Gleevec (imatinib)

Zvemukati

• Chii chinonzi Gleevec?
• Zvazvinoita
• Kubudirira kweGleevec
• Gleevec generic
• Gleevec mhedzisiro
• Zvimwe zvakajairika mhedzisiro
• Yakakomba mhedzisiro
• Rutivi mhedzisiro mhedzisiro
• Zvikanganiso muvana
• Gleevec yeCML
• Kubudirira
• Kumwe kushandiswa kweGleevec
• Gleevec yeacute lymphocytic leukemia (ZVESE)
• Gleevec yemamwe marudzi ekenza yeropa
• Gleevec yekenza yeganda
• Gleevec yekenza yemudumbu
• Kunze-chitaridzi kunoshandisa Gleevec
• Gleevec yevana
• Gleevec mutengo
• Mari uye inishuwarenzi rubatsiro
• Gleevec chipimo chemushonga
• Mafomu emishonga uye simba
• Gleevec madhiri
• Chiremba wevana
• Ko kana ndikapotsa dosi?
• Ndichada here kushandisa mushonga uyu kwenguva refu?
• Dzimwe nzira dzeGleevec
• Dzimwe nzira dzeCML
• Dzimwe nzira dzeGIST
• Gleevec vs. Tasigna
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Gleevec vs. Sprycel
• Zvishandiso
• Mafomu emishonga uye manejimendi
• Side migumisiro uye njodzi
• Kubudirira
• Mariro
• Gleevec uye doro
• Gleevec kudyidzana
• Gleevec nemimwe mishonga
• Gleevec uye St. John's wort
• Gleevec uye grapefruit
• Maitiro ekutora Gleevec
• Nguva yekutora
• Kutora Gleevec nechikafu
• Inogona Gleevec kupwanywa, kupatsanurwa, kana kutsengwa here?
• Mashandiro anoita Gleevec
• Zve Ph + CML
• ZveGISITI
• Zvinotora nguva yakareba sei kuti zvishande?
• Gleevec uye nhumbu
• Gleevec uye kuyamwisa
• Gleevec ovhadhozi
• Ovhadhozi zviratidzo
• Zvekuita kana ovhadhozi
• Mibvunzo yakajairika nezveGleevec
• Gleevec iri mhando yekemotherapy here?
• Iko generic fomu yeGleevec inoshanda seiyo zita-zita zita mushonga?
• Ini ndinogona kukudziridza kuramba kurapwa naGleevec?
• Pane here zvirango zvekudya zvandinofanira kutevera ndichitora Gleevec?
• Ini ndichave nezviratidzo zvekuregera kana ndikamira kushandisa Gleevec?
• Ndichada here kushandisa mimwe mishonga naGleevec pakurapwa?
• Gleevec kupera, kuchengetedza, uye kurasa
• Kuchengetedza
• Kubvisa
• Ruzivo rwehunyanzvi rweGleevec
• Zviratidzo
• Nzira yekuita
• Pharmacokinetics uye metabolism
• Contraindications
• Kuchengeta nekubata

Chii chinonzi Gleevec?

Gleevec izita-zita mushonga mushonga. Inoshandiswa kurapa mamwe marudzi egomarara reropa muvakuru nevana. Gleevec inoshandiswawo kurapa mhando yegomarara reganda uye rudzi rwegomarara remudumbu.

Gleevec ine mushonga imatinib mesylate, inova yekirasi yemishonga inonzi tyrosine kinase inhibitors.

Gleevec inouya sehwendefa raunotora nemuromo. Iwe unotora mushonga kamwe kana kaviri pazuva, zvinoenderana nemuyero unorayirwa nachiremba wako.

Zvazvinoita

Chikafu neDrug Administration (FDA) yakabvumidza Gleevec kurapa mamwe marudzi egomarara reropa, kusanganisira:

• Philadelphia chromosome-positive (Ph +) chisingaperi myeloid leukemia (CML) muvakuru nevana
• Ph + acute lymphocytic leukemia (ZVESE) izvo zvadzokazve * kana kuramba * muvanhu vakuru
• achangobva kuongororwa Ph + ZVESE muvana
• myelodysplastic / myeloproliferative zvirwere (bone marrow cancer) mune vanhu vakuru vane platelet-yakatorwa kukura factor receptor (PDGFR) gene rearrangements
• hypereosinophilic syndrome kana chisingaperi eosinophilic leukemia muvanhu vakuru
• hasha systemic mastocytosis muvakuru vasina iyo D816v c-Kit mutation

Kenza yakadzokazve yadzoka mushure mekuregererwa, iko kudzikira kwezviratidzo zvekenza nezviratidzo. Kenza inokanganisa haina kupindura kune yapfuura kurapwa kenza.

Gleevec inobvumidzwawo kurapa:

• mhando yekenza yeganda inonzi dermatofibrosarcoma protuberans (DFSP) muvakuru
• rudzi rwegomarara remudumbu rinonzi Kit-Positive gastrointestinal stromal tumors (GIST) muvakuru

Kuti uwane rumwe ruzivo, ona zvikamu zve "Gleevec yeCML" uye "Zvimwe zvinoshandiswa zveGleevec."

Kubudirira kweGleevec

Gleevec yakawanikwa ichibudirira pakurapa mhando dzakasiyana dzekenza yeropa.

Mune imwe kiriniki yekudzidza, vakuru vane vachangobva kuongororwa CML muchikamu chisingaperi vakatora Gleevec kwemakore manomwe. Muboka iri, 96.6% yevanhu vakapindura zvakakwana kumushonga. Izvi zvinoreva kuti hapana masero ane gomarara akawanikwa muropa ravo, uye vanga vasina zviratidzo zvecancer.

Mhinduro yakazara imwe nzira yekutsanangudza mwero wekubudirira. Muboka revanhu vakagamuchira chemotherapy, 56.6% vakapindura zvakakwana.

Gleevec yakawanikwa zvakare ichibudirira pakurapa utumbo stromal tumors (GIST) muzvidzidzo zvekiriniki. Huwandu hwese hwekupona hwaive makore angangoita mana. Izvi zvinoreva kuti hafu yevanhu vari muchidzidzo vakararama makore angangoita mana mushure mekunge vatanga kutora Gleevec. Vanhu vakatora Gleevec mushure mekuvhiyiwa vakararama makore angangoita mashanu mushure mekutanga mushonga.

Kuti udzidze kuti Gleevec inoshanda sei pakurapa mamwe marudzi ekenza, ona iyo "Zvimwe zvinoshandiswa zveGleevec" chikamu.

Gleevec generic

Gleevec inowanikwa sezita-zita mushonga uye seyakajairika fomu.

Gleevec ine chinhu chinoshanda chinodhaka imatinib mesylate.

Gleevec mhedzisiro

Gleevec inogona kukonzera manyoro kana zvakakomba mhedzisiro. Aya anotevera mazita ane zvimwe zvakakosha mhedzisiro mhedzisiro inogona kuitika uchitora Gleevec. Aya mazita haabatanidzi zvese zvinokanganisa mhedzisiro.

Kuti uwane rumwe ruzivo nezve zvinogona kuitika mhedzisiro yeGleevec, taura nachiremba wako kana wemishonga. Ivo vanogona kukupa iwe matipi ekuti ungatarise sei nechero mhedzisiro mhedzisiro inogona kunetsa.

Zvimwe zvakajairika mhedzisiro

Iyo yakajairika mhedzisiro mhedzisiro yeGleevec inogona kusanganisira:

• manyoka
• kurwadziwa mudumbu
• kuneta (kushaya simba)
• edema (kuzvimba, kazhinji mumakumbo ako, makumbo, kana tsoka uye kutenderedza maziso ako)
• tsandanyama kana kurwadziwa
• kusvotwa
• kurutsa
• mapundu

Mazhinji emhedzisiro iyi anogona kuenda mukati memazuva mashoma kana mavhiki mashoma. Kana vakanyanya kuoma kana kuti vasingaendi, taura nachiremba wako kana wemishonga.

Yakakomba mhedzisiro

Matambudziko akakomba kubva kuGleevec haana kujairika, asi anogona kuitika. Fonera chiremba wako ipapo kana uine zvakakomba mhedzisiro. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Yakanyanya mhedzisiro mhedzisiro uye zviratidzo zvavo zvinogona kusanganisira zvinotevera:

• Kuchengetedza kwakanyanya kwemvura (yakawandisa mvura kana mvura) mukati uye nemukati memwoyo wako, mapapu (pleural effusion), uye dumbu (ascites). Zviratidzo zvinogona kusanganisira:
  • zvisingatarisirwi, kukurumidza kuwedzera uremu
  • kurwadziwa pachipfuva
  • mweya wekufema
  • kunetseka kutora kufema kwakadzika
  • kunetseka kufema kana iwe ukarara pasi
  • chikosoro chakaoma
  • dumbu rakazvimba
• Zvinetso zveropa, zvinosanganisira kupererwa neropa (mashoma masero matsvuku eropa), neutropenia (yakaderera masero eropa chena), uye thrombocytopenia (mashoma masero emaplatelet) Zviratidzo zvinogona kusanganisira:
  • kuneta (kushaya simba)
  • kukurumidza kurova kwemoyo
  • mweya wekufema
  • kazhinji hutachiona
  • fivha
  • kukuvadza zviri nyore
  • maronda anobuda ropa
  • ropa mune weti kana chigaro
• Kuunganidzwa kwemoyo kukundikana uye mamwe matambudziko emoyo, senge kuruboshwe-kuruboshwe moyo kutadza. Zviratidzo zvinogona kusanganisira:
  • zvisingatarisirwi kuwedzera uremu
  • edema (kuzvimba kwetsoka dzako, makumbo, uye makumbo)
  • kurova kwemoyo zvisina kujairika kana mutinhimira (kurova kwemoyo kuchikurumidza, kunonoka, kana kusajairika)
  • kurwadziwa pachipfuva
  • mweya wekufema
• Kukuvara kwechiropa kana kutadza kwechiropa. Zviratidzo zvinogona kusanganisira:
  • kusvotwa
  • manyoka
  • kurasikirwa nenzara
  • ganda rinonhuwa
  • jaundice (yero yeruvara rweganda rako uye akachena emeso ako)
  • edema (kuzvimba kwemakumbo ako, makumbo, uye tsoka)
  • ascites (fluid buildup mudumbu rako)
  • kupwanya kazhinji
  • kubuda ropa kazhinji
• Kubuda ropa kwakanyanya (kubuda ropa kusingamire), kazhinji mumatumbu ako. Zviratidzo zvinogona kusanganisira:
  • ropa muzvigaro
  • nhema kana chekugara chigaro
  • kuneta (kushaya simba)
  • kukosora ropa
  • kukosora sludge nhema
  • kusvotwa
  • kurwadziwa nemudumbu
• Matambudziko emudumbu, kusanganisira kupetwa (misodzi) mudumbu kana mumatumbu. Zviratidzo zvinogona kusanganisira:
  • kusvotwa
  • kurutsa
  • kurwadziwa kwakanyanya mudumbu rako
  • kupindwa nechando
  • mweya wekufema
  • kukurumidza kurova kwemoyo
• Zvinetso zvakakomba zveganda. Zviratidzo zvinogona kusanganisira:
  • erythema multiforme (zvigamba zvitsvuku kana blister, kazhinji pazvitsoka zvetsoka dzako kana zvanza zvemaoko ako)
  • Stevens-Johnson syndrome (fever; maronda anorwadza pamuromo wako, pahuro, maziso, sikarudzi, kana muviri wese)
  • kupindwa nechando
  • muviri kurwadza
• Hypothyroidism (yakaderera thyroid ngazi) muvanhu vakabviswa utachiona uye vari kutora utachiona kutsiva mishonga. Zviratidzo zvinogona kusanganisira:
  • kuneta (kushaya simba)
  • kuvimbiswa
  • kuora mwoyo
  • kunzwa kutonhora
  • ganda rakaoma
  • kurema kuwedzera
  • matambudziko ekurangarira
• Kunonoka kukura muvana. Zviratidzo zvinogona kusanganisira:
  • isingakure pamwero wakajairika
  • kukura kudiki pane vamwe vana vezera ravo
• Tumor lysis syndrome (apo maseru emukenza anoburitsa makemikari anokuvadza muropa rako). Zviratidzo zvinogona kusanganisira:
  • kuneta (kushaya simba)
  • kusvotwa
  • kurutsa
  • manyoka
  • tsandanyama
  • isina kujairika moyo mutinhimira (kurova kwehana kuchikurumidza, kunonoka, kana kusarongeka)
  • pfari
• Itsvo kukuvara. Zviratidzo zvinogona kusanganisira:
  • kuita weti zvishoma nezvishoma kupfuura zvakajairwa
  • edema (kuzvimba kwemakumbo ako, makumbo, uye tsoka)
  • kuneta (kushaya simba)
  • kusvotwa
  • kuvhiringidzika
  • BP
• Zvimwe zvinokonzeresa izvo zvinogona kukonzeresa tsaona dzemotokari. Zviratidzo zvinogona kusanganisira:
  • dzungu
  • hope
  • kusaona zvakanaka

