Chii chinonzi Primary Progressive MS?

Zvemukati

• Dzimwe mhando dzeMS
• Ndechipi chirevo chePPMS?
• PPMS vs. SPMS
• PPMS vs. RRMS
• Ndezvipi zviratidzo zvePPMS?
• Chii chinokonzera PPMS?
• PPMS inoonekwa sei?
• PPMS inorapwa sei?
• Ndeapi mararamiro ehupenyu anobatsira nePPMS?
• PPMS modifiers
• Tsigiro
• Outlook
• Tora woenda nazvo

Multiple sclerosis (MS) chirwere chisingagumi autoimmune chinokanganisa mitsipa yemaziso, musana, uye huropi.

Vanhu vanoonekwa kuti vane MS vanowanzove nezviitiko zvakasiyana zvakanyanya. Izvi zvinonyanya kuitika kune avo vanowanikwa vane primary progressive multiple sclerosis (PPMS), imwe yemhando dzakasiyana dzeMS.

PPMS rudzi rwakasiyana rweMS. Izvo hazvisanganise zvakanyanya kuzvimba semafomu eMS anodzokazve.

Zviratidzo zvikuru zvePPMS zvinokonzerwa nekukuvara kwetsinga. Zviratidzo izvi zvinoitika nekuti tsinga hadzikwanise kutumira nekutambira meseji kune mumwe nemumwe zvakanaka.

Kana iwe uine PPMS, kune zvimwe zviitiko zvekufamba kwekuremara kupfuura zvimwe zviratidzo, kana uchienzaniswa nevanhu vane mamwe marudzi eMMS.

PPMS haina kujairika zvakanyanya. Inobata nezvegumi kusvika gumi neshanu muzana yeavo vanoonekwa vaine MS. PPMS inofambira mberi kubva panguva yaunotarisa yako ekutanga (ekutanga) zviratidzo.

Dzimwe mhando dzeMS dzine nguva dzekudzokazve zvakanyanya uye kuregererwa. Asi zviratidzo zvePPMS zvinonyanya kuoneka zvishoma nezvishoma asi zvakadzikama nekufamba kwenguva. Vanhu vane PPMS vanogona zvakare kudzokazve.

PPMS inokonzeresa neurological basa kudzika nekukurumidza zvakanyanya kupfuura mune mamwe maMS mhando. Asi kuomarara kwePPMS uye nekukurumidza kwainokura kunoenderana nenyaya imwe neimwe.

Vamwe vanhu vanogona kunge vakaenderera mberi PPMS inowedzera kunyanyisa. Vamwe vanogona kunge vaine nguva dzakadzikama pasina kupenya kwezviratidzo, kana kunyange nguva dzekuvandudzwa kudiki.

Vanhu vaimboonekwa kuti vane progressive-relapsing MS (PRMS) vava kunzi primary progressive.

Dzimwe mhando dzeMS

Mamwe marudzi eSMS ndeaya:

• kliniki yakasarudzika chirwere (CIS)
• kudzokerazve-kuregera MS (RRMS)
• yechipiri inofambira mberi MS (SPMS)

Aya marudzi, anonziwo makosi, anotsanangurwa nemabatiro ainoita muviri wako.

Mhando yega yega ine marapirwo akasiyana siyana nemishonga yakawanda inopindirana. Kuomarara kwezviratidzo zvavo uye maonero erefu-nguva zvakare zvinosiyana.

CIS iri ichangobva kutsanangurwa mhando yeMS. CIS inoitika kana iwe uine imwe chete nguva yezviratidzo zveeurologic izvo zvinogara kweinenge maawa makumi maviri nemana.

Ndechipi chirevo chePPMS?

Kufungidzira kwePPM kwakasiyana kune wese munhu uye kusatarisika.

Zviratidzo zvinogona kuwedzera kuoneka nekufamba kwenguva, kunyanya kana uchikura uye wotanga kurasikirwa nemimwe mitezo munhengo dzakadai sedundira rako, ura, uye nhengo dzesikarudzi nekuda kwezera nePPMS.

PPMS vs. SPMS

Heano mutsauko mukuru pakati pePPMS nePSMS:

• SPMS kazhinji inotanga sekuongororwa kweRRMS iyo inozopedzisira yanyanya kuoma nekufamba kwenguva pasina kuregererwa kana kugadzirisa kwezviratidzo.
• SPMS inogara iri yechipiri chikamu cheMS kuongororwa, nepo RRMS iri yekutanga kuongororwa iri yega.

PPMS vs. RRMS

Heano mutsauko mukuru pakati pePPMS neRRMS:

• RRMS ndiyo yakajairika mhando yeMS (inenge 85 muzana yezviongororwo), nepo PPMS iri imwe yeasingawanzo.
• RRMS inopetwa kaviri kana katatu zvakajairika muvakadzi sevarume.
• Zvikamu zvezviratidzo zvitsva zvakajairika muRRMS kupfuura muPPMS.
• Munguva yekuregererwa muRRMS, unogona kusatomboona chero zviratidzo zvachose, kana kungova nezviratidzo zvishoma zvisina kunyanya kukuvadza.
• Kazhinji, maronda mazhinji ehuropi anoonekwa pahuropi MRIs neRRMS pane nePPMS kana isina kurapwa.
• RRMS inowanzoonekwa ichinyanya kukosha muhupenyu kupfuura PPMS, kutenderedza makumi maviri nemakumi matatu, zvichipesana neana40 ne50 nePPMS.

