Mishonga Yevanhu vane Ulcerative Colitis

Zvemukati

• Aminosalicylates (5-ASA)
• Mesalamine
• Sulfasalazine
• Olsalazine
• Balsalazide
• Corticosteroids
• Budesonide
• Prednisone uye prednisolone
• Immunomodulators
• Neworleansghbb
• Methotrexate
• Azathioprine
• Mercaptopurine
• Zvimwe zvinokanganisa methotrexate, azathioprine, uye mercaptopurine
• Biologics
• Dzivisa NSAIDs
• Taura nachiremba wako

Nhanganyaya

Ulcerative colitis rudzi rwechirwere chinoputira chirwere (IBD) chinonyanya kukanganisa colon (ura hukuru). Zvinogona kukonzerwa nemhinduro isina kujairika kubva kuzvirwere zvemuviri wako. Kunyangwe pasina mushonga unozivikanwa we ulcerative colitis, mhando dzinoverengeka dzemishonga dzinogona kushandiswa kubata zviratidzo.

Zviratidzo zve ulcerative colitis zvinogona kusanganisira:

• kurwadziwa mumimba, kusagadzikana, kana kurwadza
• chirwere chinoramba chiripo
• ropa muchitsiko

Zviratidzo zvinogona kuramba zvichingoitika kana kuti zvingatonyanya kukura panguva yemoto.

Mishonga yakasiyanasiyana inogona kushandiswa kudzikisira kuzvimba (kuzvimba uye kutsamwa), kudzikisa huwandu hwekupenga iwe, uye kubvumira colon yako kupora. Makirasi mana makuru emishonga anoshandiswa kurapa vanhu vane ulcerative colitis.

Aminosalicylates (5-ASA)

Aminosalicylates anofungidzirwa kudzikisa zviratidzo zve ulcerative colitis nekudzora kuzvimba mukoloni. Iyi mishonga inoshandiswa muvanhu vane hunyoro kusvika pakuenzanisa ulcerative colitis. Vanogona kubatsira kudzivirira kuburitsa-kumusoro kana kudzikisa huwandu hwekupenga-hwauinako.

Mienzaniso yemishonga iyi inosanganisira:

Mesalamine

Mesalamine inogona kutorwa nemuromo (nemuromo) sekunonoka-kuburitsa piritsi, yakawedzera-kuburitsa kapuleti, kana kunonoka-kuburitsa capsule. Mesalamine inowanikwawo sey rectal suppository kana rectal enema.

Mesalamine inowanikwa seyakajairika mushonga mune mamwe maitiro. Iyo zvakare ine akati wandei ezita-zita shanduro, senge Delzicol, Apriso, Pentasa, Rowasa, sfRowasa, Canasa, Asacol HD, uye Lialda.

Izvo zvinowanzoitika mhedzisiro yemesalamine inogona kusanganisira:

• manyoka
• musoro
• kusvotwa
• kurwadziwa mumimba, kurwadza, uye kusagadzikana
• kuwedzerwa mudumbu acidity kana reflux
• kurutsa
• burping
• mapundu

Kazhinji asi zvakakomba mhedzisiro yemesalamine inogona kusanganisira:

• kurwadziwa pachipfuva
• mweya wekufema
• irregular moyo mutinhimira

Mienzaniso yemishonga iyo mesalamine inogona kusangana nayo inosanganisira:

• thioguanine
• warfarin
• Varicella zoster mushonga

Sulfasalazine

Sulfasalazine inotorwa nemuromo seyekukurumidza-kuburitsa kana kunonoka-kuburitsa piritsi. Sulfasalazine inowanikwa seyakajairika mushonga uye sezita rezita remishonga Azulfidine.

Iyo yakajairika mhedzisiro mhedzisiro yesulfasalazine inogona kusanganisira:

• kurasikirwa nenzara
• musoro
• kusvotwa
• kurutsa
• kugumbuka mudumbu
• kuderera kwehurume muhurume

Zvimwe zvisingawanzo asi zvakakomba mhedzisiro ye sulfasalazine inosanganisira:

• kusagadzikana kweropa senge anemia
• zvakanyanya kukanganiswa nemagetsi seStevens-Johnson syndrome
• chiropa kutadza
• matambudziko eitsvo

Sulfasalazine inogona kusangana nemimwe mishonga, yakadai se:

• digoxin
• folic acid

Olsalazine

Olsalazine inouya sekapuleti iwe yaunotora nemuromo. Inowanikwa sezita rezita rechinodhaka Dipentum. Haisi kuwanikwa seyakajairika mushonga.

