Myelofibrosis

Myelofibrosis kusagadzikana kwemongo wemapfupa umo mongo unotsiviwa ne fibrous scar tishu.

Mongo wefupa ndiwo munyoro, une mafuta mukati memapfupa ako. Masero emadzinde maseru asina kukura mumongo wemapfupa anokura kuva ako ese maseru eropa. Ropa rako rakagadzirwa ne:

• Masero matsvuku eropa (anotakura okisijeni kumatumbu ako)
• Masero machena eropa (ayo anorwisa hutachiona)
• Maplatelet (ayo anobatsira ropa rako kugwamba)

Kana mwongo wemabhonzo watsvuka, haukwanise kuita masero eropa akakwana. Anemia, matambudziko ekubuda ropa, uye njodzi yakakwira yezvirwere zvinogona kuitika.

Nekuda kweizvozvo, chiropa uye chirwatata chinoedza kugadzira mamwe emasero eropa aya. Izvi zvinoita kuti nhengo idzi dzizvimbe.

Chikonzero che myelofibrosis kazhinji hachizivikanwe. Iko hakuna kuzivikanwa njodzi zviitiko. Kana zvikaitika, zvinowanzo kukura zvishoma nezvishoma muvanhu vanopfuura makore makumi mashanu. Vakadzi nevarume vanobatwa zvakaenzana. Iko kune kwakawedzera kuitika kweichi chiitiko muAshkenazi maJuda.

Ropa uye mapfupa emukenza, senge myelodysplastic syndrome, leukemia, uye lymphoma, zvinogona kukonzera marora pfupa. Izvi zvinonzi zvechipiri myelofibrosis.

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Kuzara kwemimba, kurwadziwa, kana kunzwa kuzere usati wapedza kudya (nekuda kweshure rakawedzera)
• Kurwadziwa kwepfupa
• Kubuda ropa nyore, kupwanya
• Kuneta
• Kuwedzera mukana wekuwana hutachiona
• Ganda rakachenuruka
• Kufema nekufema
• Kuonda
• Night sweats
• Low fever fever
• Yakawedzera chiropa
• Kuoma kukosora
• Itchy ganda

Anopa hutano anoita bvunzo dzepanyama uye obvunza nezvezviratidzo.

Miedzo inogona kuitwa inosanganisira:

• Pedzisa kuverenga ropa (CBC) neropa smear kutarisa mhando dzakasiyana dzemasero eropa
• Kuyera kukuvara kwemasuru (LDH enzyme level)
• Kuongorora genetic
• Bone marrow biopsy kuti uongorore mamiriro acho uye kuti utarise kanzira dzemongo wemapfupa

Bone marora kana stem cell kuisirwa inogona kugadzirisa zviratidzo, uye inogona kuporesa chirwere. Iyi kurapwa inowanzo kutarisirwa kune vechidiki.

Kumwe kurapwa kunogona kusanganisira:

• Kuisirwa ropa uye mishonga kugadzirisa kupererwa neropa
• Radiation uye chemotherapy
• Mishonga yakanangwa
• Kubviswa kwepleen (splenectomy) kana kuzvimba kuchikonzera zviratidzo, kana kubatsira neropa

Sezvo chirwere ichi chichiwedzera, mwongo wemabhonzo unononoka kumira kushanda. Yakaderera platelet kuverenga inotungamira mukubuda ropa nyore. Spleen kuzvimba kunogona kuwedzera pamwe neanemia.

Kupona kwevanhu vane primary myelofibrosis anenge makore mashanu. Asi vamwe vanhu vanopona kwemakumi emakore.

Zvinetso zvinogona kusanganisira:

• Kubudirira kweacute myelogenous leukemia
• Zvirwere
• Kubuda ropa
• Ropa rinovhara
• Chiropa kutadza

Ita musangano nemupi wako kana iwe uine zviratidzo zvechirwere ichi. Tsvaga kurapwa kwenguva pfupi nekuda kwekubuda ropa kusingadzoreke, kufema kufema, kana jaundice (yero ganda uye vachena vemeso) izvo zvinowedzera kuwedzera.

Idiopathic myelofibrosis; Myeloid metaplasia; Agnogenic myeloid metaplasia; Primary myelofibrosis; Sekondari myelofibrosis; Bone mwongo - myelofibrosis

Gotlib J. Polycythemia vera, yakakosha thrombocythemia, uye yekutanga myelofibrosis. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chitsiko 157.

Yakareba NM, Kavanagh EC. Myelofibrosis. Muna: Papa TL, Bloem HL, Beltran J, Morrison WB, Wilson DJ, eds. Musculoskeletal Kufungidzira. 2nd ed. Philadelphia, PA: Elsevier Saunders; 2015: chits. 76.

Mascarenhas J, Najfeld V, Kremyanskaya M, Keyzner A, Salama ME, Hoffman R. Primary myelofibrosis. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits. 70.