Coronavirus zvinodhaka (COVID-19): inogamuchirwa uye iri pasi pekudzidza

Zvemukati

• Mvumo inogamuchirwa yecoronavirus
• Mishonga iri kudzidza
• 1. Ivermectin
• 2. Plitidepsin
• 3. Remdesivir
• 4. Dexamethasone
• 5. Hydroxychloroquine uye chloroquine
• 6. Colchicine
• 7. Mefloquine
• 8. Tocilizumab
• 9. Convalescent plasma
• 10. Avifavir
• 11. Baricitinib
• 12. EXO-CD24
• Natural mishonga yekurapa sarudzo ye coronavirus

Parizvino, hapana mishonga inozivikanwa inokwanisa kubvisa iyo coronavirus nyowani kubva mumuviri uye, nekuda kwechikonzero ichi, kazhinji, kurapwa kunoitwa nematanho mashoma uye mishonga inokwanisa kubvisa zviratidzo zve COVID-19.

Zviitiko zvinotyisa, zvine zviratidzo zvakafanana nefuruu, zvinogona kurapwa kumba nekuzorora, hydration uye kushandiswa kwemafivha mishonga uye marwadzo ekudzora. Zviitiko zvakakura kwazvo, umo zviratidzo zvakanyanya uye zvinetso zvakaita semabayo anoonekwa, zvinoda kurapwa pakurapwa kuchipatara, kazhinji muIntensive Care Units (ICU), kuve nechokwadi, kunyanya, kukwana kwakakwana kweoksijeni uye kuongorora kwe zviratidzo zvakakosha.

Ona zvimwe zvakawanda nezve kurapwa kwe COVID-19.

Pamusoro pemishonga, mamwe majekiseni ekudzivirira COVID-19 ari kuongororwawo, kugadzirwa nekuparadzirwa. Mishonga yekudzivirira iyi inovimbisa kudzivirira hutachiona hwe COVID-19, asi zvakare inoita kunge inoderedza kusimba kwezviratidzo kana hutachiona hwaitika. Zvirinani nzwisisa kuti ndeapi majekiseni anorwisa COVID-19 aripo, mashandiro ainoita uye nemhedzisiro mhedzisiro.

Mvumo inogamuchirwa yecoronavirus

Mishonga inogamuchirwa kurapwa kwecoronavirus, naAnvisa uye neHurumende yehutano, ndevaya vanokwanisa kubvisa zviratidzo zvehutachiona, seizvi:

• Antipyretics: kudzikisa tembiricha uye kurwisa fever;
• Marwadzo anoderedza: kubvisa marwadzo emhasuru mumuviri wese;
• Mishonga inorwisa mabhakitiriya: kurapa zvinogona kuitika hutachiona hunogona kumuka neCOVID-19.

Iyi mishonga inofanirwa kushandiswa chete pasi pekutungamirirwa nachiremba uye, kunyangwe ichitenderwa kurapwa kweiyo coronavirus nyowani, havakwanise kubvisa hutachiona kubva mumuviri, asi vanongoshandiswa kubvisa zviratidzo uye kugadzirisa nyaradzo munhu ane hutachiona.

Mishonga iri kudzidza

Pamusoro pemishonga inobatsira kubvisa zviratidzo, nyika dzinoverengeka dziri kuvandudza zvidzidzo mumhuka dzerabhoritari uye varwere vane hutachiona kuyedza kutsvaga mushonga unogona kubvisa hutachiona kubva mumuviri.

Mishonga irikudzidzwa haifanire kushandiswa pasina kutungamirwa nachiremba, kana senzira yekudzivirira hutachiona, sezvo inogona kukonzeresa mhedzisiro uye kutyisidzira hupenyu.

Iri rinotevera runyorwa rweiyo mikuru mishonga iri kufundwa yeiyo nyowani coronavirus:

1. Ivermectin

Ivermectin ivhavha yemafirosi inoratidzirwa pakurapwa kwezvipembenene, izvo zvinokonzeresa matambudziko senge onchocerciasis, elephantiasis, pediculosis (inda), ascariasis (roundworms), scabies kana intestinal strongyloidiasis uye iyo, munguva pfupi yapfuura, yakaratidza mibairo yakanaka kwazvo mukubviswa coronavirus itsva, in vitro.

