Cryoglobulinemia

Cryoglobulinemia ndiko kuvapo kwemapuroteni asina kujairika muropa. Aya mapuroteni anowedzera mukutonhora kutonhora.

Cryoglobulins masoja ekudzivirira chirwere. Hazvisati zvazivikanwa kuti nei vachiita vakasimba kana gel-senge pane tembiricha yakaderera murabhoritari. Mumumuviri, masoja ekudzivirira chirwere aya anogona kugadzira zvimiro zvekudzivirira muviri izvo zvinogona kukonzera kuzvimba uye kuvhara mitsipa yeropa. Izvi zvinonzi cryoglobulinemic vasculitis. Izvi zvinogona kukonzera matambudziko kubva paganda rashes kusvika kukundikana kwetsvo.

Cryoglobulinemia chikamu cheboka rezvirwere zvinokanganisa uye kuzvimba kwemitsipa yeropa mumuviri wese (vasculitis). Kune matatu makuru marudzi eichi chiitiko. Iwo akarongedzwa zvichienderana nerudzi rweantibody iyo inogadzirwa:

• Tora I
• Rudzi rwechipiri
• Rudzi rwechitatu

Mhando II uye III inonziwo seyakavhenganiswa cryoglobulinemia.

Type I cryoglobulinemia inowanzo kuve yakabatana nekenza yeropa kana immune system.

Mhando II ne III dzinowanzo kuwanikwa muvanhu vane chirwere chisingaperi (chisingaperi) chekuputira, senge autoimmune chirwere kana hepatitis C. Vazhinji vanhu vane mhando yechipiri fomu ye cryoglobulinemia vane chirwere chisingaperi chehepatitis C.

Mimwe mamiriro angave ane hukama necryoglobulinemia anosanganisira:

• Leukemia
• Akawanda myeloma
• Yakanyanya macroglobulinemia
• Rheumatoid arthritis
• Systemic lupus erythematosus

Zviratidzo zvinosiyana, zvinoenderana nerudzi rwechirwere chauinacho uye nhengo dzinobatanidzwa. Zviratidzo zvinogona kusanganisira:

• Matambudziko ekufema
• Kuneta
• Glomerulonephritis
• Joint kurwadziwa
• Kutambudzika kwemhasuru
• Purpura
• Raynaud chiitiko
• Rufu rweganda
• Maronda eganda

Anopa hutano anoita bvunzo dzepanyama. Iwe unozoongororwa zviratidzo zvechiropa uye spleen kuzvimba.

Miedzo ye cryoglobulinemia inosanganisira:

• Yakazara kuverenga ropa (CBC).
• Kuteedzera kuyedza - nhamba dzinenge dzakaderera.
• Cryoglobulin bvunzo - inogona kuratidza kuvepo kwema cryoglobulins. (Iyi ndiyo nzira yakaoma yerabhoritari inosanganisira matanho mazhinji. Zvakakosha kuti lab rinoita bvunzo iri rinoziva maitiro acho.)
• Chiropa chebasa bvunzo - inogona kunge yakakwira kana hepatitis C iripo.
• Rheumatoid factor - yakanaka mumhando II uye III.
• Ganda biopsy - inogona kuratidza kuzvimba mumidziyo yeropa, vasculitis.
• Protein electrophoresis - ropa - inogona kuratidza isina kujairika antibody protein.
• Urinalysis - inogona kuratidza ropa mumurini kana itsvo dzichikanganiswa.

Mimwe bvunzo inogona kusanganisira:

• Angiogram
• Chest x-ray
• ESR
• Hepatitis C bvunzo
• Tsinga conduction bvunzo, kana munhu aine utera mumaoko kana makumbo

YAKASANGANISWA CRYOGLOBULINEMIA (TYPES II NA III)

Zvinyoro kana zvine mwero mafomu e cryoglobulinemia anogona kurapwa kazhinji nekutora matanho ekugadzirisa chinokonzeresa.

Yazvino yakananga-inoshanda mishonga yehepatitis C inobvisa hutachiona mune vangangoita vanhu vese. Sezvo hepatitis C inoenda, iyo cryoglobulins ichanyangarika mune inenge hafu yevanhu vese pamwedzi gumi nemiviri inotevera. Wako mupi acharamba achiongorora cryoglobulins mushure mekurapwa.

Yakakomba cryoglobulinemia vasculitis inosanganisira yakakosha mitezo kana nzvimbo hombe dzeganda. Inorapwa necorticosteroids nemimwe mishonga inodzvinyirira immune system.

• Rituximab mushonga unoshanda uye une njodzi shoma pane mimwe mishonga.
• Cyclophosphamide inoshandiswa muhupenyu hunotyisidzira mamiriro apo rituximab isiri kushanda kana kuwanikwa. Mushonga uyu waishandiswa kazhinji kare.
• Mushonga unonzi plasmapheresis unoshandiswa zvakare. Mune maitiro aya, plasma yeropa inotorwa kunze kweropa uye zvisina kujairika cryoglobulin antibody mapuroteni anobviswa. Iyo plasma inotsiviwa ne fluid, protein, kana plasma yakapihwa.

TYPE I CRYOGLOBULINEMIA

Ichi chirwere chinokonzerwa nekenza yeropa kana immune system yakadai seakawanda myeloma. Kurapa kunoendeswa kunopesana nekenza maseru maseru ayo anogadzira iyo cryoglobulin.

Kazhinji yenguva, yakavhenganiswa cryoglobulinemia haina kutungamira kurufu. Maonero anogona kuve mashoma kana itsvo dzichikanganiswa.

Matambudziko anosanganisira:

• Kubuda ropa munzvimbo yekugaya (zvisingawanzoitika)
• Chirwere chemwoyo (chisingawanzoitiki)
• Zvirwere zvezvironda
• Itsvo kutadza
• Chiropa kutadza
• Rufu rweganda
• Rufu

Fonera mupiki wako kana:

• Iwe unovandudza zviratidzo zve cryoglobulinemia.
• Iwe une hepatitis C uye unovandudza zviratidzo zve cryoglobulinemia.
• Iwe une cryoglobulinemia uye unovandudza zviratidzo zvitsva kana kuwedzera.

Iko hakuna kunozivikanwa kudzivirira kweiyo mamiriro.

• Kugara kure nechando kutonhora kunogona kudzivirira zvimwe zviratidzo.
• Kuedzwa uye kurapwa kwehutachiona hwehepatitis C kunoderedza njodzi yako.

• Cryoglobulinemia yeminwe
• Cryoglobulinemia - minwe
• Masero eropa

Patterson ER, Winters JL. Hemapheresis. Mune: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis uye Management nemaLabhoritari Maitiro. 23rd ed. St Louis, MO: Elsevier; 2017: chits. 37.

Roccatello D, Saadoun D, ​​Ramos-Casals M, uye al. Cryoglobulinaemia. Nat Rev Dis Primers. 2018; 4 (1): 11. PMID: 30072738 pubmed.ncbi.nlm.nih.gov/30072738/.

Dombo JH. Immune yakaoma-yakagadziriswa diki-mudziyo vasculitis. Mune: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelley uye Firestein's Bhuku reRheumatology. 10th ed. Philadelphia, PA: Elsevier; 2017: chits. 91.