Methionine: Mabasa, Chikafu Sosi uye Matambudziko

Zvemukati

• Chii chinonzi Methionine?
• Iyo Inogona Kuburitsa Mamorekuru Akakomba kune Akajairwa Cell Kushanda
• Inoita Basa muDNA Methylation
• Kudya-kweMethionine Kudya Kunowedzera Hupenyu Hwehupenyu muMhuka
• Kudya Zvitubu zveMethionine
• Kudya, Kushatisa uye Nezvakakomba Mhedzisiro
• Yakakurudzirwa Intake
• Migumisiro paHomocysteine
• Side Migumisiro
• Icho Chinokosha

Amino acids anobatsira kuvaka mapuroteni anoita matishu uye nhengo dzemuviri wako.

Pamusoro peiri basa rakakomba, mamwe maamino acids ane mamwe mabasa akakosha.

Methionine iamino acid inogadzira mamorekuru akakosha mumuviri wako. Aya mamorekuru akakosha pakushanda kwakakodzera kwemasero ako.

Nekuda kwemamorekuru akakosha ainogadzira, vamwe vanokurudzira kuwedzera kwemethionine. Nekudaro, vamwe vanokurudzira kudzikamisa nekuda kwekukanganisa kwakashata mhedzisiro.

Chinyorwa ichi chichataura nezvekukosha kwemethionine uye kana iwe uchifanira kunetseka nezve huwandu hwayo mukudya kwako. Zvinyorwa uye zvinogona kuitika mhedzisiro zvinokurukurwawo.

Chii chinonzi Methionine?

Methionine iamino acid inowanikwa mumapuroteni mazhinji, kusanganisira mapuroteni muzvikafu uye ayo anowanikwa mumatumbu uye nhengo dzemuviri wako.

Pamusoro pekuve chivakwa chemapuroteni, ine zvimwe zvakawanda zvakasarudzika maficha.

Imwe yeiyi kugona kwayo kushandurwa kuve yakakosha sarufa-ine mamorekuru ().

Sulphur-ine mamorekuru ane akasiyana mabasa, kusanganisira kuchengetedzwa kwemasuru ako, kugadzirisa yako DNA uye nekuchengetedza kushanda kwakanaka kwemasero ako (, 3).

Aya mamorekuru akakosha anofanirwa kugadzirwa kubva kumaamino acids ane sarufa. Pamamino acids anoshandiswa kugadzira mapuroteni mumuviri, chete methionine uye cysteine ​​ine sarufa.

Kunyangwe muviri wako uchigona kuburitsa amino acid cysteine ​​iri yega, methionine inofanira kubva pane chako chikafu (4).

Pamusoro pezvo, methionine inoita basa rakakosha mukutanga maitiro ekugadzira mapuroteni matsva mukati memasero ako, chimwe chinhu chiri kuramba chichiitika apo mapuroteni ekare anodonha ().

Semuenzaniso, iyi amino acid inotanga maitiro ekugadzira mapuroteni matsva mumhasuru dzako mushure memusangano wekurovedza muviri unovakuvadza (,).

Methionine yakasarudzika amino acid. Ine sarufa uye inogona kuburitsa mamwe mamorekuru ane sarufa mumuviri. Inobatanidzwawo kutanga kugadzirwa kweprotein mumasero ako.

Iyo Inogona Kuburitsa Mamorekuru Akakomba kune Akajairwa Cell Kushanda

Imwe yemabasa makuru emethionine mumuviri ndeyekuti inogona kushandiswa kugadzira mamwe mamorekuru akakosha.

Inobatanidzwa mukugadzirwa kwecysteine, imwe sarufa-ine amino acid inoshandiswa kuvaka mapuroteni mumuviri (,).

Cysteine ​​inogona, zvakare, kugadzira mamorekuru akasiyana siyana, kusanganisira mapuroteni, glutathione uye taurine ().

Glutathione dzimwe nguva inonzi "master antioxidant" nekuda kwebasa rayo rakakomba mukudzivirira kwemuviri wako (,).

Inoitawo basa mune metabolism yezvinhu zvinovaka muviri mumuviri uye kugadzirwa kweDNA nemapuroteni ().

Taurine ine akawanda mabasa anobatsira kuchengetedza hutano uye kushanda mushe kwemasero ako ().

Imwe yemamorekuru akakosha methionine inogona kushandurwa kuita S-adenosylmethionine, kana "SAM" ().

SAM inobatanidzwa mukuchinja kwakasiyana kwemakemikari kuburikidza nekuendesa chikamu chayo kune mamwe mamorekuru, kusanganisira DNA nemapuroteni (3,).