Rutivi mhedzisiro mhedzisiro

Iwe unogona kushamisika kuti kangani mamwe maratidziro anoitika nemushonga uyu, kana kuti kana mamwe maratidziro ane chekuita nezvawo.Heano mamwe marondedzero pane akati wandei emhedzisiro mhedzisiro iyi mishonga inogona kana isingakonzere.

Allergic reaction

Sezvazvakaita nemishonga yakawanda, vamwe vanhu vanogona kusangana nehuswa mushure mekutora Gleevec. Zviratidzo zvehunhu husina kugadzikana hunogona kusanganisira:

• kuputika kweganda
• kuvava
• kuburitsa (kudziya uye kutsvuka mukati meganda rako)

Imwe yakanyanya kukonzeresa kusagadzikana isingawanzo asi inogoneka. Zviratidzo zveakanyanya kusagadzikana maitiro zvinogona kusanganisira:

• angioedema (kuzvimba pasi peganda rako, kazhinji mumaziso ako, miromo, maoko, kana tsoka)
• kuzvimba kwerurimi rwako, muromo, kana huro
• kunetseka kufema

Fonera chiremba wako ipapo kana iwe uine chirwere chakakomba chega chega kuGleevec. Fonera 911 kana zviratidzo zvako zvichinzwa kutyisidzira hupenyu kana kana iwe uchifunga kuti une chirwere chekukurumidzira.

Yakareba-nguva mhedzisiro

Mimwe yemhedzisiro inoonekwa muzvidzidzo zvekiriniki inogona kuitika nekushandisa kwenguva refu kweGleevec. Izvi zvinosanganisira matambudziko emoyo, akadai seye congestive moyo kutadza uye kuruboshwe-kuruboshwe moyo kutadza.

Mune kiriniki yekudzidza, vanhu vanopfuura mazana mashanu vakatora Gleevec yechirwere chemyeloid leukemia (CML) vakateverwa kwemakore anosvika gumi nerimwe. Vanhu vari muchidzidzo chenguva yakareba-vakave nezvakawanda zvakafanana mhedzisiro mhedzisiro iyo yakataurwa muzvidzidzo zvipfupi. Nekudaro, iyi mhedzisiro mhedzisiro yaiita kunge inovandudzika nekufamba kwenguva.

Yakakomba mhedzisiro mhedzisiro inoonekwa nekureba-kwenguva refu kushandisa inosanganisira:

• kukanganiswa kwakanyanya kweropa (yakaderera masero matsvuku eropa, machena masero eropa, kana maplatelet) muvanhu vatanhatu
• matambudziko emwoyo, kusanganisira congestive moyo kutadza, muvanhu vanomwe
• zviitiko zvitanhatu zvekenza nyowani, kusanganisira akawanda myeloma mune mumwe munhu uye colon kenza mune mumwe munhu

Zvimwe zvinokanganisa zvaiwanzoitika mukati megore rekutanga rekurapwa naGleevec. Asi iyo yakareba iyo vanhu vakatora Gleevec, iko kushomeka kwavakave nezvakawanda zveiyi mhedzisiro. Semuenzaniso, mugore rekutanga rechidzidzo, vanhu vatatu vaive nedambudziko rakakura reropa, asi mushure megore rechishanu, munhu mumwe chete ndiye akabatwa.

Mune chidzidzo chemakore mashanu chevanhu vane huturu hwemudumbu (GIST), 16% yevanhu vakamira kutora Gleevec nekuda kwemhedzisiro. Iyo mhedzisiro mhedzisiro yaive yakafanana neiya inotsanangurwa muchirongwa cheCML pamusoro. Makumi mana muzana yevanhu vari muchidzidzo vakatemerwa madosi epasi emushonga kurerutsa mhedzisiro yavo.

Kana iwe uine hanya nezve zvinogona kuitika kwenguva refu-mhedzisiro mhedzisiro yeGleevec, taura nachiremba wako. Vanogona kuratidza nzira dzekudzora njodzi dzako kune mamwe maratidziro.

Mhedzisiro inoenderana nemeso

Muzvidzidzo zvekiriniki zveGleevec, vamwe vanhu vaive nemhedzisiro-inoenderana nemhedzisiro sekuzvimba uye kuona kwakasviba.

Kuvhiringidzika kweziso uye kuzvimba kwakatenderedza maziso ndiwo mamwe emhedzisiro. Kusvika pa74.2% yevanhu vakatora Gleevec vaive neperiorbital edema (kuzvimba kwenzvimbo yeziso).

Kana iwe uine iyi divi mhedzisiro, chiremba wako anogona kunyorera diuretic (inowanzo kunzi piritsi remvura). Diuretics inobatsira muviri wako kubvisa imwe mvura uye munyu kana iwe uchiita weti. Izvi zvinorerutsa kuyerera kwemvura. Chiremba wako anogona zvakare kudzikisa dhizaini yako yeGleevec, kana zvichidikanwa.

Pamusoro pezvo, zvidzidzo zvemakiriniki zvakashuma kuti vanosvika 11.1% yevanhu vakatora Gleevec vaive nemaonero asina kujeka. Kana iwe uine kuona kwakashata, usatyaire kana kushandisa michina inorema. Uye iva nechokwadi chekuudza chiremba wako kuti haugone kuona zvakajeka.

Mimwe mhedzisiro isingawanzoenderana nemhedzisiro inosanganisirwa:

• ziso rakaoma
• maziso emvura
• kutsamwa kweziso
• conjunctivitis (inowanzozonzi pink ziso)
• mitsipa yeropa yakatyoka muziso
• kuzvimba kweiyo retina (rukoko rwechitunha kuseri kweziso rako)

Kana iwe uri kutora Gleevec uye uine chero ane chekuita nemeso-ane hukama mhedzisiro, taura nachiremba wako. Vanogona kuratidza nzira dzekurerutsa zviratidzo zvako.

Bvudzi kurasikirwa

Bvudzi kurasikirwa (alopecia) ingangoita mhedzisiro mhedzisiro yekutora Gleevec.

Imwe ongororo yakaedza mashandiro anoita Gleevec muvanhu vane Philadelphia chromosome-positive (Ph +) chronic myeloid leukemia (CML). Vanomwe muzana muzana yevanhu ava vakarasikirwa nevhudzi mushure mekunge vatora mushonga.

Mune kumwe kuongorora, vanhu vakatora Gleevec kurapa matumbo emimba stromal tumarara (GIST). Pakati pe11,9% uye 14.8% yevanhu ava vakarasikirwa nevhudzi. Iyi divi mhedzisiro yaionekwa kazhinji muvanhu vakatora madosi epamusoro eGleevec.

Bvudzi kurasikirwa nekuda kwekenza kurapwa kazhinji ndekwenguva pfupi. Kana iwe uine hanya nezve iyi divi mhedzisiro, taura nachiremba wako. Vanogona kupa mazano ekukubatsira kudzikisa kurasikirwa kwebvudzi panguva yekurapa kwako.

Rash uye zvimwe zvinokanganisa ganda

Gleevec inogona kukonzera zvinyoro uye zvakakomba mhedzisiro paganda rako.

Zvimwe zvakajairika kuita kweganda

Rashes uye kumwe kugadzikana kweganda kunoitika zvakanyanya muvanhu vanotora Gleevec.

Mune zvidzidzo zvemakiriniki, vanhu vakatora Gleevec kurapa Ph + chisingaperi myeloid leukemia (CML). Kusvika pa40.1% yevanhu ava vaive nehuswa kana kumwe kugadzirwa kweganda mushure mekutora mushonga.

Mune zvimwe zvidzidzo zvemakiriniki, vanhu vakatora Gleevec yezvironda zvemudumbu (GIST). Mushure mekutora mushonga uyu, vanosvika makumi masere nepfumbamwe kubva muzana pavanhu ava vaive nehuswa kana kumwe kugadzirwa kweganda. Izvi zvaisanganisira:

• kubvisa ganda
• ganda rakaoma
• kugadzirwa kweganda (bhuruu tint kune ganda)
• hutachiona hwevhudzi follicles (masaga pasi peganda rako anobata midzi yebvudzi rako)
• erythema (kutsvuka kweganda)
• purpura (mavara epepuru-paganda)

Iyi mhedzisiro yaive yakajairika muvanhu vakatora yakakwira madosi eGleevec.

Kana iwe uine hanya nezvekuputika kana kumwe kugadzikana kweganda nekuda kweGleevec, taura nachiremba wako. Vanogona kuratidza nzira dzekubatsira kudzikisira zviratidzo zvako.

Kuita kwakakomba kweganda

Mune zvidzidzo zvemakiriniki, kukomba kwakakomba kweganda kwaive kusingawanzoitika kune vanhu vakatora Gleevec. Kusvika pa1% yevanhu vakatora mushonga uyu vaive neakakomba ganda maitiro. Mienzaniso yezvakakomba zvine chekuita nezvinodhaka zvine chekuita nezvinodhaka zvinosanganisira:

• Stevens-Johnson syndrome (fever; maronda anorwadza pamuromo wako, pahuro, maziso, sikarudzi, kana muviri wese)
• exfoliative dermatitis (ganda rinotarisa pamusoro pezvikamu zvikuru zvemuviri wako)
• vesicular mapundu (madiki mablisters uye mapundu)

Rashes uye blisters zvinogona kurwadza kwazvo. Uye kana vasina kurapwa, vanogona kuteya hutachiona uye kutungamira kuzvirwere zvakakomba. Saka kana iwe uri kutora Gleevec uye uine mapundu kana mablister ane fivha kana iwe usinganzwe zvakanaka, udza chiremba wako ipapo ipapo. Uyezve taura chero kumwe kugadzirwa kweganda kwauinako.

