Pemphigoid Gestationis Panguva Yepamuviri

Zvemukati

• Mifananidzo yepemphigoid gestationis
• Pemphigoid gestation zviratidzo
• Pemphigoid gestation inokonzera
• Pemphigoid gestationis vs. PUPPP
• Pemphigoid gestationis kuongororwa
• Pemphigoid gestationis kurapwa
• Mishonga yekumba
• Dzimwe nyaya dzakaomarara
• Pemphigoid gestationis zvinetso
• Maonero

Mhedziso

Pemphigoid gestationis (PG) chinhu chisingawanzo, chinopisa ganda rinowanzoitika mune yechipiri kana yechitatu trimester yepamuviri. Iyo inowanzo kutanga nekuonekwa kweakanyanya kutsvuka mapundu kana blister padumbu rako uye trunk, kunyange inogona kuratidza pane mamwe mativi emuviri wako.

PG inokonzerwa nema immune system ako achirwisa zvisizvo ganda rako. Inowanzoenda yega mukati memazuva kana mavhiki mushure mekusununguka. Mune zvisingawanzoitika zviitiko, zvinogona kugara kwenguva refu.

PG inofungidzirwa kuti inoitika mu1 pamakumi mana emakumi mana kusvika makumi mashanu ekuzvitakura.

Pemphigoid gestation yaimbozivikanwa seherpes gestationis, asi ikozvino yakanzwisiswa kuti haina hukama nehutachiona hweherpes. Kunewo mamwe marudzi epemphigus kana pemphigoid kuputika kweganda, isina hukama nepamuviri.

Pemphigus zvinoreva blister kana pustule, uye gestationis zvinoreva "kubata pamuviri" muchiLatin.

Mifananidzo yepemphigoid gestationis

Pemphigoid gestation zviratidzo

NePG, mapundu matsvuku anoonekwa akatenderedza dumbu bhatani uye anopararira kune dzimwe nhengo dzemuviri mukati memazuva mashoma kana vhiki. Chiso chako, ganda romusoro, zvanza, uye tsoka dzetsoka hazviwanzo kukanganiswa.

Mushure memasvondo maviri kana mana, mapundu anochinja kuita mablister akakura, matsvuku, akazara nemvura. Aya mapundu anogona zvakare kunzi bulla. Vanogona kunge vasina kugadzikana zvakanyanya.

Panzvimbo pemablister kana bulla, vamwe vanhu vanogadzira yakakwidziridzwa matsvuku makwapa anonzi mabwe.

Iyo PG mablister anogona kudzikira kana kuenda ega padhuze nepakuguma kwekubata kwako, asi makumi manomwe neshanu kusvika makumi masere muzana evakadzi vane PG vanoziva kupenga panguva yekutakura.

PG inogona kudzoka panguva yekuenda kumwedzi kana mune inotevera nhumbu. Kushandiswa kwekudzivirira kubata pamuviri kunogona kuunza kumwe kurwiswa.

Muzviitiko zvisingawanzo - nezve - PG inogona kuoneka mune vacheche.

Pemphigoid gestation inokonzera

Pemphigoid gestationis yave kunzwisiswa seicho autoimmune chirwere. Izvi zvinoreva kuti immune system yako inotanga kurwisa zvikamu zvemuviri wako. MuPG, maseru anouya achirwiswa ndeavo vepa placenta.

Placental tishu ine maseru kubva kune vese vabereki. Masero anenge abva kuna baba anogona kunge aine mamorekuru anoonekwa seakatorwa nemaitiro ezvirwere zvaamai. Izvi zvinoita kuti immune system yamai iungane navo.

Masero ababa aripo pakubata kwese, asi autoimmune hosha senge PG inongoitika mune dzimwe nguva. Hazvina kunyatsonzwisiswa kuti sei immune yemadzimai inobata nenzira iyi mune dzimwe nguva, uye kwete mune vamwe.

Asi mamwe mamorekuru anozivikanwa seMHC II ayo asingawanzo kuwanikwa muplacenta akawanikwa mune vakadzi vane PG. Kana immune yemadzimai akazvitakura ikaziva aya mamorekuru, inotanga kurwisa.

Iyo MHC II-kirasi mamorekuru inokonzeresa kunamatira pamwe ako marara eganda. Kana immune system yako ikangotanga kuvarwisa, zvinogona kukonzeresa mablister uye plaque inova chiratidzo chikuru chePG.

Imwe chiyero cheiyi autoimmune reaction ndiko kuvapo kweproteinini yava kunzi Collagen XVII (yaimbozivikanwa seBP180).

Pemphigoid gestationis vs. PUPPP

Kumwe kuputika kweganda kunozivikanwa sePUPP (pruritic urticarial papules uye mabara epamuviri) kunogona kufanana nepemphigoid gestationis. Seizvo zita rinoratidzira, PUPPP inotyisa (pruritic) uye mikoko-yakafanana (urticarial).

PUPPP inoitika kazhinji muchitatu chetatu, inova zvakare nguva yakajairika yekuti PG ioneke. Uye senge PG, inowanzo kuoneka kutanga padumbu seyakatsvuka mabhuru matsvuku kana mabara.

Asi PUPPP haiwanzo kufambira mberi kune yakakura, inoyerera-yakazara blister sePG. Uye kusiyana nePG, inowanzopararira kumakumbo uye dzimwe nguva zvombo zvepasi.

PUPPP inorapwa neanti-itch kirimu nemafuta, uye dzimwe nguva nemapiritsi e antihistamine. Mapundu acho anowanzo nyangarika ari ega mukati memavhiki matanhatu mushure mekusununguka.