Chidzidzo chakaitwa muAustralia, chakaedzwa ivermectin murabhoritari, mumasero tsika in vitro, uye zvakaonekwa kuti chinhu ichi chakakwanisa kubvisa hutachiona hweSARS-CoV-2 mukati memaawa makumi mana nemasere ^[7]. Nekudaro, zviyero zvemakiriniki muvanhu zvinodiwa kuti zvioneke kushanda kwayo mu vivo, pamwe neiyo yekurapa dhizaini uye kuchengetedzeka kwemushonga, uyo unotarisirwa kuitika munguva iri pakati pemwedzi mitanhatu kusvika pamipfumbamwe.

Uye zvakare, kumwe kuongorora kwakaratidza kuti kushandiswa kweIvermectin nevarwere vakawanikwa vaine COVID-19 kwaimiririra kudzikira kwenjodzi yematambudziko uye kuwedzera kwechirwere, zvichiratidza kuti ivermectin inogona kuvandudza kufungidzira kwechirwere ^[33]. Panguva imwecheteyo, ongororo yakaitwa muBangladesh yakaratidza kuti kushandiswa kweIvermectin (12 mg) kwemazuva mashanu kwaishanda uye kwakachengeteka mukurapa COVID-19 ^[34].

MunaNovember 2020 ^[35] fungidziro yevaongorori vemuIndia yekuti ivermectin yaizogona kukanganisa kutakurwa kweutachiona kuenda kunukosi yemasero, ichitadzisa kukura kwehutachiona, yakaburitswa mumagazini yesainzi, zvisinei mhedzisiro iyi yaizogona chete ivermectin, iyo inogona kunge ine chepfu kumunhu muviri.

Chimwe chidzidzo chakaburitswa muna Zvita 2020 ^[36] zvakaratidza zvakare kuti kushandiswa kwema nanoparticles ane ivermectin kunogona kudzikisira kutaura kwemasero 'ACE2 receptors, zvichideredza mukana wehutachiona kusunga kune aya ma receptors uye kukonzera hutachiona. Zvisinei, chidzidzo ichi chakaitwa mu vitro chete, uye hazviite kutaura kuti mhedzisiro yacho ichave yakafanana mu vivo. Uye zvakare, sezvo iri iri fomu nyowani yekurapa, zvidzidzo zvine chekuita nehuturu zvakakosha.

Kunyangwe paine mhedzisiro iyi, kumwe kuongorora kunodiwa kuratidza kushanda kweIvermectin pakurapa kweECVID-19, pamwe nemhedzisiro yayo mukudzivirira hutachiona. Ona zvimwe nezvekushandiswa kwe ivermectin kurwisa COVID-19.

Chikunguru 2, 2020 Kwidziridzo:

São Paulo Regional Pharmacy Council (CRF-SP) yakaburitsa chinyorwa chehunyanzvi ^[20] umo inotaura kuti mushonga ivermectin inoratidza antiviral chiito mune mamwe ma-vitro zvidzidzo, asi kuti kumwe kuferefetwa kunodiwa kuti tione kuti ivermectin inogona kushandiswa zvakachengeteka muvanhu kurwisa COVID-19.

Nekudaro, ivo vanopa zano kuti kutengeswa kweivermectin kunofanira kungoitwa chete nekuratidzwa kwemushonga wekurapa uye mukati medosi uye nguva dzakarairwa nachiremba.

Chikunguru 10, 2020 Kwidziridzo:

Zvinoenderana netsananguro yekujekesa yakaburitswa neAVISA ^[22], hapana ongororo dzinojekesa dzinoratidza kushandiswa kwe ivermectin pakurapa kwe COVID-19, uye kushandiswa kwemushonga kurapa hutachiona neiyo coronavirus nyowani rinofanira kuve basa rachiremba ari kutungamira kurapwa.

Uye zvakare, mhedzisiro yekutanga yakaburitswa neongororo neUSP's Institute of Biomedical Sayenzi (ICB) ^[23], ratidza kuti ivermectin, kunyangwe ichikwanisa kubvisa hutachiona kubva mumasero ane hutachiona murabhoritari, inokonzeresawo kufa kwemasero aya, izvo zvinogona kuratidza kuti mushonga uyu unogona kunge usiri mushonga wakanyanya kurapa.

