Tyrosine: Bhenefiti, Side Mhedzisiro uye Dosage

Zvemukati

• Chii chinonzi Tyrosine uye Chii Chainoita?
• Iyo Inogona Kuvandudza Kwepfungwa Kuita Mumamiriro Anonetsa
• Inogona Kubatsira Avo Vane Phenylketonuria
• Humbowo Nezve Maitiro Awo Pakushungurudzika Kwakasanganiswa
• Side Migumisiro yeTyrosine
• Monoamine Oxidase Inhibitors (MAOIs)
• Utachiona Hormone
• Levodopa (L-dopa)
• Maitiro Ekuwedzera neTyrosine
• Icho Chinokosha

Tyrosine inozivikanwa yekudya yekuwedzera inowedzera kugadzirisa kungwarira, kutarisisa uye kutarisisa.

Iyo inogadzira yakakosha makemikari ehuropi ayo anobatsira maseru etsinga kutaurirana uye anogona kunyange kugadzirisa mamiriro ().

Kunyangwe paine mabhenefiti aya, kuwedzera ne tyrosine kunogona kuve nemhedzisiro uye kusangana nemishonga.

Ichi chinyorwa chinokuudza zvese zvaunoda kuti uzive nezve tyrosine, kusanganisira mabhenefiti ayo, mhedzisiro uye madhivhosi akakurudzirwa.

Chii chinonzi Tyrosine uye Chii Chainoita?

Tyrosine iamino acid iyo inowanzo gadzirwa mumuviri kubva kune imwe amino acid inonzi phenylalanine.

Inowanikwa mune zvakawanda zvekudya, kunyanya muchizi, kwayakatanga kuwanikwa. Muchokwadi, "tyros" zvinoreva "chizi" muchiGiriki ().

Inowanikwawo muhuku, turkey, hove, zvigadzirwa zvemukaka uye zvimwe zvakawanda zvine mapuroteni-ekudya ().

Tyrosine inobatsira kugadzira zvinhu zvinoverengeka zvakakosha, zvinosanganisira (4):

• Dopamine: Dopamine inodzora yako mubairo uye mafaro nzvimbo. Ichi chakakosha chemakemikari ehuropi chakakoshawo kune ndangariro uye mota hunyanzvi ().
• Adrenaline uye noradrenaline: Aya mahormone ane chekuita nekurwira-kana-kubhururuka kupindura kune kunetsa mamiriro. Ivo vanogadzirira muviri "kurwa" kana "kutiza" kubva kunofungidzirwa kurwisa kana kukuvara ().
• Utachiona mahormone: Mahormone ehutachiona anogadzirwa neiyo gland yegland uye anonyanya kukonzera kudzora metabolism ().
• Melanin: Iyi pigment inopa ganda rako, bvudzi uye maziso avo ruvara. Vanhu vane ganda rakasviba vane melanin yakawanda mukati meganda ravo pane vanhu vane ganda jena ().

Inowanikwawo sekuwedzera kwekudya. Unogona kuitenga iri yoga kana kusanganiswa nezvimwe zvinoshandiswa, senge mune pre-Workout yekuwedzera.

Kuwedzera ne tyrosine kunofungidzirwa kuwedzera mazinga eiyo neurotransmitters dopamine, adrenaline uye norepinephrine.

Nekuwedzera aya maurotransmitter, zvinogona kubatsira kuvandudza ndangariro uye kuita mune zvinonetsa mamiriro (4).

Pfupiso Tyrosine iamino acid inogadzirwa nemuviri kubva kune phenylalanine. Kuwedzera nayo kunofungidzirwa kuwedzera kwakakosha makemikari ehuropi, ayo anokanganisa manzwiro ako uye kupindura kwekushushikana.

Iyo Inogona Kuvandudza Kwepfungwa Kuita Mumamiriro Anonetsa

Kushungurudzika chinhu chinosangana nemunhu wese.

Kushushikana uku kunogona kukanganisa kufunga kwako, ndangariro, kutarisisa uye ruzivo kuburikidza nekuderedza maurotransmitter (,).

Semuenzaniso, makonzo aisangana nechando (kushungurudzika kwezvakatipoteredza) aive neakaremara ndangariro nekuda kwekuderera kwemaurotransmitter (10,).