Zvimwe zvinokanganisa kukanganisa kutyaira

Mune zvidzidzo zvemakiriniki, vamwe vanhu vakatora Gleevec vakave nemhedzisiro inogona kukanganisa kugona kwavo kutyaira. Izvi zvaisanganisira:

• dzungu: inosvika pa19.4% yevanhu
• kuona kwakashata: in kusvika pa11.1% yevanhu
• kuneta: mu74.9% yevanhu

Iyi mhedzisiro inogona kukanganisa kugona kwako kutyaira kana kushandisa michina inorema. Pakave nemishumo yetsaona dzemotokari nevanhu vakatora Gleevec. Saka iwe unofanirwa kushandisa chenjera pakutyaira kana kushandisa michina uchitora Gleevec.

Kunonoka kupora kwemaronda (kwete mhedzisiro)

Kupora kwakapora kwemaronda hakuna kutaurwa muzvidzidzo zvekiriniki zveGleevec.

Dzimwe mhando dzekenza kurapwa, senge radiation uye chemotherapy, inogona kunetesa immune system yako. Izvi zvinogona kuita kuti maronda apore zvishoma nezvishoma.

Kana iwe uine hanya nezve kunonoka kupora kwemaronda, bvunza chiremba wako kana iwe uine njodzi yakakwira yedambudziko iri zvichienderana nehutano hwako.

Kenza yechiropa (inogona kunge isiri mhedzisiro)

Gomarara rechiropa harina kutaurwa semhedzisiro mhedzisiro muzvidzidzo zvekiriniki zveGleevec. Nekudaro, kukuvara kwechiropa kwakaitika mune ese mapfupi- uye marefu-marefu kushandisa kweGleevec. Zvimwe zviitiko zvekukuvara kwechiropa zvakakonzera kukundikana kwechiropa uye kuisirwa chiropa.

Kukuvara kwechiropa kunowanzo kuwanikwa apo vanachiremba vanoongorora enzymes (mapuroteni akakosha) ayo anogadzirwa muchiropa. Mazinga enzyme akakwirira kupfuura akajairwa anogona kuve chiratidzo chekukuvara kwechiropa.

Zvimwe zviratidzo zvemuviri zvekukuvara kwechiropa zvinosanganisira:

• kusvotwa
• manyoka
• kurasikirwa nenzara
• ganda rinonhuwa
• jaundice (yero yeruvara rweganda rako uye nevachena vemeso)
• edema (kuzvimba kwemakumbo ako, makumbo, uye tsoka)
• ascites (fluid buildup mudumbu rako)
• kupwanya kazhinji
• kubuda ropa kazhinji

Munguva yezvidzidzo zvemakiriniki, vanosvika mashanu muzana yevanhu vane chirwere chisingaperi chemyeloid leukemia (CML) vaive nemazinga enzyme eropa zvakanyanya panguva yekurapa kwaGleevec. Kusvika pa6,8% yevanhu vane dumbu remudumbu stromal tumors (GIST) vaive nehuremu hwakanyanya hwechiropa enzyme panguva yekurapwa. Uye kusvika pa0,1% yevanhu vakatora Gleevec vaive nechiropa chakundikana.

Paunenge uchitora Gleevec, chiremba wako anoongorora mashandiro anoita chiropa chako. Kana iwe uine zviratidzo zvekukuvara kwechiropa paunenge uchitora Gleevec, chiremba wako anogona kudzora dosi yako. Izvi zvinogona kudzivirira kukuvara uko kunogona kutungamira kuchiropa kutadza.

Zvikanganiso muvana

Vana muzvidzidzo zvemakiriniki vakatora Gleevec vaive nemhedzisiro yaive yakafanana neiya yevakuru. Asi vaongorori vakawana izvi zvakasiyana:

• vana vashoma vaive nemhasuru kana kurwadziwa kwepfupa kupfuura vanhu vakuru
• edema (kuzvimba kwemakumbo, makumbo, tsoka, nenzvimbo yakatenderedza maziso) haina kutaurwa muvana

Mhedzisiro inowanzozivikanwa inotaurwa muvana yaive yekuda kusvotwa uye kurutsa. Iwo akanyanya kuzivikanwa mhedzisiro mhedzisiro aive akaderera masero eropa chena uye maplatelet.

Kana mwana wako aine izvi mhedzisiro, taura nachiremba wemwana wako nezvenzira dzekuzvibata.

Gleevec yeCML

Chikafu neDrug Administration (FDA) yakabvumidza Gleevec kune vamwe vanhu vane Philadelphia chromosome-positive (Ph +) chisingaperi myeloid leukemia (CML). Chromosome yePhiladelphia chromosome nhamba makumi maviri nemasere ine hurema. Vanhu vane Ph + CML vane imwe shanduko muDNA yavo inokonzeresa machena machena eropa kuti aumbe.

CML yakakamurwa muzvikamu zvitatu:

• Chikamu chisingaperi. Ichi chikamu chekutanga cheCML. Vanhu vazhinji vanoonekwa kuti vane CML panguva yechikamu chisingaperi. Zviratidzo zvinowanzo nyoro, kana zviripo zvachose.
• Yakawedzera chikamu. Muchikamu chino chechipiri, huwandu hwekenza maseru muropa rako unowedzera. Iwe unogona kunge uine zvimwe zviratidzo, senge fivha uye kuonda.
• Blast dambudziko danho. Muchikamu chino chemberi, maseru egomarara muropa rako apararira kune dzimwe nhengo uye nyama. Zviratidzo zvako zvinogona kunyanyisa.

Gleevec inobvumidzwa kurapa ichangobva kuongororwa Ph + CML muchikamu chisingaperi muvanhu veese mazera.

Inotenderwawo kurapa Ph + CML muchikamu chisingaperi, chakakurumidza, kana chekuputika kune vanhu vasina kurapwa kurapwa neinterferon-alpha therapy. Interferon-alpha mushonga waishandiswa kakawanda munguva yakapfuura kurapa CML. Yakatsiviwa nemishonga yakadai saGleevec iyo yakaratidzirwa kuve inoshanda.

Kubudirira

Mune makore manomwe emakiriniki ekudzidza, mwero wekupona wevakuru wakatora Gleevec yeiyo ichangobva kuongororwa Ph + CML yaive 86.4%. Izvi zvinoreva kuti 86.4% yevakuru vakapona kwemakore manomwe mushure mekunge vatanga kutora Gleevec. Izvi zvakafananidzwa ne83.3% yevanhu vakatora chemotherapy mishonga yakajairwa.

Muchidzidzo chemakiriniki, vanhu vakamboedza interferon-alpha yeCML vakatora Gleevec. Vamwe vevanhu ava vakapindura zvakakwana kurapa kwaGleevec. Izvi zvinoreva kuti hapana masero ane gomarara akawanikwa muropa ravo, uye vanga vasina zviratidzo zvecancer. Heano vanhu vangani vane CML vane mhinduro yakazara pakutora Gleevec:

• 95% yevanhu vari muchikamu chisingaperi
• 38% yevanhu vari muchikamu chinokurumidza
• 7% yevanhu vari muchikamu chekuputika dambudziko

Chidzidzo chekiriniki chaisanganisira vana vane Ph + CML muchikamu chisingaperi. Muboka rakatora Gleevec, 78% yevana vaive nemhinduro yakakwana kumushonga.

Kumwe kushandiswa kweGleevec

Mukuwedzera isingagumi myeloid leukemia (ona pamusoro), Chikafu neDrug Administration (FDA) yakabvumidza Gleevec kurapa mamwe akati wandei mamiriro.

Gleevec yeacute lymphocytic leukemia (ZVESE)

Gleevec is FDA-inogamuchirwa kurapa:

• Philadelphia chromosome-positive (Ph +) acute lymphocytic leukemia (ZVESE) izvo zvadzokazve * kana kukanganisa * muvakuru
• ichangobva kuongororwa Ph + Yese muvana painoshandiswa nekemotherapy

Kenza yakadzokazve yadzoka mushure mekuregererwa, iko kudzikira kwezviratidzo zvekenza nezviratidzo. Kenza inokanganisa haina kupindura kune yapfuura kurapwa kenza.

Muchidzidzo chemakiriniki, 19% yevakuru vakadzokazve kana kusagadzikana VOSE vakatora Gleevec vaive nemhinduro yakakwana muropa ravo pakurapwa. Izvi zvinoreva kuti vanga vasina zviratidzo zvecancer.

Chidzidzo chekiriniki chakatarisawo vana vane VOSE vakatora Gleevec uye vakave nekemotherapy. Kune 70% yevana, gomarara ravo harina kunyanya kukura kwemakore mana.

Gleevec yemamwe marudzi ekenza yeropa

Gleevec is FDA-inogamuchirwa kurapa mamwe marudzi ekenza yeropa, kusanganisira:

• Myelodysplastic / myeloproliferative zvirwere (bone marrow cancer) mune vanhu vakuru vane platelet-yakatorwa kukura factor receptor (PDGFR) gene rearrangements. Muchidzidzo chidiki chemakiriniki, makumi mashanu muzana yevanhu vakabatwa naGleevec vaive nemhinduro yakakwana muropa ravo pakurapwa. Izvi zvinoreva kuti hapana masero ekenza akawanikwa muropa ravo, uye vanga vasina zviratidzo zvecancer.
• Hypereosinophilic syndrome uye / kana chisingaperi eosinophilic leukemia muvanhu vakuru, kusanganisira vanhu vane FIP1L1-PDGFRcy fusion kinase. Muzvidzidzo zvidiki zvemakiriniki, zana muzana revanhu vane PDGFR gene mutation vakatora Gleevec vakapindura zvakakwana muropa ravo pakurapwa. Pakati pe21% ne58% yevanhu vasina gene gene mutation kana vane chinzvimbo chisingazivikanwe chekuchinja vakatora Gleevec vaive nemhinduro yakakwana muropa ravo.
• Aggressive systemic mastocytosis muvakuru vasina iyo D816v c-Kit mutation. Muchidzidzo chidiki chemakiriniki, 100% yevanhu vane FIP1L1-PDGFRcy fusion kinase mutation avo vaibatwa naGleevec vaive nemhinduro yakakwana pakurapwa.

Gleevec yekenza yeganda

Gleevec iri FDA-inogamuchirwa kurapa dermatofibrosarcoma protuberans, iri isingawanzo mhando yekenza yeganda, muvanhu vakuru. Inotenderwa kune vanhu vane cancer.

• haigoni kuvhiyiwa
• adzoka mushure mekurapwa
• metastatic (yakapararira kune zvimwe zvikamu zvemuviri)

Chiverengero chidiki chevanhu vakarapwa naGleevec kwechiitiko ichi muzvidzidzo zvekiriniki. Pakati peavo vanhu vakatora Gleevec, 39% yaive nemhinduro yakakwana pakurapwa. Izvi zvinoreva kuti biopsy yeganda (kubvisa uye kuyedza kamuenzaniso keganda) hakuna kuratidza zviratidzo zvegomarara.

