Yakasanganiswa Inobatanidza Tissue Chirwere

Zvemukati

• Chii chakasanganiswa chinobatanidza tishu chirwere?
• Ndezvipi zviratidzo?
• Chii chinokonzera?
• Pane here zvinenjodzi?
• Inoonekwa sei?
• Inorapwa sei?
• Ndeapi maonero?

Chii chakasanganiswa chinobatanidza tishu chirwere?

Yakasanganiswa inobatanidza matishu echirwere (MCTD) iri isingawanzo autoimmune kusagadzikana. Iyo dzimwe nguva inonzi chirwere chinopindirana nekuti mazhinji ezviratidzo ayo anowirirana neaya ezvimwe zvinobatanidza matishu echirwere, akadai se:

• systemic lupus erythematosus
• scleroderma
• polymyositis

Zvimwe zviitiko zveMCTD zvinogoverana zviratidzo neiyo rheumatoid arthritis.

Iko hakuna mushonga weMCTD, asi inogona kazhinji kutarisirwa nemushonga uye nemararamiro ekuchinja.

Sezvo chirwere ichi chichigona kukanganisa nhengo dzakasiyana senge ganda, mhasuru, gadziriro yekugaya nemapapu, pamwe nemajoini ako, kurapwa kwakanangidzirwa kugadzirisa nzvimbo huru dzekubatanidzwa.

Iyo kiriniki mharidzo inogona kuve yakapfava kusvika pakati nepakati kusvika kune yakaoma, zvinoenderana nehurongwa hunobatanidzwa.

Yekutanga-mutsara maajenzi senge nonsteroidal anti-anogumbura anokwanisa kushandiswa pakutanga, asi vamwe varwere vangangoda kurapwa kwakapfurikidza neantimalarial drug hydroxychloroquine (Plaquenil) kana zvimwe zvinoshandura chirwere uye biologics.

Maererano neNational Institutes of Health, makore gumi ekupona kwevanhu vane MCTD ingangoita makumi masere muzana. Izvi zvinoreva kuti makumi masere muzana yevanhu vane MCTD vachiri vapenyu makore gumi mushure mekuonekwa.

Ndezvipi zviratidzo?

Zviratidzo zveMCTD zvinowanzo kuratidza zvichiteedzana pamusoro pemakore akati wandei, kwete ese kamwechete.

Vanenge makumi mapfumbamwe muzana vevanhu vane MCTD vane zvaRaynaud. Ichi chiitiko chinoratidzirwa nekurwiswa kwakanyanya kwechando, minwe ine chiveve inova bhuruu, chena, kana pepuru. Iyo dzimwe nguva inoitika mwedzi kana makore pamberi pezvimwe zviratidzo.

Zvimwe zviratidzo zveMCTD zvinosiyana kubva kumunhu kuenda kumunhu, asi zvimwe zvinonyanya kusanganisira:

• kuneta
• kupindwa nechando
• kurwadziwa muzvibatanidzwa zvakawanda
• mapundu
• kuzvimba mumajoini
• kushaya simba kwetsandanyama
• kutonhora kutonhora nekushanduka kwemavara kwemaoko uye netsoka

Zvimwe zvinogona kuitika zvinosanganisira:

• kurwadziwa pachipfuva
• dumbu kuzvimba
• asidhi Reflux
• kunetseka kufema nekuda kwekuwedzera kweropa mumapapu kana kuzvimba kwemapapu emapapu
• kuomesa kana kuomesa zvigamba zveganda
• maoko akazvimba

Chii chinokonzera?

Chikonzero chaicho cheMCTD hachizivikanwe. Iyo autoimmune kusagadzikana, zvichireva kuti zvinosanganisira immune system yako nekukanganisa kurwisa hutano hwakanaka.

MCTD inoitika kana immune system yako ikarwisa iyo inobatanidza iyo inopa hwaro hwenhengo dzemuviri wako.

Pane here zvinenjodzi?

Vamwe vanhu vane MCTD vane nhoroondo yemhuri nezvazvo, asi vaongorori havana kuwana yakajeka genetic chinongedzo.

Sekureva kweGenetic uye Rare Diseases Information Center (GARD), vakadzi vane mukana wakapetwa katatu kupfuura varume kuvandudza mamiriro acho. Inogona kurova chero zera, asi chaiwo makore ekutanga ari pakati pemakore gumi nemashanu kusvika makumi maviri nemashanu.

Inoonekwa sei?

MCTD inogona kuve yakaoma kuongorora nekuti inogona kufanana nemamiriro akati wandei. Iyo inogona kuve iine akakosha maficha e scleroderma, lupus, myositis kana rheumatoid arthritis kana musanganiswa wezvinetso izvi.

