Viagra YeVakadzi: Inoshanda Sei, uye Yakachengeteka Here?

Zvemukati

• Addyi vs. Viagra
• Chinangwa uye mabhenefiti
• Mashandiro anoita flibanserin
• Kubudirira
• Mumadzimai ekumira kwemwedzi
• Zvimwe zvinokanganisa
• FDA yambiro: Pachirwere chechiropa, enzyme inhibitors, uye doro
  
• Yambiro nekudyidzana
• Addyi nedoro
• Zvinetso zvekubvumidzwa
• Kutora

Mhedziso

Flibanserin (Addyi), chinodhaka chakaita seViagra, chakagamuchirwa neKudya neDrug Administration (FDA) muna2015 kurapwa kwevakadzi kufarira / kumutsa kusagadzikana (FSIAD) mune vakadzi ve premenopausal.

FSIAD inozivikanwa se hypoactive bonde chishuwo kusagadzikana (HSDD).

Parizvino, Addyi inongowanikwa chete kuburikidza nevamwe varairidzi nemishonga. Inorayirwa nevanopa vanotenderwa muchibvumirano pakati pemugadziri uye FDA. Muchengeti anofanira kusimbiswa nemuiti kuti asangane nezvimwe zvido zveDFA.

Inotorwa kamwe chete pazuva, panguva yekurara.

Addyi ndiye wekutanga HSDD mushonga wekugamuchira FDA tendero. MunaJune 2019, bremelanotide (Vyleesi) yakave yechipiri. Addyi ipiritsi rezuva nezuva, nepo Vyleesi iri yega-inobaiwa jekiseni rinoshandiswa sezviri kudikanwa.

Addyi vs. Viagra

Iyo FDA haina kubvumidza Viagra (sildenafil) pachayo yevakadzi kuti vashandise. Nekudaro, izvo zvakatemerwa kurebesa kune vakadzi vane yakaderera bonde drive.

Off-label kushandisa zvinodhaka zvinoreva mushonga unobvumidzwa neDFA nechinangwa chimwe unoshandiswa nechinangwa chakasiyana icho chisati chagamuchirwa. Nekudaro, chiremba achiri kugona kushandisa mushonga wechinangwa icho. Izvi zvinodaro nekuti iyo FDA inodzora kuyedzwa uye kubvumidzwa kwemishonga, asi kwete mashandisiro anoita vanachiremba mishonga yekurapa varwere vavo. Nekudaro, chiremba wako anokwanisa kukunyorera mushonga asi ivo vanofunga zvakanakira iwe.

Uchapupu hwekushanda kwayo hwakasanganiswa zvakanyanya. A yemiedzo yeViagra muvakadzi inofungidzira kuti mhedzisiro yakanaka inoonekwa maererano nekusimudzira muviri. Zvisinei, iyi haisi iyo mamiriro ezvinhu akaoma zvikuru eFSIAD.

Semuenzaniso, iyo ongororo yakadzama chidzidzo chakapa Viagra kune vakadzi makumi maviri nevaviri vanonzi postmenopausal vane primary FSIAD.

Vatsvakurudzi vakaona huwandu hwakawanda hwekunzwa kwekumutsa, kusangana nekutsi kwemukadzi, uye orgasm muvatori vechikamu vechidzidzo. Nekudaro, vakadzi vane yechipiri FSIAD-inosanganisirwa kusagadzikana (senge multiple sclerosis (MS) uye chirwere cheshuga) vakashuma hapana kuwedzera kwechido kana kunakidzwa.

Chidzidzo chechipiri chakakurukurwa mukudzokorora chakawana kuti vese premenopausal uye postmenopausal vakadzi vakashuma hapana akakosha mhinduro kana vachishandisa Viagra.

Chinangwa uye mabhenefiti

Pane zvikonzero zvinoverengeka zvekuti vakadzi vangangotsvaga iyo Viagra-yakaita piritsi. Sezvo pavanosvika zera repakati nepashure, hazvishamise kuti vanhukadzi vacherechedze kudzikira kwevatano yavo yekuita bonde.

Kuderera kwekutyaira pabonde kunogona zvakare kutanga kubva kunetsekana kwezuva nezuva, zviitiko zvakakosha zvehupenyu, kana mamiriro asingaperi akadai seMS kana chirwere cheshuga.

Nekudaro, vamwe vakadzi vanoona kudzikira kana kusavapo pabonde dhiraivha nekuda kweFSIAD. Zvinoenderana neimwe nyanzvi nyanzvi uye ongororo, FSIAD inofungidzirwa kukanganisa ingangoita gumi muzana yevakadzi vakuru.

