PDL1 (Immunotherapy) Miedzo

Zvemukati

• Chii chinonzi PDL1 bvunzo?
• Chii chinoshandiswa?
• Nei ini ndichida PDL1 bvunzo?
• Chii chinoitika panguva ye PDL1 bvunzo?
• Ndichafanira here kuita chero chinhu kugadzirira bvunzo?
• Pane here njodzi kune bvunzo?
• Zvinorevei mhedzisiro yacho?
• Pane chimwe chinhu here chandinofanira kuziva nezve PDL1 bvunzo?
• Zvinyorwa

Chii chinonzi PDL1 bvunzo?

Uyu muyedzo unoyera huwandu hwePDL1 pane maseru ekenza. PDL1 ipuroteni inobatsira kuchengetedza maseru ekudzivirira kubva pakurwisa masero asina kukuvadza mumuviri. Kazhinji, immune system inorwisa zvinhu zvekune dzimwe nyika semavirusi uye mabhakitiriya, uye kwete ako maseru ane hutano. Mamwe maseru ekenza ane huwandu hwakawanda hwePDL1. Izvi zvinobvumira maseru egomarara "kunyengedza" immune system, uye kudzivirira kudenhwa sezvinhu zvekunze, zvinokuvadza.

Kana masero ekenza yako aine huwandu hwakawanda hwePDL1, unogona kubatsirwa kubva pakurapwa kunonzi immunotherapy. Immunotherapy kurapwa kunosimudzira immune system yako kuti ibatsire kuziva uye kurwisa gomarara maseru. Immunotherapy yakaratidzirwa kuve inoshanda kwazvo pakurapa mamwe marudzi ekenza. Izvo zvinowanzo kuve nemhedzisiro mashoma pane mamwe marapirwo ekenza.

Mamwe mazita: yakagadzirirwa kufa-ligand 1, PD-LI, PDL-1 ne immunohistochemistry (IHC)

Chii chinoshandiswa?

Kuongororwa kwePDL1 kunoshandiswa kutsvaga kana uine kenza inogona kubatsirwa nemununotherapy.

Nei ini ndichida PDL1 bvunzo?

Iwe ungangoda PDL1 kuyedzwa kana iwe waonekwa uine imwe yeanotevera cancer.

• Isiri-diki kenza yemapapu kenza
• Melanoma
• Hodgkin lymphoma
• Gomarara redundira
• Kenza yeitsvo
• Gomarara repazamu

Akakwira mazinga ePDL1 anowanzo kuwanikwa mune aya, pamwe nemamwe marudzi ekenza. Gomarara rine mazinga akakwirira ePDL1 anokwanisa kurapwa nemushonga we immunotherapy.

Chii chinoitika panguva ye PDL1 bvunzo?

Mazhinji miedzo yePDL1 inoitwa mune imwe nzira inonzi biopsy. Iko kune matatu makuru marudzi ebiopsy maitiro:

• Yakanaka tsono aspiration biopsy, iyo inoshandisa tsono yakatetepa kubvisa sampuli yemasero kana fluid
• Core tsono biopsy, iyo inoshandisa tsono hombe kubvisa sampuli
• Kuvhiya biopsy, inobvisa sampuro mune diki, yekurapa maitiro

Yakanaka tsono kushuvira uye yakakosha tsono biopsies kazhinji inosanganisira anotevera matanho:

• Iwe unozorara parutivi rwako kana kugara patafura yebvunzo.
• Anopa hutano anozochenesa iyo biopsy saiti uye ojoinise neanesthetic kuti usazonzwa chero kurwadziwa panguva yekuita.
• Kana imwe nzvimbo yangova chiveve, mupi anoisa kana yakanaka aspiration tsono kana yakakosha biopsy tsono mune iyo biopsy saiti uye kubvisa sampuro yetissue kana fluid.
• Unogona kunzwa kumanikidzwa kuduku kana muyenzaniso wabviswa.
• Dzvinyiriro inozoiswa kune iyo biopsy saiti kusvikira kubuda kweropa kwamira.
• Wako mupi achazadza chena bhandiji pane iyo biopsy saiti.

Mune biopsy yekuvhiya, chiremba anovhiya anozoita kucheka kudiki paganda rako kubvisa zvese kana chikamu chebundu remuzamu. Bhiopsy yekuvhiya dzimwe nguva inoitwa kana bundu risingakwanise kusvikwa neine tsono biopsy. Kuvhiya biopsies kunowanzo sanganisira anotevera matanho.