Gleevec yekenza yemudumbu

Gleevec is FDA-approved to treat Kit-positive gastrointestinal stromal tumors (GIST) muvakuru isingakwanise kuvhiyiwa kana metastatic (yakapararira kune zvimwe zvikamu zvemuviri). Gleevec inobvumidzwawo kurapa GIST muvakuru vakambovhiyiwa kubvisa mamota. Iyi nzira yekurapa (adjuvant kurapwa) inoshandiswa kudzivirira cancer kuti isadzoke mushure mekuvhiyiwa.

Mune zvidzidzo zvemakiriniki, vanhu vane GIST iyo isingakwanise kuvhiyiwa vakabvisa vakatora mazana mana kana mazana masere emamiriyoni eGleevec. Vakapona kweanenge makore mana.

Vamwe vanhu vane GIST vakavhiyiwa. Pakati pemazuva gumi nemana nemakumi manomwe gare gare, vakatanga kutora Gleevec muchidzidzo. Ivo vaive neinenge 60% yakaderera njodzi yekufa kana kuve nekenza kudzoka mukati memwedzi gumi nemaviri. Izvi zvakafananidzwa nevanhu vakatora placebo (kurapwa pasina mushonga unoshanda).

Kunze-chitaridzi kunoshandisa Gleevec

Pamusoro pekushandisa kwakanyorwa pamusoro, Gleevec inogona kushandiswa kure-chitaridzi kune zvimwe zvinoshandiswa. Kunze-chitambi kushandiswa kwemishonga ndiko apo mushonga unobvumidzwa kushandiswa kumwechete unorayirwa kune imwe isingatenderwe.

Gleevec inogona kushandiswa kure-kunyorerwa mamwe makenza, kusanganisira:

• kenza yeprostate, sekureva kwechidzidzo cha2015
• melanoma, maererano neNational Comprehensive Cancer Network nhungamiro yekurapa
• Type 1 chirwere cheshuga, zvinoenderana nechirwere chekiriniki che2018

Nekudaro, hapana yakawanda tsvagiridzo yekuti Gleevec anoshanda sei muvanhu vane aya mamiriro. Zvimwe zvidzidzo zvinodiwa kuti uone kana Gleevec inobatsira kurapa mamiriro ese.

Gleevec yevana

Gleevec FDA-inogamuchirwa senzira yekurapa kwevana vane inotevera mamiriro:

• ichangobva kuongororwa Philadelphia-positive (Ph +) chisingaperi myeloid leukemia (CML) muchikamu chisingaperi (chikamu chekutanga chechirwere)
• ichangobva kuongororwa Ph + acute lymphocytic leukemia (ZVESE) painoshandiswa nekemotherapy

Gleevec inogamuchirwa kuti ishandiswe muvana veese mazera. Nekudaro, hapana kunge kwave nezvidzidzo zvekuti Gleevec yakachengeteka kana inoshanda sei mune vana vadiki pane zera rimwe gore.

Gleevec mutengo

Sezvo nemishonga yese, mutengo weGleevec unogona kusiyana.

Mutengo chaiwo wauchabhadhara unoenderana neinishuwarenzi yako yekuvhara uye pharmacy yaunoshandisa.

Mari uye inishuwarenzi rubatsiro

Kana iwe uchida rutsigiro rwemari yekubhadhara Gleevec, kana kana iwe uchida rubatsiro kuti unzwisise yako inishuwarenzi kufukidzwa, rubatsiro rwuripo.

Novartis Pharmaceutical Corporation, iyo inogadzira Gleevec, inopa chirongwa chinonzi Novartis Oncology Universal Co-pay Chirongwa. Kuti uwane rumwe ruzivo uye kuti uzive kana iwe uchikodzera rutsigiro, fona 877-577-7756 kana shanyira iyo webhusaiti chirongwa.

Gleevec chipimo chemushonga

Iyo Gleevec muyero unorayirwa nachiremba wako inoenderana nezvakawanda zvinhu. Izvi zvinosanganisira:

• mhando uye kuomarara kwechimiro chauri kushandisa Gleevec kurapa
• zera
• uremu (hwevana)
• kuvapo kwekuchinja kwemajini
• mamwe marapirwo aungave uine
• imwe mishonga yaungatora
• mhedzisiro yaungave uine

Muyero waunogamuchira unoenderana nekenza yako. Kune mamwe kanzira, chiremba wako anogona kutanga iwe pane yakaderera dosi. Ipapo vanozozvigadzirisa nekufamba kwenguva kuti vasvike padosi yakakukodzera.

Ruzivo runotevera runotsanangura madosi ayo anowanzo shandiswa kana kukurudzirwa. Zvisinei, iva nechokwadi chekutora muyero uyo chiremba wako anokuraira iwe. Chiremba wako achasarudza yakanakisa dosi kuti ienderane nezvaunoda.

Mafomu emishonga uye simba

Gleevec inouya sehwendefa raunotora nemuromo (unoimedza). Inowanikwa mumapiritsi e100-mg uye 400-mg mahwendefa.

Iwo 100-mg uye 400-mg mapiritsi anouya mumabhodhoro. Mahwendefa e400-mg anouyawo mumablister pack akaomesera vana kuvhura.

Gleevec madhiri

Aya anotevera madhizaini akajairwa ekutanga madheji kune yega mamiriro.

• Vakuru vane Philadelphia-positive (Ph +) chisingaperi myeloid leukemia (CML) muchikamu chisingaperi (chikamu chekutanga chechirwere): 400 mg / zuva
• Vakuru vane Ph + CML muchikamu chinokurumidza kana chekuputika dambudziko (yechipiri neyechitatu zvikamu zvechirwere): 600 mg / zuva
• vanhu vakuru vane Ph + acute lymphocytic leukemia (ZVESE): 600 mg / zuva
• vanhu vakuru vane myelodysplastic / chirwere chemyeloproliferative: 400 mg / zuva
• vanhu vakuru vane hasha systemic mastocytosis: 100 mg kana 400 mg / zuva
• vanhu vakuru vane hypereosinophilic syndrome uye / kana chisingaperi eosinophilic leukemia: 100 mg / zuva kana 400 mg / zuva
• Vakuru vane dermatofibrosarcoma protuberans: 800 mg / zuva
• vakuru vane gastrointestinal stromal tumors (GIST): 400 mg / zuva

Chiremba wako anogona kukunyorera dosi yakasiyana. Vanozoiisa pamusoro pekuti muviri wako unopindura sei kune mushonga, kuti wakanyanya sei wako mhedzisiro, uye zvimwe zvinhu. Kana iwe uine mibvunzo nezve iyo chaiyo dosi yeGleevec yako, taura nachiremba wako.

Chiremba wevana

Dosi dzevana ndidzo dzinotevera:

• vana vane Ph + CML muchikamu chisingaperi (chikamu chekutanga chechirwere): 340 mg / m2 / zuva
• vana vane Ph + VOSE: 340 mg / m2 / zuva rinofanira kutorwa nekemotherapy

Chiremba wemwana wako anozoisa muyero pakureba uye uremu hwemwana wako. (Saka 340 mg / m2 zvinoreva 340 mg pasikweya mita imwe yenzvimbo yemuviri.) Semuenzaniso, kana mwana wako akareba mamita mana uye achirema 49 lbs., Nzvimbo yavo yemuviri iri pamusoro pe0.87 m2. Saka muyero weP Ph + CML unenge uri 300 mg.

Ko kana ndikapotsa dosi?

Kana iwe ukarasikirwa neiyo dose yeGleevec, tora imwe nekukurumidza iwe pauchayeuka. Kana ingangoita nguva yedosi yako inotevera, mira utore iyo inotevera dosi sezvakarongwa. Usatore madosi maviri kuti uwane iyo yakarasika dose. Izvi zvinogona kuwedzera njodzi yako kune zvakakomba mhedzisiro.

Ndichada here kushandisa mushonga uyu kwenguva refu?

Gleevec inofanirwa kushandiswa seyakareba kurapwa. Kana iwe nachiremba wako mukaona kuti Gleevec yakachengeteka uye inoshanda kwauri, unogona kuitora kwenguva refu.

Dzimwe nzira dzeGleevec

Mimwe mishonga iripo inogona kurapa mamiriro ako. Zvimwe zvinogona kunge zvakakukodzera iwe kupfuura vamwe. Kana iwe uchifarira kutsvaga imwe nzira kuna Gleevec, taura nachiremba wako kuti udzidze zvimwe nezve mimwe mishonga inogona kukushandira zvakanaka.

Ongorora: Mimwe yemishonga yakanyorwa pano inoshandiswa kure-chitaridzi kurapa aya chaiwo mamiriro.

Dzimwe nzira dzeCML

Mienzaniso yemimwe mishonga inogona kushandiswa kurapa Philadelphia-positive (Ph +) chisingaperi myeloid leukemia (CML) ndeiyi:

• dasatinib (Sprycel)
• nilotinib (Tasigna)
• bosutinib (Bosulif)
• ponatinib (Iclusig)
• omacetaxine (Synribo)
• daunorubicin (Cerubidine)
• cytarabine
• interferon-alpha (Intron A)

Dzimwe nzira dzeGIST

Mienzaniso yemamwe madhiragi ayo anogona kushandiswa kurapa gastrointestinal stromal tumors (GIST) ndeaya:

• sunitinib (Sutent)
• regorafenib (Stivarga)
• sorafenib (Nexavar)
• nilotinib (Tasigna)
• dasatinib (Sprycel)
• pazopanib (Votrient)

Dzimwe nzira dzemamwe mamiriro Gleevec anogona kurapa dziripo. Taura nachiremba wako pamusoro pemishonga ipi inogona kushandiswa pamamiriro ako ezvinhu.

Gleevec vs. Tasigna

Unogona kushamisika kuti Gleevec inofananidzwa sei nemimwe mishonga yakatemerwa kushandiswa kwakafanana. Pano tinotarisa kuti Gleevec naTasigna vakafanana uye vakasiyana sei.

Zvishandiso

Chikafu neDrug Administration (FDA) yakabvumidza vese Gleevec naTasigna kurapa mamwe marudzi egomarara reropa.

Mishonga iyi miviri iri FDA-inogamuchirwa kurapa ichangobva kuongororwa Philadelphia-positive (Ph +) chisingaperi myeloid leukemia (CML) muchikamu chisingaperi muvakuru nevana.

Chisingaperi myeloid leukemia (CML) chakakamurwa muzvikamu zvitatu:

• Chikamu chisingaperi. Ichi chikamu chekutanga cheCML. Vanhu vazhinji vanoonekwa kuti vane CML panguva yechikamu chisingaperi. Zviratidzo zvinowanzo nyoro, kana zviripo zvachose.
• Yakawedzera chikamu. Muchikamu chino chechipiri, huwandu hwekenza maseru muropa rako unowedzera. Iwe unogona kunge uine zvimwe zviratidzo, senge fivha uye kuonda.
• Blast dambudziko danho. Muchikamu chino chemberi, maseru egomarara muropa rako apararira kune dzimwe nhengo uye nyama. Zviratidzo zvako zvinogona kunyanyisa.