Gadziridza Zvita 9, 2020:

Mune gwaro rakaburitswa neBrazilian Society yeInfectious Diseases (SBI) ^[37] zvakaratidzirwa kuti hapana kurudziro yekutanga kurapwa kwemishonga uye / kana prophylactic kurapwa kwe COVID-19 nemushonga chero upi zvawo, kusanganisira ivermectin, sezvo zvakaitiswa zvekiriniki zvakaitwa parizvino hazviratidze mabhenefiti uye, zvichienderana nedosi, yakashandiswa, inogona kuve nemhedzisiro mhedzisiro iyo inogona kuve nemhedzisiro kuhutano hwese hwemunhu.

Gadziridza Kukadzi 4, 2021:

Merck, inova kambani yemishonga inoona nezve kugadzirwa kwemushonga Ivermectin, yakaratidza kuti muzvidzidzo zvakagadzirwa hazvina kuratidza humbowo hwesainzi hunoratidza kugona kwekurapa kwechirwere ichi kurwisa COVID-19, uye haina kuratidza zvinoitika muvarwere. atoonekwa kuti ane chirwere.

2. Plitidepsin

Plitidepsin mushonga unorwisa-bundu unoburitswa neLabhorabhoritari murabhoritari iyo inoratidzirwa yekurapa kweimwe kesi yeakawanda myeloma, asi iyo zvakare ine yakasimba anti-hutachiona mitezo inopesana neiyo nyowani coronavirus.

Maererano neongororo yakaitwa muUnited States ^[39], plitidepsin yakakwanisa kudzikamisa hutachiona hwe coronavirus inosvika 99% mumapapu emakonzo erabhoritari akatapukirwa neCOVID-19. Vatsvagiri vanopembedza budiriro yemushonga mukugona kwayo kuvhara puroteni iri mumasero yakakosha kuti hutachiwana huwande uye hupararire mumuviri wese.

Mhedzisiro iyi, pamwe nenyaya yekuti mushonga uyu watove kushandiswa muvanhu pakurapa myeloma yakawanda, zvinoratidza kuti mushonga uyu ungangove wakachengeteka kuti uongororwe muvarwere vevanhu vane hutachiona hweCOVID-19. Saka, saka, zvakafanira kumirira mhedzisiro yeiyi kiriniki bvunzo kuti unzwisise muyero uye zvinogona kutyisa mishonga.

3. Remdesivir

Uyu mushonga unodzivirira hutachiona wakagadzirwa kuti urape chirwere chehutachiona hweEbola, asi hauna kuratidza semhedzisiro sedzimwe zvinhu. Nekudaro, nekuda kwekuita kwayo kwakawanda kurwisa hutachiona, iri kuongororwa kuti inzwisise kana ichigona kupa mhedzisiro iri nani mukubviswa kweiyo coronavirus nyowani.

Zvidzidzo zvekutanga zvakaitwa murabhoritari nemushonga uyu, zvese muUnited States ^{[1] [2]}, sekuChina ^[3], yakaratidza mhedzisiro inovimbisa, sezvo chinhu chakakwanisa kudzivirira kudzokorora uye kuwanda kweiyo coronavirus nyowani, pamwe nemamwe mavhairasi emhuri yekoronavirus.

Nekudaro, usati wakurudzirwa senzira yekurapa, uyu mushonga unofanirwa kuita ongororo dzinoverengeka nevanhu, kuti unzwisise kushanda kwayo kwechokwadi uye kuchengetedzeka. Nekudaro, kune, parizvino, dzinenge zvidzidzo zvitanhatu zviri kuitiswa nenhamba yepamusoro yevarwere vane hutachiona hweCOVID-19, vese muUnited States, muEurope uye muJapan, asi mhedzisiro inofanirwa kungoburitswa muna Kubvumbi. , kwechinguvana, hapana humbowo hwekuti Remdesivir inogona, pachokwadi, kushandiswa zvakachengeteka kubvisa iyo nyowani coronavirus muvanhu.