Iyo inowanzoitika mhedzisiro mhedzisiro yeolsalazine inogona kusanganisira:

• manyoka kana tsvina yakasununguka
• kurwadziwa mudumbu mako
• mapundu kana kuvava

Yakakomba mhedzisiro mhedzisiro yeolsalazine inogona kusanganisira:

• kusagadzikana kweropa senge anemia
• chiropa kutadza
• matambudziko emoyo senge pamoyo mutinhimira unoshanduka uye kuzvimba kwemoyo wako

Mienzaniso yemishonga iyo olsalazine inogona kusangana nayo inosanganisira:

• heparin
• yakaderera-mamorekuru uremu heparini senge enoxaparin kana dalteparin
• chemura
• thioguanine
• Varicella zoster mushonga

Balsalazide

Balsalazide inotorwa nemuromo sekapisi kana piritsi. Iyo capsule inowanikwa seyakajairika mushonga uye sezita rezita zvinodhaka Colazal. Piritsi racho rinongowanikwa chete sezita rezita rekuti Giazo.

Iyo inowanzoitika mhedzisiro mhedzisiro yebhalsalazide inogona kusanganisira:

• musoro
• marwadzo emudumbu
• manyoka
• kusvotwa
• kurutsa
• mweya wekufema
• kurwadza kwemajoini

Matambudziko akakomba ebalsalazide anogona kusanganisira:

• kusagadzikana kweropa senge anemia
• chiropa kutadza

Mienzaniso yemishonga iyo balsalazide inogona kusangana nayo inosanganisira:

• thioguanine
• warfarin
• Varicella zoster mushonga

Corticosteroids

Corticosteroids inoderedza muviri wako wese immune system kupindura kudzikisa kuzvimba mumuviri wako. Aya marudzi emishonga anoshandiswa kurapa vanhu vane mwero kusvika kune wakasimba unoshanda ulcerative colitis. Corticosteroids inosanganisira:

Budesonide

Mafomu maviri ebudesonide ayo anotenderwa ulcerative colitis akawedzeredzwa-mapiritsi ekusunungura uye rectal foam. Ose ari maviri anowanikwa sezita rezita remushonga Uceris. Hazviwanikwe semishonga inowanzoitwa.

Iyo yakajairika mhedzisiro mhedzisiro yebudesonide inogona kusanganisira:

• musoro
• kusvotwa
• kuderera kwehuremu hwehomoni cortisol
• kurwadziwa mudumbu rako repamusoro
• kuneta
• kuzvimba
• acne
• Urinary turakiti hutachiona
• kurwadza kwemajoini
• kuvimbiswa

Yakakomba mhedzisiro mhedzisiro yebudesonide inogona kusanganisira:

• matambudziko ekuona senge glaucoma, cataract, uye kupofomara
• BP

Budesonide inogona kusangana nemimwe mishonga yakadai se:

• protease inhibitors senge ritonavir, indinavir, uye saquinavir, ayo anoshandiswa kurapa hutachiona hweHIV
• antifungal zvinodhaka zvakadai itraconazole uye ketoconazole
• erythromycin
• mishonga yekudzivirira pamuromo ine ethinyl estradiol

Prednisone uye prednisolone

Prednisone inowanikwa mune piritsi, inononoka-kuburitsa piritsi, uye mafomu emvura mhinduro. Iwe unotora chero cheizvi nemuromo. Prednisone inowanikwa seyakajairika mushonga uye sezita rezita zvinodhaka Deltasone, Prednisone Intensol, naRayos.

