Chisingaperi granulomatous chirwere

Chisingaperi granulomatous chirwere (CGD) chirwere chinogarwa nhaka umo mamwe maseru ezvirwere zvemuviri asingashande nemazvo. Izvi zvinotungamira kuzvirwere zvinodzokororwa uye zvakakomba.

MuCGD, immune system maseru anonzi phagocytes haakwanise kuuraya mamwe marudzi ebacteria nefungi. Ichi chirwere chinotungamira kune kwenguva refu (chisingaperi) uye chakadzokororwa (chinowanzoitika) hutachiona. Mamiriro acho anowanzo kuwanikwa kutanga kwehudiki. Mafomu akaomarara anogona kuongororwa mukati memakore ekuyaruka, kana kunyangwe mukukura.

Njodzi zvinhu zvinosanganisira nhoroondo yemhuri yezvazvino kana zvisingaperi hutachiona.

Inenge hafu yezviitiko zveCGD zvinopfuudzwa kuburikidza nemhuri sehunhu hwakabatana-hunobatanidza hunhu. Izvi zvinoreva kuti vakomana vane mukana wekuwana chirwere ichi kupfuura vasikana. Iyo yakashata geni inoendeswa pane X chromosome. Vakomana vane 1 X chromosome uye 1 Y chromosome. Kana mukomana aine X chromosome ine chakaremara gene, anogona kugara nhaka iyi mamiriro. Vasikana vane 2 X chromosomes. Kana musikana aine 1 X chromosome neyakaremara jeni, imwe X chromosome inogona kuve neinoshanda geni yekuigadzirira. Musikana anofanirwa kugara nhaka chakaremara X chemubereki wega wega kuti awane chirwere.

CGD inogona kukonzera marudzi mazhinji ehutachiona hweganda ayo akaoma kurapa, kusanganisira:

• Blister kana maronda kumeso (impetigo)
• Eczema
• Kukura kwakazara pus (abscesses)
• Pus-izere mapundu muganda (mamota)

CGD inogona zvakare kukonzera:

• Kuramba uine manyoka
• Kuzvimba lymph node mumutsipa
• Zvirwere zvemapapu, senge pneumonia kana abscess yemapapu

Anopa hutano anozoongorora uye anogona kuwana:

• Chiropa kuzvimba
• Spleen kuzvimba
• Kuzvimba lymph node

Panogona kuve nezviratidzo zvehutachiona hutachiona, izvo zvinogona kukanganisa mapfupa mazhinji.

Miedzo inogona kuitwa inosanganisira:

• Bone scan
• Chest x-ray
• Yakazara kuverenga ropa (CBC)
• Kuyerera cytometry bvunzo kubatsira kusimbisa chirwere
• Genetic kuyedza kusimbisa kuongororwa
• Kwayedza yechena ropa sero rinoshanda
• Tissue biopsy

Mishonga inorwisa mabhakitiriya inoshandiswa kurapa chirwere ichi, uye inogona zvakare kushandiswa kudzivirira hutachiona. Mushonga unonzi interferon-gamma unogona zvakare kubatsira kudzikisa huwandu hwehutachiona hwakanyanya. Kuvhiya kunogona kudiwa kubata mamwe mapundu.

Mushonga chete weCGD ipfupa kana pfupa rekusimudza masero.

Yenguva refu mishonga inorwisa mabhakitiriya inogona kubatsira kudzikisira hutachiona, asi kufa kwekutanga kunogona kuitika kubva mukudzokororwa kwemapapu hutachiona.

CGD inogona kukonzera matambudziko aya:

• Kukuvara kwepfupa uye hutachiona
• Zvirwere zvisingaperi mumhino
• Mabayo anoramba achidzoka uye akaoma kupora
• Kukanganiswa kwemapapu
• Kukuvara kweganda
• Kuzvimba lymph node dzinogara dzakazvimba, dzinoitika kazhinji, kana kuumba mamota anoda kuvhiyiwa kuti aaburitse

Kana iwe kana mwana wako aine chirwere ichi uye uchifungidzira mabayo kana chimwe chirwere, danaidza mupiki wako ipapo ipapo.

Udza mupi wako kana mapapu, ganda, kana chimwe hutachiona chisingapindure pakurapwa.

Genetic counselling inokurudzirwa kana iwe uri kuronga kuita vana uye une mhuri nhoroondo yechirwere ichi. Kufambira mberi mukuongorora majini uye kuwedzera kushandiswa kwechorionic villus sampling (bvunzo inogona kuitwa panguva yemukadzi yegumi kusvika yegumi nembiri vhiki yekuzvitakura) yakaita kuti kuonekwa kweCGD kukurumidza. Zvisinei, maitiro aya haasati apararira kana kutambirwa zvizere.

CGD; Inouraya granulomatosis yehudiki; Chisingaperi granulomatous chirwere chehudiki; Kufambira mberi septic granulomatosis; Kushayikwa kwePhagocyte - chirwere chisingaperi chegranulomatous

Glogauer M. Kukanganiswa kwepa phagocyte basa. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 169.

Holland SM, Uzel G. Kushaya kwePhagocyte. Mune: Rich RR, Fleisher TA, Shearer WT, Schroeder JR. HW, Frew AJ, Weyand CM, eds. Clinical Immunology: Misimboti uye Maitiro. 5 ed. Philadelphia, PA: Elsevier; 2019: chitsiko 22.