Yepamberi Cancer Breast Kurapa uye Tsvagiridzo: Chii chiri paHuroni?

Zvemukati

• Targeted Therapies
• Mishonga yekurapa padhuze
• Anti-angiogenesis zvinodhaka
• Biosimilar zvinodhaka
• Immunotherapy
• PI3 kinase inhibitors
• Enhanced kufungidzira uye kuongorora
• Kupinda muchirongwa chemakiriniki

Metastatic kenza yemazamu inogona kurapwa, asi kazhinji kazhinji haigone kurapwa. Parizvino, zvinangwa zvekurapa zvinosanganisira kudzikisa zviratidzo zvako, kugadzirisa hupenyu hwako, uye kuwedzera hupenyu hwako.

Kurapa kazhinji kunosanganisira kurapa kwehomoni, chemotherapy, kurapwa kwakanangwa, kana musanganiswa weizvi.

Heano mamwe emarapirwo azvino uye emangwana aunogona kutarisira kunzwa nezvazvo kana iwe wakagamuchira yepamusoro kenza yemazamu kuongororwa.

Targeted Therapies

Vatsvakurudzi vakagadzira mishonga yakati wandei mitsva inotarisisa shanduko yesero. Shanduko idzi dzinokonzera maseru ekenza kuti akurumidze kukura nekupararira. Izvi zvakasiyana nekemotherapy, inovavarira maseru ese anokura nekukurumidza, anosanganisira cancer maseru uye maseru ane hutano.

Mazhinji emishonga iyi yakanangwa yakatenderwa kurapa metastatic kenza yemazamu. Vamwe vari kuongororwa mumakiriniki ekuedzwa, uye mazhinji akawanda ari mukuyedzwa kwepamberi.

Mimwe mienzaniso yekurapa kwakanangwa kunosanganisira:

• Lapatinib (Tykerb). Mushonga uyu ndeye tyrosine kinase inhibitor. Inoshanda nekudzivirira ma enzyme anokurudzira kukura kwesero. Inowanikwa sepiritsi yaunonwa mazuva ese kurapa metastatic kenza yemazamu. Inogona kusanganiswa nemamwe mishonga yemakemikari kana ekurapa kwehomoni.
• Neratinib (Nerlynx). Mushonga uyu unobvumidzwa kurapa HER2-inovhenekera kenza yemazamu yekutanga. Zvimwe zvidzidzo zvinoratidza kuti zvinogona kushanda pakurapa vanhu vane metastatic kenza yemazamu futi.
• Olaparib (Lynparza). Kurapwa uku kunotenderwa HER2-isina metastatic kenza yemazamu mune vanhu vane BRCA gene mutation. Inowanikwa sepiritsi yezuva nezuva.

CDK4 / 6 inhibitors iri rimwe kirasi remishonga yekurapa yakanangwa. Iyi mishonga inovhara mamwe mapuroteni anoita kuti maseru ekenza akure. Abemaciclib (Verzenio), palbociclib (Ibrance), uye ribociclib (Kisqali) ndiwo maCDK4 / 6 inhibitors ayo akabvumidzwa neFood and Drug Administration (FDA) yekurapa kenza yemazamu. Izvo zvinoshandiswa musanganiswa nehormone kurapwa kurapa HR-yakanaka uye HER2-isina metastatic kenza yemazamu.

Mishonga yekurapa padhuze

Kune akawanda marapirwo aripo ekurapa metastatic kenza yemazamu, asi zvidzidzo zvichiri kuitiswa kuti udzidze zvakawanda nezve mashandiro anoita maseru egomarara aya uye nekuchinja kwemajini. Pazasi pane mamwe marapiro achiri kuongororwa.

Anti-angiogenesis zvinodhaka

Angiogenesis ndiyo nzira inogadzirwa mitsva yeropa. Anti-angiogenesis zvinodhaka zvakagadzirirwa kubvisa ropa kuwedzerwa mumidziyo. Izvi zvinobvisa cancer maseru eropa rinodiwa kuti rikure.

Iyo anti-angiogenesis drug bevacizumab (Avastin) parizvino FDA-inogamuchirwa kurapa mamwe kanzira. Mushonga uyu wakaratidza kumwe kushanda kuvakadzi vane gomarara repamazamu repamberi, asi iyo FDA yakasiya kubvumidzwa kwekushandisa ikoko muna 2011. Bevacizumab nemimwe mishonga inorwisa angiogenesis vachiri kuita ongororo yekurapa kenza yemazamu.

Biosimilar zvinodhaka

Biosimilar zvinodhaka zvakafanana nemazita ezita zvinodhaka, asi zvinogona kudhura. Ivo inoshanda nzira yekurapa.

Mazhinji biosimilar mishonga yekenza yemazamu iri kuongororwa. Iyo biosimilar fomu yetrastuzumab (Herceptin), chemotherapy mushonga, ndiyo chete biosimilar inogamuchirwa yekurapa HER2-yakanaka metastatic kenza yemazamu. Inonzi trastuzumab-dkst (Ogivri).

Immunotherapy

Immunotherapy inzira yekurapa iyo inobatsira immune system yemuviri mukuparadza cancer maseru.

Imwe kirasi yemununotherapy mishonga ndeye PD1 / PD-L1 inhibitors. Pembrolizumab (Keytruda) yakagamuchirwa kurapa kenza yemapapu. Iri kuitiswa kiriniki kuyedzwa kuti ibudirire mune varwere vane hutatu hwakashata metastatic kenza yemazamu.

PI3 kinase inhibitors

Iyo PIK3CA geni inobatsira kudzora PI3 kinase, iyo enzyme inokonzeresa kuti mamota akure. PI3 kinase inhibitors yakagadzirirwa kukanganisa uye kumisa kukura kweiyo P13 enzyme. Izvi zviri kuongororwa kuitira kurapwa kwekenza yemazamu.

Enhanced kufungidzira uye kuongorora

Nehurombo, vanhu vanogona kukudziridza kuramba kumwe kurapwa kwekenza. Izvi zvinokonzera kuti kurapwa kumire kushanda zvinobudirira. Vatsvagiri vari kugadzira nzira nyowani dzekuona kuti varwere vanopindura sei kurapwa.

Kuongorora kwekutenderera kwechipfuva DNA (inozivikanwawo semvura biopsy) kuri kuongororwa senzira yekutungamira kurapwa. Vatsvagiri vari kuyedza kuona kana bvunzo iyi inobatsira mukutarisa varwere vane metastatic kenza yemazamu uye kufungidzira maitiro avachapindura pakurapwa.

Kupinda muchirongwa chemakiriniki

Kubatanidzwa mukutongwa kwechipatara kunogona kubatsira vatsvakurudzi kuziva kana mishonga mitsva ichashanda. Kana iwe uchifarira kujoina imwe, yakanaka nzvimbo yekutanga ndeye ClinicalTrials.gov, dhatabhesi inotsvaga yezvidzidzo izvozvi zviri kutora pasi rese. Uyezve tarisa zvirongwa senge Metastatic Breast Cancer Project. Iyi internet-based chikuva inobatanidza vanhu vane metastatic kenza yemazamu nemasayendisiti ari kushandisa tekinoroji kuongorora izvo zvinokonzera kenza.

Taura nemupi wako wezvehutano kuti uone kana kujoina kiriniki kutongwa kwakakukodzera.Ivo vanogona kukubatsira iwe kuona kana iwe uchikodzera uye kukubatsira iwe kunyoresa.