Mafomu e prednisolone anotenderwa ulcerative colitis ndeaya:

• mahwendefa
• mahwendefa ekunyungudika
• mhinduro yemvura
• manyuchi

Iwe unogona kutora chero eaya mafomu nemuromo. Prednisolone inowanikwa seyakajairika mushonga uye sezita rezita zvinodhaka Millipred.

Iyo inowanzoitika mhedzisiro mhedzisiro ye prednisone uye prednisolone inogona kusanganisira:

• kuwedzera huwandu hweshuga yeropa
• kusagadzikana kana kushushikana
• kuwedzerwa kweropa
• kuzvimba nekuda kwekuchengetwa kwemvura mumakumbo ako kana makumbo
• kuwedzera kudya
• kurema kuwedzera

Migumisiro yakakomba ye prednisone uye prednisolone inogona kusanganisira:

• osteoporosis uye kuwedzera njodzi yekutyoka kwepfupa
• matambudziko emwoyo akadai sekurwadziwa kwemoyo, kurwadziwa pachipfuva, uye moyo mutinhimira unoshanduka
• pfari

Mienzaniso yemishonga iyo prednisone uye prednisolone inogona kusangana nayo inosanganisira:

• antiseizure zvinodhaka zvakadai se phenobarbital uye phenytoin
• vanoonda ropa senge warfarin
• rifampin
• ketoconazole
• asipurini

Immunomodulators

Immunomodulators mishonga inoderedza mhinduro yemuviri kune yayo immune system. Mhedzisiro yacho yakadzikira kuzvimba mumuviri wemunhu. Immunomodulators inogona kudzikisa huwandu hwe ulcerative colitis flare-ups yauinayo uye nekukubatsira iwe kugara usina chiratidzo kwenguva refu.

Immunomodulators inowanzo shandiswa muvanhu vane zviratidzo zvisina kudzorwa neaminosalicylates uye corticosteroids. Nekudaro, iyi mishonga inogona kutora mwedzi yakati kuti kuti itange kushanda.

Immunomodulators anosanganisira:

Neworleansghbb

Kusvikira munguva pfupi yapfuura, ma immunomodulators haana kubvumidzwa neU.S.Food uye Drug Administration (FDA) kurapa vanhu vane ulcerative colitis. Kunyange zvakadaro, iri kirasi remishonga yaive dzimwe nguva anoshandiswa kure-chitaridzi kurapa vanhu vane ulcerative colitis.

Imwe yakadaro-isiri-yekushandisa yakazova chinhu chekare muna 2018 apo FDA yakabvumidza kushandiswa kweiyo immunomodulator kune vanhu vane ulcerative colitis. Iyi immunomodulator inonzi tofacitinib (Xeljanz). Yaimbove FDA-yakatenderwa kune vanhu vane rheumatoid arthritis asi yaishandiswa off-label kune vanhu vane ulcerative colitis. Xeljanz ndiyo yekutanga mishonga yerudzi rwayo inopihwa nemuromo - kwete nejekiseni - yekurapa-kwenguva refu kwevanhu vane ulcerative colitis.

Dzidza zvakawanda nezve off-label kushandisa zvinodhaka.

Methotrexate

Methotrexate inowanikwa sehwendefa raunotora nemuromo. Izvo zvakare zvinopihwa neiyo intravenous (IV) infusion pamwe nemajekiseni epasi uye epamo. Piritsi racho rinowanikwa semushonga unogadzirwa neakajairika uye sezita rezita rekuti drug Trexall. Mhinduro ye IV uye jekiseni repamuviri zvinongowanikwa semishonga inowanzoitwa. Iyo subcutaneous jekiseni inongowanikwa chete sezita rezita-zvinodhaka Otrexup naRasuvo.

Azathioprine

Nezve ulcerative colitis kurapwa, azathioprine inouya sehwendefa raunotora nemuromo. Inowanikwa seyakajairika mushonga uye sezita rezita -mishonga Azasan uye Imuran.

Mercaptopurine

Mercaptopurine inowanikwa sehwendefa kana kumiswa kwemvura, ese anotorwa nemuromo. Piritsi racho rinongowanikwa chete seyakajairika mushonga, uye kumiswa kwacho kunongowanikwa sezita rezita rekuti Purixan.