Kuti uwane kuongororwa, chiremba wako achakupa bvunzo yemuviri. Ivo zvakare vachakubvunza iwe kune yakazara nhoroondo yezviratidzo zvako. Kana zvichibvira, chengeta danda rezviratidzo zvako, uchicherekedza pazvinoitika uye kuti zvinogara kwenguva yakareba sei. Ruzivo urwu rwunobatsira chiremba wako.

Kana chiremba wako achiziva zviratidzo zvekiriniki zveMCTD, senge kuzvimba kwakakomberedza majoini, mapundu, kana humbowo hwekunzwa kutonhora, vanogona kuraira kuongororwa kweropa kuti vatarise mamwe maantibhakitiriya ane hukama neMCTD, senge anti-RNP, pamwe nekuvapo yeanopisa mamaki.

Vanogona zvakare kuraira bvunzo kuti vatarise kuvapo kwemaantibhakitiriya zvakanyanya kusanganiswa nezvimwe zvirwere zvemuviri kuti ive nechokwadi chekuongororwa uye / kana kusimbisa chirwere chinopindirana.

Inorapwa sei?

Mishonga inogona kubatsira kubata zviratidzo zveMCTD. Vamwe vanhu vanongoda kurapwa kwechirwere chavo pachinomuka, asi vamwe vangangoda kurapwa kwenguva refu.

Mishonga inoshandiswa kurapa MCTD inosanganisira:

• Nonsteroidal anti-anogumbura zvinodhaka (NSAIDs). Over-the-counter NSAIDs, senge ibuprofen (Advil, Motrin) uye naproxen (Aleve), inogona kubata marwadzo akabatana uye kuzvimba.
• Corticosteroids. Steroid mishonga, senge prednisone, inogona kurapa kuzvimba uye kubatsira kumisa immune system yako pakurwisa matukisi ane hutano. Nekuti zvinogona kukonzeresa mhedzisiro yakawanda, yakadai seBP, kukwirisa, kushanduka kwemamiriro ekunze, uye kuwedzera uremu, zvinowanzo shandiswa kwenguva pfupi chete kudzivirira njodzi dzenguva refu.
• Antimalarial zvinodhaka. Hydroxychloroquine (Plaquenil) inogona kubatsira neine hunyoro MCTD uye pamwe inobatsira kudzivirira kupisa-ups.
• Calcium chiteshi blockers. Mishonga yakadai sa nifedipine (Procardia) uye amlodipine (Norvasc) inobatsira kubata chiitiko chaRaynaud.
• Immunosuppressants. Yakakomba MCTD inogona kuda kurapwa kwenguva refu nemaununosuppressants, iri mishonga inodzvinyirira immune system yako. Mienzaniso yakajairwa inosanganisira azathioprine (Imuran, Azasan) uye mycophenolate mofetil (CellCept). Iyi mishonga inogona kushomeka panguva yepamuviri nekuda kwekugona kwekukanganisa kwemucheche kana chepfu.
• Pulmonary hypertension zvinodhaka. Pulmonary hypertension ndiyo inokonzera rufu pakati pevanhu vane MCTD. Vanachiremba vanogona kupa mishonga senge bosentan (Tracleer) kana sildenafil (Revatio, Viagra) kubatsira kudzivirira pulmonary hypertension kubva pakuwedzera.

Pamusoro pekurapa, shanduko dzinoverengeka dzemararamiro dzinogona kubatsira:

• Ndeapi maonero?

  Kunyangwe paine huwandu hwayo hwakaomarara hwezviratidzo, MCTD inogona kuratidza uye uye kuramba iri yakapfava kusvika pakuenzanisa chirwere.

  Nekudaro, vamwe varwere vanogona kufambira mberi nekukudziridza chirwere chakakomba kutaura chinosanganisira nhengo huru senge mapapu.

  Zvirwere zvakawanda zvinobatana zvinoonekwa sezvirwere zvemultisystem uye zvinofanirwa kutariswa saizvozvo. Kuongorora nhengo hombe chikamu chakakosha chikamu chakazara chekurapa.

  Muchiitiko cheMCTD, kuongororwa kwenguva nenguva kwehurongwa kunofanira kusanganisira zviratidzo nezviratidzo zvine chekuita ne:

  • SLE
  • polymyositis
  • scleroderma

  Nekuti MCTD inogona kuve nezvimiro zvezvirwere izvi, nhengo huru senge mapapu, chiropa, itsvo, uye huropi zvinogona kubatanidzwa.

  Taura nachiremba wako nezve kutanga kwenguva refu kurapwa uye manejimendi chirongwa chinoshanda zvakanyanya kune ako zviratidzo.

  Kuendeswa kune nyanzvi yerheumatology kunogona kubatsira nekuda kwekugona kuoma kwechirwere ichi.