Yemhuri dysbetalipoproteinemia

Yemhuri dysbetalipoproteinemia chirwere chinopfuura nemumhuri. Inokonzera huwandu hwakawanda hwecholesterol uye triglycerides muropa.

Kuremara kwemajini kunokonzera mamiriro aya. Iko kukanganisa kunoguma nekuwedzera kwemahombe lipoprotein zvidimbu zvine zvese cholesterol uye nerudzi rwemafuta anonzi triglycerides. Chirwere ichi chakabatanidzwa nehurema mujeni reapolipoprotein E.

Hypothyroidism, kufutisa, kana chirwere cheshuga zvinogona kuita kuti mamiriro acho awedzere. Njodzi zvinhu zvemhuri dysbetalipoproteinemia inosanganisira nhoroondo yemhuri yechirwere kana coronary arteri chirwere.

Zviratidzo zvinogona kunge zvisingaonekwe kusvika zera makumi maviri kana kupfuura.

Yero inochengeterwa mafuta zvinhu muganda zvinonzi xanthomas zvinogona kuoneka pane eyelids, zvanza zvemaoko, tsoka dzetsoka, kana pane tendon yemabvi nemagokora.

Zvimwe zviratidzo zvinogona kusanganisira:

• Kurwadziwa pachifuva (angina) kana zvimwe zviratidzo zvecoronary arteri chirwere zvinogona kunge zviripo pazera diki
• Kukakama kweimwe kana mhuru mbiri kana uchifamba
• Maronda pazvigunwe zvisingarape
• Kungoerekana kurohwa-kunge zviratidzo sekutambudzika kutaura, kudonha kune rumwe rutivi rwechiso, kushaya simba kweruoko kana gumbo, uye kurasikirwa kwehuremu

Miedzo inogona kuitwa kuti uongorore mamiriro aya inosanganisira:

• Genetic kuyedza apolipoprotein E (apoE)
• Lipid pani yeropa bvunzo
• Triglyceride nhanho
• Yakadzika kwazvo density lipoprotein (VLDL) bvunzo

Chinangwa chekurapa ndechekudzora mamiriro senge kufutisa, hypothyroidism, uye chirwere cheshuga.

Kuita chikafu chinoshanduka kudzikisa macalorie, akazara mafuta, uye cholesterol inogona kubatsira kudzikisa ropa cholesterol.

Kana cholesterol uye triglyceride mazinga achiri akakwirira mushure mekunge iwe waita shanduko yekudya, wako mupi wekuchengetedza hutano anogona kunge iwe uchitorawo mishonga zvakare. Mishonga yekudzikisa ropa triglyceride uye cholesterol mazinga anosanganisira:

• Bhaidhi acid-inotsvaga resini.
• Fibrates (gemfibrozil, fenofibrate).
• Nicotinic asidhi.
• Statins.
• PCSK9 inhibitors, senge alirocumab (Yakakosha) uye evolocumab (Repatha). Izvi zvinomiririra kirasi nyowani yemishonga yekurapa cholesterol.

Vanhu vane chirwere ichi vane njodzi yakanyanya kuwanda yecoronary arteri chirwere uye peripheral vascular chirwere.

Nekurapa, vanhu vazhinji vanokwanisa kudzikisa zvakanyanya iwo macholesterol uye triglycerides.

Zvinetso zvinogona kusanganisira:

• Kumira kurova kwemoyo
• Kurohwa
• Peripheral vascular chirwere
• Kupindirana kwepakati
• Gangrene yemakona ezasi

Fonera waunopa kana iwe waonekwa uine chirwere ichi uye:

• Zviratidzo zvitsva zvinokura.
• Zviratidzo hazviite nekurapwa.
• Zviratidzo zvinowedzera kuwedzera.

Kuongorora nhengo dzemhuri dzevanhu vane chirwere ichi kunogona kutungamira mukuonekwa nekukurumidza kurapwa.

Kurapwa nekukurumidza uye kudzikisira zvimwe zvine njodzi sekusvuta kunogona kubatsira kudzivirira kutanga kwekurwadziwa kwemoyo, kurohwa, uye kuvharika mitsipa yeropa.

Type III hyperlipoproteinemia; Apolipoprotein isina kukwana kana isina kukwana

• Coronary tsinga chirwere

Genest J, Libby P. Lipoprotein kusagadzikana uye chirwere chemoyo. Mune: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Chirwere Chemwoyo cheBraunwald: A Chinyorwa cheCardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019: chitsuwa 48.

Robinson JG. Kushushikana kwe lipid metabolism. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chits. 195.