Ko Ketamine Inogona Kubatsira Kurapa Kushungurudzika?

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Kushungurudzika kwakanyanya kupfuura zvaunogona kufunga. Inobata vanopfuura mamirioni gumi nemashanu vekuAmerican, uye World Health Organisation inofungidzira kuti huwandu hunokura kusvika pamamirioni mazana matatu kana iwe ukawedzera pasirese. Kune akaurayiwa emhando dzakasiyana dzekurapa dziripo kubatsira kubatsira kudzikisira zviratidzo-kufunga kunetseka, kushaya hope, kuneta, uye kurasikirwa nechido pakati pevamwe-neyakajairika kurapwa iyo serotonin reuptake inhibitors (kana SSRIs). Asi kubva munenge muna 2000, vanachiremba nevatsvakurudzi vave vachiedza ketamine-pakutanga mishonga yekugadzirisa marwadzo, ikozvino inoshandiswa semushonga wemumugwagwa nekuda kwehallucinogenic migumisiro-seimwe nzira inogona kurapa mamiriro acho, maererano naRuben Abagyan, Ph.D. , purofesa wezvemishonga paYunivhesiti yeCalifornia San Diego (UCSD).

Pamwe uri kufunga, "Wait! Chii?" Kana iwe wakambonzwa nezve ketamine, inozivikanwawo seSpecial K, iwe unoziva haisi joke kana generic OTC zvinodhaka. Muchokwadi, inozivikanwa se dissociative anesthetic (zvinoreva mushonga unokanganisa maonero ekuona uye ruzha, uchigadzira manzwiro chaiwo ekuzvibata kubva kune wega uye nharaunda). Inonyanya kushandiswa neveterinarians pakurapa marwadzo emhuka, asi inogonawo kurongerwa kune vanhu kuti vagadzirise kurwadziwa kwakanyanya, kunyanya avo vane neuropathic nyaya, rudzi rwechirwere chisingaperi chetsinga, maererano nekuongorora kwe2014 kwakabudiswa mu British Journal ye Pharmacology.

"Zvinozivikanwa kuti kurwadziwa uye kushushikana zvakabatana," anodaro Isaac Cohen, mudzidzi wezvemishonga akashanda pachidzidzo ichi. "Vanhu vakaora mwoyo vanowanzogara pakurwadziwa uye vanhu vane kurwadziwa kusingaperi vanowanzoora mwoyo nekuda kwekuderera kwekufamba, kuderera kwekuita maekisesaizi, nezvimwe zvinhu," anodaro. kushushikana panguva imwe chete, zvichitungamira kumhedzisiro iri nani yemamiriro ese ari maviri. "Uye izvozvi masayendisiti ari kuita nharo kuti hapana humbowo hweanecdotal chete, asiwo ruzivo rwehuwandu runoratidza ketamine inogona kubatsira kudzikisa zviratidzo zvekuora mwoyo."

Mukutanga-kwese kukura kwakakura kwemhando kwayo, kwakaburitswa muna Zvisikwa, vatsvakurudzi vakawana kuti varwere vakagamuchira ketamine vakarondedzera zvakanyanya kuderera zviitiko zvekuora mwoyo. Iyi tsvagiridzo, inoitiswa neChikoro cheFarmacy uye Chemishonga Sayenzi kuUCSD, inosimbisa anecdotal dhata uye zvidiki zvidzidzo zvevanhu izvo zvakare zvakaratidza ketamine's antidepression mhedzisiro.

Chii chinoisa ketamine kusiri kune mamwe marapirwo, kunyanya, ndeyekuti zvinokurumidza sei kushanda. "Iyezvino FDA-inotenderwa marapirwo ekuora mwoyo anokundikana kumamirioni nekuti haashande nekukurumidza," anodaro Abaygan. Ketamine inoshanda mune imwe nguva yemaawa. Izvo zvakaderera kwazvo kupfuura SSRIs, semuenzaniso, izvo zvinogona kutora mavhiki matanhatu kusvika gumi kuti vakwanise kuzara kwavo. Uye iwo mutsauko wenguva inogona chaizvo kunge iri nyaya yehupenyu kana kufa, kunyanya nevaya vari kuzviuraya.

Zvekutsvagisa kwavo, Abaygan nechikwata chake vakaongorora data kubva kuDFA's Adverse Chiitiko Chirevo Sisitimu, iyo agency inounganidza ruzivo nezve zvakashata mhedzisiro (kana zvinokanganisa zvisirizvo zvemhando ipi neipi) yemushonga upi noupi unobvumidzwa uyo wakataurwa nevemishonga navanachiremba. Kunyanya, vakawana varwere ve40,000 avo vakanyorerwa mishonga yemarwadzo uye vakaparadzanisa mumapoka maviri-avo vakatora ketamine uye avo vanobatwa nemamwe mishonga inorwadza (kunze kweNSAIDs).

Mhedzisiro yacho yakaratidza chakakosha "bhonasi," kunyangwe zvaisatarisirwa, mhedzisiro. Hafu yevanhu vairapa marwadzo avo ne ketamine vakashuma kushushikana zvakanyanya pane avo vaive vatora mamwe marapirwo ekudzora marwadzo. Kunyangwe isu tisingazive kana mumwe weava varwere, kunyanya avo vari ketamine, vanga vachirwara nezviratidzo zvisati zvaitika vasati vatora chero mishonga, mhedzisiro pamamiriro ezvinhu, pamwe nehukama hwakajairika pakati pekutambudzika nekushungurudzika, zvinogona kupa hurukuro yekuenderera mberi pamusoro pekushandisa ketamine ku bata kushungurudzika zvakanyanya.

Sekureva kwevaongorori, ketamine haina mutengo uye kana iwe wakamboedza kanenge katatu mimwe mishonga yekudzvinyirira isina kubudirira, inowanzo kuvharwa nezvirongwa zveinishuwarenzi zvehutano. Chiripo here? Usakurumidza kunyora ketamine se hallucinogen. Zvinogona kunge zvichinyanya kukosha mushure mezvose. (Uye kana pasina chimwe chinhu, varume, tarisai nzira idzi dzekugadzirisa kushungurudzika kana kuora mwoyo manzwiro chero nguva.)

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