Chii chinonzi Phage Therapy?

Zvemukati

• Imwe nzira yekurwisa mabhakitiriya
• Mashandiro anoita phage kurapwa
• Phage kurapa vs. mishonga inorwisa mabhakitiriya
• 1. Mishonga inorwisa mabhakitiriya inorwisa anopfuura mhando imwechete yebhakitiriya
• 2. Mishonga inorwisa mabhakitiriya inogona kutungamira ku "superbugs"
• Phage kurapa kunobatsira
• Phage kurapa kwakaipira
• Phage shandisa muUnited States
• Muindasitiri yezvokudya
• Mamiriro ezvinhu anogona kubatsirwa kubva kurapa kwepage
• Kutora

Imwe nzira yekurwisa mabhakitiriya

Phage therapy (PT) inonziwo bacteriophage therapy. Inoshandisa hutachiona kurapa hutachiona hutachiona. Hutachiona hwehutachiona hunonzi mapaji kana bacteriophages. Vanorwisa mabhakitiriya chete; mapaji haakuvadzi kuvanhu, mhuka, uye zvinomera.

Bacteriophages ndiyo chaiyo vavengi vebhakitiriya. Izwi rekuti bacteriophage rinoreva "anodya mabhakitiriya." Izvo zvinowanikwa muvhu, tsvina, mvura, uye dzimwe nzvimbo mabhakitiriya anogara. Aya mavhairasi anobatsira kuchengetedza hutachiona kukura mukutarisa mune zvakasikwa.

Kurapa kwepage kunganzwika kutsva, asi kwave kuchishandiswa kwemakore. Zvisinei, kurapwa hakusi kuzivikanwa. Kumwe kutsvagurudza kunodiwa pane bacteriophages. Iyi kurapa kwemabhakitiriya anokonzera chirwere inogona kunge iri nzira inobatsira kune maantibioti.

Mashandiro anoita phage kurapwa

Bacteriophages inouraya mabhakitiriya nekuita iwo anoputika kana lyse. Izvi zvinoitika apo hutachiona hunosungira kubhakitiriya. Utachiona hunotapukira hutachiona nekubaya majeni ayo (DNA kana RNA).

Iyo phage hutachiona inozviteedzera pachayo (inoberekana) mukati mehutachiona. Izvi zvinogona kuita mavhairasi matsva mubhakitiriya rega rega. Pakupedzisira, hutachiona hunovhura mabhakitiriya, zvichiburitsa mabacteriophages matsva.

Bacteriophages inogona chete kuwedzera uye kukura mukati mehutachiona.Kana mabhakitiriya ese akangoita lys (akafa), anomira kuwanda. Kufanana nemamwe hutachiona, mapages anogona kurara (mune hibernation) kusvikira mamwe mabhakitiriya aonekwa.

Phage kurapa vs. mishonga inorwisa mabhakitiriya

Mishonga inorwisa mabhakitiriya inonziwo anti-bacterials. Ndidzo mhando dzinonyanya kurapwa dzehutachiona hwehutachiona. Mishonga inorwisa mabhakitiriya makemikari kana zvinodhaka zvinoparadza mabhakitiriya mumuviri wako.

Mishonga inorwisa mabhakitiriya inoponesa hupenyu uye inodzivirira hosha pakupararira. Nekudaro, ivo vanogona kukonzera matambudziko makuru maviri:

1. Mishonga inorwisa mabhakitiriya inorwisa anopfuura mhando imwechete yebhakitiriya

Izvi zvinoreva kuti vanogona kuuraya zvese zvakaipa uye zvakanaka mabhakitiriya mumuviri wako. Muviri wako unoda mamwe marudzi ebhakitiriya kuti akubatsire kugaya chikafu, kugadzira zvimwe zvinovaka muviri, uye kukuchengetedza uine hutano.