Kubvumbi 29, 2020 Kwidziridzo:

Maererano nekuferefetwa neGilead Sayenzi ^[8], muUnited States, kushandiswa kweRemdesivir mune varwere vane COVID-19 kunoita kunge kunopa mhedzisiro yakafanana munguva yekurapwa kwemazuva mashanu kana gumi, uye muzviitiko zvese izvi varwere vanoburitswa muchipatara mukati memazuva gumi nemana uye nerutivi rwechiitiko. mhedzisiro yakadererawo. Ichi chidzidzo hachiratidze mwero wekushanda kwemushonga kubvisa iyo nyowani coronavirus uye, nekudaro, zvimwe zvidzidzo zvichiri kuitwa.

Chivabvu 16, 2020 Kwidziridzo:

Chidzidzo kuChina pane 237 varwere vane zvakakomba mhedzisiro yeiyo COVID-19 hutachiona ^[15] akataura kuti varwere vakarapwa nemushonga uyu vakaratidza kupora nekukasira zvichienzaniswa nevarwere, neavhareji yemazuva gumi ichienzaniswa nemazuva gumi nemana akapihwa neboka rakarapwa ne placebo.

Gadziridza May 22, 2020:

Chirevo chekutanga chekumwe kuongorora kwakaitwa muUnited States naRemdesivir ^[16] akataura zvakare kuti kushandiswa kwemushonga uyu zvinoita sekuderedza nguva yekudzosa muvanhu vakuru vari muchipatara, pamwe nekudzora njodzi yehutachiona hwehutachiona hwehutachiona.

Gadziridza Chikunguru 26, 2020:

Zvinoenderana neongororo yakaitwa neBoston University Chikoro cheRuzhinji Hutano ^[26], remdesivir inoderedza nguva yekurapa muvarwere vanobvumirwa kuICU.

Mbudzi 5, 2020 Kwidziridzo:

Chirevo chekupedzisira chechidzidzo chiri kuitwa muUnited States neRemdesivir chinoratidza kuti kushandiswa kwemushonga uyu, kutaura zvazviri, kunoderedza avhareji yekupora nguva muvanhu vakuru vari muchipatara, kubva pamazuva gumi kusvika gumi ^[31].

Mbudzi 19, 2020 Kwidziridzo:

Iyo FDA muUnited States yakapa mvumo yekukurumidzira ^[32] iyo inobvumira kushandiswa kwakabatana kweRemdesivir nemushonga weBaricitinib, mukurapa kwevarwere vane hutachiona hwakakomba hwecoronavirus uye vanoda oxygenation kana mweya wekufema.

Mbudzi 20, 2020 Kwidziridzo:

WHO yakaraira pamusoro pekushandiswa kweRemdesivir pakurapa kwevanorwara neCOBV-19 nekuda kwekushayikwa kwemashoko akajeka anoratidza kuti Remdesivir inoderedza mwero wekufa.

4. Dexamethasone

Dexamethasone imhando yecorticosteroid inoshandiswa zvakanyanya muvarwere vane matambudziko ekurapa asingaperi, senge asthma, asi inogona zvakare kushandiswa mune mamwe matambudziko ekuzvimba, senge arthritis kana ganda kuzvimba. Mushonga uyu wakaedzwa senzira yekudzora zviratidzo zveCOVID-19, sezvo ichigona kubatsira kudzikisa kuzvimba mumuviri.

Zvinoenderana nechidzidzo chiri kuitwa kuUK ^[18], dexamethasone inoita kunge mishonga yekutanga yakaedzwa kuti ideredze zvakanyanya mwero wekufa kwevarwere vanorwara zvakanyanya vane COVID-19. Zvinoenderana nezvakabuda mutsvakiridzo iyi, dexamethasone yakakwanisa kudzikisa huwandu hwevanhu vanofa kusvika mazuva makumi maviri nemasere mushure mekutapukirwa necoronavirus nyowani, kunyanya kune vanhu vanoda kubatsirwa nemuchina wekufema kana kupa oxygen.

Izvo zvakakosha kuti urangarire kuti dexamethasone haibvise coronavirus kubva mumuviri, ichingobatsira kubvisa zviratidzo uye kudzivirira kunetseka kwakanyanya.