SAM inoshandiswa zvakare mukugadzira kwe creatine, yakakosha mamorekuru esimba remagetsi (,).

Pakazara, methionine yakanangana kana zvisina kunangana mune akawanda akakosha maitiro mumuviri nekuda kwema mamorekuru ayo anogona kuve.

Methionine inogona kushandura kuita akati wandei ane sulfur ane mamorekuru ane akakosha mashandiro, senge glutathione, taurine, SAM uye creatine. Aya mamorekuru akakosha kune zvakajairika mashandiro emaseru mumuviri wako.

Inoita Basa muDNA Methylation

DNA yako ine ruzivo runokuita iwe zvauri.

Nepo yakawanda yeruzivo iyi inogona kuramba yakafanana kune hwako hwese hupenyu, zvakatipoteredza zvinhu zvinogona chaizvo kuchinja zvimwe zveDNA rako.

Iyi ndiyo imwe yemabasa anonyanya kunakidza emethionine - kuti inogona kushanduka kuita mamorekuru anonzi SAM. SAM inogona kuchinja yako DNA nekuwedzera methyl boka (kabhoni atomu uye rakabatanidzwa maatomu ehydrogen) kwairi (3,).

Huwandu hwemethionine mukudya kwako hunogona kukanganisa kuwanda kweichi chiitiko chinoitika, asi kune akawanda asina mhinduro mibvunzo nezve izvi.

Izvo zvinokwanisika kuti kuwedzera methionine mukudya kunogona kuwedzera kana kudzikira kuti DNA yako inoshanduka zvakadii semhedzisiro yeSAM ().

Pamusoro pezvo, kana shanduko idzi dzikaitika, dzinogona kubatsira mune dzimwe nguva asi dzichizokuvadza mune vamwe ().

Semuenzaniso, kumwe kutsvagurudza kwakaratidza kuti kudya kwakanyanya muzvinhu zvinovaka muviri zvinowedzera mapoka emethyl kuDNA yako kunogona kudzikisira njodzi yekenza yakajeka ().

Nekudaro, kumwe kutsvagurudza kwakaratidza kuti kukwirira kwemethionine kunogona kuwedzera mamiriro akaita seschizophrenia, pamwe nekuda kwekuwedzera mamwe mapoka emethyl kuDNA (,).

Imwe yemamorekuru inogadzirwa ne methionine, SAM, inogona kuchinja yako DNA. Hazvinyatso kujekeswa kuti izvo methionine zvemukati mekudya kwako zvinokanganisa sei maitiro aya, uye zvinokwanisika kuti maitiro aya anobatsira mune dzimwe nguva uye anokuvadza mune vamwe.

Kudya-kweMethionine Kudya Kunowedzera Hupenyu Hwehupenyu muMhuka

Kunyangwe methionine ine akakosha mabasa mumuviri, kumwe kutsvagurudza kunoratidza bhenefiti yezvikafu zvakaderera mune ino amino acid.

Mamwe maseru ekenza anoenderana nemethionine yekudya kuti ikure. Muzviitiko izvi, kudzikisira kudya kwaunodya kunogona kubatsira kubatsira kufa nenzara maseru ekenza ().

Sezvo mapuroteni anobva kuzvirimwa achiwanzo kudzikira mumethionine pane mapuroteni emhuka, vamwe vaongorori vanodavira kuti kudya kunodyarwa nemiti kunogona kuva chishandiso chekurwisa mimwe kanzira (,).

Pamusoro pezvo, ongororo dzinoverengeka dzemhuka dzinoratidza kuti kudzikisa methionine kunogona kuwedzera hupenyu uye kuvandudza hutano (,,).

Imwe ongororo yakawana kuti hupenyu hwaive pamusoro pe40% yakareba mumakonzo aidyisa yakaderera-methionine kudya ().

Hupenyu hurefu uhwu hunogona kunge hwakakonzerwa nekunetseka kusagadzikana uye metabolism pamwe nekuchengetedza kugona kwemasero emuviri kubereka (,).

Vamwe vaongorori vakagumisa kuti yakaderera methionine zvemukati zvinoshanda kudzikisira chiyero chekweguru mumakonzo ().

Kunyangwe kana kwete izvo mabhenefiti anowedzera kuvanhu hazvisi pachena izvozvi, asi zvimwe bvunzo-chubhu zvidzidzo zvakaratidza mabhenefiti ezvakaderera methionine zvemukati mumasero evanhu (,).

