Chii chinonzi Trimetazidine?

Zvemukati

• Kushandisa sei
• Ndeipi nzira yekuita
• Ndiani asingafanire kushandisa
• Zvinogona kuitika mhedzisiro

Trimetazidine chinhu chinoshanda chinoratidzirwa pakurapa ischemic moyo kutadza uye ischemic moyo chirwere, chinova chirwere chinokonzerwa nekushomeka kweropa mukutenderera mutsinga.

Trimetazidine inogona kutengwa mumapharmasi nemutengo unosvika makumi mashanu kusvika gumi neshanu nepfumbamwe, pakapihwa mushonga.

Kushandisa sei

Iyo yakakurudzirwa muyero ndeye 1 piritsi ye35 mg, kaviri pazuva, kamwe chete mangwanani, panguva yekudya kwemangwanani uye kamwe manheru, panguva yekudya kwemanheru.

Ndeipi nzira yekuita

Trimetazidine inochengetedza simba metabolism yemasero eschemic, akaoneswa kune yakaderera oxygen musanganiswa, ichidzivirira kuderera kwema intracellular mazinga eATP (simba), nekudaro ichivimbisa kushanda kwakaringana kwemapombi eionic uye kuyerera kwekutenderera kwesodium uye potasium, uku ichichengetedza homeostasis cell.

Uku kuchengetedza kwesimba metabolism kunowanikwa nekudzivisa iyo β-oxidation yemafuta acids, inoitwa ne trimetazidine, iyo inowedzera iyo oxydation yeglucose, inova nzira yekuwana simba rinoda kushomeka kweoxygen kushandiswa kana ichienzaniswa ne β-oxidation maitiro. Nekudaro, iko kugona kweiyo glucose oxidation inogonesa maseru esimba maitiro, ichichengetedza yakakodzera simba metabolism panguva yeschemia.

Mune varwere vane ischemic moyo chirwere, trimetazidine inoshanda seye metabolic mumiriri inochengetedza iwo masisitimu emagetsi emamyocardial akakwira simba phosphates.

Ndiani asingafanire kushandisa

Mushonga uyu unopikiswa nevarwere vane hypersensitivity kune trimetazidine kana chimwe chezvinhu zvemufomula, vanhu vane chirwere chePasinson, zviratidzo zveparkinsonism, kudedera, kusagadzikana kwegumbo chirwere uye zvimwe shanduko zvine chekuita nekufamba uye neakakomba itsvo kutadza nekubvisa creatinine isingasviki 30mL / min.

Pamusoro pezvo, mushonga uyu haufanire kushandiswa nevana vari pasi pemakore gumi nemasere, vakadzi vakazvitakura kana vakadzi vari kuyamwisa.

Zvinogona kuitika mhedzisiro

Mimwe yemhedzisiro inowanzoitika panguva yekurapwa ne trimetazidine dzungu, kutemwa nemusoro, kurwadziwa mudumbu, manyoka, kusagaya zvakanaka, kusvotwa, kurutsa, kuputika, kuruma, mikoko uye kushaya simba.