Inozivikanwa nezviratidzo zvinotevera:

• pfungwa shoma kana kusavapo pabonde kana fungidziro
• kuderedzwa kana kusavapo mhinduro yechishuwo chekuita zvepabonde kana kukurudzira
• kurasikirwa kwechido kana kutadza kuchengetedza kufarira zviitiko zvepabonde
• kunzwa kwakakosha kwekushungurudzika, kusakwanisa, kana kunetseka nekushomeka kwekuda bonde kana kumutsa

Mashandiro anoita flibanserin

Flibanserin yakatanga kugadzirwa seanodzvinyirira, asi yakagamuchirwa neDFA yekurapa FSIAD muna2015.

Maitiro ayo ekuita sekuenderana neFSIAD haina kunyatsonzwisiswa. Zvinozivikanwa kuti kutora flibanserin nguva dzose kunomutsa huwandu hwedopamine uye norepinephrine mumuviri. Panguva imwecheteyo, inoderedza huwandu hweserotonin.

Zvese dopamine uye norepinephrine zvakakosha pakufadza pabonde. Dopamine ine basa mukusimudzira chishuwo chepabonde. Norepinephrine ine basa mukusimudzira kumutsa zvepabonde.

Kubudirira

Iyo FDA tendero yeflibanserin yaive yakavakirwa pamhedzisiro yezvikamu zvitatu zvechikamu chechitatu chemakiriniki ekuedzwa. Kuedzwa kwega kwega kwakatora mavhiki makumi maviri nemana uye kuyedza kushanda kweflibanserin kana ichienzaniswa ne placebo mune premenopausal vakadzi.

Vatsvagiri pamwe neDFA vakaongorora mhedzisiro yemiyedzo mitatu. Kana yagadziriswa mhinduro ye placebo, yevatori vechikamu vakataura "yakanyanya kuvandudzwa" kana "yakanyanya kuvandudzwa" chinzvimbo mumavhiki ekuyedza 8 kusvika 24. Uku ndiko kugadzirisa zvine mwero kana uchienzaniswa neViagra.

Ongororo yakaburitswa makore matatu mushure mekubvumidzwa kweViagra's FDA yekurapa erectile dysfunction (ED) inopfupisa mhinduro dzepasirese pakurapwa. MuUnited States, semuenzaniso, vevatori vechikamu vakapindura zvakanaka. Izvi zvinofananidzwa ne19 muzana mhinduro yakanaka kune avo vari kutora placebo.

Mumadzimai ekumira kwemwedzi

Flibanserin haisi FDA-inogamuchirwa kuti ishandiswe mumadzimai ekumaopaopausal. Nekudaro, kushanda kweflibanserin mune ino huwandu kwakaongororwa mune imwe muyedzo.

Izvo zvakataurwa zvakafanana nezvakataurwa mumadzimai epamberi pekuguma kuenda kumwedzi. Izvi zvinoda kudzokororwa mumimwe miedzo kuti igamuchire vakadzi vanopera kuenda kumwedzi.

Zvimwe zvinokanganisa

Mhedzisiro inowanzoitika yeflibanserin inosanganisira:

• dzungu
• kunetseka kurara kana kuramba wakarara
• kusvotwa
• muromo wakaoma
• kuneta
• yakaderera BP, inozivikanwawo se hypotension
• kufenda kana kurasikirwa nekuziva

FDA yambiro: Pachirwere chechiropa, enzyme inhibitors, uye doro

• Mushonga uyu une yambiro dzebhokisi. Idzi ndidzo yambiro dzakanyanya kubva kuFood and Drug Administration (FDA). Yambiro yebhokisi inozivisa vanachiremba nevarwere nezvezvinodhaka zvinogona kuva nenjodzi.
• Flibanserin (Addyi) inogona kukonzera kupera simba kana kukanganiswa kwehosha kana ikatorwa nevanhu vane chirwere chechiropa kana padivi pemimwe mishonga, kusanganisira doro.
• Iwe haufanire kushandisa Addyi kana iwe ukatora imwe zvine mwero kana yakasimba CYP3A4 inhibitors. Iri boka re enzyme inhibitors rinosanganisira sarudza maantibioti, antifungals, uye mishonga yeHIV, pamwe nemamwe marudzi emishonga. Grapefruit muto zvakare iri pakati nepakati CYP3A4 inhibitor.
• Kuti udzivise iyi mhedzisiro, iwe unofanirwa zvakare kurega kunwa doro kweanenge maawa maviri usati watora yako husiku dhizaini yeAddyi. Mushure mekutora dosi yako, iwe unofanirwa kurega kunwa doro kusvika mangwana mangwanani. Kana iwe wakambonwa doro risingasviki maawa maviri nguva yako yekurara yaunofungidzira isati yasvika, unofanirwa kusvetuka dhosi rehusiku ihwohwo.