Zvisinei, kutsvagurudzwa kwevanhu kunodiwa pasati paitwa mhedziso.

Mune mhuka, kudzikisa methionine zvemukati mechikafu kunogona kudzora chiyero chekweguru uye kuwedzera hupenyu hwehupenyu. Zvimwe zvidzidzo zvakaratidza mabhenefiti ekuderedza methionine mumasero emunhu, asi kutsva kunodiwa muvanhu vapenyu.

Kudya Zvitubu zveMethionine

Kunyange hazvo zvese zvine mapuroteni-zvine zvekudya zvine imwe methionine, huwandu hwacho hunosiyana zvakanyanya. Mazai, hove uye dzimwe nyama zvine huwandu hwakawanda hweiyi amino acid (23).

Inofungidzirwa kuti ingangoita 8% yemamino acids mumazai machena ane sarufa-ine amino acids (methionine uye cysteine) ().

Iyi kukosha ingangoita mashanu muzana muhuku nemombe uye 4% muzvigadzirwa zvemukaka. Mapuroteni ekudyara anowanzove neakawanda zvakaderera aya maamino acids.

Kumwe kutsvagurudza kwakaongororawo huwandu hwesarufa-ine amino acids (methionine uye cysteine) mumhando dzakasiyana dzezvikafu ().

Izvo zvemukati zvakanyanya (6.8 gramu pazuva) zvakataurwa mune yakakwira-mapuroteni madhayeti, nepo kwakadzika kuwanda kwaive kuripo kune vezvirimwa (3.0 magiramu pazuva) uye vegans (2.3 magiramu pazuva).

Kunyangwe kudya kwakaderera pakati pevanodya nyama, kumwe kutsvagurudza kwakaratidza kuti ivo chaizvo vane kuwanda kweropa kwemethionine pane avo vanodya nyama nehove ().

Uku kutsvaga kwakatungamira vatsvagiridzi kugumisa kuti dhayeti yezvinyorwa uye kuwanda kweropa kwemethionine hazviwanzo kuenderana zvakananga.

Nekudaro, izvi zvidzidzo zvakawana kuti ma vegans ane zvese zvakaderera zvekudya kudya uye kwakadzika kuwanda kweropa re methionine (,).

Mapuroteni emhuka anowanzo kuve nemethionine hombe pane mapuroteni ekudyara. Avo vanotevera kudya kunovakwa muzvirimwa vane kudya kwakaderera kudya kwesarufa-ine amino acids, kunyangwe ivo vachigona kuve nematanho epamusoro kana ezasi emethionine muropa.

Kudya, Kushatisa uye Nezvakakomba Mhedzisiro

Vatsvagiri vakagadza kudya kwezuva nezuva kwesarufa-ine amino acids (methionine uye cysteine), asi zvidzidzo zvakaongororawo mhedzisiro yemadhosi akakwirira.

Yakakurudzirwa Intake

Kudya kwemazuva ese kwakakurudzirwa kwemethionine pamwe necysteine ​​i8,6 mg / lb (19 mg / kg) pazuva kune vanhu vakuru, iri rinotenderera 1.3 magiramu kune mumwe munhu anorema 150 pondo (68 kilograms) (4).

Zvisinei, vamwe vatsvakurudzi vakurudzira kushandisa zvakapetwa kaviri mari iyi zvichibva pakushayikwa kwezvidzidzo zvinoshandiswa kumisikidza kudya kwakakurudzirwa ().

Vakwegura kazhinji vane yakaderera methionine inodya, uye zvidzidzo zvakaratidza kuti vangangoda yakakwira inotora ye2 kusvika ku3 gramu pazuva (,).

Kunyangwe paine chokwadi chekuti mamwe mapoka anogona kubatsirwa nekuwedzera kudya kwavo kwemethionine, zvikafu zvakawanda zvinopfuura magiramu maviri pazuva remethionine pamwe necysteine.

Kudya kwakasiyana siyana, kusanganisira vegan, zvinomera, zvetsika uye zvine mapuroteni akawanda zvinofungidzirwa kuti zvine pakati pe2.3 ne6.8 gramu pazuva reawa amino acids ().

Migumisiro paHomocysteine

Zvichida kunetseka kukuru kwakabatana neakakwira methionine kunwiwa kunokonzerwa neimwe yemamorekuru ayo amino acid anogona kuburitsa.

Methionine inogona kushandurwa kuita homocysteine, amino acid inosanganisirwa neakawanda mamiriro ehurwere hwemwoyo (,).