Chikumi 19, 2020 Kwidziridzo:

Iyo Brazilian Society yeZvinotapukira Zvirwere yakakurudzira kushandiswa kwe dexamethasone kwemazuva gumi ekurapa kwevarwere vese vane COVID-19 vanobvumirwa kuICU nemuchina wekufema mweya kana avo vanoda kugamuchira oxygen. Zvisinei, corticosteroids haifaniri kushandiswa mumamiriro mashoma kana senzira yekudzivirira utachiona ^[19].

Gadziridza Chikunguru 17, 2020:

Zvinoenderana nekutsvaga kwesainzi kunoitwa muUnited Kingdom ^[24], kurapwa ne dexamethasone kwemazuva gumi akateedzana kunoita sekudzikira kufa kwevarwere vane hutachiona hwakanyanya neiyo coronavirus nyowani, inoda mweya wekufema. Muzviitiko izvi, mwero wekufa unoratidzika kunge wakadzikira kubva pa41.4% kusvika pa29.3%. Mune vamwe varwere, mhedzisiro yekurapwa ne dexamethasone haina kuratidza mhedzisiro yakadaro.

Gadziridza Nyamavhuvhu 2, 2020:

Meta-ongororo yakavakirwa pamakiriniki e7 ^[29] akagumisa kuti kushandiswa kwe dexamethasone uye mamwe ma corticosteroids anogona, kutaura zvazviri, kudzikisa kufa kwevarwere vanorwara zvakanyanya vane hutachiona hwe COVID-19.

Gadziridza Gunyana 18, 2020:

Iyo European Medicines Agency (EMA) ^[30] yakabvumidza kushandiswa kwe dexamethasone mukurapa kwevechiri kuyaruka nevakuru vane hutachiona neiyo coronavirus nyowani, avo vari kuda rutsigiro rweoksijeni kana meya mweya mweya.

5. Hydroxychloroquine uye chloroquine

Hydroxychloroquine, pamwe ne chloroquine, zvinhu zviviri zvinoshandiswa pakurapa varwere vane malaria, lupus uye mamwe matambudziko ehutano, asi izvo zvisati zvichionekwa zvakachengeteka mune zvese zviitiko zve COVID-19.

Kudzidza kwakaitwa muFrance ^[4] uye muChina ^[5], yakaratidza mhedzisiro inovimbisa ye chloroquine uye hydroxychloroquine mukuderedza huwandu hwehutachiona uye kudzikisa kutakurwa kwehutachiona kupinda mumasero, ichideredza kugona kwehutachiona kuwanda, zvichipa, nekudaro, kukurumidza kupora. Nekudaro, izvi zvidzidzo zvakaitwa pane zvidiki sampuli uye kwete zvese bvunzo zvaive zvakanaka.

Parizvino, sekureva kwe Ministry of Health yeBrazil, chloroquine inogona chete kushandiswa muvanhu vakabvumirwa kuchipatara, kwemazuva mashanu, pasi pekucherechedzwa zvachose, kuongorora kutaridzika kwemhedzisiro yakaipa, senge matambudziko emoyo kana shanduko muchiono. .

Kubvumbi 4, 2020 Kwidziridzo:

Imwe yeongororo dziri kuenderera mberi, pamwe nekushandiswa kwakabatana kwehydroxychloroquine uye antibiotic azithromycin ^[9], muFrance, yakaratidza mhedzisiro inovimbisa muboka revarwere makumi masere vane zviratidzo zvine mwero zve COVID-19. Muboka iri, kuderedzwa kwehutachiona hweiyo coronavirus nyowani mumuviri kwakazivikanwa, mushure memazuva masere ekurapwa, zvinova zviri pasi pevhareji yevhiki nhatu dzakapihwa nevanhu vasina kurapwa.

Mukuferefeta uku, pavarwere makumi masere vakadzidza, munhu mumwe chete ndiye akazopedzisira afa, sezvo angadai akagamuchirwa muchipatara padanho repamusoro rehutachiona, izvo zvinogona kunge zvakatadzisa kurapwa.

Mhedzisiro iyi inoenderera ichitsigira dzidziso yekuti kushandiswa kwehydroxychloroquine inogona kunge iri nzira yakachengeteka yekurapa hutachiona hweCOVID-19, kunyanya mune zviratidzo zvine hunyoro kusvika pakati nepakati, kuwedzera pakuderedza njodzi yekutapurirana chirwere. Zvakadaro, zvakafanira kumirira mhedzisiro yezvimwe zvidzidzo zviri kuitiswa nemushonga, kuti uwane mhedzisiro ine yakakura huwandu hwevanhu.