Ndezvipi zviratidzo zvePPMS?

PPMS inobata munhu wese zvakasiyana.

Kazhinji zviratidzo zvekutanga zvePPMS zvinosanganisira kushaya simba mumakumbo ako uye kunetseka kufamba. Zviratidzo izvi zvinowanzo kuve zvinoonekwa pamusoro pemakore maviri.

Zvimwe zviratidzo zvinowanzoitika zvechiitiko zvinosanganisira:

• kuomarara mumakumbo
• matambudziko nekuenzanisa
• kurwadziwa
• kushaya simba uye kuneta
• dambudziko nekuona
• dundira kana ura kusagadzikana
• kuora mwoyo
• kuneta
• chiveve uye / kana kugwinha munzvimbo dzakasiyana dzemuviri

Chii chinokonzera PPMS?

Chikonzero chaicho chePPMS, uye MS mune zvese, hazvizivikanwe.

Dzidziso yakajairika ndeyekuti MS inotanga kana immune system yako ikatanga kurwisa yako yepakati tsinga system. Izvi zvinoguma nekurasikirwa nemyelin, iyo yekudzivirira inofukidza yakakomberedza tsinga mune yako yepakati tsinga system.

Kunyange vanachiremba vasingatendi kuti PPMS inogona kugarwa nhaka, inogona kunge iine chibereko. Vamwe vanotenda kuti inogona kukonzerwa nehutachiona kana nehupfu mune zvakatipoteredza izvo kana zvikabatanidzwa nemajini zvinogona kuwedzera njodzi yekukura MS.

PPMS inoonekwa sei?

Shanda pamwe chete nachiremba wako kuti ubatsire kuongorora kuti ndedzipi mhando ina dzeMS dzaungave uine.

Mhando yega yega yeMS ine maonero akasiyana uye akasiyana marapirwo anoda. Iko hakuna chaiyo bvunzo inopa iyo PPMS kuongororwa.

Vanachiremba vanowanzoomerwa nekutarisa PPMS zvichienzaniswa nemamwe marudzi eMS uye mamwe mamiriro ekuenderera.

Izvi zvinodaro nekuti nyaya yetsinga inoda kuve yakafambira mberi kwe1 kana maviri makore kuitira kuti mumwe munhu agamuchire yakasimba PPMS kuongororwa.

Mimwe mamiriro ane zviratidzo zvakafanana nePPMS anosanganisira:

• hunhu hwakagarwa nhaka hunokonzeresa, makumbo asina kusimba
• kushomeka kwevhitamini B-12 kunokonzeresa zviratidzo zvakafanana
• Chirwere cheLyme
• hutachiona hutachiona, senge munhu T-cell leukemia hutachiona mhando 1 (HTLV-1)
• mafomu eArthritis, senge spinal arthritis
• bundu padhuze nemuzongoza

Kuti uongorore PPMS, chiremba wako anogona:

• ongorora zviratidzo zvako
• dzokorora nhoroondo yako yetsinga
• ita kuongorora kwepanyama uchitarisa mhasuru dzako uye tsinga
• kuitisa MRI scan yehuropi hwako uye musana
• ita lumbar puncture kutarisa zviratidzo zveMS mune musana mvura
• kuitisa bvunzo dzinogona (EP) bvunzo kuti uone yakadii mhando yeMS; EP bvunzo dzinosimudzira yekunzwa tsinga nzira dzekuti uone zvemagetsi zviitiko zvehuropi

PPMS inorapwa sei?

Ocrelizumab (Ocrevus) ndiyo chete mishonga inogamuchirwa neKudya neDrug Administration (FDA) yekurapa PPMS. Inobatsira kudzora kushomeka kwenzara.

Mimwe mishonga inobata zvimwe zviratidzo zvePPMS, senge:

• kusimba kwemhasuru
• kurwadziwa
• kuneta
• dambudziko redundiro uye ura.

Kune akawanda marapirwo ekugadzirisa marapirwo (DMTs) uye steroid inogamuchirwa neDFA yekudzokorodza mafomu eMS.

Aya maDMTs haanyatso kurapa PPMS.

Mimwe mishonga mitsva iri kugadzirirwa PPMS kubatsira kudzikisa kuzvimba kunonyatsorwisa tsinga dzako.

Zvimwe zveizvi zvakare zvinobatsira kugadzirisa kukuvara uye kugadzirisa maitiro ayo anokanganisa tsinga dzako. Aya marapirwo anogona kunge achikwanisa kubatsira kudzosera myelin kutenderedza tsinga dzako dzakakuvara nePPMS.