• Iwe ucharara pamusoro petafura yekushandisa. IV (mutsetse unopinza) unogona kuiswa muruoko rwako kana ruoko.
• Unogona kupihwa mushonga, unonzi kunyaradza, kuti ubatsire kuzorora.
• Iwe unozopihwa zvemuno kana zvakajairika kutindivadza kuti usazonzwa kurwadziwa panguva yekuita
  • Kune yeanesthesia yemuno, mupi wezvehutano anojowa iyo biopsy saiti nemushonga kuti ubaye nzvimbo.
  • Kune general anesthesia, nyanzvi inonzi anesthesiologist inokupa mushonga saka unenge usisazive panguva yekuita.
• Kana iyo nzvimbo yebhaopsy yave chiveve kana iwe usinga zive, chiremba anovhiya anozoita kucheka kudiki muzamu uye kubvisa chikamu kana bundu rese. Dzimwe nyama dzakakomberedza bundu dzinogona zvakare kubviswa.
• Iyo yakatemwa mukati meganda rako ichavharwa nezvisungo kana zvidimbu zvekunamira.

Kune mhando dzakasiyana dze biopsies. Mhando yebhiopsy yaunowana inoenderana nenzvimbo uye saizi yemota yako.

Ndichafanira here kuita chero chinhu kugadzirira bvunzo?

Iwe hauzodi chero gadziriro yakasarudzika kana iwe uri kuwana yemuno anesthesia (chiveve cheiyo biopsy saiti). Kana iwe uri kuwana general anesthesia, iwe ungangoda kutsanya (kwete kudya kana kunwa) kwemaawa akati wandei usati wavhiyiwa. Chiremba wako anovhiya anokupa yakanyanya kurongeka mirairo. Zvakare, kana iwe uri kuwana inonyaradza kana yakajairwa anesthesia, ita shuwa yekuronga kuti mumwe munhu akutyaire kumba. Iwe unogona kunge uchigunun'una uye uchivhiringidzika mushure mekunge wamuka kubva munzira.

Pane here njodzi kune bvunzo?

Iwe unogona kuve nekupwanya zvishoma kana kubuda ropa pane iyo biopsy saiti. Dzimwe nguva saiti inotapukirwa. Kana izvo zvikaitika, iwe unozorapwa nemishonga inorwisa mabhakitiriya. Bhiopsy yekuvhiya inogona kukonzera mamwe marwadzo uye kusagadzikana. Anokuchengetedza hutano anogona kukurudzira kana kupa mishonga kuti ikubatsire kunzwa zviri nani.

Zvinorevei mhedzisiro yacho?

Kana mhedzisiro yako ikaratidza kuti mamota ako maseru ane akakwirisa e PDL1, unogona kutanga pane immunotherapy. Kana mhedzisiro yako isingaratidze huwandu hwakawanda hwePDL1, immunotherapy inogona kunge isingakubatsire iwe. Asi iwe unogona kubatsirwa neimwe mhando yekurapa kenza. Kana iwe uine mibvunzo nezve mhedzisiro yako, taura nemupi wako wezvehutano.

Dzidza zvakawanda nezve bvunzo dzemarabhoritari, mareferenzi masosi, uye mhinduro dzekunzwisisa

Pane chimwe chinhu here chandinofanira kuziva nezve PDL1 bvunzo?

Immunotherapy haishande kune wese munhu, kunyangwe iwe uine mamota ane akakwirira mazinga ePDL1. Cancer maseru akaomarara uye kazhinji haatarisike. Vanopa hutano uye vatsvagiri vachiri kudzidza nezve immunotherapy uye maitiro ekufanotaura kuti ndiani achabatsirwa zvakanyanya kubva pakurapwa uku.

Zvinyorwa

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4. American Cancer Society [Internet]. Atlanta: American Cancer Society Inc .; c2018. Chii chitsva mukenza immunotherapy research ?; [yakagadziridzwa 2017 Gumiguru 31; yakataurwa 2018 Aug 14]; [angangoita mana skrini. Inowanikwa kubva ku: https://www.cancer.org/treatment/treatment-and-side-effects/treatment-types/immunotherapy/whats-new-in-immunotherapy-research.html
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7. Yakabatanidzwa Oncology [Internet]. Laboratory Corporation yeAmerica, c2018. PDL1-1 neHC, Opdivo; [yakataurwa 2018 Aug 14]; [angangoita matatu skrini. Inowanikwa kubva: https://www.integratedoncology.com/test-menu/pd-l1-by-ihc-opdivo%C2%AE/cec2cfcc-c365-4e90-8b79-3722568d5700
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Ruzivo ruri pane ino saiti harufanire kushandiswa sekutsiva kwehunyanzvi kurapwa kana kurairwa. Bata mupi wehutano kana iwe uine mibvunzo nezve hutano hwako.