Kubvumbi 23, 2020 Kwidziridzo:

Federal Council of Medicine yeBrazil yakabvumidza kushandiswa kweHydroxychloroquine pamwe neAzithromycin pakuona kwachiremba, mune varwere vane zviratidzo zvakapfava kana zvine mwero, asi vasingade kubvumidzwa kweICU, mune zvimwe hutachiona hutachiona, seFuruenza kana H1N1 , uye kuongororwa kwe COVID-19 kunosimbiswa ^[12].

Nekudaro, nekuda kwekushayikwa kwemhedzisiro yakasimba yesainzi, kusangana uku kwemishonga kunofanira kungoshandiswa nemvumo yemurwere uye nezano rachiremba, mushure mekuongorora njodzi dzinogona kuitika.

Chivabvu 22, 2020 Kwidziridzo:

Sekureva kweongororo yakaitwa muUnited States nevarume mazana masere negumi nemapfumbamwe ^[13], kushandiswa kweChloroquine uye Hydroxychloroquine, kwakabatana kana kwete neazithromycin, zvinoita kunge kusingabatsiri pakurapa kwe COVID-19, kutoratidzika kunge kuri kuwedzera huwandu hwekufa kwevarwere, sezvo mishonga iyi ichiwedzera njodzi yezvinetso zvemoyo, kunyanya arrhythmia uye atrial fibrillation.

Parizvino, ichi ndicho chikuru kudzidza chakaitwa nehydroxychloroquine uye chloroquine. Sezvo mhedzisiro yakapihwa inopesana nezvakataurwa pamusoro pemishonga iyi, zvimwe zvidzidzo zvichiri kudikanwa.

Chivabvu 25, 2020 Kwidziridzo:

Sangano reWorld Health Organisation (WHO) rakambomisa kutsvagisa nezvehydroxychloroquine iyo yaibatanidza munyika dzinoverengeka. Kumiswa kwacho kunofanirwa kuchengetwa kudzamara kuchengetedzwa kwechirwere kwadzokororwazve.

Chivabvu 30, 2020 Kwidziridzo:

Nyika yeEspírito Santo, muBrazil, yakabvisa chiratidzo chekushandiswa kwechloroquine mune varwere vane COVID-19 mune yakaipa mamiriro.

Pamusoro pezvo, vachuchisi vanobva kuFederal Public Ministry yeSão Paulo, Rio de Janeiro, Sergipe naPernambuco vanokumbira kumiswa kwemitemo inoratidza kushandiswa kwehydroxychloroquine uye chloroquine mukurapa kwevarwere vane COVID-19.

Chikumi 4, 2020 Kwidziridzo:

Magazini yeLancet yakabvisa kuburitswa kwevarwere mazana masere negumi nemasere zvakaratidza kuti kushandiswa kwehydroxychloroquine uye chloroquine hakuna zvazvakabatsira pakurapa kweCOVID-19, nekuda kwekuomerwa nekuwana iyo yekutanga data yakaratidzwa muchidzidzo.

Chikumi 15, 2020 Kwidziridzo:

Iyo FDA, inova United States 'chikuru chinodzora chinodzora mutumbi, yabvisa mvumo yechimbichimbi yekushandisa chloroquine uye hydroxychloroquine mukurapa COVID-19 ^[17], ichipembedza iyo yakakwira nhanho yengozi yemushonga uye zvinoita sezvakaderera mikana yekurapa iyo nyowani coronavirus.

Gadziridza Chikunguru 17, 2020:

Iyo Brazilian Society Yezvirwere zvinotapukira ^[25] inokurudzira kuti kushandiswa kwehydroxychloroquine mukurapa COVID-19 kusiyiwa, panguva ipi neipi yehutachiona.

Chikunguru 23, 2020 Kwidziridzo:

Maererano neongororo yeBrazil ^[27], yakaitwa pamwe chete pakati paAlbert Einstein, HCor, Sírio-Libanês, Moinhos de Vento, Oswaldo Cruz uye Beneficência Portuguesa Hospitals, kushandiswa kwehydroxychloroquine, inosanganiswa kana kwete neazithromycin, zvinoita kunge isina mhedzisiro pakurapa kwehutachiona hune hunyoro kusvika pakati nepakati. varwere vane coronavirus nyowani.

