Biologics uye Crohn's Chirwere Kuregererwa: Izvo Zvaunofanirwa Kuziva

Zvemukati

• Maitiro ebiologics anotarisa kuzvimba
• Maitiro ekuudza kana iwe uri mukuregererwa
• Maitiro ebiologics anokuchengetedza sei mukuregererwa
• Chii chinonzi biosimilars?
• Kurapa panguva yekuregererwa
• Kutora

Mhedziso

Muna 1932, Dr. Burrill Crohn nevamwe vaviri vaaishanda navo vakapa pepa kuAmerican Medical Association vachitsanangura ruzivo rwechatinoti chirwere cheCrohn.

Kubva ipapo, sarudzo dzekurapa dzakashanduka kuti dzibatanidze biologics, inova mishonga inogadzirwa kubva kumasero mapenyu akagadzirirwa kunongedzera kuzvimba.

Kuzvimba ndicho chikonzero chikuru chechiratidzo cheCrohn zviratidzo uye matambudziko. Paunenge uri mukuregererwa, kuzvimba kwako kunopera. Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchityairwa naCrohn, kuzvimba kwako kunodzoka.

Nepo pasina mushonga weCrohn's, chinangwa chekurapa ndechekuderedza kuzvimba kuisa chirwere mukuregererwa, uye kuchichengeta ipapo.

Maitiro ebiologics anotarisa kuzvimba

Tumor necrosis factor, kana TNF, ipuroteni inokonzera kuzvimba sechikamu chedziviriro yema immune system. Anti-TNF biologics inoshanda nekutarisana neprotein iyi kuti idzikise kupisa kwayo.

Kana iwe ukatora Remicade (infliximab), Humira (adalimumab), Cimzia (certolizumab), kana Simponi (golimumab), uri kutora anti-TNF biologic.

Nechirwere cheCrohn, immune system yako inotumira akawanda machena maseru eropa kune yemudumbu (GI) turakiti, izvo zvinokonzeresa kuzvimba. Imwe nzira iyo biologics inotarisa kuzvimba ndeye kugadzirisa nyaya yekuve yakawandisa machena masero eropa mune iyo GI turakiti.

Entyvio (vedolizumab) uye Tysabri (natalizumab) inoshanda nenzira iyi. Vanomisa masero machena eropa kupinda mudumbu. Ichi chiito chekuvharira chinochengeta maseru machena eropa ari kure neguvhu, kwaanogona kukonzera kuzvimba. Nekudaro, izvi zvinobvumira nzvimbo kupora.

Biologics inogona kunongedza dzimwe nzira mumuviri dzinotungamira mukuzvimba. Stelara (ustekinumab) inonzi interleukin inhibitor. Inotarisa mapuroteni maviri chaiwo anofungidzirwa kukonzera kuzvimba. Vanhu vane maCrohn vane mazinga epamusoro emapuroteni aya mumuviri wavo.

Nekunangisa aya mapuroteni, Stelara anovharira kuzvimba mune yeGI turakiti uye inoderedza zviratidzo zvechirwere cheCrohn.

Maitiro ekuudza kana iwe uri mukuregererwa

Zvakajairika kuva nemazuva akanaka uye mazuva akashata kana iwe uine Crohn's, saka unoziva sei kana iwe uri mukuregererwa uye kwete kungova nemazuva akati wandei akanaka?

Pane zvinhu zviviri zvekuregerera. Kuregererwa kwemakiriniki zvinoreva kuti hauna zviratidzo zvinoonekwa. Kuregererwa kwetishu zvinoreva kuti bvunzo dzinoratidza kuti maronda ako ari kupora uye ropa rako rine mwero wekuzvimba.

Chiremba wako anoshandisa chinhu chinonzi Crohn's disease activity index (CDAI) kuyera mwero unoshanda neCrohn yako kana kuregererwa. ICDAI inofunga nezvezviratidzo zvako, senge kuwanda kwematumbo uye kuti uri kunzwa sei.

Izvo zvinotorawo kufunga nezvematambudziko echirwere cheCrohn uye mhedzisiro yemayedzo ako.

Kunyangwe iwe uchiri mukuregererwa, zvakajairika kuti biopsy iratidze microscopic shanduko kumaturu ako ayo anoratidza kuzvimba kwakapfuura. Dzimwe nguva, mune yekuregererwa kwenguva refu uye kwakadzika, mhedzisiro yebhiopsy yakajairika, asi izvi hazviwanzo kuitika.

Maitiro ebiologics anokuchengetedza sei mukuregererwa

Biologics inokuchengeta iwe mukuregererwa nekuvharira yako immune system yekunyanyisa kuzvimba kupindura. Kana iwe ukaenda uchibva pamushonga wako uchinge wakanganwirwa, iwe uri panyatwa yekuita kune chinokonzeresa chine mwoto.

Dzimwe nguva zvinokonzera zvinogona kuva zvakaoma kufungidzira. Zvimwe, senge zvinotevera, zviri nyore kuziva:

• kuchinja kwekudya
• kusvuta fodya
• mishonga inochinja
• kunetseka
• kusvibiswa kwemhepo

Kana iwe uri pamushonga iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchikonzera

Chii chinonzi biosimilars?

Biosimilars ndidzo dzekare shanduro dzebiologics ine yakafanana yakafanana chimiro, chengetedzo, uye kugona. Hadzisi generic shanduro dzepakutanga biologics. Pane kudaro, iwo makopi eepakutanga biologics ane patent akapera.

Ivo kazhinji vanodhura zvishoma uye zvakare anoshanda ekuchengetedza kuregererwa.

Kurapa panguva yekuregererwa

Kana uchinge wave mukuregererwa, unogona kuyedzwa kuti umire kurapwa. Kana iwe ukadaro, iwe uri panjodzi yekusangana nemoto mutsva.

Kana iwe ukarega kutora mushonga wako, pane mukana wekuti inogona kusashanda futi nguva inotevera iwe paunenge uine flare. Izvi zvinodaro nekuti paunomira kutora biologic, muviri wako unogona kukura masoja ekudzivirira mushonga, izvo zvinoita kuti zvisashande mune ramangwana.

Zvinogona kutotungamira mukukanganisa kwakashata.

Biologics inodzvinyirira immune system yako, iyo inokuisa iwe panjodzi yekutapukirwa. Nekuda kweizvi, pane mamwe mamiriro apo chiremba wako anogona kukuraira iwe kutora zororo remushonga. Izvi zvinosanganisira:

• kuvhiya
• majekiseni
• nhumbu

Zvikasadaro, tsika yakakurudzirwa ndeyekugara pamushonga kunyangwe iwe uri mukuregererwa.

Zvidzidzo zvakaratidza kuti ingangoita hafu chete yevanhu vanoregedza kushandisa yavo anti-TNF biologic vachiri mukuregererwa vanoramba vachiregererwa kweanopfuura makore maviri, uye iyo nhamba inoderera nenguva.

Kutora

Chinangwa chekurapwa kwaCrohn kuwana uye kuchengetedza kuregererwa. Kushaya mishonga kunogona kutungamira kumoto. Zvakakosha kushanda nachiremba wako kuti ugadzire zano rakanakisa rekugara mukuregererwa. Izvi zvinosanganisira kugara uchiongororwa uye kuchengetedza rako regimen remushonga.