ACTH kukurudzira bvunzo

Iyo ACTH yekusimudzira bvunzo inoyera kuti adrenal gland inopindura sei kune adrenocorticotropic hormone (ACTH). ACTH ihormone inogadzirwa mupituitary gland inokurudzira adrenal gland kuburitsa hormone inonzi cortisol.

Muedzo unoitwa nenzira inotevera:

• Ropa rako rakavhomorwa.
• Iwe unobva wagamuchira pfuti (jekiseni) yeACTH, kazhinji mumhasuru iri mubendekete rako. Iyo ACTH inogona kunge iri yakagadzirwa nevanhu (synthetic) fomu.
• Mushure memaminetsi makumi matatu kana makumi matanhatu, kana maviri, zvichienderana nekuti unogamuchira ACTH yakawanda sei, ropa rako rinodhonzwa zvakare.
• Irabhu inoongorora muyero wekortisol mumasampuli eropa ese.

Iwe unogona zvakare kunge uine kumwe kuongorora kweropa, kusanganisira ACTH, sechikamu chekutanga kuongororwa ropa. Pamwe pamwe nekuongororwa kweropa, iwe unogona zvakare kunge uine urine cortisol bvunzo kana weti 17-ketosteroids bvunzo, iyo inosanganisira kuunganidza weti pamusoro peawa makumi maviri nemaviri-nguva.

Ungangoda kudzikamisa zviitiko uye udye zvekudya zvakakwirira muma makabhohaidhiretsi maawa gumi nemaviri kusvika makumi maviri nemaviri bvunzo isati yaitwa. Unogona kukumbirwa kuti utsanye kwemaawa matanhatu muyedzo usati waitwa. Dzimwe nguva, hapana gadziriro inokosha inodiwa. Iwe unogona kubvunzwa kumbomira kutora mishonga, senge hydrocortisone, iyo inogona kukanganisa iyo cortisol yeropa bvunzo.

Kana tsono ikaiswa kukweva ropa, vamwe vanhu vanonzwa kurwadziwa zvine mwero. Vamwe vanongonzwa kubaya kana kubaya. Mushure meizvozvo, panogona kuve nekurohwa kana kupwanya zvishoma. Izvi zvinokurumidza kuenda.

Iyo jekiseni mupfudzi inogona kukonzera kurwadziwa zvine mwero kana kuruma.

Vamwe vanhu vanonzwa kuputirwa, kutya, kana kusvotwa mushure mekubaiwa kweACTH.

Muedzo uyu unogona kubatsira kuona kuti adrenal uye pituitary gland ako akajairika. Iyo inowanzo shandiswa kana wako wekuchengeta hutano achifunga kuti une adrenal gland dambudziko, senge Addison chirwere kana pituitary kusakwana. Iyo zvakare inoshandiswa kuona kana yako pituitary uye adrenal glands apora kubva mukushandisa kwenguva refu kwemishonga yeglucocorticoid, senge prednisone.

Kuwedzera kwecortisol mushure mekusimudzira ne ACTH kunotarisirwa. Chikamu cheCortisol mushure mekusimudzirwa kweACTH chinofanira kunge chakakwirira kudarika 18 kusvika 20 mcg / dL kana 497 kusvika 552 nmol / L, zvinoenderana nedosi yeACTH yakashandiswa.

Zvakajairika kukosha masenduru anogona kusiyana zvishoma pakati pemarabhoritari akasiyana. Mamwe marabhoritari anoshandisa zviyero zvakasiyana kana anogona kuyedza mhando dzakasiyana. Taura nemupi wako nezve zvinorehwa nemimwe miedzo yako.

Bvunzo iyi inobatsira mukutsvaga kana iwe uine:

• Acute adrenal dambudziko (kutyisidzira hupenyu kunoitika kana pasina kukwana cortisol)
• Addison chirwere (adrenal gland haigadzi yakakwana cortisol)
• Hypopituitarism (pituitary gland haisi kuburitsa mahormone akakwana senge ACTH)

Pane njodzi shoma inosanganisirwa nekutorwa kweropa rako. Tsinga uye tsinga zvinosiyana muhukuru kubva kumunhu kuenda kune mumwe, uye kubva kune rimwe divi remuviri kuenda kune rimwe. Kutora ropa kubva kune vamwe vanhu kunogona kunge kwakaoma kupfuura kubva kune vamwe.

Dzimwe njodzi dzinosangana nekutorwa kweropa idiki, asi dzinogona kusanganisira:

• Kuwedzera kubuda ropa
• Kufenda kana kunzwa kushaya musoro
• Akawanda punctures ekutsvaga mutsinga
• Hematoma (ropa rinoungana pasi peganda)
• Utachiona (hushoma njodzi chero nguva ganda parinovhunika)

Kwayedza yeadrenal reserve; Cosyntropin kukurudzira bvunzo; Cortrosyn kukurudzira bvunzo; Synacthen kukurudzira bvunzo; Tetracosactide inosimudzira bvunzo

Barthel A, Willenberg HS, Gruber M, Bornstein SR. Adrenal kusakwana. Muna: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Vakuru uye Chiremba. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016: chits. 102.

Chernecky CC, Berger BJ. ACTH yekusimudzira bvunzo - kuongorora. Mune: Chernecky CC, Berger BJ, eds. Rabhoritari Kuyedza uye Maitiro Ekuongorora. 6th ed. St Louis, MO: Elsevier Saunders; 2013: 98.

Stewart PM, Newell-Mutengo JDC. Iyo adrenal cortex. Mune: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. Williams Chinyorwa cheEndocrinology. 13 ed. Philadelphia, PA: Elsevier; 2016: chits.