Gleevec inobvumidzwa kurapa Philadelphia-positive (Ph +) CML mune vanhu vakuru vari mune isingagumi, yakamhanyisa, kana blast dambudziko danho kana interferon-alpha kurapa kusati kwashanda.

Interferon-alpha mushonga waiwanzoshandiswa kurapa CML munguva yakapfuura. Icho chigadzirwa chakagadzirwa nevanhu chinoshanda sevamwe immune system mapuroteni uye chinodzivirira kukura kwemasero ekenza.

Tasigna inotenderwa kurapa Ph + CML muzvikamu zvisingaperi kana zvinokurumidza muvanhu vakuru kana kumwe kurapwa kusati kwashanda, kusanganisira kurapwa naGleevec. Tasigna haina kubvumidzwa kune iyo blast dambudziko danho.

Tasigna inobvumidzwawo kurapa Ph + CML muvana vane makore ane gore kana kupfuura kana mamwe marapirwo asina kushanda. Gleevec inobvumidzwa kurapa ichangobva kuongororwa Ph + CML muvana.

Gleevec inobvumidzwawo kurapa mamwe marudzi ekenza. Ona iyo "Zvimwe zvinoshandiswa zveGleevec" chikamu kuti udzidze zvimwe.

Mafomu emishonga uye manejimendi

Gleevec ine imatinib yemushonga. Tasigna ine mushonga nilotinib.

Gleevec inouya sehwendefa. Tasigna inouya sekapisi. Mishonga yose inotorwa nemuromo.

Gleevec inotorwa kamwe chete kana kaviri pazuva, zvichienderana nedosi rako. Tasigna inotorwa kaviri pazuva.

Gleevec inouya se100-mg uye 400-mg mapiritsi. Tasigna inouya se50-mg, 150-mg, uye 200-mg capsules.

Side migumisiro uye njodzi

Gleevec naTasigna vane mishonga yakafanana. Naizvozvo, ese ari maviri mishonga anogona kukonzera akafanana akafanana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemamwe mhedzisiro mhedzisiro anokwanisa kuitika naGleevec, neTasigna, kana nezvose zviri zviviri zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika naGleevec:
  • edema (kuzvimba kwemakumbo ako, makumbo, uye tsoka, uye kutenderedza maziso ako)
  • tsandanyama
  • kurwadziwa kwemhasuru
  • kurwadziwa kwepfupa
  • kurwadziwa nemudumbu
• Zvinogona kuitika neTasigna:
  • musoro
  • ganda rinonhuwa
  • kukosora
  • kuvimbiswa
  • kurwadza kwemajoini
  • nasopharyngitis (yakajairika kutonhora)
  • kupindwa nechando
  • husiku hweziya
• Zvinogona kuitika nezvose Gleevec naTasigna:
  • kusvotwa
  • kurutsa
  • manyoka
  • mapundu
  • kuneta (kushaya simba)

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yezvakakomba mhedzisiro inogona kuitika naGleevec, neTasigna, kana nezvose zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika naGleevec:
  • congestive moyo kutadza kana matambudziko emoyo senge kuruboshwe-sided moyo kutadza
  • gastrointestinal perforations (maburi mudumbu rako kana mumatumbu)
  • kugadzikana kwakanyanya kweganda, kusanganisira Stevens-Johnson syndrome (fever; maronda anorwadza pamuromo wako, pahuro, maziso, sikarudzi, kana muviri wese)
  • kukuvara kweitsvo
  • hypothyroidism (low thyroid levels) mune vanhu vakabviswa utachiona
• Zvinogona kuitika neTasigna:
  • yakareba QT nguva (isina kujairika magetsi chiitiko mumoyo mako), izvo zvisingawanzo asi zvinogona kutungamira mukufa kamwe kamwe
  • yakavharika tsinga dzeropa mumoyo
  • chirwatata
  • kusaenzana kwe electrolyte (yakakwira kana yakadzika mazinga emamwe maminera)
• Zvinogona kuitika nezvose Gleevec naTasigna:
  • kusagadzikana kweropa, kusanganisira kupererwa neropa (mashoma masero matsvuku eropa), neutropenia (yakadzika masero machena eropa), uye thrombocytopenia (mashoma maplatelet)
  • kukuvara kwechiropa
  • tumor lysis syndrome (kenza maseru anoburitsa makemikari anokuvadza muropa rako)
  • hemorrhage (kubuda ropa kusingamire)
  • kuchengetedza kwakasimba kwemvura (yakawandisa mvura kana mvura)
  • kunonoka kukura muvana

Kubudirira

Gleevec naTasigna vane akasiyana FDA-anotenderwa mashandisiro. Asi ivo vese vanobata Ph + CML muzvikamu zvisingaperi uye zvinokurumidza kana mamwe marapirwo asina kushanda. CML ine zvikamu zvitatu: chisingaperi (chikamu 1), chinokurumidza (chikamu chechipiri), uye dambudziko redutu (chikamu 3).

Iko kushandiswa kweGleevec naTasigna pakurapa kuchangobva kuongororwa Ph + CML muvakuru kwakafananidzwa zvakananga muchidzidzo chemakiriniki. Vanotsvagurudza vakafananidza vanhu vaitora 400 mg yeGleevec kamwe pazuva kana 300 mg yeTasigna kaviri pazuva.

Mushure memwedzi gumi nemaviri ekurapwa, 65% yevanhu vakatora Gleevec vaive vasina maP + masero mumapfupa avo (uko masero eCML aneropa anokura). Kune vanhu vakatora Tasigna, 80% yakanga isina maPh + maseru mumapfupa avo.

Mushure memakore mashanu ekurapwa, makumi matanhatu muzana yevanhu vakatora Gleevec vaive nenhamba yakadzikira zvikuru yemagen'a egomarara muropa ravo. Izvi zvakafananidzwa ne77% yevanhu vakatora Tasigna.

Zvakare mushure memakore mashanu ekurapwa, 91.7% yevanhu vakatora Gleevec vachiri vapenyu. Izvo zvinofananidzwa ne93,7% yevanhu vakatora Tasigna.

Mhedzisiro yechidzidzo ichi inoratidza kuti Tasigna inogona kushanda zvakanyanya kupfuura Gleevec pakurapa ichangobva kuongororwa Ph + CML muchikamu chisingaperi.

Mariro

Gleevec naTasigna zvese zvinodhaka zita. Tasigna haina generic fomu, asi Gleevec ine generic fomu inonzi imatinib. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira paGoodRx.com, zita rezita Gleevec rinogona kudhura zvishoma pane Tasigna. Iyo generic fomu yeGleevec (imatinib) inodhurawo zvishoma pane Tasigna. Mutengo chaiwo wauchabhadhara chero mushonga unotsamira padosi yako, chirongwa cheinishuwarenzi, nzvimbo yako, uye pharmacy yaunoshandisa.

Gleevec vs. Sprycel

Unogona kushamisika kuti Gleevec inofananidzwa sei nemimwe mishonga yakatemerwa kushandiswa kwakafanana. Pano tinotarisa kuti Gleevec naSprycel vakafanana uye vakasiyana sei.

Zvishandiso

Chikafu neDrug Administration (FDA) yakabvumidza zvese zviri zviviri Gleevec uye Sprycel kurapa mamwe marudzi egomarara reropa.

Ose madhiragi ese ari maviri FDA-anotenderwa kurapa achangobva kuongororwa Philadelphia-positive (Ph +) chisingaperi myeloid leukemia (CML) muchikamu chisingaperi muvakuru nevana.

CML yakakamurwa muzvikamu zvitatu:

• Chikamu chisingaperi. Ichi chikamu chekutanga cheCML. Vanhu vazhinji vanoonekwa kuti vane CML panguva yechikamu chisingaperi. Zviratidzo zvinowanzo nyoro, kana zviripo zvachose.
• Yakawedzera chikamu. Muchikamu chino chechipiri, huwandu hwekenza maseru muropa rako unowedzera. Iwe unogona kunge uine zvimwe zviratidzo, senge fivha uye kuonda.
• Blast dambudziko danho. Muchikamu chino chemberi, maseru egomarara muropa rako apararira kune dzimwe nhengo uye nyama. Zviratidzo zvako zvinogona kunyanyisa.

Gleevec uye Sprycel anoshandiswa kurapa Ph + CML muvanhu vakuru muchikamu chisingaperi.

Gleevec inoshandiswawo kurapa Ph + CML muvanhu vakuru muzvikamu zvisingaperi, zvinokurumidza, kana kuputika-dambudziko kana interferon-alpha therapy isina kushanda. Interferon-alpha mushonga waiwanzoshandiswa kurapa CML munguva yakapfuura. Icho chigadzirwa chakagadzirwa nevanhu chinoshanda sevamwe immune system mapuroteni uye chinodzivirira kukura kwemasero ekenza.

Sprycel inoshandiswawo kurapa Ph + CML mune vanhu vakuru muzvikamu zvisingaperi, zvinokurumidza, kana kuputika-dambudziko kana Gleevec ikasashanda.

Ose maGleevec naSprycel anotenderwa kurapa Ph + CML muchikamu chisingaperi muvana. Ivo vaviri zvakare vanobvumidzwa kurapa Ph + acute lymphocytic leukemia (ZVESE) muvana pamwe nekemotherapy.

Gleevec inobvumidzwawo kurapa mamwe marudzi ekenza. Ona iyo "Zvimwe zvinoshandiswa zveGleevec" chikamu kuti udzidze zvimwe.

Mafomu emishonga uye manejimendi

Gleevec ine imatinib yemushonga. Sprycel ine dasatinib yezvinodhaka.

Gleevec uye Sprycel ese anouya semapiritsi aunotora nemuromo (iwe unomedza iwo).

Mahwendefa eGleevec anouya musimba mbiri: 100 mg uye 400 mg. Inotorwa kamwe kana kaviri pazuva, zvichienderana nedosi rako.

Sprycel mahwendefa anouya mune anotevera masimba: 20 mg, 50 mg, 70 mg, 80 mg, 100 mg, uye 140 mg. Sprycel inotorwa kamwe pazuva.

Side migumisiro uye njodzi

Gleevec neSprycel zvakafanana asi zvine mishonga yakasiyana. Naizvozvo, ese ari maviri mishonga anogona kukonzera akafanana akafanana mhedzisiro. Pazasi pane mienzaniso yemhedzisiro iyi.

Zvimwe zvakajairika mhedzisiro

Aya mazita ane mienzaniso yemamwe mhedzisiro mhedzisiro anokwanisa kuitika neGleevec, neSprycel, kana nemishonga iyi miviri (kana ikatorwa zvakasiyana).

• Zvinogona kuitika naGleevec:
  • kurutsa
  • tsandanyama
  • kurwadziwa mudumbu
  • ziso-nharaunda edema (kuzvimba kwakatenderedza maziso)
• Zvinogona kuitika neSprycel:
  • kunetseka kufema
  • musoro
  • kubuda ropa
  • immune system isina simba (muviri wako haugone kurwisa hutachiona zvakare)
• Zvinogona kuitika nezvose Gleevec uye Sprycel:
  • edema (kuzvimba kwemakumbo ako, makumbo, uye tsoka)
  • kusvotwa
  • kurwadziwa kwemhasuru
  • kurwadziwa kwepfupa
  • manyoka
  • mapundu
  • kuneta (kushaya simba)

Yakakomba mhedzisiro

Aya mazita ane mienzaniso yemhedzisiro mhedzisiro mhedzisiro inogona kuitika neGleevec, neSprycel, kana nezvose zviri zviviri zvinodhaka (kana zvichitorwa zvakasiyana).