Nekudaro, apo aya makonzo akapihwa tyrosine yekuwedzera, kuderera kwemaurotransmitter kwakadzoserwa uye ndangariro yavo yakadzorerwa.

Nepo data yemakonzo isingashandure kuvanhu, zvidzidzo zvevanhu zvakawana zvakafanana.

Mune kumwe kuongorora muvakadzi makumi maviri nevaviri, tyrosine yakanyanya kuvandudza ndangariro yekushanda panguva yebasa rinoda mupfungwa, zvichienzaniswa nenzvimbo inogara panzvimbo. Kushanda ndangariro kunoita basa rakakosha mukutapa nekutevera mirairo ().

Mune chidzidzo chakafanana, vatori vechikamu makumi maviri nevaviri vakapihwa tyrosine yekuwedzera kana placebo vasati vapedza bvunzo inoshandiswa kuyera kugona kwekuziva. Inofananidzwa neiyo placebo, tyrosine yakawanikwa ichivandudza kugadzirisa kushanduka ().

Kufunga kushanduka ndiko kugona kushanduka pakati pemabasa kana pfungwa. Iyo inokurumidza kuti munhu anogona kushandura mabasa, iwo makuru avo ekuziva kushanduka.

Pamusoro pezvo, kuwedzera ne tyrosine kwakaratidzirwa kubatsira avo vasina hope. Chinhu chimwe chete chakabatsira vanhu vakarasikirwa nehusiku kurara vakangwarira kwemaawa matatu kupfuura zvavangadai ().

Uyezve, wongororo mbiri dzakagumisa kuti kuwedzera ne tyrosine kunogona kudzora kuderera kwepfungwa uye kugadzirisa kugona munguva pfupi, inonetsa kana mamiriro ekumanikidza epfungwa (15,).

Uye nepo tyrosine ichipa ruzivo rwekuziva, hapana humbowo hwakaratidza kuti hunosimbisa kuita kwemunhu muvanhu (,,).

Chekupedzisira, hapana tsvakiridzo inoratidza kuti kuwedzera ne tyrosine mukushaikwa kwekushushikana kunogona kuvandudza mashandiro epfungwa. Mune mamwe mazwi, hazvizowedzere yako brainpower.

Pfupiso Zvidzidzo zvinoratidza kuti tyrosine inogona kubatsira kuchengetedza kugona kwako kwepfungwa kana uchitorwa usati waita basa rinonetsa. Nekudaro, hapana humbowo hwekuti kuwedzera nayo kunogona kuvandudza ndangariro dzako.

Inogona Kubatsira Avo Vane Phenylketonuria

Phenylketonuria (PKU) chinhu chisingawanzoitika pamajini chinokonzerwa nehurema mugene hunobatsira kugadzira iyo enzyme phenylalanine hydroxylase ().

Muviri wako unoshandisa iyi enzyme kushandura phenylalanine kuita tyrosine, iyo inoshandiswa kugadzira maurotransmitter (4).

Nekudaro, pasina iyi enzyme, muviri wako haugone kupaza phenylalanine, ichikonzera kuti ivakwe mumuviri.

Iyo yekutanga nzira yekurapa PKU ndeyekutevera yakasarudzika chikafu chinogumira chikafu chine phenylalanine (20).

Nekudaro, nekuti tyrosine inogadzirwa kubva phenylalanine, vanhu vane PKU vanogona kushomeka mu tyrosine, iyo inogona kupa kumatambudziko ekuzvibata ().

Kuwedzeredza ne tyrosine inogona kunge iri sarudzo inoshanda yekudzora izvi zviratidzo, asi humbowo hwakasanganiswa.

Mune kumwe kuongorora, vatsvaguriri vakaferefeta mhedzisiro ye tyrosine yekuwedzera padivi kana panzvimbo pe phenylalanine-inorambidzwa kudya pahungwaru, kukura, chimiro chehutano, huwandu hwekufa uye hupenyu hwehupenyu ().

Vatsvagurudzo vakaongorora zvidzidzo zviviri zvinosanganisira vanhu makumi manomwe nenomwe asi havana kuwana mutsauko pakati pekuwedzera ne tyrosine uye placebo.

Kuongororwa kwezvidzidzo zvitatu kusanganisira makumi mashanu nevatanhatu kwakawanikwa pasina mutsauko wakakura pakati pekuwedzera ne tyrosine uye placebo pane mhedzisiro yakayerwa ().