Zvimwe zvinokanganisa methotrexate, azathioprine, uye mercaptopurine

Iyo yakajairika mhedzisiro mhedzisiro yeaya immunomodulators inogona kusanganisira:

• musoro
• kusvotwa
• kurutsa
• manyoka
• maronda emuromo
• kuneta
• masero eropa akaderera

Mienzaniso yemishonga iyo immunomodulators inogona kusangana nayo inosanganisira:

• musapa
• aminosalicylates s sulfasalazine, mesalamine, uye olsalazine
• angiotensin-inoshandura enzyme (ACE) inhibitors senge lisinopril uye enalapril
• warfarin
• ribavirin
• nonsteroidal anti-inflammatory drug (NSAIDs) senge naproxen uye ibuprofen
• phenylbutazone
• phenytoin
• sulfonamides
• zvimiro
• retinoids
• theophylline

Biologics

Biologics mishonga inogadzirwa nemajini yakagadzirwa murabhoritari kubva kune mupenyu hupenyu. Iyi mishonga inodzivirira mamwe mapuroteni mumuviri wako kubva mukukonzera kuzvimba. Biologic zvinodhaka zvinoshandiswa kune vanhu vane zvine mwero kusvika zvakanyanya ulcerative colitis. Izvo zvinoshandiswawo kune vanhu vane zviratidzo zvisina kudzorwa nemishonga yakadai seaminosalicylates, immunomodulators, kana corticosteroids.

Kune mishanu biologic zvinodhaka zvinoshandiswa kune ulcerative colitis chiratidzo manejimendi. Izvi zvinongowanikwa chete sezita-zita zvinodhaka, zvinosanganisira:

• adalimumab (Humira), yakapihwa jekiseni rinotsvedza
• golimumab (Simponi), yakapihwa jekiseni rinotsvedza
• infliximab (Remicade), yakapihwa IV infusion
• infliximab-dyyb (Inflectra), yakapihwa IV infusion
• vedolizumab (Entyvio), yakapihwa IV kumisikidzwa

Ungangoda kutora adalimumab, golimumab, infliximab, kana infliximab-dyyb kwemavhiki masere usati waona chero kuvandudzwa. Vedolizumab kazhinji inotanga kushanda mumavhiki matanhatu.

Iyo inowanzoitika mhedzisiro mhedzisiro ye biologic zvinodhaka inogona kusanganisira:

• musoro
• kupindwa nechando
• chills
• mikoko kana mapundu
• kuwedzera hutachiona

Biologic zvinodhaka zvinogona kubatana nemamwe ma biologic vamiririri. Mienzaniso yeiyi inosanganisira:

• natalizumab
• adalimumab
• golimumab
• infliximab
• anakinra
• abva
• tocilizumab
• warfarin
• cyclosporine
• theophylline
• rarama mishonga yekudzivirira yakadai sevicella zoster vaccine

Dzivisa NSAIDs

NSAIDs, senge ibuprofen uye naproxen, zvinowanzo deredza kuzvimba mumuviri. Kana iwe uine ulcerative colitis, zvakadaro, izvi zvinodhaka zvinogona kuita kuti zviratidzo zvako zviwedzere. Ive neshuwa yekutaura nachiremba wako usati watora NSAID.

Taura nachiremba wako

Mishonga yakawanda inogona kubatsira kudzikisa ulcerative colitis yako zviratidzo. Kana iwe uine ulcerative colitis, dzokorora ichi chinyorwa nachiremba wako uye taura nezve iyo mishonga ingave yakakunakira iwe. Chiremba wako anozopa mishonga zvichibva pazvinhu zvakaita sehutano hwako hwese uye kuti mamiriro ako akanyanya sei.

Ungangoda kuedza mishoma mishonga usati wawana chirongwa chekurapa chinokushandira. Kana kutora mushonga mumwe chete kusingadzikise zviratidzo zvako zvakakwana, chiremba wako anogona kuwedzera wechipiri mushonga unoita kuti wekutanga ubudirire. Zvinogona kutora nguva, asi chiremba wako achashanda newe kuti uwane mishonga yakakodzera yekubatsira kupora ulcerative colitis zviratidzo.