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Zvemukati

• Nezve PCSK9 Inhibitors
• Nyowani Inhibitor Kurapwa
• Dzazvino Ongororo
• Mutengo
• Iyo Ramangwana rePCSK9 Inhibitors

Zvinoenderana neiyo, vanhu vanosvika zviuru mazana matanhatu negumi vanofa nechirwere chemwoyo muUnited States gore rega rega. Chirwere chemwoyo ndicho chinonyanya kukonzera kufa kwevarume nevakadzi.

Sezvo cholesterol yakakwira iri dambudziko rakapararira, mishonga mitsva yave iri mumabasa kubatsira kuibata uye kuibata. PCSK9 inhibitors ndiyo mutsara mutsva wemishonga muhondo yekurwisa chirwere chemwoyo.

Aya cholesterol-achideredza jekiseni zvinodhaka zvinoshanda kuwedzera chiropa chako kugona kubvisa "yakaipa" LDL cholesterol kubva muropa rako uye nekudaro inoderedza njodzi yako yekurwadziwa kwemoyo kana sitiroko.

Ramba uchiverenga kuti uwanezvazvino paPCSK9 inhibitors, uye kuti vangangokubatsira sei.

Nezve PCSK9 Inhibitors

PCSK9 inhibitors inogona kushandiswa pamwe kana pasina kuwedzerwa kwe statin, zvisinei ivo vanogona kubatsira kudzikisa LDL cholesterol nemazana makumi manomwe neshanu muzana kana ichishandiswa pamwe chete nesitamin drug.

Izvi zvinogona kuve zvinonyanya kubatsira kune avo vasingakwanise kutsungirira tsandanyama aches uye nezvimwe zvinokonzeresa zvemastins kana avo vasingatombogona kutora cholesterol yavo pasi pekutonga nekushandisa statins chete.

Iyo yakakurudzirwa kutanga dosi ndeye 75 mg jekiseni kamwe chete pasvondo mbiri. Uyu muyero unogona kuwedzerwa kusvika ku150 mg masvondo maviri ega ega kana chiremba wako achinzwa ako mazinga eLDL asiri kupindura zvakaringana kudiki diki.

Nepo kutsvagisa uye kuyedza mhedzisiro neiyi jekiseni zvinodhaka zvichiri zvitsva, zvinoratidza hukuru vimbiso.

Nyowani Inhibitor Kurapwa

Iyo ichangobvumidzwa Yakakosha (alirocumab) uye Repatha (evolocumab), yekutanga cholesterol-kudzikisa jekiseni kurapwa mukirasi nyowani yePCSK9 inhibitors. Izvo zvakagadzirirwa kushandiswa mukubatana ne statin therapy uye dhayeti shanduko.

Zvakakosha uye Repatha ndezvevakuru vane heterozygous yemhuri hypercholesterolemia (HeFH), iyo nhaka nhaka mamiriro ayo anokwirisa mwero weLLL cholesterol muropa, uye avo vane chirwere chekiriniki chemoyo.

Iyi mishonga inorwisa mabhakitiriya inotarisa puroteni mumuviri inonzi PCSK9. Nekudzivirira kugona kwePCSK9 kushanda, maantibhakitiriya aya anokwanisa kubvisa cholesterol yeLDL kubva muropa uye kudzikira huwandu hwese hweLLL cholesterol.

Dzazvino Ongororo

Miedzo uye kutsvagisa zvakaratidza mibairo yakanaka kune ese Akakosha uye Repatha. Mune kuyedza kwazvino kuRedatha, vatori vechikamu vane HeFH nevamwe vane njodzi dzakanyanya dzekurwadziwa kwemoyo kana sitiroko vakadzikisa LDL cholesterol yavo neavhareji ye.

Mhedzisiro inowanzozivikanwa yemigumisiro yeRepatha yaive:

• chirwere chepamusoro chekufema
• nasopharyngitis
• kurwadziwa shure
• flu
• nekupwanya, kutsvuka, kana kurwadziwa panzvimbo yejekiseni

Allergic reaction, kusanganisira mikoko uye mapundu, zvakaonekwawo.

Mumwe muedzo uchishandisa Praluent wakaratidzawo zvakanaka mhedzisiro. Ava vatori vechikamu, avo vaitove kushandisa statin kurapa uye vaine HeFH kana kuwedzera njodzi yekurohwa kana kurohwa nemoyo, vakaona kudonha muLDL cholesterol.

kubva pakushandisa kwakakosha kwaive kwakafanana neRedatha, kusanganisira:

• kurwadziwa uye kupwanya panzvimbo yejojo
• furu-kunge zviratidzo
• nasopharyngitis
• neutachiona, zvakadai se hypersensitivity vasculitis

Mutengo

Sezvazviri mukufambira mberi kwakawanda kwemishonga, iyi mishonga mitsva yekujekesa ichauya nemutengo unorema. Nepo mutengo wevarwere uchizoenderana nehurongwa hweinishuwarenzi, mari zhinji inotanga pamadhora gumi nemazana matanhatu nemazana matanhatu pagore.

Mukuenzanisa, zita rechiratidzo statin zvinodhaka zvinodhura chete $ 500 kusvika $ 700 pagore, uye iwo manhamba anodonha zvakanyanya kana uchitenga generic statin fomu.

Vaongorori vari kutarisira kuti mishonga ienderere mberi ichitengesa chinzvimbo munguva yekunyora uye kuunza mabhiriyoni emadhora mukutengesa kutsva.

Iyo Ramangwana rePCSK9 Inhibitors

Ongororo dzichiri kuenderera mberi maererano nekubudirira kweaya majekiseni emishonga. Vamwe vezvehutano vanonetsekana kuti mishonga mitsva inoisa mukana wenjodzi yekusaziva, nekuda kwevamwe vatori vechikamu vatori vechikamu vanotaura matambudziko nekuvhiringidzika uye kutadza kuterera.

Makuru makiriniki miedzo ichave yapera muna 2017. Kusvika panguva iyoyo nyanzvi dzinokurudzira kungwarira sezvo kuyedzwa kwakaitwa kusvika parizvino kwave kuri kwenguva pfupi, zvichiita kuti zvinyatsoziva kana PCSK9 inhibitors inogona kudzikisira njodzi yehosha yemoyo uye kuwedzera hupenyu.