Nephrotic chirwere

Nephrotic syndrome iboka rezviratidzo zvinosanganisira mapuroteni mumuti weti, mapuroteni eropa mashoma muropa, cholesterol yakawanda, mwero we triglyceride, kuwanda kweropa, uye kuzvimba.

Nephrotic syndrome inokonzerwa nezvinetso zvakasiyana zvinokanganisa itsvo. Uku kukuvara kunotungamira mukuburitswa kweprotein yakawandisa mumuguta.

Chikonzero chakajairika muvana kushoma shanduko chirwere. Membranous glomerulonephritis ndiyo inonyanya kukonzera vanhu vakuru. Muzvirwere zvese izvi, glomeruli muitsvo dzakakuvara. Glomeruli ndizvo zvivakwa zvinobatsira kusefa marara uye mvura.

Aya mamiriro anogona zvakare kuitika kubva:

• Gomarara
• Zvirwere zvakaita seshuga, systemic lupus erythematosus, akawanda myeloma, uye amyloidosis
• Matambudziko eGenetic
• Zvirwere zvemuviri
• Zvirwere (zvakadai se strep throat, hepatitis, kana mononucleosis)
• Kushandiswa kwemimwe mishonga

Izvo zvinogona kuitika neitsvo kusagadzikana senge:

• Focal uye segmental glomerulosclerosis
• Glomerulonephritis
• Mesangiocapillary glomerulonephritis

Nephrotic syndrome inogona kukanganisa ese mazera mapoka. Muvana, zvinowanzoitika pakati pemakore maviri neatanhatu. Dambudziko iri rinoitika zvishoma nezvishoma muvanhurume kupfuura vanhukadzi.

Kuzvimba (edema) ndicho chiratidzo chinowanzoonekwa. Zvinogona kuitika:

• Kumeso nekutenderedza maziso (kumeso kuzvimba)
• Mumaoko nemakumbo, kunyanya mutsoka nemagumbo
• Munzvimbo yedumbu (dumbu rakazvimba)

Zvimwe zviratidzo zvinosanganisira:

• Kuputika kweganda kana maronda
• Kutaridza kupenga kweiyo weti
• Chido chisina kunaka
• Kurera huremu (kusaziva) kubva mukuchengetedza kwemvura
• Kufenda

Anopa hutano anoita bvunzo dzepanyama. Kuongororwa kwerabhoritari kuchaitwa kuti uone kuti itsvo dziri kushanda zvakadii. Zvinosanganisira:

• Albumin kuongorora ropa
• Ropa chemistry bvunzo, senge yakakosha metabolic pani kana yakazara metabolic pani
• Ropa urea nitrogen (BUN)
• Creatinine - kuongororwa kweropa
• Kubvumwa kweCreatinine - weti bvunzo
• Kuongorora urinal

Mafuta anowanzo kuvepo mune weti. Ropa cholesterol uye triglyceride mazinga anogona kunge akareba.

Ipiops biopsy inogona kudiwa kuti uwane chikonzero chechirwere.

Kuyedza kutonga kunze kwakasiyana zvikonzero kunogona kusanganisira zvinotevera:

• Antinuclear antibody
• Cryoglobulins
• Zadzisa mazinga
• Glucose kubvumidza bvunzo
• Hepatitis B uye maC antibodies
• Kuongororwa HIV
• Rheumatoid chinhu
• Serum protein electrophoresis (SPEP)
• Njovhera serology
• Weti mapuroteni electrophoresis (UPEP)

Chirwere ichi chinogona zvakare kuchinja mhedzisiro yemiedzo inotevera:

• Vitamin D mwero
• Serum iron
• Urinary inokanda

Zvinangwa zvekurapa ndezvekununura zviratidzo, kudzivirira kunetseka, uye kunonoka kukuvara kweitsvo. Kuchengetedza nephrotic syndrome, kusagadzikana kuri kukonzeresa kunofanirwa kurapwa. Ungangoda kurapwa kwehupenyu hwese.

Mishonga inogona kusanganisira chero yeanotevera:

• Kuchengeta kumanikidzwa kweropa pa kana pazasi pe 130/80 mm Hg kunonoka kukuvara kweitsvo. Angiotensin-inoshandura enzyme (ACE) inhibitors kana angiotensin receptor blockers (ARBs) ndiyo mishonga inowanzo shandiswa. ACE inhibitors uye maARB anogona zvakare kubatsira kudzikisa huwandu hwepuroteni yakarasika mumuti.
• Corticosteroids nemimwe mishonga inodzvinyirira kana kudzikamisa immune system.
• Kurapa yakakwira cholesterol kuti ideredze njodzi yemoyo nemidziyo yeropa matambudziko - Kudya kwakaderera-mafuta, kwakaderera-cholesterol kazhinji hakukwane kune vanhu vane nephrotic syndrome. Mishonga yekuderedza cholesterol uye triglycerides (kazhinji statins) inogona kudikanwa.
• Kudya kwakaderera-sodium kunogona kubatsira nekuzvimba mumaoko nemakumbo. Mapiritsi emvura (diuretics) anogona zvakare kubatsira padambudziko iri.
• Zvikafu zvine mapuroteni mashoma zvinogona kubatsira. Wako mupi anogona kupa zvine mwero-protein chikafu (1 gramu yeprotein pa kilogiramu yehuremu hwemuviri pazuva).
• Kutora vhitamini D inowedzera kana nephrotic syndrome iri kwenguva refu uye isiri kupindura kurapwa.
• Kutora mishonga yakatetepa yeropa kurapa kana kudzivirira kuwonda kweropa.

Mhedzisiro inosiyana. Vamwe vanhu vanopora kubva pamamiriro ezvinhu. Vamwe vanoita chirwere cheitsvo chenguva refu uye vanoda dialysis uye pakupedzisira kuisirwa itsvo.

Matambudziko ehutano anogona kukonzerwa nephrotic syndrome anosanganisira:

• Yakakomba itsvo kutadza
• Kuomarara kwetsinga pamwe nezvirwere zvemwoyo zvinoenderana
• Chirwere chetsvo chisingaperi
• Kuwedzera kwemvura, kutadza kwemoyo, kuwanda kwemvura mumapapu
• Zvirwere, kusanganisira pneumococcal pneumonia
• Kushaya zvokudya zvinovaka muviri
• Renal vein thrombosis

Fonera mupiki wako kana:

• Iwe kana mwana wako anokura zviratidzo zvephrotic syndrome, kusanganisira kuzvimba kumeso, dumbu, kana maoko nemakumbo, kana maronda eganda.
• Iwe kana mwana wako muri kurapwa nephrotic syndrome, asi zviratidzo hazvivandudze
• Zviratidzo zvitsva zvinokura, kusanganisira kukosora, kudzikira kwekuburitsa weti, kusagadzikana nekuita weti, fivha, kutemwa nemusoro kwakanyanya

Enda kuimba yekukurumidzira kana kufonera iyo yemuno emergency emergency (yakadai se911) kana iwe uine pfari.

Kurapa mamiriro anogona kukonzera nephrotic syndrome kunogona kubatsira kudzivirira iyo syndrome.

Nephrosis

• Itsvo anatomi

Erkan E. Nephrotic chirwere. Mune: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Chinyorwa chePediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020: chap 545.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Chirwere chepakutanga chinoratidzira. Mune: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner uye Rector Iyo Itsvo. 11th ed. Philadelphia, PA: Elsevier; 2020: chits. 31.