Thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura (TTP) chirwere cheropa umo maplatelet clumps anoumba mumidziyo midiki yeropa. Izvi zvinotungamira kune yakaderera platelet kuverenga (thrombocytopenia).

Chirwere ichi chinogona kukonzerwa nematambudziko ane enzyme (rudzi rweprotein) iyo inobatanidzwa mukugwamba kweropa. Iyi enzyme inonzi ADAMTS13. Kushaikwa kweiyo enzyme kunoguma nekuumbika kweplatelet. Maplatelet chikamu cheropa iro rinobatsira mukugwamba kweropa.

Sezvo maplatelet anonamira pamwe chete, mashoma maplatelet anowanikwa muropa mune zvimwe zvikamu zvemuviri kubatsira nekugwamba. Izvi zvinogona kutungamira mukubuda ropa pasi peganda.

Mune zvimwe zviitiko, kusagadzikana kunopfuudzwa kuburikidza nemhuri (nhaka). Mune zviitiko izvi, vanhu vanozvarwa vaine huwandu hwakaderera hweiyi enzyme.

Aya mamiriro zvakare anogona kukonzerwa ne:

• Gomarara
• Chemotherapy
• Hematopoietic stem sero kuisirwa
• Mukondombera
• Hormone kutsiva kurapa uye estrogens
• Mishonga (inosanganisira ticlopidine, clopidogrel, quinine, uye cyclosporine A)

Zviratidzo zvinogona kusanganisira chero zvinotevera:

• Kubuda ropa mukati meganda kana mucus membranes
• Kuvhiringidzika
• Kuneta, kushaya simba
• Kupindwa nechando
• Kutemwa nemusoro
• Ruvara rweganda rakachenuruka kana ganda reyero
• Kufema kwekufema
• Kutsanya kwemoyo kurovera (anopfuura zana kurova paminiti)

Miedzo inogona kurairwa inosanganisira:

• ADAMTSI 13 chikamu chezviitiko
• Bilirubin
• Ropa kuzora
• Yakazara kuverenga ropa (CBC)
• Chikamu cheCreatinine
• Lactate dehydrogenase (LDH) nhanho
• Platelet kuverenga
• Kuongorora urinal
• Haptoglobin
• Coombs bvunzo

Unogona kunge uine kurapwa kunonzi plasma kuchinjana. Inobvisa yako isina kujairika plasma uye kuitsiva neyakajairwa plasma kubva kune akanaka mupi. Plasma chikamu chemvura cheropa chine masero eropa nemaplatelet. Plasma kuchinjanisa zvakare inotsiva iyo isipo enzyme.

Maitiro acho anoitwa seinotevera:

• Kutanga, iwe unotora ropa rako rakadhonzwa sekunge uri kupa ropa.
• Ropa parinopfuura nemuchina unopatsanura ropa muzvikamu zvaro zvakasiyana, plasma isina kujairika inobviswa uye masero ako eropa anoponeswa.
• Masero ako eropa anobva asanganiswa neyakajairwa plasma kubva kune waakapa, uye ndokuzodzorerwa kwauri.

Uku kurapwa kunodzokororwa zuva nezuva kusvikira kuongororwa kweropa kuchiratidza kuvandudzika.

Vanhu vasingateerere kurapwa uku kana vane mamiriro anowanzo dzoka vangangoda ku:

• Ita kuvhiyiwa kubvisa yavo spleen
• Wana mishonga inodzvinyirira immune system, senge steroids kana rituximab

Vazhinji vanhu vanochinjaniswa neplasma vanopora zvakakwana. Asi vamwe vanhu vanofa nechirwere ichi, kunyanya kana chikasabatwa ipapo ipapo. Muvanhu vasina kupora, mamiriro aya anogona kuve akareba-kwenguva refu (asingagumi).

Zvinetso zvinogona kusanganisira:

• Itsvo kutadza
• Yakadzika platelet kuverenga (thrombocytopenia)
• Yakadzika tsvuku masero eropa kuverenga (kunokonzerwa nekukurumidza kuparara kwemasero matsvuku eropa)
• Zvinotyisa system matambudziko
• Kubuda ropa kwakanyanya (kubuda ropa)
• Kurohwa

Fonera wako mupi wezvehutano kana iwe uine chero zvisina kutsanangurwa kubuda ropa.

Nekuti chikonzero hachizivikanwe, hapana nzira inozivikanwa yekudzivirira iyi mamiriro.

TTP

• Masero eropa

Abrams CS. Thrombocytopenia. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 172.

National Moyo, Lung, uye Ropa Institute webhusaiti. Thrombotic thrombocytopenic purpura. www.nhlbi.nih.gov/health-topics/thrombotic-thrombocytopenic-purpura. Yakasvika March 1, 2019.

Schneidewend R, Epperla N, Friedman KD. Thrombotic thrombocytopenic purpura uye iyo hemolytic uremic syndrome. Muna: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Misimboti uye Maitiro. 7th ed. Philadelphia, PA: Elsevier; 2018: chits. 134.