Glucagonoma

Zvemukati

• Ndezvipi Zviratidzo zveGlucagonoma?
• Ndezvipi Zvinokonzera Glucagonoma?
• Glucagonoma Inoonekwa Sei?
• Ndeapi marapirwo aripo eGlucagonoma?
• Ndezvipi Zvinetso zveGlucagonoma?
• Chii Chandinogona Kutarisira Munguva Yakareba?

Chii chinonzi Glucagonoma?

Glucagonoma ibundu risingawanzo rinosanganisira rwatata. Glucagon ihormone inogadzirwa nepancreas inoshanda ne insulin kudzora huwandu hweshuga muropa rako. Glucagonoma bundu maseru rinoburitsa yakawanda yeglucagon, uye aya akakwirira mazinga anogadzira zvakakomba, zvinorwadza, uye zvinotyisidzira hupenyu zviratidzo. Inenge mashanu kusvika gumi muzana ezviyo zveeuroendocrine zvinokura mupancreas ndeyeglucagonomas.

Ndezvipi Zviratidzo zveGlucagonoma?

Kana iwe uine bundu rinoburitsa yakawanda yeglucagon, zvinokanganisa zvinhu zvakawanda zvehutano hwako. Glucagon inoenzanisa mhedzisiro ye insulin nekugadzirisa huwandu hweshuga muropa rako. Kana uine glucagon yakawandisa, masero ako haachengete shuga uye pachinzvimbo shuga inogara muropa rako.

Glucagonoma inotungamira kune chirwere cheshuga-senge zviratidzo uye zvimwe zvinorwadza uye zvine njodzi zviratidzo, zvinosanganisira:

• shuga yakakwira muropa
• nyota yakawandisa uye nzara nekuda kweshuga yakakwira muropa
• kazhinji kumuka husiku kuti uite weti
• manyoka
• kuputika kweganda, kana dermatitis, kumeso, dumbu, magaro, uye tsoka zvinowanzo kuve zvakakora kana kuzadzwa ne pus
• kurasikirwa nemaune uremu
• kuvhara ropa mumakumbo, iyo inonziwo yakadzika vein thrombosis

Ndezvipi Zvinokonzera Glucagonoma?

Iko hakuna kuzivikanwa kwakanangana zvikonzero zveglucagonoma. Kana iwe uine nhoroondo yemhuri yechirwere chinonzi multiple endocrine neoplasia type 1 (MEN1) une njodzi huru yekukudziridza glucagonoma. Zvisinei, avo vasina zvimwe zvinokonzera njodzi vanogona kukudziridza matumbo aya.

Glucagonomas vane cancer, kana yakaipa, nezve iyo nguva. Malignant glucagonomas inopararira mune mamwe matishu, kazhinji chiropa, uye wotanga kupindira nekuita kweimwe nhengo.

Glucagonoma Inoonekwa Sei?

Zvinogona kuve zvakaoma kuongorora glucagonoma. Kazhinji, zviratidzo zvinoita kunge zvinokonzereswa neimwe mamiriro, uye zvinogona kunge zviri makore pamberi pekuongororwa kwakanaka.

Kuongororwa kunoitwa pekutanga pamwe nekuongororwa kweropa kwakawanda. High glucagon mazinga ndiwo chiratidzo cheichi chiitiko. Zvimwe zviratidzo zvinosanganisira shuga yakakwira muropa, huwandu hwakawanda hwechromogranin A, inova puroteni inowanzo kuwanikwa mumatota ecarcinoid, uye kupererwa neropa, inova mamiriro ayo ane mwero wakaderera wemasero matsvuku eropa.

Chiremba wako anozoteedzera iyi bvunzo neCT scan yedumbu kuti utsvage kuvapo kwemamota.

Zvikamu zviviri kubva muzvitatu zveglucagonomas ese zvakaipa. Aya mamota anogona kupararira mumuviri wese uye opinda dzimwe nhengo. Mamota anowanzo kuve akakura uye anogona kuva mana kusvika kumatanhatu masendimita paanowanikwa. Gomarara iri rinowanzoonekwa risati rapararira kuchiropa.