Mabhakitiriya akanaka anobatsira kumisa mamwe mabhakitiriya, hutachiona, uye hutachiona hutachiona kubva mukukura mumuviri wako. Ichi ndicho chikonzero maantibayoti anogona kukonzera mhedzisiro senge:

• kugumbuka mudumbu
• kusvotwa uye kurutsa
• cramping
• kuputika uye gassiness
• manyoka
• mbiriso zvirwere

2. Mishonga inorwisa mabhakitiriya inogona kutungamira ku "superbugs"

Izvi zvinoreva kuti pachinzvimbo chekumira, mamwe mabhakitiriya anova anopikisa kana kudzivirira mishonga yekurwisa mabhakitiriya. Kuramba kunoitika kana mabhakitiriya achishanduka kana kushanduka kuti ave akasimba kupfuura mishonga inorwisa mabhakitiriya.

Vanogona kutoparadzira iyi "simba guru" kune mamwe mabhakitiriya. Izvi zvinogona kukonzera hutachiona hune hutachiona husingarapike. Mabhakitiriya asingarapike anogona kuuraya.

Shandisa mishonga inorwisa mabhakitiriya nenzira kwayo kubatsira kudzivirira mabhakitiriya anodzivirira. Semuyenzaniso:

• Ingoshandisa mishonga inorwisa mabhakitiriya kune hutachiona hutachiona. Mishonga inorwisa mabhakitiriya haizorape hutachiona hutachiona kunge dzihwa, dzihwa, uye bronchitis.
• Usashandise mishonga inorwisa mabhakitiriya kana iwe usingade iwo.
• Usamanikidze chiremba wako kuti akupe mishonga inorwisa mabhakitiriya iwe kana mwana wako.
• Tora mishonga yese inorwisa mabhakitiriya sezvakanyorwa.
• Pedzisa muyero wakazara wemishonga inorwisa mabhakitiriya, kunyangwe iwe uchinzwa zvirinani.
• Usatora maantibioti akapera.
• Kanda mishonga inorwisa mabhakitiriya yakapera basa kana kuti isina kushandiswa.

Phage kurapa kunobatsira

Iwo mabhenefiti epage Therapiki anotarisana nekukanganisa kwemishonga inorwisa mabhakitiriya.

Kungofanana sezvo paine marudzi mazhinji ebhakitiriya, kune akati wandei marudzi ebacteriophages. Asi mhando yega yega yefaji inorwisa chete hutachiona. Hazvizokanganisa mamwe marudzi ebacteria.

Izvi zvinoreva kuti paji inogona kushandiswa kunanga zvakananga hutachiona hunokonzera chirwere. Semuenzaniso, strep bacteriophage inongouraya mabhakitiriya anokonzeresa hutachiona hutachiona.

Tsvagurudzo ya2011 yakaratidza zvimwe zvebacteriophages:

• Phages anoshanda kurwisa mabhakitiriya anorapika nemishonga inorwisa mabhakitiriya.
• Inogona kushandiswa yoga kana nemishonga inorwisa mabhakitiriya uye mimwe mishonga.
• Phages inowanda uye inowedzera huwandu ivo pachavo panguva yekurapa (imwe chete dose inogona kudikanwa).
• Ivo vanongovhiringidza zvishoma bhakitiriya "akanaka" mumuviri.
• Phages zvakasikwa uye zviri nyore kuwana.
• Izvo hazvikuvadze (chepfu) kumuviri.
• Izvo hazvina chepfu kumhuka, zvirimwa, uye nharaunda.

Phage kurapa kwakaipira

Bacteriophages haisati yashandiswa zvakanyanya. Iyi kurapa inoda kumwe kuongorora kuti uone kuti inoshanda sei. Hazvizivikanwe kana mapaji anogona kukuvadza vanhu kana mhuka nenzira dzisinei nekunangisa chepfu.

Pamusoro pezvo, hazvizivikanwe kana kurapa kwepage kunogona kukonzera utachiona kuti huve hwakasimba kupfuura iyo bacteriophage, zvichikonzera kuramba kwepaji.