6. Colchicine

Zvinoenderana neongororo yakaitwa muCanada ^[38], colchicine, mushonga unoshandiswa zvakanyanya pakurapa rheumatological matambudziko, senge gout, inogona kubatsira pakurapa kwevarwere vane COVID-19.

Sekureva kwevaongorori, iro boka revarwere rakarapwa nemushonga uyu kubva pakuonekwa kwehutachiona, kana ichienzaniswa neboka raishandisa placebo, yakaratidza kuderera kwakanyanya mungozi yekukudziridza fomu rakasimba rehutachiona. Uye zvakare, kuderedzwa kwekugara muchipatara uye kufa kwehuwandu kwakave kwataurwawo.

7. Mefloquine

Mefloquine imushonga unoratidzwa mukudzivirira uye kurapwa kwemarariya, muvanhu vane chinangwa chekuenda kunzvimbo dzinonetsa. Kubva pane zvidzidzo zvakaitwa kuChina neItaly^[6], chirongwa chekurapa umo mefloquine inosanganiswa nemamwe madhiragi iri kuongororwa muRussia kuti ishandise kushanda kwayo mukudzora chirwere cheCOVID-19, asi hapana mhedzisiro yakajeka.

Nekudaro, kushandiswa kwe mefloquine kurapa hutachiona neiyo nyowani coronavirus haisati yakurudzirwa nekuti zvimwe zvidzidzo zvinodiwa kuti zviratidze kushanda kwayo nekuchengeteka.

8. Tocilizumab

Tocilizumab imushonga unoderedza maitiro ezvirwere zvemuviri uye, nekudaro, unowanzo shandiswa pakurapa kwevarwere vane rheumatoid arthritis, kudzikisira kuwedzera kwe immune immune, kudzora kuzvimba uye kubvisa zviratidzo.

Mushonga uyu urikudzidziswa kubatsira mukurapa kwe COVID-19, kunyanya mumatanho epamberi ehutachiona, kana paine huwandu hwakawanda hwezvinhu zvinopisa zviri kugadzirwa ne immune system, izvo zvinogona kukuvadza mamiriro emakiriniki.

Zvinoenderana nekudzidza kuChina ^[10] muvarwere gumi nevashanu vane hutachiona hwe COVID-19, kushandiswa kwe tocilizumab kwakaratidza kuve kunoshanda uye kunokonzeresa mhedzisiro, zvichienzaniswa necorticosteroids, ndiyo mishonga inowanzo shandiswa kudzora kuzvimba kunogadzirwa ne immune reaction

Zvakadaro, zvimwe zvidzidzo zvinofanirwa kuitiswa, kuti unzwisise kuti ndeupi muyero wakanyanya kunaka, sarudza regimen yekurapa uye uone kuti ndeipi mhedzisiro.

Kubvumbi 29, 2020 Kwidziridzo:

Sekureva kwechidzidzo chitsva chakaitwa kuChina nevarwere makumi maviri nemumwe vakatapukirwa neCOVID-19^[14], kurapwa ne tocilizumab inoita kunge inokwanisa kudzikisa zviratidzo zvehutachiona nguva pfupi mushure mekutarisirwa kwechirwere, kudzikisira fivha, kudzikamisa kunzwa kwekusimba muchipfuva nekuvandudza mazinga eokisijeni.

Chidzidzo ichi chakaitwa kuvarwere vane zviratidzo zvakakomba zvehutachiona uye zvinoratidza kuti kurapwa ne tocilizumab kunofanira kutanga nekukurumidza pazvinokwanisika kana murwere achibva kubva pakati nepakati kuenda kune yakakomba mamiriro ehutachiona neiyo coronavirus nyowani.

Gadziridza Chikunguru 11, 2020:

Kutsva kutsva neYunivhesiti yeMichigan muUnited States ^[28], akagumisa kuti kushandiswa kwe tocilizumab mune varwere vane COVID-19 inoita kunge inoderedza huwandu hwekufa kwevarwere vari kufemerwa mweya, kunyangwe zvawedzera njodzi yehumwe hutachiona.

