Prolactinoma

Prolactinoma isinganzwisisike (benign) pituitary bundu rinoburitsa hormone inonzi prolactin. Izvi zvinoguma neprotactin yakawandisa muropa.

Prolactin ihormone inokonzeresa kuti mazamu aburitse mukaka (lactation).

Prolactinoma ndiyo yakajairika mhando yepituitary bundu (adenoma) inogadzira mahormone. Iyo inoumba inosvika makumi matatu muzana ezve pituitary adenomas. Anenge ese mamota pituitary haana-cancer (benign). Prolactinoma inogona kuitika sechikamu cheyakagarwa nhaka inonzi yakawanda endocrine neoplasia mhando 1 (MEN 1).

Prolactinomas inowanzoitika muvanhu vari pasi pemakore makumi mana. Dzinowanzoitika kune vakadzi kupfuura varume, asi hazviwanzo muvana.

Inenge hafu yezvose prolactinomas idiki kwazvo (isingasviki 1 sentimita kana 3/8 ye inch pakureba). Aya mamota madiki anoitika kazhinji muvakadzi uye anonzi microprolactinomas.

Mamota mahombe akajairika muvarume. Vanowanzoitika pazera rakura. Bundu rinogona kukura kusvika pakukura kukuru zviratidzo zvisati zvaonekwa. Mamota akakura kupfuura 3/8 inch (1 cm) dhayamita anonzi macroprolactinomas.

Bundu rinowanzoonekwa padanho rekutanga mumadzimai pane kuvarume nekuda kwekutadza kuenda kumwedzi.

Mune vakadzi:

• Mukaka usina kujairika unoyerera kubva pazamu mumukadzi asina nhumbu kana mukoti (galactorrhea)
• Zamu unyoro
• Kuderedza kufarira zvepabonde
• Kupera kwemaonero ekunze
• Kutemwa nemusoro
• Kushaya mbereko
• Kumisa kuenda kumwedzi kusinei nemwedzi, kana kuenda kumwedzi zvisina kujairika
• Chiono chinoshanduka

Mune varume:

• Kuderedza kufarira zvepabonde
• Kupera kwemaonero ekunze
• Kuwedzera kwemazamu tishu (gynecomastia)
• Kutemwa nemusoro
• Matambudziko ekumisikidza (kushaya simba)
• Kushaya mbereko
• Chiono chinoshanduka

Zviratidzo zvinokonzerwa nekumanikidzwa kubva pabundu rakakura zvinogona kusanganisira:

• Kutemwa nemusoro
• Lethargy
• Nasal drainage
• Kusvotwa uye kurutsa
• Matambudziko nemanzwiro ekunhuwidza
• Sinus kurwadziwa kana kumanikidza
• Chiono chinoshanduka, senge kuona kwakapetwa, maziso anodonha kana kurasikirwa kwekuona munda

Panogona kunge pasina zviratidzo, kunyanya muvarume.

Anopa hutano anoita bvunzo dzepanyama uye obvunza nezve zviratidzo zvako. Iwe zvakare uchabvunzwa nezvemishonga uye zvinhu zvauri kutora.

Miedzo inogona kurairwa inosanganisira:

• Pituitary MRI kana uropi CT scan
• Testosterone level mune varume
• Chikamu cheprolactin
• Utachiona hwebasa
• Mimwe bvunzo yepituitary basa

Mushonga unowanzo kubudirira mukurapa prolactinoma. Vamwe vanhu vanofanira kutora mishonga iyi kweupenyu hwese. Vamwe vanhu vanogona kumira kutora mishonga mushure memakore mashoma, kunyanya kana bundu ravo raive diki pavakawanikwa kana kuti rakanyangarika kubva kuMRI. Asi kune njodzi yekuti bundu rinogona kukura uye kuburitsa prolactin zvakare, kunyanya kana raive bundu rakakura.

Prolactinoma yakakura dzimwe nguva inogona kukura panguva yekuzvitakura.

Kuvhiya kunogona kuitirwa chero yeanotevera:

• Zviratidzo zvakakomba, sekukurumidza kuwedzera kwechiratidzo
• Iwe haugone kushivirira iyo mishonga yekurapa bundu
• Bundu haripindure kumishonga

Radiation inowanzo shandiswa muvanhu vane prolactinoma iyo inoramba ichikura kana kuwedzera kuipa mushure mekunge zvese mishonga nekuvhiya zvayedzwa. Radiation inogona kupihwa nenzira ye:

• Kwakajairika mwaranzi
• Gamma banga (stereotactic radiosurgery) - mhando ye radiation radiation iyo inotarisa yakakwira-inopihwa x-rays pane diki nzvimbo muuropi.

Maonero acho anowanzo kuve akanaka, asi zvinoenderana nekubudirira kwekurapwa kana kuvhiyiwa. Kuongororwa kuti uone kana bundu radzoka mushure mekurapwa kwakakosha.

Kurapa kweprolactinoma kunogona kuchinja iwo mamwe mahormone mumuviri, kunyanya kana kuvhiya kana radiation kuitwa.

Yakakwira mazinga eestrogen kana testosterone inogona kuve inobatanidzwa mukukura kweprolactinoma. Vakadzi vane prolactinomas vanofanirwa kuteverwa zvakanyanya panguva yekuzvitakura. Ivo vanofanirwa kukurukura bundu iri nemupi wavo vasati vatora mapiritsi ekudzivirira kubereka ane yakakwira kupfuura yakajairwa yesrogen meseji

Ona mupiki wako kana iwe uine chero zviratidzo zveprolactinoma.

Kana iwe wakambove neprolactinoma munguva yakapfuura, fonera mupi wako kune yakawanda yekutevera, kana kana zviratidzo zvako zvichidzoka.

Adenoma - kuvanza; Prolactin - yekuvharira adenoma yepituitary

• Endocrine masero

Bronstein MD. Kukanganiswa kweprolactin secretion uye prolactinomas. Muna: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Vakuru uye Chiremba. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits.

Tirosh A, Shimon I. Yazvino maitiro ekurapa kweprolactinomas. Minerva Endocrinol. 2016; 41 (3): 316-323. PMID: 26399371 www.ncbi.nlm.nih.gov/pubmed/26399371.