HLA-B27 antigen

HLA-B27 kuongororwa kweropa kutsvaga puroteni inowanikwa pamusoro pemasero machena eropa. Protein inonzi human leukocyte antigen B27 (HLA-B27).

Evanhu leukocyte antigen (HLAs) mapuroteni anobatsira immune system kutaurira musiyano pakati pemasero ayo nezvinhu zvekunze, zvinokuvadza. Izvo zvinogadzirwa kubva kumirayiridzo nemagene anogarwa nhaka.

Muenzaniso weropa unodiwa. Kazhinji yenguva, ropa rinotorwa kubva mutsinga iri mukati megokora kana kumashure kweruoko.

Muzviitiko zvakawanda, hapana matanho akakosha anodiwa kugadzirira bvunzo.

Kana tsono ikaiswa kuti utore ropa, unogona kunzwa kurwadziwa kwepakati nepakati, kana kungobaya-baya kana kunzwa. Mushure meizvozvo, panogona kunge paine kurovera.

Wako wekuchengeta hutano anogona kuraira iyi bvunzo kuti ibatsire kuona chinokonzera kurwadziwa pamwe chete, kuomarara, kana kuzvimba. Muedzo unogona kuitwa pamwe chete nezvimwe bvunzo, zvinosanganisira:

• C-inoshanda mapuroteni
• Erythrocyte sedimentation chiyero (ESR)
• Rheumatoid chinhu
• X-ray

Kuongororwa kweHLA kunoshandiswa zvakare kuenzanisa yakapihwa matissue netissue yemunhu ari kuwana chiumbwa chekuiswa. Semuenzaniso, zvinogona kuitwa kana munhu achida kuisirwa itsvo kana kupfuudzwa kwemongo wemapfupa.

Mhedzisiro (isina kunaka) mhedzisiro zvinoreva kuti HLA-B27 haipo.

Chiyero chakanaka chinoreva HLA-B27 iripo. Iyo inoratidza yakakura-kupfuura-avhareji njodzi yekukudziridza kana kuve nehumwe autoimmune kusagadzikana. Kuzvimiririra autoimmune kusagadzikana chiitiko chinoitika apo immune system inorwisa nekukanganisa nekuparadza hutano hwemuviri.

Mhedzisiro yakanaka inogona kubatsira mupi wako kuti aongorore chimiro cheArthritis chinonzi spondyloarthritis. Rudzi urwu rweArthritis runosanganisira matambudziko anotevera:

• Ankylosing spondylitis
• Arthritis yakabatana neCrohn chirwere kana ulcerative colitis
• Psoriatic arthritis (arthritis yakabatana ne psoriasis)
• Reactive arthritis
• Sacroiliitis (kuzvimba kwechikamu che sacroiliac)
• Uveitis

Kana iwe uine zviratidzo kana zviratidzo zve spondyloarthritis, yakanaka HLA-B27 bvunzo inogona kubatsira kusimbisa kuongororwa. Nekudaro, HLA-B27 inowanikwa mune vamwe vanhu chaivo uye hazvireve kuti unogara uine chirwere.

Njodzi kubva pakutorwa ropa idiki, asi dzinogona kusanganisira:

• Kuwedzera kubuda ropa
• Kufenda kana kunzwa kushaya musoro
• Hematoma (ropa rinoungana pasi peganda)
• Utachiona (hushoma njodzi chero nguva ganda parinovhunika)

Leukocyte yevanhu antigen B27; Ankylosing spondylitis-HLA; Psoriatic arthritis-HLA; Reactive arthritis-HLA

• Kuongorora ropa

Chernecky CC, Berger BJ. Yevanhu Leukocyte Antigen (HLA) B-27 - ropa. Mune: Chernecky CC, Berger BJ, eds. Rabhoritari Kuyedza uye Maitiro Ekuongorora. 6th ed. St Louis, MO: Elsevier Saunders; 2013: 654-655.

Fagoaga OR. Yevanhu leukocyte antigen: iyo hombe histocompatibility yakaoma yemurume. Mune: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis uye Management nemaLabhoritari Maitiro. 23rd ed. St Louis, MO: Elsevier; 2017: chits. 49.

Inman RD. Iyo spondyloarthropathies. Mune: Goldman L, Schafer AI, eds. Goldman-Cecil Mushonga. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016: chitsiko 265.

McPherson RA, Massey HD. Mhedziso yemasoja ekudzivirira uye immune immune. Mune: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis uye Management nemaLabhoritari Maitiro. 23rd ed. St Louis, MO: Elsevier; 2017: chitsiko 43.

Reveille JD. Spondyloarthritis. Mune: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Vashoma AJ, Weyand CM, eds. Clinical Immunology: Misimboti uye Maitiro. 5 ed. Philadelphia, PA: Elsevier; 2019: chitsiko 57.