Ndeapi marapirwo aripo eGlucagonoma?

Kurapa glucagonoma kunosanganisira kubvisa mamota maseru uye kurapa mhedzisiro yekuwandisa kweglucagon pamuviri wako.

Zviri nani kutanga kurapwa nekudzikamisa mhedzisiro yeakawandisa glucagon. Izvi zvinowanzo sanganisira kutora somatostatin analog drug, senge jekiseni re octreotide (Sandostatin). Octreotide inobatsira kurwisa mhedzisiro yeglucagon paganda rako uye kugadzirisa kuputika kweganda.

Kana iwe wakarasikirwa nehuremu hwakawanda, ungangoda IV kuti ubatsire kudzoreredza huremu hwemuviri wako. Yakakwira shuga yeropa inogona kurapwa ne insulini uye nekuvharisisa padyo ropa rako re glucose.

Iwe unogona zvakare kupihwa anticoagulant mishonga, kana ropa mutete. Izvi zvinodzivirira kuumbwa kweropa mumakumbo ako, inozivikanwawo seyakadzika vein thrombosis. Kune vanhu vari panjodzi yeakadzika vein thrombosis, firita inogona kuiswa mune imwe yetsinga dzako hombe, yakaderera vena cava, kudzivirira kugwamba kusasvika pamapapu ako.

Kana uchinge waita hutano zvakakwana, bundu racho rinogona kuzobviswa nekuvhiya. Rudzi urwu rwebundu haruwanzo pindura zvakanaka kune chemotherapy. Kuvhiya kunonyanya kubudirira kana bundu rikabatwa richiri rakavharirwa nepancreas.

Kuvhiya kwekutsvaga kwemudumbu kunogona kuitwa kungaita laparoscopically, nekucheka kudiki kubvumidza makamera, mwenje, uye maturusi, kana nekugadzira yakakura yakavhurika incision.

Mazhinji glucagonomas anoitika kuruboshwe kana muswe wepancreas. Kubviswa kwechikamu ichi kunonzi distal pancreatectomy. Mune vamwe vanhu, iyo spleen inobviswa zvakare. Kana bundu rechipfuva rikaongororwa pasi pe microscope, zvinonetsa kuziva kana iri cancer. Kana iri gomarara, chiremba wako anovhiya achabvisa bundu rakawanda sezvinobvira kudzivirira kuti risapararire mberi. Izvi zvinogona kusanganisira chikamu chepancreas, ma lymph node emuno, uye kunyangwe chikamu chechiropa.

Ndezvipi Zvinetso zveGlucagonoma?

Kuwedzeredza glucagon kunotungamira kuchirwere cheshuga-kunge zviratidzo. Yakawanda shuga yeropa inogona kukonzera:

• kukuvara kwetsinga
• upofu
• matambudziko emagetsi
• kukuvara kwehuropi

Yakadzika vein thrombosis inogona kukonzera kuwanda kweropa kuenda kumapapu, uye inogona kutokonzeresa kufa.

Kana bundu rikapinda muchiropa, rinogona kupedzisira rakonzera kutadza kwechiropa.

Chii Chandinogona Kutarisira Munguva Yakareba?

Kazhinji, nenguva iyo glucagonoma ichionekwa, kenza yapararira kune dzimwe nhengo, senge chiropa. Kazhinji, kuvhiyiwa hakubatsiri nekuti zvinonetsa kuiona nekukurumidza.

Kamwe bundu parinobviswa, mhedzisiro yeakawandisa glucagon inoderera ipapo ipapo. Kana bundu racho rakaganhurirwa kune pancreas chete, makore mashanu ekupona ari, zvichireva kuti 55 muzana yevanhu vanorarama kwemakore mashanu mushure mekuvhiyiwa.Kune makore mashanu ekupona kana mamota asingakwanise kubviswa nekuvhiyiwa.