Cons of phage Therapy inosanganisira zvinotevera:

• Phages parizvino inonetsa kugadzirira kushandiswa muvanhu nemhuka.
• Hazvizivikanwe kuti chiyero kana huwandu hwemapaji hunofanira kushandiswa.
• Hazvizivikanwe kuti kurapwa kwepageji kunotora nguva yakareba sei kuti ishande.
• Zvinogona kuve zvakaoma kuwana iyo chaiyo phage inodiwa kurapa hutachiona.
• Phages inogona kukonzera immune system kuti iwedzere kana kukonzera kusaenzana.
• Mimwe mhando yemapaji haishande pamwe nemamwe marudzi kurapa hutachiona hutachiona.
• Panogona kusave nemhando dzakaringana dzemapaji ekurapa hutachiona hwese.
• Mamwe mapages anogona kukonzera kuti mabhakitiriya ave anopikisa.

Phage shandisa muUnited States

Phage therapy haisati yatenderwa kuvanhu vari muUnited States kana muEurope. Pakave nekuyedzwa kwepaji kushandiswa mune mashoma mashoma kesi chete.

Chimwe chikonzero cheizvi ndechekuti mishonga inorwisa mabhakitiriya inowanikwa zvirinyore uye inoonekwa seyakachengeteka kushandisa. Iko kune kuenderera mberi kwekutsvaga pamusoro penzira yakanakisa yekushandisa bacteriophages muvanhu nemhuka. Kuchengetedzwa kwepage kurapa kunodawo kumwe kutsvagisa.

Muindasitiri yezvokudya

Phage kurapa kuri kushandiswa muindasitiri yezvikafu, zvakadaro. Sangano reU.S.Food and Drug Administration (FDA) rakabvumidza mimwe misanganiswa yepaji kubatsira kumisa mabhakitiriya kubva mukukura muzvikafu. Kurapa kwepage muzvikafu kunodzivirira mabhakitiriya anogona kukonzera chikafu chepfu, senge:

• Salmonella
• Listeria
• E. coli
• Mycobacterium tibhii
• Campylobacter
• Pseudomonas

Iwo mafaji anowedzerwa kune zvimwe zvakagadziriswa chikafu kubatsira kudzivirira hutachiona kukura.

Kumwe kushandiswa kwerapaji kurapa kuri kuyedzwa kunosanganisira kuwedzera bacteriophages kune yekuchenesa zvigadzirwa kuti uparadze mabhakitiriya ari pamusoro. Izvi zvinogona kubatsira muzvipatara, mumaresitorendi, uye dzimwe nzvimbo.

Mamiriro ezvinhu anogona kubatsirwa kubva kurapa kwepage

Phage kurapa kunogona kuve kwakakosha pakurapa hutachiona husinga pindure mishonga inorwisa mabhakitiriya. Semuenzaniso, inogona kushandiswa kupokana neane simba Staphylococcus(staph) hutachiona hutachiona hunonzi MRSA.

Pakave nezviitiko zvinobudirira zvepage kurapa kushandiswa. Imwe yenyaya yekubudirira yakadaro yaisanganisira murume ane makore makumi matanhatu nemasere muSan Diego, California, akarapwa rudzi rusingagone rwehutachiona hunodaidzwa Acinetobacter baumannii.

Mushure memwedzi inopfuura mitatu yekuedza mishonga inorwisa mabhakitiriya, vanachiremba vake vakakwanisa kumisa hutachiona nema bacteriophages.

Kutora

Phage therapy haisi nyowani, asi mashandisiro ayo muvanhu nemhuka zvakare haina kunyatso kuongororwa. Dzidzo dzazvino uye dzimwe dzakabudirira kesi dzinogona kureva kuti zvinogona kuve zvakajairika. Sezvo phage kurapa kuchinzi kwakachengeteka uye kwakabvumidzwa kushandiswa muindasitiri yezvikafu, izvi zvinogona kunge zvichakurumidza.

Phage Therapy ndeyechisikigo "maantibioti" uye inogona kunge iri imwe nzira yakanaka yekurapa. Zvinogona zvakare kubatsira kune kumwe kushandiswa sekuvhiya uye chipatara disinfectant. Kumwe kutsvagurudza kunodikanwa kushandiswa kwayo kusati kwatenderwa kuvanhu.