuchengetedza

Darzalex inofanira kuchengetwa mufiriji pa36 ° F kusvika 46 ° F (2 ° C kusvika 8 ° C).

Usazunungusa kana kupisa Darzalex. Mushonga unofanirwa kuchengetedzwa kubva pachiedza. Darzalex haina chero zvinodzivirira.

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.