• Zvinogona kuitika naGleevec:
  • matambudziko emwoyo, akadai seye congestive moyo kutadza
  • kukuvara kwechiropa
  • gastrointestinal perforations (maburi mudumbu kana mumatumbu)
  • kukuvara kweitsvo
  • hypothyroidism (low thyroid levels) mune vanhu vakabviswa utachiona
• Zvinogona kuitika neSprycel:
  • pulmonary arterial hypertension (kuwedzerwa kweropa mumidziyo yeropa mumapapu ako)
  • nguva refu yeQT (rudzi rwechiitiko chisina kujairika chemagetsi mumoyo mako)
  • ischemic moyo kurwisa (kushaya okisijeni kune mhasuru yemwoyo)
• Zvinogona kuitika nezvose Gleevec uye Sprycel:
  • kuchengetedza kwakasimba kwemvura (yakawandisa mvura kana mvura) kutenderedza mapapu ako, moyo, uye dumbu
  • kukanganiswa kwakanyanya kweropa (yakaderera masero matsvuku eropa, maplatelet, kana machena masero eropa)
  • kubuda ropa kwakanyanya (kubuda ropa kusingamire)
  • kugadzikana kwakanyanya kweganda, kusanganisira Stevens-Johnson syndrome (fever; maronda anorwadza pamuromo wako, pahuro, maziso, sikarudzi, kana muviri wese)
  • tumor lysis syndrome (kenza maseru anoburitsa makemikari anokuvadza muropa rako)
  • kurova kwemoyo zvisina kujairika kana mutinhimira (kurova kwemoyo kuchikurumidza, kunonoka, kana kusajairika)
  • kudzikira kukura muvana

Kubudirira

Gleevec uye Sprycel vane akasiyana FDA-anotenderwa mashandisiro. Asi ivo vese vanorapa vachangobva kuongororwa Ph + CML muchikamu chisingaperi (chikamu chekutanga cheCML) muvakuru nevana. Gleevec naSprycel zvakare vese vanorapa Ph + Vese muvana kana ichishandiswa pamwe chete nemakemikari.

Uye zvakare, ese ari maviri Gleevec uye Sprycel anorapa Ph + CML mune epamberi uye nekufashukira zvikamu muvakuru, kana Ph + ZVESE, kana mimwe mishonga isina kuvashandira.

Iko kushandiswa kweGleevec uye Sprycel pakurapa kuchangobva kuongororwa Ph + CML muvakuru kwakafananidzwa zvakananga muchidzidzo chemakiriniki. Vanoongorora vakafananidza vanhu vakatora 400 mg yeGleevec pazuva kana 100 mg yeSprycel pazuva.

Mukati memwedzi gumi nembiri, 66.2% yevanhu vakatora Gleevec vaive vasina maPh + maseru mumapfupa avo (uko masero eCML aneropa anokura). Muboka rakatora Sprycel, 76.8% yevanhu vaive vasina maPh + maseru mumongo wavo wepfupa.

Mushure memakore mashanu ekurapwa, inofungidzirwa kuti 89.6% yevanhu vakatora Gleevec vachiri vapenyu. Izvo zvinofananidzwa neinofungidzirwa 90.9% yevanhu vakatora Sprycel.

Mhedzisiro yenyaya iyi inoratidza kuti Sprycel inogona kunge ichinyatso shanda kupfuura Gleevec pakurapa ichangobva kuongororwa Ph + CML muchikamu chisingaperi.

Mariro

Gleevec naSprycel zvese zvinodhaka zita. Sprycel haina generic fomu, asi Gleevec ine generic fomu inonzi imatinib. Brand-zita mishonga kazhinji inodhura kupfuura ejeniki.

Zvinoenderana nekufungidzira paGoodRx.com, zita rezita Gleevec rinogona kudhura zvishoma pane Sprycel. Iyo generic fomu yeGleevec (imatinib) inogona zvakare kudhura zvishoma pane Sprycel. Mutengo chaiwo wauchabhadhara chero mushonga unotsamira padosi yako, chirongwa chako cheinishuwarenzi, nzvimbo yako, uye pharmacy yaunoshandisa.

Gleevec uye doro

Hazvizivikanwe kana Gleevec nedoro zvinopindirana.

Zvisinei, chiropa chako chinogadzirisa (chinoputsa) zvose Gleevec uye doro. Saka kunwa doro rakawandisa paunenge uchitora Gleevec kunogona kudzivirira chiropa chako kubva pakuputsa mushonga. Izvi zvinogona kukwidza mazinga eGleevec mumuviri wako uye kuwedzera njodzi yako kune zvakakomba mhedzisiro, kusanganisira kukuvara kwechiropa.

Ose maviri Gleevec uye doro zvinogona kukonzera mhedzisiro senge:

• kusvotwa
• manyoka
• musoro
• kuneta (kushaya simba)

Kunwa doro panguva yekurapa kwaGleevec kunogona kuwedzera njodzi yako yekuve nemhedzisiro.

Kana iwe uchinwa doro, taura nachiremba wako nezvekuti yakadii yakachengeteka kwauri iwe panguva yekurapwa kwako kweGleevec.

Gleevec kudyidzana

Gleevec inogona kusangana nemimwe mishonga yakati wandei. Inogona zvakare kudyidzana nezvimwe zvinowedzera pamwe nezvimwe zvekudya.

Kukurukurirana kwakasiyana kunogona kukonzera mhedzisiro. Semuenzaniso, vamwe vanogona kukanganisa mashandiro anoita mushonga, asi mamwe anogona kukonzera kuwedzera mhedzisiro.

Gleevec nemimwe mishonga

Pazasi pane runyorwa rwemishonga inogona kusangana naGleevec. Urongwa urwu hauna mishonga yose inogona kuwirirana neGleevec.

Usati watora Gleevec, taura nachiremba wako uye wemishonga. Vaudze nezvese zvinyorwe, pamusoro-pe-counter, uye mimwe mishonga yaunotora. Vaudzewo nezve chero mavitamini, mahebhu, uye zvinowedzera zvaunoshandisa. Kugovera ruzivo urwu kunogona kubatsira iwe kudzivirira kusangana kunogona kuitika.

Kana iwe uine mibvunzo nezve kudyidzana kwezvinodhaka zvinogona kukukanganisa, bvunza chiremba wako kana wemishonga.

Gleevec uye Tylenol

Kutora Gleevec neTylenol (acetaminophen) kunogona kuwedzera njodzi yako kune zvakakomba mhedzisiro, sekukuvara kwechiropa.

Enzymes (akakosha mapuroteni) muchiropa chako anotsemura ese ari maviri Gleevec uye Tylenol. Pamwe chete, iyo mishonga miviri inogona kukurisa ma enzymes uye kukuvadza masero ari muchiropa chako.

Bvunza chiremba wako kana zvakachengeteka kuti iwe utore Tylenol panguva yako yekurapa kweGleevec.

Gleevec uye mimwe mishonga yekubatwa

Kutora Gleevec nemimwe mishonga yekubata kunogona kudzikisa mazinga eGleevec mumuviri wako. Izvi zvinogona kuita kuti Gleevec isanyanya kushanda (shanda zvishoma zvakanaka).

Mienzaniso yemishonga yekubvuta iyo inogona kudzikisa mazinga eGleevec inosanganisira:

• phenytoin (Dilantin, Phenytek)
• carbamazepine (Carbatrol, Tegretol)
• phenobarbital

Kana iwe uri kutora Gleevec uye imwe mishonga yekubata, chiremba wako anogona kupa mushonga wakasiyana wekubata kana kugadzirisa muyero weGleevec.

Gleevec uye mamwe maantibioti

Kutora Gleevec nemamwe maantibayoti (mishonga inorapa hutachiona) inogona kuwedzera mazinga eGleevec mumuviri wako. Mishonga inorwisa mabhakitiriya inodzivirira Gleevec kubva mukutyora mumuviri wako. Izvi zvinowedzera njodzi yako kune zvakakomba mhedzisiro.

Muenzaniso wemishonga inorwisa mabhakitiriya inogona kuwedzera mazinga eGleevec ndeye clarithromycin (Biaxin XL).

Kana iwe uri kutora Gleevec uye uchida mushonga unorwisa mabhakitiriya, chiremba wako anogona kukutarisa iwe nezve mhedzisiro. Ivo vanogona zvakare kudzikisa yako Gleevec muyero kwenguva.

Gleevec uye mamwe antifungal

Kutora Gleevec nemamwe maantifungal (mishonga inorapa hutachiona) inogona kudzivirira kuparara kweGleevec mumuviri wako. Izvi zvinogona kukwidziridza Gleevec mazinga muropa rako uye kuwedzera njodzi yako kune zvakakomba mhedzisiro.

Mienzaniso yezvimisikidzo zvinogona kuwedzera mazinga eGleevec ndeaya:

• itraconazole (Onmel, Sporanox, Tolsura)
• ketoconazole (Extina, Ketozole, Xolegel)
• voriconazole (Vfend)

Kana iwe uri kutora Gleevec uye uchida antifungal kurapwa, chiremba wako anozokutarisa iwe nezve mhedzisiro. Ivo vanogona zvakare kudzikisa yako Gleevec muyero kwenguva.

Gleevec uye maopioid

Kutora Gleevec nemimwe mishonga yekurwadziwa kunogona kuwedzera mwero weanodzora marwadzo mumuviri wako. Izvi zvinogona kuita kuti iwe uwedzere kuve nemhedzisiro mhedzisiro senge sedation (kunzwa kukotsira uye kushoma kusvinura) uye mweya wekufema (kunonoka kufema).

Mienzaniso yeopioid pain mishonga inogona kuwedzera mazinga eGleevec anosanganisira:

• oxycodone (Oxycontin, Roxicodone, Xtampza ER)
• tramadol (ConZip, Ultram)
• methadone (Dolophine, Methadose)

Taura nachiremba wako nezvekuti zvakachengeteka here kutora mishonga yekurwadziwa panguva yako yekurapa kweGleevec. Vanogona kutaura dzimwe nzira dzekurerutsa kurwadziwa kwako.

Gleevec uye mimwe mishonga yeHIV

Kutora Gleevec nemimwe mishonga yeHIV kunogona kuwedzera njodzi yako kumatambudziko akakomba. Mimwe mishonga yeHIV inogona kudzivirira Gleevec kubva pakuputsa, zvichitungamira kumatunhu akakwirira eGleevec mumuviri wako.

Mienzaniso yemishonga yeHIV inogona kuwedzera mazinga eGleevec anosanganisira:

• atazanavir (Reyataz)
• nevirapine (Viramune)
• saquinavir (Invirase)

Mumwe mushonga weHIV, efavirenz (Sustiva), unogona kudzikisa huwandu hweGleevec mumuviri wako. Izvi zvinogona kukonzera kuti Gleevec isanyanya kushanda.