9. Convalescent plasma

Convalescent plasma rudzi rwekurapa kwoutachiona uko kunotorwa muyero weropa, kubva kuvanhu vakatotapukirwa necoronavirus uye avo vakaporeswa, avo vanozoita mamwe maitiro ecentrifugation kupatsanura plasma kubva kumasero matsvuku eropa. Chekupedzisira, plasma inoiswa mukati memunhu anorwara kubatsira immune system kurwisa hutachiona.

Pfungwa iri seri kwerudzi urwu rwekurapa ndeyekuti ma antibodies akagadzirwa nemuviri wemunhu akatapukirwa, uye akasara ari muplasma, anogona kuendeswa kuropa remumwe munhu achiri nechirwere ichi, achibatsira kusimbisa hutachiona uye kufambisa kubviswa kwehutachiona.

Sekureva kweTechnical Note Nhamba 21 yakaburitswa naAnvisa, muBrazil, convalescent plasma inogona kushandiswa senzira yekurapa muvarwere vane hutachiona necorona coronavirus, chero bedzi mitemo yese yeUtano Yekutarisa ichiteerwa. Pamusoro pezvo, zviitiko zvese zvinoshandisa convalescent plasma pakurapa kwe COVID-19 inofanirwa kuziviswa kuGeneral Coordination yeRopa neRopa Zvigadzirwa zveMinistry of Health.

10. Avifavir

Avifavir imishonga inogadzirwa muRussia ine chinhu chinoshanda ndicho chinhu favipiravir, iyo zvinoenderana neRussia Direct Investment Fund (RDIF) ^[21] inokwanisa kurapa hutachiona hwecoronavirus, ichinge yakaverengerwa mukurapa nekudzivirira kwezvirongwa zve COVID-19 muRussia.

Zvinoenderana nezvidzidzo zviri kuitwa, mukati memazuva gumi, Avifavir anga asina mhedzisiro mitsva uye, mukati memazuva mana, 65% yevarwere vanorapwa vaive nemuedzo wakashata weECVID-19.

11. Baricitinib

Iyo FDA yakabvumidza kushandiswa kwechimbichimbi kwechinodhaka Baricitinib mukurapa kwakakomba hutachiona hweCOVID-19 ^[32]pamwe neRemdesivir. Baricitinib chinhu chinoderedza kupindura kwema immune system, kudzikisira kuita kwemaenzyme anokurudzira kuzvimba uye akamboshandiswa mumamiriro erheumatoid arthritis.

Sekureva kwe FDA, kusangana uku kunogona kushandiswa muvarwere vakuru uye vana vane makore anodarika maviri, vari muchipatara uye vari kuda kurapwa neoksijeni kana meya mweya mweya.

12. EXO-CD24

EXO-CD24 mushonga unoratidzwa pakurapa kenza yeovari uye wakakwanisa kurapa varwere makumi maviri nevapfumbamwe makumi matatu vane COVID-19. Nekudaro, zvimwe zvidzidzo zvichiri kuitwa, pamwe nevanhu vakawanda, nechinangwa chekuona kana mushonga uyu uchizobudirira pakurapa chirwere uye muyero unoonekwa wakachengeteka kuti ushandiswe.

Natural mishonga yekurapa sarudzo ye coronavirus

Parizvino hapana maratidziro echisikigo ekugadzirisa coronavirus uye kubatsira kurapa COVID-19, zvisinei, WHO inoziva kuti chirimwa Artemisia annua inogona kubatsira pakurapa ^[11], kunyanya munzvimbo dzinowanikwa mishonga zvakanyanya uye chirimwa chinoshandiswa pakurapa kwechivanhu, sezvinoitika kumatunhu akasiyana siyana eAfrica.

Mashizha emuti Artemisia annua anowanzo shandiswa mu Africa kubatsira kurapa malaria uye, nekudaro, WHO inoziva kuti panodiwa zvidzidzo kuti unzwisise kana chirimwa ichi chingashandiswawo pakurapa COVID-19, sezvo mimwe mishonga yekugadzira marariya yakaratidzawo mibairo inovimbisa .

Zvakadaro, zvakakosha kuti urangarire kuti kushandiswa kwechirimwa hakuna kusimbiswa kupokana neCOVID-19 uye kuti kumwe kuferefetwa kunodiwa.