PUPPP inoitika mune ingangoita 1 mune yega yega 150 nhumbu, ichiita kuti ive yakajairika kupfuura PG. PUPPP yakajairika zvakanyanya mukutanga kubata pamuviri, uye mumadzimai akatakura mapatya, katatu, kana kuwanda kwepamusoro kuwanda.

Pemphigoid gestationis kuongororwa

Kana chiremba wako achifungidzira PG, vanogona kukuendesa kune dermatologist yeganda biopsy. Izvi zvinosanganisira kuisa zveshuwa kana kupisa kwechando munzvimbo diki yeganda uye kucheka sampu diki kuti itumirwe murabhoritari.

Kana rabhoritari ikawana zviratidzo zve pemphigoid pasi pe microscope, ivo vanozoita imwe bvunzo inozivikanwa seye immunofluorescence ongororo inogona kusimbisa PG.

Chiremba wako achatorawo masampuli eropa kuti aone iwo mwero wepemphigoid antigen Collagen XVII / BP180 muropa. Izvi zvinogona kuvabatsira kuti vaongorore chiitiko chechirwere.

Pemphigoid gestationis kurapwa

Kana zviratidzo zvako zviri zvinyoro, chiremba wako anogona kupa anti-itch makirimu anozivikanwa setopical corticosteroids. Izvi zvinodzikamisa ganda nekudzora chikamu chemuviri immune system panzvimbo yeblisters.

Over-the-counter allergies zvinodhaka (antihistamines) zvinogona kubatsira. Izvi zvinosanganisira izvo zvisina-kutsumwa zvigadzirwa:

• cetirizine (Zyrtec)
• fexofenadine (Allegra)
• loratadine (Claritin)

Diphenhydramine (Benadryl) inokonzeresa kukotsira uye inonyanya kutorwa husiku. Iyo zvino inoshanda senge yekurara yekubatsira mukuwedzera kune ayo zvivakwa seye itch reliever.

Zvese izvi zvinowanika pakaunda. Shanduro dzeGeneric dzakaenzana mukuita kumazita ezita, uye kazhinji kacho anodhura zvakanyanya.

Gara uchitaura nachiremba wako usati watora chero mishonga, kunyangwe pamusoro-pe-iyo zvigadzirwa, panguva yekuzvitakura.

Mishonga yekumba

Chiremba wako anogona zvakare kukurudzira mishonga yekumba kurwisa itch uye kusagadzikana kwenyoro nyoro yePG. Izvi zvinogona kusanganisira:

• kuchengetedza ganda kutonhorera nechando kana kutonhora kumanikidza
• kugara munzvimbo inotonhorera kana inotonhorera
• kugeza muEpsom munyu kana oatmeal kugadzirira
• kupfeka mbatya dzakanaka dzedonje

Dzimwe nyaya dzakaomarara

Kana kuchenesa uye kutsamwa kuri kwakanyanya, chiremba wako angango gadza muromo corticosteroids. Sezvo madhiragi aya anoita nekudzora mashandiro ezvirwere zvemuviri, iro diki risingashande rinofanira kugara richishandiswa.

Chiremba wako anozofunga mhedzisiro yako iwe nemwana wako, uye chengetedza muyero uye nguva yekurapa kusvika padiki.

Immunosuppressive zvinodhaka senge azathioprine kana cyclosporine inogona zvakare kushandiswa kubatsira kudzikisa itch uye kusagadzikana. Kuchenjerera kutarisa kwemhedzisiro kunodiwa. Izvi zvinogona kusanganisira:

• kutarisa BP kamwe kana kaviri pavhiki kwemwedzi wekutanga wekushandisa
• kuongorora kushanda kweitsvo neropa uye neweti bvunzo
• kuongorora chiropa chinoshanda, uric acid, uye kutsanya lipid mazinga

Pemphigoid gestationis zvinetso

Chidzidzo cha2009 chakawana kuti kuputika kwePG blisters mune yekutanga kana yechipiri trimester kunogona kutungamira kune yakaipa nhumbu mhedzisiro.

Chidzidzo ichi chakaongorora zvinyorwa zvemadzimai makumi matanhatu nenomwe vakazvitakura vane PG vanobva kuUnited Kingdom nekuTaiwan. Mhedzisiro yakaipa inowanikwa kuvakadzi vane kutanga-kutanga (yekutanga kana yechipiri trimester) PG yaisanganisira:

• preterm kuberekwa
• huremu hwekuzvarwa huremu
• diki kune zera rekubata

Zvinowanzoitika kuti PG ioneke gare gare mune nhumbu. Kana zvikaitika mune yekutanga kana yechipiri trimester, vanyori vekudzidza vanokurudzira kuibata seyakanyanya nhumbu kubata pamwe nekungwarira kutarisa uye kutarisa.

Padivi rakanaka, chidzidzo chakawana zvakare kuti kurapwa ne systemic (muromo) corticosteroids haina zvakanyanya kukanganisa mhedzisiro yepamuviri.

Maonero

Pemphigoid gestationis ishoma kuputika kweganda kazhinji kunoitika kunonoka pakubata. Zvinosemesa uye kusagadzikana, asi kwete kutyisidzira hupenyu iwe kana mwana wako.

Kana zvikaitika pakutanga kwepamuviri pane kuwedzera kudiki mumikana yekuzvarwa preterm kana kushomeka kwekuzvarwa kwemucheche. Pedyo yekutarisa neyako OB-GYN chiremba uye kubatana kwekurapa nedermatologist yako inokurudzirwa.

Iwe ungangoda kuve unosangana neInternational Pemphigus uye Pemphigoid Foundation, iyo ine mapoka ehurukuro uye varairidzi vevezera revanhu vane PG.