Mishonga yakawanda yeHIV inouya semapiritsi akasanganiswa, zvinoreva kuti anosanganisira anopfuura mumwe mushonga. Saka ive shuwa yekutaura nachiremba wako nezve mishonga yese yeHIV yaunotora.

Kana iwe uchida kutora Gleevec nemimwe mishonga yeHIV, chiremba wako anogona kuchinja yako Gleevec dosage.

Gleevec uye mimwe mishonga yeropa

Kutora Gleevec nemamwe mishonga yeropa kunogona kuwedzera kana kudzikisa iwo mwero weimwe mishonga mumuviri wako. Izvi zvinogona kuita kuti iwe uwedzere kuve nemhedzisiro kana kudzora mashandiro anoita mishonga.

Muenzaniso wemishonga iyi unosanganisira verapamil (Calan, Tarka).

Kana iwe uchida kutora Gleevec nechero ipi yemishonga iyi, chiremba wako anozokutarisa zvakanyanya padanho remhedzisiro. Vanogona zvakare kugadzirisa chipimo chemushonga kana kukurudzira mumwe mushonga.

Gleevec uye warfarin

Kutora Gleevec newarfarin (Coumadin, Jantoven) kunogona kuwedzera njodzi yako yekubuda ropa. Gleevec inodzivirira warfarin kubva pakuputsa mumuviri wako. Izvi zvinowedzera mazinga ewarfarin uye zvinogona kutungamira mukubuda ropa izvo zvakaoma kudzora.

Kana iwe uchida anticoagulant (ropa rakatetepa) paunenge uchitora Gleevec, chiremba wako anogona kupa mushonga mumwe asiri warfarin.

Gleevec uye St. John's wort

Kutora Gleevec neSt. John's wort kunogona kudzikira mazinga eGleevec mumuviri wako. Izvi zvinogona kuita kuti Gleevec isanyanya kushanda (isashande zvakare).

Kumbira chiremba wako kuti St. John's wort yakachengeteka here kuti iwe utore panguva yekurapwa kwako kweGleevec. Ivo vanogona kukurudzira imwe nzira kune St. John's Wort kana kuwedzera yako Gleevec dose.

Gleevec uye grapefruit

Kudya grapefruit kana kunwa muto wemazambiringa panguva yekurapwa kwako kweGleevec kunogona kuwedzera njodzi yako yemhedzisiro. Grapefruit ine makemikari anodzivirira Gleevec kubva mukutyora mumuviri wako. Izvi zvinokonzeresa kuwanda kweGleevec, izvo zvinogona kutungamira kune akanyanya mhedzisiro mhedzisiro.

Ive neshuwa yekurega kudya grapefruit uye kunwa muto wemazambiringa panguva yako yekurapa kweGleevec.

Maitiro ekutora Gleevec

Ive neshuwa yekutora Gleevec zvinoenderana nachiremba wako kana wehutano wezve mirairo.

Nguva yekutora

KweGleevec doses e600 mg kana mashoma, mushonga unofanirwa kutorwa kamwe pazuva. Unogona kutora chero nguva.

Kana chiremba wako akaraira 800 mg yeGleevec pazuva, iwe unotora muzvikamu zviviri: 400 mg mangwanani uye 400 mg manheru.

Chiremba wako achakupa mirairo pane paunofanira kutora dosi yako.

Kutora Gleevec nechikafu

Tora Gleevec nechikafu uye girazi hombe remvura. Izvi zvinogona kubatsira kudzivirira kunetseka mudumbu.

Inogona Gleevec kupwanywa, kupatsanurwa, kana kutsengwa here?

Iwe haufanire kupwanya, kupatsanura, kana kutsenga mahwendefa eGleevec. Mahwendefa akapwanywa uye akapatsanurwa anogona kukuvadza kune chero ganda kana zvimwe zvikamu zvemuviri zvinosangana navo.

Kana uchinetseka kumedza mahwendefa eGleevec, isa iyo piritsi mugirazi hombe remvura kana muto wemaapuro. Kurudzira mvura nehupuni kubatsira iyo piritsi kunyungudika. Wobva wanwa musanganiswa ipapo.

Mashandiro anoita Gleevec

Gleevec ine imatinib yemushonga, iri yekirasi yemishonga inonzi tyrosine kinase inhibitors (TKIs). Mishonga iri muTKI kirasi yemishonga inotarisirwa kurapwa. Dzinokanganisa chaiwo mapuroteni mumasero ekenza.

Gleevec inobvumidzwa kurapa akati wandei akasiyana mamiriro. Pano tichaongorora mashandiro anoita Gleevec kubata vaviri vavo.

Zve Ph + CML

MuPhiladelphia-positive (Ph +) chisingaperi myeloid leukemia (CML), iwo maseru anogadzira machena eropa masero ane kukanganisa mune avo magene maitiro. Iko kukanganisa kwemajini kunowanikwa pane tambo yeDNA inonzi Philadelphia chromosome.

Iyo chromosome yePhiladelphia ine geni risina kujairika (BCR-ABL1) iyo inokonzeresa machena machena eropa kuumba. Aya masero eropa machena haakure uye anofa sezvaanofanirwa. Masero eropa asina kuchena anonzi "blasts" anounganidza mamwe marudzi emasero eropa ayo ropa rako rinoda kushanda nemazvo.

Gleevec inoshanda nekubatanidza puroteni, inonzi tyrosine kinase, mumasero akagadzirwa neBCR-ABL1. Kana Gleevec ichisunga kune ichi protein, mushonga unodzivirira sero kubva kutumira masign anotaurira kuti sero kukura. Pasina zviratidzo zvekukura, masero eropa ane gomarara anofa. Izvi zvinobatsira kudzoreredza huwandu hweanofefetera masero kune hutano nhamba.

ZveGISITI

Gleevec inobatsirawo kugadzirisa matumbo emimba stromal tumarara (GIST). Mune mazhinji GIST bundu maseru, kune huwandu hwakakwira hwemamwe mapuroteni, anonzi Kit uye platelet-yakatorwa kukura chinhu (PDGF), kupfuura mumasero akajairwa. Aya mapuroteni anobatsira maseru ekenza kukura uye kupatsanuka.

Gleevec inovavarira mapuroteni aya uye anovadzivirira kushanda. Izvi zvinoderedza kukura kwekenza. Izvo zvinoitawo kuti cancer maseru afe.

Zvinotora nguva yakareba sei kuti zvishande?

Zvinoenderana. Nguva yekuti Gleevec inotanga kushanda yakasiyana kumunhu wega wega.

Zvidzidzo zvekuchipatara zvakatarisa vanhu vane CML vakatora Gleevec. Mumwedzi mumwe, huwandu hwemaseru ane gomarara muropa wakadzikiswa muhafu yenguva yevanhu vari padanho redambudziko rekupaza (nhanho yepamusoro yeCML). Mune zvidzidzo zvevanhu vane GIST vakatora Gleevec, mamota akamira kukura kana kudzikira mumwedzi mitatu.

Chiremba wako anogara achiongorora ropa rako kuti aone kana Gleevec iri kukushandira.

Gleevec uye nhumbu

Iwe unofanirwa kudzivirira Gleevec kana iwe uri nepamuviri. Pakave nemishumo yekuparara uye kukuvadza kune fetus mune vakadzi vakatora Gleevec vachiri nepamuviri. Uye muzvidzidzo zvemhuka, vakadzi vane nhumbu vakapihwa Gleevec vaive nenjodzi yakawedzera yekuremara kwekuzvarwa.

Kana iwe uri nepamuviri, chiremba wako anogona kukuraira iwe kumirira kusvikira iwe mushure mekusununguka kuti utange kutora Gleevec. Kana ivo vanokurudzira mumwe mushonga.

Kana iwe uri kutora Gleevec, zvakakosha kuti ushandise inoshanda yekubata kudzivirira kuti usazove nepamuviri. Mushure mekutora dosi rako rekupedzisira reGleevec, ramba uchishandisa kuberekwa kwemazuva gumi nemana.

Gleevec uye kuyamwisa

Zvidzidzo zvinoratidza kuti Gleevec anopfuura mumukaka wemunhu wemukaka. Izvi zvinogona kukonzera kukuvadza kwakakomba kumucheche anoyamwisa.

Kana iwe uchiyamwisa uye uchifunga kutora Gleevec, chiremba wako anogona kukuraira kuti umise kuyamwisa paunotanga kurapwa.

Mushure mekutora dosi rako rekupedzisira reGleevec, mirira mwedzi mumwe chete usati watanga kuyamwa.

Gleevec ovhadhozi

Kutora yakawandisa Gleevec kunogona kuwedzera njodzi yako kune zvakakomba mhedzisiro.

Ovhadhozi zviratidzo

Zviratidzo zvekuwedzeredza zvinogona kusanganisira:

• kusvotwa
• kurutsa
• manyoka
• kurwadziwa mudumbu
• mapundu akakomba
• mhasuru mhasuru (dzinokanganisa)
• musoro
• kushaya nzara
• kushaya simba kwetsandanyama
• kuneta (kushaya simba)
• kuzvimba
• kusagadzikana kweropa, senge mashoma maplatelet, masero matsvuku eropa, kana machena masero eropa
• kupindwa nechando

Zvekuita kana ovhadhozi

Kana iwe uchifunga kuti watora zvakawandisa zvemushonga uyu, fonera chiremba wako. Iwe unogona zvakare kufonera iyo American Association yePoison Control Centres pa800-222-1222 kana kushandisa yavo yepamhepo chishandiso. Asi kana zviratidzo zvako zvakakomba, fonera 911 kana kuenda kukamuri yepedyo yevanokurumidza ipapo.

Mibvunzo yakajairika nezveGleevec

Heano mhinduro kumimwe inowanzo bvunzwa mibvunzo nezve Gleevec.

Gleevec iri mhando yekemotherapy here?

Gleevec haisi technically chimiro chemotherapy. Gleevec chirwere chakanangwa chinokanganisa chaiwo mamorekuru mumasero ekenza.

Nokusarudza mamwe mamorekuru, zvakanangwa marapirwo akaita seGleevec anobatsira kudzora kukura nekupararira kwemasero ekenza. Chiremba wako anowanzo kupa kurapwa kwakanangwa iwe zvichienderana nerudzi rwekenza yauinayo.

Chemotherapy zvinodhaka zvakasiyana nezvakanangwa kurapwa. Chemotherapy mishonga inoshanda pane ese maseru mumuviri ari kukura nekukurumidza, kwete chete maseru ekenza. Chemotherapy mishonga inowanzo kuuraya masero ari kukura uye inokanganisa mamwe maseru mumuviri kupfuura kurapwa kwakanangwa.

Iko generic fomu yeGleevec inoshanda seiyo zita-zita zita mushonga?

Chikafu neDrug Administration (FDA) inoda kuti vagadziri vezvinodhaka generic varatidze kuti chigadzirwa chavo chine:

• chinhu chimwe chete chinoshanda sezita rechiratidzo remushonga
• simba rakafanana uye muyero fomu sezita-zita mushonga
• nzira imwechete yekutungamira (maitiro aunotora mushonga)

Iyo generic mushonga inodawo kuti ishande nenzira imwechete uye pamwe chete neyechigadzirwa-zita chigadzirwa.

