C1 esterase inhibitor

C1 esterase inhibitor (C1-INH) ipuroteni inowanikwa mune inoyerera chikamu cheropa rako. Iyo inodzora protein inonzi C1, inova chikamu cheyeyeyeyeyekodhi system.

Iyo yekuwedzera system iboka remapuroteni anoda kusvika makumi matanhatu muplasma yeropa kana pamusoro pemamwe maseru. Iwo ekuwedzera mapuroteni anoshanda nema immune system ako kudzivirira muviri kubva kuzvirwere. Dzinobatsirawo kubvisa masero akafa uye zvekune dzimwe nyika. Iko kune mapfumbamwe makuru ekuwedzera mapuroteni. Ivo vakanzi C1 kuburikidza neC9. Kazhinji, vanhu vanogona kugara nhaka kushomeka kwevamwe vanozadzisa mapuroteni. Vanhu ava vanowanzo tenderwa nezvimwe hutachiona kana autoimmune kusagadzikana.

Ichi chinyorwa chinokurukura bvunzo inoitwa kuyera huwandu hweC1-INH muropa rako.

Muenzaniso weropa unodiwa. Izvi zvinowanzo kutorwa kuburikidza netsinga. Maitiro acho anonzi venipuncture.

Hapana gadziriro inokosha inodiwa.

Kana tsono ikaiswa kukweva ropa, vamwe vanhu vanonzwa kurwadziwa zvine mwero. Vamwe vanogona kungonzwa kubaya kana kuruma. Mushure meizvozvo, panogona kunge paine kurovera.

Iwe ungangoda bvunzo iyi kana iwe uine zviratidzo zvekugara nhaka kana kuwana angioedema. Ese maviri mafomu eangioedema anokonzerwa neakaderera mazinga eC1-INH.

Kuzadzikisa zvinhu zvinogona zvakare kuve zvakakosha mukuyedza kwe autoimmune hosha, senge systemic lupus erythematosus.

Zvakajairika kukosha masenduru anogona kusiyana zvishoma pakati pemarabhoritari akasiyana. Wako wekuchengeta hutano anozoyerawo chiitiko chinoshanda cheC1 esterase inhibitor yako. Taura nemupi wako nezve zvinorehwa nemimwe miedzo yako.

Kuderera kweC1-INH kunogona kukonzera mamwe marudzi eangioedema. Angioedema inoguma nekukurumidza kuzvimba kwetishu kwechiso, chepamusoro huro nerurimi. Izvo zvinogona zvakare kukonzera kunetseka kufema. Kuzvimba mumatumbo uye mudumbu kurwadziwa kunogona kuitika. Kune maviri marudzi eangioedema ayo anokonzerwa nekudzikira kwemazinga eC1-INH. Hereditary angioedema inokanganisa vana nevakuru vechidiki vari pasi pemakore makumi maviri. Kuwana angioedema kunoonekwa kune vakuru vane makore anodarika makumi mana. Vakuru vane angioedema vakawana vane mikana yakawanda yekuvewo nemimwe mamiriro akadai secancer kana autoimmune chirwere.

Njodzi dzakabatana nekutorwa kweropa idiki, asi dzinogona kusanganisira:

• Kuwedzera kubuda ropa
• Kufenda kana kunzwa kushaya musoro
• Hematoma (ropa rinoungana pasi peganda)
• Utachiona (hushoma njodzi chero nguva ganda parinovhunika)

C1 inhibiting factor; C1-INH

• Kuongorora ropa

Cicardi M, Aberer W, Banerji A, uye al. Kurongwa, kuongororwa, uye nzira yekurapwa kweangioedema: chibvumirano chebvumirano kubva kuHereditary Angioedema International Working Group. Allergy. 2014; 69 (5): 602-616. PMID: 24673465 www.ncbi.nlm.nih.gov/pubmed/24673465.

Leslie TA, Greaves MW. Nhaka angioedema. Mune: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, eds. Kurapa kweGanda Rezvirwere: Dzakakwana Therapeutic Strategies. 5 ed. Philadelphia, PA: Elsevier; 2018: chits. 101.

Zanichelli A, Azin GM, Wu MA, et al. Kuongororwa, kosi, uye manejimendi yeangioedema mune varwere vakawana C1-inhibitor kushomeka. J Allergy Clin Immunol Dzidzira. 2017; 5 (5): 1307-1313. PMID: 28284781 www.ncbi.nlm.nih.gov/pubmed/28284781.