Vatsvakurudzi vakagumisa kuti hapana mazano anogona kuitwa nezvekuti tyrosine zvinowedzera zvinobatsira pakurapa PKU.

Pfupiso PKU mamiriro akakomba anogona kukonzera kushaikwa kwe tyrosine. Dzimwe dzidzo dzinodiwa pasati paitwa kurudziro yekurapa neiyo tyrosine zvinowedzera.

Humbowo Nezve Maitiro Awo Pakushungurudzika Kwakasanganiswa

Tyrosine inonzi zvakare inobatsira nekushushikana.

Kushungurudzika kunofungidzirwa kuti kunoitika kana maurotransmitter ari muuropi hwako ave asina kuenzana. Mishonga yekudzvinyirira inowanzo gadzirirwa kubatsira kuamisa uye kuenzanisa iwo ().

Nekuti tyrosine inogona kuwedzera kugadzirwa kwemaurotransmitter, zvinonzi zvinoshanda seanodzvinyirira ().

Zvisinei, kutsvagurudza kwekutanga hakutsigire kuda uku.

Mune kumwe kuongorora, vanhu makumi matanhatu nevashanu vane kushushikana vakagamuchira chero 100 mg / kg ye tyrosine, 2.5 mg / kg yeakajairika antidipressant kana placebo zuva rega rega kwevhiki ina. Tyrosine yakawanikwa isina antidepressant mhedzisiro ().

Kushungurudzika idambudziko rakaoma uye rakasiyana. Izvi zvinogona kunge nei chikafu chinowedzerwa sa tyrosine chisingashandi pakurwisa zviratidzo zvacho.

Zvakangodaro, vanhu vakaora mwoyo vane yakaderera masosi e dopamine, adrenaline kana noradrenaline vanogona kubatsirwa nekuwedzera ne tyrosine.

Muchokwadi, kumwe kuongorora pakati pevanhu vane dopamine-kushomeka kwekushushikana kwakacherekedza kuti tyrosine yakapa makiriniki akakosha mabhenefiti ().

Dopamine-inoenderana nekushungurudzika kunoonekwa nesimba rakaderera uye kushomeka kwekusimudzira ().

Kusvikira kumwe kutsvagurudza kwavapo, humbowo hwazvino hautsigire kuwedzera ne tyrosine kurapa zviratidzo zvekuora mwoyo ().

Pfupiso Tyrosine inogona kushandurwa kuita maurotransmitter anokanganisa manzwiro. Zvisinei, kutsvagurudza hakutsigire kwekuwedzera nako kurwisa zviratidzo zvekuora mwoyo.

Side Migumisiro yeTyrosine

Tyrosine "inowanzozivikanwa seyakachengeteka" (GRAS) neKudya neDrug Administration (28).

Yakawedzeredzwa zvakachengeteka padanho re68 mg paundi (150 mg pa kg) yehuremu hwemuviri pazuva kwemwedzi mitatu (15,,).

Nepo tyrosine yakachengeteka kune vanhu vazhinji, inogona kukonzera mhedzisiro uye kusangana nemishonga.

Monoamine Oxidase Inhibitors (MAOIs)

Tyramine iamino acid iyo inobatsira kudzora BP uye inogadzirwa nekuparara kwe tyrosine.

Tyramine inoungana muzvikafu kana tyrosine uye phenylalanine zvashandurwa kuita tyramine ne enzyme mune zvidiki (31).

Cheeses yakaita cheddar uye bhuruu chizi, kurapwa kana nyama inoputa, zvigadzirwa zve soy uye doro zvine huwandu hwakanyanya hwe tyramine (31).

Mishonga yekudzvinyirira inozivikanwa se monoamine oxidase inhibitors (MAOIs) inovhara iyo enzyme monoamine oxidase, iyo inopwanya yakawandisa tyramine mumuviri (,,).

Kubatanidza MAOIs neakakwira-tyramine chikafu kunogona kuwedzera kuwedzera kweropa kusvika padanho rine njodzi.

Nekudaro, hazvizivikanwe kana kuwedzera ne tyrosine kunogona kutungamira mukuvaka tyramine mumuviri, saka kungwarira kunokosha kune avo vanotora MAOIs (, 35).