Imwe kurapwa, ibudilast, yanga ichishandiswa muJapan kweanopfuura makore makumi maviri kurapa asima uye inogona kuve nehunyanzvi hwekurapa kuzvimba muPPMS.

Kumwe kurapwa kunonzi masitinib kwave kuchishandiswa kwehutachiona nekutarisa mamast maseru anobatanidzwa mukugadzikana uye kuratidza kuvimbisa sekurapa kwePPMS, futi.

Izvo zvakakosha kuti uzive kuti aya marapirwo maviri achiri achiri ekutanga zvakanyanya mukuvandudza nekutsvaga.

Ndeapi mararamiro ehupenyu anobatsira nePPMS?

Vanhu vane PPMS vanogona kubvisa zviratidzo nekurovedza muviri uye kutambanudzira ku:

• gara uchifambisa sezvinobvira
• gara kuti unorema zvakadii
• kuwedzera masimba esimba

Heano zvimwe zviito zvaunogona kutora kugadzirisa ako PPMS zviratidzo uye chengetedza hupenyu hwako hupenyu:

• Idya kudya kunovaka muviri uye kunovaka muviri.
• Gara pane yakajairwa nguva yekurara.
• Enda kune kurapwa kwepanyama kana kwebasa, uko kunogona kukudzidzisa marongero ekuwedzera kufamba uye kugadzirisa zviratidzo.

PPMS modifiers

Modifera ina dzinoshandiswa kuratidza PPMS nekufamba kwenguva:

• Inoshanda nekufambira mberi: PPMS ine zviratidzo zvinowedzera uye inodzokazve kana iine chiitiko chitsva cheMRI; kuwedzera hurema kuchaitikawo
• Inoshanda pasina kufambira mberi: PPMS nekudzokazve kana chiitiko cheMRI, asi hapana hurema hunowedzera
• Kwete kushanda nekufambira mberi: PPMS isina kudzokazve kana chiitiko cheMRI, asi nekuwedzera kuremara
• Haishande pasina kufambira mberi: PPMS isina kudzokazve, chiitiko cheMRI, kana kuwedzera hurema

Hunhu hwakakosha hwePPMS kushomeka kwekuregererwa.

Kunyangwe kana munhu ane PPMS akaona zviratidzo zvavo zvakamira - zvichireva kuti havaoni kuwedzera kuita kwechirwere kana kuwedzera kwehurema - zviratidzo zvavo hazvinyatso kuvandudza. Neichi chimiro cheMS, vanhu havadzokezve mashandiro avanogona kunge vakarasikirwa nawo.

Tsigiro

Kana iwe uri kurarama nePPMS, zvakakosha kuti uwane masosi ekutsigirwa. Pane sarudzo dzekutsvaga rutsigiro pane mumwe munhu mushe kana munharaunda yeMS nharaunda.

Kurarama nechirwere chisingaperi kunogona kutora kukuvara kwepamoyo. Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge waita Ivo vanogona kukuendesa iwe kune wepfungwa hutano nyanzvi uyo anogona kubatsira.

Iwe unogona zvakare kutsvaga wepfungwa nyanzvi yehutano wega. Semuenzaniso, iyo American Psychological Association inopa yekushandisa yekutsvaga yekuwana vezvepfungwa muUnited States. MentalHealth.gov inopawo nhare yekuendesa kurapwa.

Unogona kuona zvichibatsira kutaura kune vamwe vanhu vari kugara neMMS. Funga kutarisa mumapoka ekutsigira, kungave online kana mu-munhu.

National Multiple Sclerosis Society inopa sevhisi kuti ikubatsire iwe kuwana mapoka ekutsigira emunharaunda yako. Ivo zvakare vane peer-to-peer kubatanidza chirongwa chinotungamirwa nevanozvipira vanozvipira vanogara neMS.

Outlook

Tarisa nachiremba wako nguva dzose kana iwe uine PPMS, kunyangwe kana usati wave nezviratidzo kwechinguva uye kunyanya kana uchinge uchinge uchinge uchinge uchinge uchinge uchiona kukanganisika muhupenyu hwako nechikamu chezviratidzo.

Zvinokwanisika kuve nehupamhi hwehupenyu nePPMS sekureba sekunge iwe uchishanda nachiremba wako kuti uone ekurapa kwakanyanya pamwe nemararamiro uye dhayeti shanduko dzinokushandira.

Tora woenda nazvo

Iko hakuna mushonga wePPMS, asi kurapwa kunoita mutsauko. Kunyange hazvo mamiriro ari kufambira mberi, vanhu vanogona kusangana nenguva yenguva apo zviratidzo zvisinganyanye kuwedzera.

Kana iwe uri kurarama nePPMS, chiremba wako anokurudzira chirongwa chekurapa zvichienderana nezviratidzo zvako uye hutano huzhinji.

Kuvandudza mararamiro ane hutano uye kugara wakabatana nenzvimbo dzekutsigirwa zvinogona zvakare kukubatsira iwe kuchengetedza hupenyu hwako uye hupenyu hwese.