Polyarteritis nodosa

Polyarteritis nodosa chirwere chakakomba cheropa. Tsinga diki nepakati nepakati dzinozvimba nekukuvara.

Arteri ndiyo tsinga dzeropa dzinotakura okisijeni-yakazara ropa kune nhengo uye nyama. Chikonzero che polyarteritis nodosa hachizivikanwe. Mamiriro acho anoitika apo mamwe masero ekudzivirira anorwisa tsinga dzakakanganiswa. Iwo matukisi anodyiswa neakakanganiswa tsinga haawane iyo oxygen uye chikafu chavanoda. Kukuvadza kunoitika semhedzisiro.

Vakuru vakawanda kupfuura vana vanowana chirwere ichi.

Vanhu vane hepatitis B inoshanda kana hepatitis C vanogona kukura chirwere ichi.

Zviratidzo zvinokonzerwa nekukuvara kwenhengo dzakakanganiswa. Ganda, majoini, mhasuru, gastrointestinal turakiti, moyo, itsvo, uye tsinga system zvinowanzo kanganiswa.

Zviratidzo zvinosanganisira:

• Marwadzo emudumbu
• Kuderedza kudya
• Kuneta
• Kupindwa nechando
• Joint aches
• Tsvina inorwadza
• Kurasikirwa kwekurema kwemaune
• Kushaya simba

Kana tsinga dzichikanganiswa, unogona kunge uine chiveve, kurwadziwa, kupisa, uye kushaya simba. Kukuvara kwenzvimbo kunogona kukonzera kurohwa kana kugwinha.

Hapana chaiwo mabvunzo bvunzo anowanikwa kuti aongorore polyarteritis nodosa. Kune akati wandei kusagadzikana ane maficha akafanana ne polyarthritis nodosa. Aya anozivikanwa se "mimics."

Iwe unenge uine bvunzo yakakwana yemuviri.

Lab miedzo inogona kubatsira kuti kuongororwa uye kutonga kunze kutevedzera kunosanganisira:

• Yakazara huwandu hweropa (CBC) nemusiyano, creatinine, kuongororwa kwehepatitis B uye C, uye urinalysis
• Erythrocyte sedimentation rate (ESR) kana C-inoshanda mapuroteni (CRP)
• Serum protein electrophoresis, cryoglobulins
• Serum inozadzisa mazinga
• Arteriogram
• Tissue biopsy
• Kumwe kuongororwa kweropa kuchaitwa kutonga kunze mamiriro akafanana, senge systemic lupus erythematosus (ANA) kana granulomatosis ine polyangiitis (ANCA)
• Bvunzo dzeHIV
• Cryoglobulins
• Anti-phospholipid antibodies
• Tsika dzeropa

Kurapa kunosanganisira mishonga yekudzvinyirira kuzvimba uye immune system. Izvi zvinogona kusanganisira steroid, senge prednisone. Mimwe mishonga yakafanana, yakadai seazathioprine, methotrexate kana mycophenolate iyo inobvumidza kudzikisira muyero westeroid inowanzo shandiswa zvakare. Cyclophosphamide rinoshandiswa zvikuru nyaya.

Kune polyarteritis nodosa ine hukama nehepatitis, kurapwa kunogona kusanganisira plasmapheresis nemishonga inorwisa hutachiona.

Kurapa kwazvino nesteroid uye mimwe mishonga inodzvinyirira immune system (senge azathioprine kana cyclophosphamide) inogona kugadzirisa zviratidzo uye mukana wekupona kwenguva refu.

Zvinetso zvakakomba zvakanyanya zvinowanzobatanidza itsvo uye nemudumbu.

Pasina kurapwa, maonero haana kunaka.

Zvinetso zvinogona kusanganisira:

• Kumira kurova kwemoyo
• Utumbo necrosis uye kupora
• Itsvo kutadza
• Kurohwa

Fonera wako mupi wezvehutano kana iwe ukaita zviratidzo zvechirwere ichi. Kutanga kuongororwa uye kurapwa kunogona kuvandudza mukana wemhedzisiro yakanaka.

Iko hakuna kunozivikanwa kudzivirira. Nekudaro, kurapwa kwekutanga kunogona kudzivirira kumwe kukuvara uye zviratidzo.

Periarteritis nodosa; PAN; Systemic necrotizing vasculitis

• Microscopic polyarteritis 2
• Kutenderera system

Luqmani R, Awisat A. Polyarteritis nodosa pamwe nezvinetso zvinoenderana. Mune: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Bhuku reRheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021: chitsiko 95.

Puéchal X, Pagnoux C, Baron G, et al. Kuwedzera azathioprine kuregererwa-induction glucocorticoids ye eosinophilic granulomatosis ine polyangiitis (Churg-Strauss), microscopic polyangiitis, kana polyarteritis nodosa isina maitiro ekufungidzira akasarudzika. Arthritis Rheumatol. 2017; 69 (11): 2175-2186. PMID: 28678392 www.pubmed.ncbi.nlm.nih.gov/28678392/.

Shanmugam VK. Vasculitis uye zvimwe zvisingawanzo arteriopathies. Mune: Sidawy AN, Perler BA, eds. Rutherford Kuvhiya kweVascular uye Endovascular Therapy. 9th ed. Philadelphia, PA: Elsevier; 2019: chitsiko 137.

Dombo JH. Iyo systemic vasculitides. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 26th ed. Philadelphia, PA: Elsevier; 2020: chitsama 254.