Kukwirira kwakanyanya kwemethionine kunogona kutungamira mukuwedzera kwehomocysteine, kunyangwe vamwe vanhu vari panjodzi yekuita izvi kupfuura vamwe ().

Sezvineiwo, kutsvagurudza kunoratidza kuti njodzi dzinogona kuitika mukukwirisa methionine kunogona kunge kuri nekuda kwehomocysteine ​​pane methionine pachayo ().

Nekudaro, pane zvimwe zvinhu zvinogona kuchinja homocysteine ​​mazinga.

Semuenzaniso, kunyangwe hazvo vaine kudya kwakaderera kwemethionine, vegans uye vezvirimwa vanogona kunge vaine homocysteine ​​yakakwira kupfuura omnivores nekuda kweiyo yakaderera vhitamini B12 kudya ().

Kumwe kutsvagurudza kwakaratidza yakakwira-protein, yakanyanya-methionine kudya haina kuwedzera homocysteine ​​mushure memwedzi mitanhatu, zvichienzaniswa neeprotein-shoma, yakaderera-methionine kudya ().

Pamusoro pezvo, kushandura kudya kusvika zana muzana hakuite sekukanganisa homocysteine ​​mune vanhu vakuru vane hutano vasina kushomeka kwevhithamini ().

Side Migumisiro

Kuti uongorore mhinduro dzemuviri kune methionine, vatsvagiri vachapa imwe hosi hombe yeiyi amino acid uye nekucherechedza mhedzisiro yacho.

Iyi dosi yakakura kwazvo kupfuura yakakurudzirwa kudya, kazhinji yakakomberedza 45 mg / lb (100 mg / kg), kana 6.8 gramu kune mumwe munhu anorema 150 pondo (68 kilograms) ().

Rudzi urwu rweyedzo rwakaitwa kanopfuura zviuru zvitanhatu, paine mhedzisiro. Iyi mhedzisiro mhedzisiro inosanganisira dzungu, kurara uye shanduko muropa ().

Chimwe chiitiko chakakomba chakaipa chakaitika panguva yeimwe yeiyi bvunzo, izvo zvakakonzera kufa kwemunhu ane BP yakakwira asi hutano hwakanaka neimwe nzira ().

Nekudaro, zvinoita sekunge mukana wekuwedzeredza netsaona kanokwana makumi manomwe kakapetwa kudya kwakakurudzirwa kwakakonzera matambudziko ().

Pakazara, zvinoita sekunge methionine haina kunyanya kutyisa muvanhu vane hutano, kunze kwekunyanyisa zvakanyanya madhizaini izvo zvingave zvisingaite kuwana kuburikidza nechikafu.

Kunyangwe methionine ichibatanidzwa mukugadzirwa kwehomocysteine, hapana humbowo hwekuti kudya mukati meyakajairika renji kune njodzi kune hutano hwemwoyo ().

Vanhu vanotevera mhando zhinji dzechikafu vanowanzo pfuura zvakatemwa kudya kwemethionine. Mhedzisiro mhedzisiro mukupindura kune yakakura madhizaini kazhinji inowanzove diki asi inogona kuve ine njodzi pamwero wakanyanya kukwirira.

Icho Chinokosha

Methionine yakasarudzika nesarufa-ine amino acid iyo inogona kushandiswa kuvaka mapuroteni uye kugadzira mamorekuru mazhinji mumuviri.

Izvi zvinosanganisira antioxidant glutathione uye molekemu SAM, iyo inoshandiswa kugadzirisa DNA nemamwe mamorekuru.

Methionine inowanikwa mune akasiyana mapuroteni-ane chikafu uye inowanzo kuve yakakwira mumapuroteni emhuka kupfuura mapuroteni emiti. Kunyangwe kudya kwakaderera-methionine kwakaratidzirwa kuwedzera hupenyu muhupenyu hwemhuka, kunyangwe izvi zvichikosha kuvanhu hazvisati zvajeka.

Ivo vanhu vanodya akawanda akasiyana marudzi ezvikafu zvinowanzosangana nezvinokurudzirwa kudya kwemethionine, kunyange vamwe vanhu vakura vangabatsirwa nekuwedzera kudya kwavo.

Mhedzisiro mhedzisiro yekupindura kune yakakura madhizaini inowanzo kuve idiki asi inogona kuve nengozi pamadosi akakwirira zvakanyanya kupfuura izvo zvinogona kuwanikwa neyakajairwa kudya.

Kubva pane kutsvagurika kunowanikwa muvanhu vane hutano, pamwe haufanire kunyanya kudzora kana kuwedzera kudya kwemethionine mukudya kwako.