Zvinoenderana neiyo FDA, iyo generic fomu yeGleevec inosangana nezvinodiwa izvi. Izvi zvinoreva kuti iyo FDA inovimbisa kuti iyo generic fomu inoshanda senge iyo zita-zita zita mushonga.

Ini ndinogona kukudziridza kuramba kurapwa naGleevec?

Ehe. Zvinogoneka kuti iwe ugadzire kuramba Gleevec. Kuramba zvinoreva kuti mushonga unomira kushanda nekufamba kwenguva. Zvinofungidzirwa kuti izvi zvinokonzerwa nekuchinja kwemajini emakenza maseru.

Kana iwe ukava nekurwisa Gleevec, chiremba wako anogona kupa mushonga wepamusoro. Vachaona kana masero ekenza achipindura zvakare kumushonga. Chiremba wako anogona zvakare kunyorera chakasiyana chinodhaka chausina kuramba nacho.

Pane here zvirango zvekudya zvandinofanira kutevera ndichitora Gleevec?

Iko hakuna marongero ezvekudya akarongeka aunofanirwa kuteedzera uchitora Gleevec. Nekudaro, iwe unofanirwa kudzivirira kudya grapefruit uye kunwa grapefruit muto. Grapefruit ine kemikari inogona kudzivirira muviri wako kubva mukugadzirisa (kuputsa) Gleevec. Izvi zvinogona kutungamira kumazinga akakwirira emushonga muropa rako. Matanho eGleevec akakwirira kupfuura akajairwa anowedzera njodzi yako kune zvakakomba mhedzisiro.

Uye zvakare, chiremba wako anogona kukupa rairo yakajairika pane chikafu chako kuti ubatsire kudzikamisa mimwe mhedzisiro. Semuenzaniso, Gleevec inokonzera kusvotwa uye kurutsa muvanhu vazhinji. Kuti ubatsire kudzivirira izvi, chiremba wako anogona kukurudzira kuti iwe udzivise chikafu chinogona kuita kuti svoto iwedzere. Izvi zvinosanganisira zvinorema, zvine mafuta, kana zvine mafuta chikafu, uye zvinonhuwirira kana acidic chikafu. Mienzaniso mizhinji masukisi matsvuku, chikafu chakakangwa, uye zvinhu zvakawanda zvinokurumidza zvekudya.

Chekupedzisira, kana iwe uri kutora Gleevec yekenza yemudumbu, senge gastrointestinal stromal tumors (GIST), chiremba wako anogona kukurudzira chaiwo marongero ezvekudya. Chinangwa ndechekudzivirira matambudziko mudumbu kana mumatumbu. Taura nachiremba wako nezve izvo zvekudya zvakakunakira iwe.

Ini ndichave nezviratidzo zvekuregera kana ndikamira kushandisa Gleevec?

Unokwanisa. Vamwe vanhu vanga vaine zviratidzo zvekurega mushure mekupedzisa kurapwa kwavo kweGleevec. Mune imwe diki yekiriniki yekudzidza, makumi matatu muzana yevanhu vaive nemhasuru kana pfupa kurwadziwa mushure mekumisa Gleevec. Marwadzo aiwanzo kuve mumapendekete, mahudyu, makumbo, uye maoko. Ichi chiratidzo chekudzora chakaitika mukati mevhiki imwe kusvika kumatanhatu yekumira kurapwa.

Inenge hafu yevanhu vakabata marwadzo avo neanopfuura-the-counter marwadzo ekudzora. Iyo imwe hafu yaida mushonga wemishonga. Muvanhu vazhinji vaive nezviratidzo zvekuregera, kurwadziwa kwemhasuru nemapfupa zvakapera mukati memwedzi mitatu kusvika pagore kana kupfuura.

Ndichada here kushandisa mimwe mishonga naGleevec pakurapwa?

Zvinoenderana nekuti kenza yako yakura zvakadii. Pamatanho epamberi ekenza kana kanzira yakapararira kuuropi kana musana, chiremba wako anogona kuwedzera chemotherapy kuchipatara chako cheGleevec. Uye zvakare, vana vane Philadelphia-positive (Ph +) acute lymphocytic leukemia (ZVESE) vanogona kugamuchira Gleevec pamwe nekemotherapy.

Kune mamwe marudzi ekenza, chiremba wako anogona zvakare kunyorera steroid. Uye iwe ungangoda kushandisa mishonga kugadzirisa mhedzisiro, senge marwadzo ekuderedza marwadzo emhasuru.

Gleevec kupera, kuchengetedza, uye kurasa

Paunowana Gleevec kubva kupharmasi, wemishonga anowedzera zuva rekupera kune zvakanyorwa pabhodhoro. Zuva iri rinowanzo kuve gore rimwe kubva pazuva ravakapa mushonga.

Zuva rekupera rinobatsira kuvimbisa kushanda kwemushonga panguva ino. Chimiro chazvino cheKudya neDrug Administration (FDA) ndechekudzivirira kushandisa akapera mishonga. Kana iwe usina kushandisa mishonga yakapfuura nguva yekupera, taura nachiremba wako. Ivo vanogona kukuudza iwe kana iwe uchiri kugona kuishandisa.

Kuchengetedza

Inguva yakareba sei mushonga unoramba wakanaka unogona zvinoenderana nezvinhu zvakawanda, zvinosanganisira kuti unochengetera mushonga kupi uye kupi.

Chengetedza mapiritsi ako eGleevec mukamuri yekushisa mukamuri rakanyatsovharwa. Ive neshuwa yekudzivirira kubva pamanyoro.

Kubvisa

Kana iwe usisiri kuda kutora Gleevec uye uine mishonga yasara, zvakakosha kuirasa zvakachengeteka.

Izvi zvinobatsira kudzivirira vamwe, kusanganisira vana nezvipfuwo, kubva pakutora mushonga netsaona. Izvo zvinobatsirawo kuchengetedza mushonga kubva mukukuvadza nharaunda.

Iyo FDA webhusaiti inopa akati wandei matipi anobatsira pakuraswa kwemishonga. Iwe unogona zvakare kubvunza wako wemishonga kuti uwane ruzivo rwekuti ungarase sei mushonga wako.

Ruzivo rwehunyanzvi rweGleevec

Ruzivo runotevera rwunopihwa varapi uye vamwe vashandi vezvehutano.

Zviratidzo

Gleevec (imatinib) iri FDA-inogamuchirwa kubata zvinotevera:

• vanhu vakuru uye vana vachangobva kuongororwa Philadelphia-positive (Ph +) chisingaperi myeloid leukemia (CML) muchikamu chisingaperi
• vakuru vane Ph + CML mune chero chikamu, zvichitevera kutadza kweiyo interferon-alpha kurapa
• vanhu vakuru vane vakadzokazve kana kusagadzikana Ph + acute lymphocytic leukemia (ZVA)
• vana vane vachangobva kuongororwa Ph + ZVESE pamwe nekubatana nemakemikari
• vanhu vakuru vane myelodysplastic / myeloproliferative chirwere chinosanganisirwa neplatelet-yakatorwa kukura factor receptor gene rearrangements
• vanhu vakuru vane hukasha systemic mastocytosis isina iyo D816V c-Kit mutation kana nec-Kit mutational chinzvimbo chisingazivikanwe
• vanhu vakuru vane hypereosinophilic syndrome uye / kana chisingaperi eosinophilic leukemia ine FIP1L1-PDGFRcy fusion kinase, isina kunaka kune iyo FIP1L1-PDGFRcy fusion kinase, kana chinzvimbo chisingazivikanwe.
• vanhu vakuru vane unresectable, vanodzokorora, kana metastatic dermatofibrosarcoma protuberans (DFSP)
• Vakuru vane unresectable kana metastatic malignant Kit + yemudumbu stromal tumors (GIST)
• adjuvant kurapwa kwevakuru vane Kit + GIST inotevera yakazara yakazara resection

Nzira yekuita

Gleevec inhibits iyo BCR-ABL tyrosine kinase, inova iyo isina kujairika tyrosine kinase inowanikwa muPh + CML. Kuvhiringidzwa kweBCR-ABL tyrosine kinase kunodzivirira kuwanda kwemaseru uye kunokonzeresa apoptosis muBCR-ABL maseru mitsara uye mune leukemic maseru mitsara. Gleevec zvakare inodzivisa iyo tyrosine kinases yeplatelet-yakatorwa kukura chinhu (PDGF) uye stem cell factor (SCF) pamwe nec-Kit, iyo inotitadzisa kuwanda uye inokonzeresa apoptosis mumasero eGIST.

Pharmacokinetics uye metabolism

Zvinoreva zvachose bioavailability ndeye 98% inotevera yemuromo manejimendi. Inenge 95% yedosi inosungirwa kumapuroteni eplasma (kazhinji albinin uye α1-acid glycoprotein).

Metabolism inoitika zvakanyanya kuburikidza neCYP3A4 kune inoshanda metabolite, ine mashoma metabolism inoitika kuburikidza neCYP1A2, CYP2D6, CYP2C9, uye CYP2C19. Iyo huru inotenderera inoshanda metabolite inoumbwa zvakanyanya neCYP3A4. Inenge 68% inobviswa mutsvina, iine 13% mune weti. Kubvisa hafu-hupenyu hweiyo isina kuchinjika mushonga maawa gumi nemasere uye kubvisa hafu-yehupenyu hweakanyanya anoshanda metabolite maawa makumi mana.

Contraindications

Iko hakuna mhedzisiro inopesana nekushandisa kweGleevec.

Kuchengeta nekubata

Mahwendefa eGleevec anofanirwa kuchengetwa mukamuri yekushisa (77 ° F / 25 ° C) mumudziyo wakasungwa-wakasungwa. Dzivirira mahwendefa kubva kuunyoro.

Mahwendefa eGleevec anoonekwa seanokuvadza, zvinoenderana nemitemo yeOccupational Safety uye Health Administration (OSHA). Mahwendefa haafanire kupwanywa. Dzivisa kubata mahwendefa akapwanyika. Kana ganda kana mucus membranes zvikasangana nemapiritsi akapwanyika, geza nzvimbo yakakanganiswa zvinoenderana nhungamiro yeOSHA

Disiki: Medical News Nhasi yaedza nepese painogona napo kuti ive neruzivo rwekuti ruzivo rwese rwuri rwechokwadi, rwakazara, uye rwechizvino-zvino. Nekudaro, chinyorwa ichi hachifanirwe kushandiswa sekutsiva ruzivo uye hunyanzvi hweane rezinesi rezvehutano. Iwe unofanirwa kugara uchibvunza chiremba wako kana imwe nyanzvi yehutano usati watora chero mushonga. Ruzivo rwezvinodhaka ruri pano runogona kuchinja uye haruna kuitirwa kufukidza ese mashandisirwo, madhairekitori, chenjedzo, kunyeverwa, kudyidzana kwezvinodhaka, allergic reaction, kana mhedzisiro. Kushaikwa kweyambiro kana rumwe ruzivo rwemushonga wakapihwa hakuratidze kuti mushonga kana musanganiswa wezvinodhaka wakachengeteka, unoshanda, kana wakakodzera kuvarwere vese kana kushandiswa kwese chaiko.