Utachiona Hormone

Utachiona mahormone triiodothyronine (T3) uye thyroxine (T4) inobatsira kudzora kukura uye metabolism mumuviri.

Izvo zvakakosha kuti T3 uye T4 mazinga haana kunyanya kukwirira kana kunyanyisa.

Kuwedzera ne tyrosine kunogona kukanganisa aya mahormone ().

Izvi zvinodaro nekuti tyrosine inzvimbo yekuvaka mahormone etachiona, saka kuwedzera nayo kunogona kukwidziridza mwero wavo zvakanyanya.

Naizvozvo, vanhu vari kutora mishonga yetachiona kana vane yakanyanyisa utachiona vanofanira kungwarira kana vachiwedzera ne tyrosine.

Levodopa (L-dopa)

Levodopa (L-dopa) mushonga unowanzoshandiswa kurapa chirwere chePasinson ().

Mumuviri, L-dopa uye tyrosine zvinokwikwidza kupinza mudumbu, izvo zvinogona kukanganisa kugona kwechirwere (38).

Nekudaro, madosi emishonga iyi miviri anofanirwa kupatsanurwa nemaawa akati wandei kudzivirira izvi.

Sezvineiwo, tyrosine iri kuongororwa kuitira kudzikamisa zvimwe zvezviratidzo zvine chekuita nekuziva kuderera kune vakuru vakuru (38,).

Pfupiso Tyrosine yakachengeteka kune ruzhinji rwevanhu. Nekudaro, inogona kusangana nemimwe mishonga.

Maitiro Ekuwedzera neTyrosine

Sekuwedzera, tyrosine inowanikwa seyakasununguka-fomu amino acid kana N-acetyl L-tyrosine (NALT).

NALT inonyungudika-mvura pane yayo yemahara-fomu fomu, asi ine yakaderera kutendeuka mwero kune tyrosine mumuviri (,).

Izvi zvinoreva kuti iwe ungazoda muhombe muhombe weNALT pane tyrosine kuti uwane zvakafanana maitiro, uchiita yemahara-fomu sarudzo yakasarudzika.

Tyrosine inowanzo kutorwa mumadhosi e500-2,000 mg 30-60 maminetsi usati waekisesaiza, kunyangwe zvayakanakira kuita kwekurovedza muviri inoramba isingazivikanwe (42, 43).

Zvinoita kunge zvinoshanda pakuchengetedza kushanda kwepfungwa panguva dzekunetseka mumuviri kana nguva dzekurara paunotorwa muzvidimbu kubva pa45-68 mg paundi (100-150 mg pa kg) yehuremu hwemuviri.

Aya angave magiramu 7-10 emunhu 150-paundi (68.2-kg) munhu.

Aya madosi epamusoro anogona kukonzeresa kugumbuka kwematumbo uye kupatsanurwa kuita madosi maviri akapatsanurwa, akatorwa maminetsi makumi matatu nemakumi matanhatu chiitiko chisati chanetsa.

Pfupiso Tyrosine seyakasununguka-fomu amino asidhi ndiyo yakanakisa fomu yekuwedzera. Yayo mikuru yekurwisa kushushikana mhedzisiro yakaonekwa painotorwa mumadhosi e45-68 mg paundi (100-150 mg pa kg) yehuremu hwemuviri maminetsi makumi matanhatu chiitiko chinoshungurudza

Icho Chinokosha

Tyrosine inozivikanwa yekudya yekuwedzera inoshandiswa kwezvikonzero zvakasiyana.

Mumumuviri, unoshandiswa kugadzira maurotransmitter, ayo anowanzo dzikira pasi pezviitiko zveanonetsa kana emamiriro ezvinhu epfungwa.

Pane humbowo hwakanaka hwekuti kuwedzera ne tyrosine kunozadza maurotransmitter anokosha uye kunovandudza mashandiro epfungwa, zvichienzaniswa nenzvimbo inogara nzvimbo.

Kuwedzera nayo yakaratidzirwa kuve yakachengeteka, kunyangwe mune yakakwira madhizaini, asi ine mukana wekudyidzana nemimwe mishonga, inofanirwa kuchenjerera.

Nepo tyrosine ine mabhenefiti mazhinji, kukosha kwayo kunoramba kusiri kujeka kudzamara humwe humbowo hwavapo.