Akawanda endocrine neoplasia (MEN) I

Akawanda endocrine neoplasia (MEN) mhando I chirwere icho umo kana akawanda ematenhe endocrine ari kushanda zvakanyanya kana kuumba bundu. Inopfuudzwa kuburikidza nemhuri.

Endocrine glands anowanzo kuverengerwa anosanganisira:

• Pancreas
• Parathyroid
• Pituitary

VARUME ndinokonzereswa nehurema mune geni rinotakura kodhi yeprotein inonzi menin. Mamiriro acho anokonzeresa kuti mamota ezvipenga zvakasiyana aonekwe mumunhu mumwe chete, asi kwete hazvo panguva imwe chete.

Dambudziko racho rinogona kuitika chero zera, uye rinobata varume nevakadzi zvakaenzana. Nhoroondo yemhuri yechirwere ichi inomutsa njodzi yako.

Zviratidzo zvinosiyana kubva pamunhu kusvika pamunhu, uye zvinoenderana nekuti gland iripapi. Zvinogona kusanganisira:

• Marwadzo emudumbu
• Kufunganya
• Nhema, tarisa zvituru
• Kuzvimba kunzwa mushure mekudya
• Kupisa, kurwadza, kana nzara kusagadzikana mudumbu repamusoro kana chipfuva chepasi chinozorodzwa nemaantacids, mukaka, kana chikafu.
• Kuderedza kufarira zvepabonde
• Kuneta
• Kutemwa nemusoro
• Kushaikwa kwekuenda kumwedzi (mune vakadzi)
• Kupererwa nechido
• Kurasikirwa kwemuviri kana bvudzi kumeso (mune varume)
• Kuchinja kwepfungwa kana kuvhiringidzika
• Kutambudzika kwemhasuru
• Kusvotwa uye kurutsa
• Kunzwisisa kunotonhora
• Kurasikirwa kwekurema kwemaune
• Matambudziko ekuona
• Kushaya simba

Anopa hutano anoita bvunzo dzemuviri uye obvunza mibvunzo nezve yako nhoroondo yezvokurapa nezviratidzo. Iyi bvunzo inotevera inogona kuitwa:

• Ropa cortisol level
• CT scan yemudumbu
• CT scan yemusoro
• Kutsanya shuga yeropa
• Kuongorora genetic
• Insulin bvunzo
• MRI yemudumbu
• MRI yemusoro
• Serum adrenocorticotropic kemikari
• Serum calcium
• Serum follicle inosimudzira mahormone
• Serum gastrin
• Serum glucagon
• Serum luteinizing mahormone
• Serum parathyroid hormone
• Serum prolactin
• Serum thyroid inokurudzira mahormone
• Ultrasound yemutsipa

Kuvhiya kubvisa gland inorwara kazhinji kurapwa kwekusarudza. Mushonga unonzi bromocriptine unogona kushandiswa pachinzvimbo chekuvhiyiwa kwepituitary tumors inosunungura iyo hormone prolactin.

Izvo zvipenga zveparathyroid, zvinodzora kugadzirwa kwecalcium, zvinogona kubviswa. Nekudaro, zvinonetsa kuti muviri utungamire huwandu hwecalcium pasina aya maronda, saka kubviswa parathyroid kwakazara hakuitwe pakutanga kazhinji.

Mushonga uripo kudzikisa kuwanda kwemudumbu asidhi kugadzirwa kunokonzerwa nemamwe mamota (gastrinomas), uye kudzikisa njodzi yezvironda.

Hormone kutsiva kurapwa kunopihwa kana gland dzese dzabviswa kana kusaburitsa mahormone akakwana.

Pituitary uye parathyroid mamota kazhinji haana cancer (benign), asi mamwe mapancreatic tumors anogona kuita cancer (yakaipa) uye kupararira kuchiropa. Izvi zvinogona kudzikisa hurefu hwehupenyu.

Zviratidzo zvepeptic ulcer chirwere, yakaderera ropa shuga, yakawandisa calcium muropa, uye pituitary kusagadzikana kazhinji inopindura mushe pakurapa kwakakodzera.

Mamota anogona kuramba achidzoka. Zviratidzo uye kunetseka kunoenderana nekuti ndeapi maronda anobatanidzwa. Kugara uchitarisa-kumusoro nemupi wako zvakakosha.

Fonera mupiki wako kana iwe ukaona zviratidzo zveVANHU ini kana uine nhoroondo yemhuri yeichi chiitiko.

Kuongorora vepedyo hama dzevanhu vane dambudziko iri kunokurudzirwa.

Wermer chirwere; VARUME I

• Endocrine masero

National Yakakwana Cancer Network webhusaiti. Clinical tsika nhungamiro mune oncology (NCCN nongedzo): neuroendocrine mamota. Shanduro 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Yakagadziridzwa Kurume 5, 2019. Yakasvika muna Kurume 8, 2020.

Newey PJ, Thakker RV. Akawanda endocrine neoplasia. Mune: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Chinyorwa cheEndocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020: chitsuwa 42.

Nieman LK, Spiegel AM. Polyglandular kusagadzikana. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chitsiko 218.

Thakker RV. Multiple endocrine neoplasia mhando 1. Muna: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Vakuru uye Chiremba. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016: chitsiko 148.