Yambiro nekudyidzana

Flibanserin haifanirwe kushandiswa muvanhu vane matambudziko echiropa.

Taura nachiremba wako pamusoro pemishonga ipi uye zvinowedzera zvaunotora usati watanga flibanserin. Iwe zvakare haufanire kutora flibanserin kana iwe uri kutora chero anotevera mishonga kana zvinowedzera:

• mimwe mishonga inoshandiswa kurapa mamiriro emwoyo, senge diltiazem (Cardizem CD) uye verapamil (Verelan)
• mamwe maantibhakitiriya, akadai ciprofloxacin (Cipro) uye erythromycin (Ery-Tab)
• mishonga yekurapa hutachiona hutachiona, senge fluconazole (Diflucan) uye itraconazole (Sporanox)
• Mishonga yeHIV, senge ritonavir (Norvir) uye indinavir (Crixivan)
• nefazodone, antidepressant
• zvinowedzera zvakadai seSt

Mazhinji emishonga iyi ndeyeboka re enzyme inhibitors inozivikanwa seCYP3A4 inhibitors.

Chekupedzisira, haufanire kunwa muto wemazambiringa paunenge uchitora flibanserin. Ichowo CYP3A4 inhibitor.

Addyi nedoro

Apo Addyi yaive yekutanga FDA-inogamuchirwa, iyo FDA yakayambira avo vanoshandisa mushonga kuti varege doro nekuda kwenjodzi yekufenda uye yakasimba hypotension. Nekudaro, iyo FDA muna Kubvumbi 2019.

Kana iwe wakarairwa Addyi, haufanire kudzivirira doro zvachose. Nekudaro, mushure mekuti iwe utore dosi rako rehusiku, unofanirwa kurega kunwa doro kusvika mangwana mangwanani.

Iwe unofanirwa zvakare kurega kunwa doro kweanenge maawa maviri pamberi kutora dosi yako yehusiku. Kana iwe wakambonwa doro risingasviki maawa maviri nguva yako yekurara yaunofungidzira isati yasvika, iwe unofanirwa kusvetuka husiku hweiyo yeAdhiyi panzvimbo.

Kana iwe ukarasikirwa neiyo dosi yeAddyi chero chikonzero, usatore dosi kuti uzviitire mangwana mangwanani. Mirira kusvikira manheru anotevera uye tangazve yako yakajairwa dosing purogiramu.

Zvinetso zvekubvumidzwa

Flibanserin yaive nenzira yakaoma kuFDA kubvumidzwa.

Iyo FDA yakaongorora mushonga katatu usati wabvuma. Paive nezvimisikidzo nezve kushanda kwayo kana ichienzaniswa nezvakashata mhedzisiro. Izvi zvinetsekana ndizvo zvikonzero zvikuru nei FDA yakurudzira kupesana nekutenderwa mushure mekuongororwa kwokutanga kwekutanga.

Pakange paine mibvunzo yaingoverengeka maererano nemabatirwo evanhukadzi pabonde anofanira kurapwa. Zvepabonde dhiraivha yakaoma kwazvo. Iko kune ese ari maviri epanyama uye epfungwa chikamu.

Flibanserin uye sildenafil vanoshanda munzira dzakasiyana. Sildenafil, semuenzaniso, haawedzere kumutsa zvepabonde muvarume. Kune rimwe divi, flibanserin inoshanda kukwidziridza mwero wedopamine uye norepinephrine kukurudzira chishuwo uye kumutsa.

Nekudaro, imwe piritsi inonongedza chimiro chemuviri chekusagadzikana pabonde. Imwe inotarisa manzwiro ekumutsa uye chishuwo, imwe nyaya yakaoma.

Kutevera ongororo yechitatu, iyo FDA yakabvumidza mushonga nekuda kwekusagadziriswa kwehutano. Zvisinei, kunetsekana kwakaramba kuripo maererano nemhedzisiro. Chinhu chakanyanya kunetsekana kwakanyanya hypotension inoonekwa apo flibanserin inotorwa nedoro.

Kutora

Kune zvakawanda zvikonzero zvepasi pabonde dhiraivha, kubva pane zvezuva nezuva zvinonetsa kusvika FSIAD.

Viagra yakaona mhedzisiro yakavhenganiswa mumadzimai kazhinji, uye haina kuwanikwa ichibudirira kune vakadzi vane FSIAD. Vakadzi vePremenopausal vane FSIAD vanogona kuona shanduko ine mwero mukushuva uye kumutsa mushure mekutora Addyi.

Taura nachiremba wako kana uchifarira kutora Addyi. Uyezve ita chokwadi chekukurukura yako mimwe mishonga kana zvinowedzerwa nachiremba wako usati washandisa Addyi.